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All Outputs (917)

Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices (2021)
Journal Article
Christensen, M. G., Cawthorne, C., Dyer, C. E., Greenman, J., & Pamme, N. (2021). Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices. Microfluidics and Nanofluidics, 25(4), Article 35. https://doi.org/10.1007/s10404-021-02434-x

Microfluidic ‘organ-on-a-chip’ devices hold great potential for better mimicking the continuous flow microenvironment experienced by tissue and cells in vivo, thereby ensuring realistic transport of nutrients and elimination of waste products. Howeve... Read More about Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices.

An evaluation of inkjet printed amino acid fingerprint test targets for ninhydrin process monitoring − and some observations (2021)
Journal Article
Croxton, R., Kent, T., Littlewood, A., & Smith, M. (2021). An evaluation of inkjet printed amino acid fingerprint test targets for ninhydrin process monitoring − and some observations. Forensic Science International, 321, Article 110741. https://doi.org/10.1016/j.forsciint.2021.110741

Ninhydrin was implemented as the primary police method of developing latent fingermarks on paper, cardboard and some other porous surfaces from the late 1960s. Some researchers have used individual amino acids, or mixtures of amino acids, as a method... Read More about An evaluation of inkjet printed amino acid fingerprint test targets for ninhydrin process monitoring − and some observations.

Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells (2021)
Journal Article
Zaibi, N., Li, P., & Xu, S.-Z. (in press). Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells. PLoS ONE, 16(2), Article e0247234. https://doi.org/10.1371/journal.pone.0247234

Elevated reactive oxygen species (ROS) in type 2 diabetes cause cellular damage in many organs. Recently, the new class of glucose-lowering agents, SGLT-2 inhibitors, have been shown to reduce the risk of developing diabetic complications; however, t... Read More about Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells.

A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities (2021)
Journal Article
Vaughan, D., Mitchell, R., Kretz, O., Chambers, D., Lalowski, M., Amthor, H., Ritvos, O., Pasternack, A., Matsakas, A., Vaiyapuri, S., Huber, T. B., Denecke, B., Mukherjee, A., Widera, D., & Patel, K. (2021). A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities. Disease Models and Mechanisms, 14(2), Article dmm047555. https://doi.org/10.1242/dmm.047555

© 2021. Published by The Company of Biologists Ltd. Activin/myostatin signalling acts to induce skeletal muscle atrophy in adult mammals by inhibiting protein synthesis as well as promoting protein and organelle turnover. Numerous strategies have bee... Read More about A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities.

Human ex vivo wound model and whole-mount staining approach to accurately evaluate skin repair (2021)
Journal Article
Wilkinson, H. N., Kidd, A. S., Roberts, E. R., & Hardman, M. J. (2021). Human ex vivo wound model and whole-mount staining approach to accurately evaluate skin repair. Journal of visualized experiments : JoVE, 168, Article e62326. https://doi.org/10.3791/62326

© 2021 JoVE Creative Commons. Chronic non-healing wounds, which primarily affect the elderly and diabetic, are a significant area of clinical unmet need. Unfortunately, current chronic wound treatments are inadequate, while available pre-clinical mod... Read More about Human ex vivo wound model and whole-mount staining approach to accurately evaluate skin repair.

NIR-quantum dots in biomedical imaging and their future (2021)
Journal Article
Gil, H. M., Price, T. W., Chelani, K., Bouillard, J. S. G., Calaminus, S. D., & Stasiuk, G. J. (2021). NIR-quantum dots in biomedical imaging and their future. iScience, 24(3), Article 102189. https://doi.org/10.1016/j.isci.2021.102189

Fluorescence imaging has gathered interest over the recent years for its real-time response and high sensitivity. Developing probes for this modality has proven to be a challenge. Quantum dots (QDs) are colloidal nanoparticles that possess unique opt... Read More about NIR-quantum dots in biomedical imaging and their future.

Recent Advancements in Hematology: Knowledge, Methods and Dissemination, Part 2 (2021)
Journal Article
Corre, J., Sabbah, M., Schjesvold, F., Zeidan, A. M., Buccisano, F., Sallman, D., Mazzucato, M., Madden, L. A., Martini, M., Van Breda, E., Dolcetti, R., Busca, A., Cook, G., Onida, F., Versari, A., Kiladjian, J. J., Walter, R. B., Garderet, L., Robin, M., & Signore, A. (2021). Recent Advancements in Hematology: Knowledge, Methods and Dissemination, Part 2. Hemato, 2(1), 79-88. https://doi.org/10.3390/hemato2010004

Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation (2021)
Journal Article
Bolanle, I. O., Riches-Suman, K., Loubani, M., Williamson, R., & Palmer, T. M. (2021). Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation. Nutrition, metabolism, and cardiovascular diseases : NMCD, https://doi.org/10.1016/j.numecd.2021.01.017

Background and Aim: Coronary artery bypass graft (CABG) using autologous saphenous vein continues to be a gold standard procedure to restore the supply of oxygen-rich blood to the heart muscles in coronary artery disease (CAD) patients with or with... Read More about Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation.

Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia (2021)
Journal Article
Lin, W. Y., Fordham, S. E., Sunter, N., Elstob, C., Rahman, T., Willmore, E., Shepherd, C., Strathdee, G., Mainou-Fowler, T., Piddock, R., Mearns, H., Barrow, T., Houlston, R. S., Marr, H., Wallis, J., Summerfield, G., Marshall, S., Pettitt, A., Pepper, C., Fegan, C., …Allan, J. M. (2021). Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia. Nature communications, 12(1), Article 665. https://doi.org/10.1038/s41467-020-20822-9

© 2021, The Author(s). Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognost... Read More about Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.

Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles (2021)
Journal Article
Baghdadi, N. E., Burke, B. P., Alresheedi, T., Nigam, S., Saeed, A., Almutairi, F., Domarkas, J., Khan, A., & Archibald, S. J. (2021). Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles. Dalton Transactions : an international journal of inorganic chemistry, 50(5), 1599-1603. https://doi.org/10.1039/d0dt02626c

The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagon... Read More about Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles.

Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia (2021)
Journal Article
Barlow, J., Sfyri, P. P., Mitchell, R., Verpoorten, S., Scully, D., Andreou, C., Papadopoulos, P., Patel, K., & Matsakas, A. (2021). Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia. Experimental Physiology, 106(3), 700-713. https://doi.org/10.1113/ep088937

Muscle satellite cells are important stem cells for skeletal muscle regeneration and repair after injury. ApoE‐deficient mice, an established mouse model of hyperlipidaemia and atherosclerosis, show evidence of oxidative stress‐induced lesions and fa... Read More about Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia.

PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma (2021)
Journal Article
Edge, S. D., Renard, I., Pyne, E., Li, C., Moody, H., Roy, R., Beavis, A. W., Archibald, S. J., Cawthorne, C. J., Maher, S. J., & Pires, I. M. (2021). PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma. British Journal of Radiology, 94(1119), Article 20201191. https://doi.org/10.1259/bjr.20201191

OBJECTIVE: Neoadjuvant chemoradiotherapy (neo-CRT) prior to surgery is the standard of care for oesophageal adenocarcinoma (OAC) patients. Unfortunately, most patients fail to respond to treatment. MiR-187 was previously shown to be downregulated in... Read More about PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma.

Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function (2021)
Journal Article
Huang, J., Peng, J., Pearson, J. A., Efthimiou, G., Hu, Y., Tai, N., Xing, Y., Zhang, L., Gu, J., Jiang, J., Zhao, H., Zhou, Z., Wong, F. S., & Wen, L. (2021). Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular and Molecular Immunology, 18(2), 328-338. https://doi.org/10.1038/s41423-020-00590-8

Innate immunity mediated by Toll-like receptors (TLRs), which can recognize pathogen molecular patterns, plays a critical role in type 1 diabetes development. TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and ho... Read More about Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function.

Arginine methylation: the promise of a ‘silver bullet’ for brain tumours? (2021)
Journal Article
Samuel, S. F., Barry, A., Greenman, J., & Beltran-Alvarez, P. (2021). Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?. Amino acids, 53(4), 489-506. https://doi.org/10.1007/s00726-020-02937-x

Despite intense research efforts, our pharmaceutical repertoire against high-grade brain tumours has not been able to increase patient survival for a decade and life expectancy remains at less than 16months after diagnosis, on average. Inhibitors of... Read More about Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?.

Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model (2020)
Journal Article
Wilkinson, H. N., Longhorne, F. L., Roberts, E. R., Brownhill, V. R., & Hardman, M. J. (in press). Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model. Wound Repair and Regeneration, https://doi.org/10.1111/wrr.12888

Negative pressure wound therapy is a widely used treatment for chronic, nonhealing wounds. Surprisingly, few studies have systematically evaluated the cellular and molecular effects of negative pressure treatment on human skin. In addition, no study... Read More about Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model.

Association Between Breastfeeding and the Development of Childhood Diabetes Mellitus Type I (DM I): The Effect of Prolonged Exclusive Breastfeeding on Gut Microbiome and the Link with DM I (2020)
Journal Article
Karagkouni, I., Sideridou, M., Stoupi, S., & Efthimiou, G. (2021). Association Between Breastfeeding and the Development of Childhood Diabetes Mellitus Type I (DM I): The Effect of Prolonged Exclusive Breastfeeding on Gut Microbiome and the Link with DM I. Acta scientific paediatrics, 4(1), 28-32

The role of breastfeeding and dietary habits was studied in 10 children with DM I (case group) and compared with 10 healthy controls. Our results showed that the case group had significantly shorter exclusive breastfeeding duration compared with the... Read More about Association Between Breastfeeding and the Development of Childhood Diabetes Mellitus Type I (DM I): The Effect of Prolonged Exclusive Breastfeeding on Gut Microbiome and the Link with DM I.