All Outputs (41)

Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis (2016)
Journal Article
Faruqi, S., Shiferaw, D., & Morice, A. H. (2016). Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis. Open Respiratory Medicine Journal, 10, 105-108. https://doi.org/10.2174/1874306401610010105

© Faruqi et al. Background and Objectives: Cough is a major symptom in cystic fibrosis. Ivacaftor is a novel drug which targets the G551D mutation and has been demonstrated to improve lung function and weight in the long term. It also improves sympto... Read More about Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis.

Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials (2016)
Journal Article
McGarvey, L., Morice, A. H., Smith, J. A., Birring, S. S., Chuecos, F., Seoane, B., & Jarreta, D. (2016). Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials. BMJ Open Respiratory Research, 3(1), Article e000148. https://doi.org/10.1136/bmjresp-2016-000148

© 2016, BMJ Publishing Group. All rights reserved. Background: Cough and sputum are troublesome symptoms in chronic obstructive pulmonary disease (COPD) and are associated with adverse outcomes. The efficacy of aclidinium bromide 400 μg twice daily i... Read More about Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials.

Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis (2016)
Journal Article
Fraser, S. D., Sadofsky, L. R., Kaye, P. M., & Hart, S. P. (2016). Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis. Scientific reports, 6(1), Article ARTN 38689. https://doi.org/10.1038/srep38689

In sarcoidosis, the proinflammatory cytokines interferon gamma, tumour necrosis factor and interleukin-6 are released by monocyte-derived macrophages and lymphocytes in the lungs and other affected tissues. Regulatory receptors expressed on monocytes... Read More about Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis.

Characterisation of duramycin as an anti-cancer agent (2016)
Thesis
Broughton, L. J. Characterisation of duramycin as an anti-cancer agent. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4219417

Duramycin is a relatively small (~2kDa) tetracyclic peptide that has a defined three-dimensional (3D) structure, this structure forms a stable binding pocket which specifically recognises the plasma membrane phospholipid phosphatidylethanolamine (PE)... Read More about Characterisation of duramycin as an anti-cancer agent.

Surgical options for management of malignant pleural mesothelioma in the current era (2016)
Journal Article
Loubani, M., Qadri, S. S., Hussain, A., Chaudhry, M. A., & Kastelik, J. A. (2016). Surgical options for management of malignant pleural mesothelioma in the current era. Current Respiratory Medicine Reviews, 12(4), 286-293. https://doi.org/10.2174/1573398X13666161230162248

© 2016 Bentham Science Publishers. Malignant pleural mesothelioma is an asbestos-linked cancer associated with a very poor prognosis. Surgical interventions form an important aspect of the management of this aggressive form of cancer. However, debate... Read More about Surgical options for management of malignant pleural mesothelioma in the current era.

EGFR and related therapeutic targets in malignant pleural mesothelioma (2016)
Thesis
Oguh, L. I. EGFR and related therapeutic targets in malignant pleural mesothelioma. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4221787

Introduction
Malignant pleural mesothelioma (MPM) is a rare but aggressive disease and the current first line treatment is associated with a survival rate of 40%. There is currently no second line therapy. This study aimed to explore the expression... Read More about EGFR and related therapeutic targets in malignant pleural mesothelioma.

Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study (2016)
Journal Article
Sathyapalan, T., Rigby, A. S., Bhasin, S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study. Journal of Clinical Endocrinology and Metabolism, 102(2), 425-433. https://doi.org/10.1210/jc.2016-2875

Context: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to h... Read More about Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study.

Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin (2016)
Journal Article
Williamson, J. D., Sadofsky, L. R., Crooks, M. G., Greenman, J., & Hart, S. P. (2016). Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin. Experimental Lung Research, 42(8-10), 397-407. https://doi.org/10.1080/01902148.2016.1243742

© 2016 Taylor & Francis. Aim of the Study: Bleomycin-induced lung disease is a serious complication of therapy characterized by alveolar injury, cytokine release, inflammatory cell recruitment, and eventually pulmonary fibrosis. The mechanisms unde... Read More about Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin.

Determination of deoxynivalenol in the urine of pregnant women in the UK (2016)
Journal Article
Rigby, A., Sathyapalan, T., Wells, L., Atkin, S., Brera, C., De Santis, B., Debegnach, F., Greetham, S., Hardie, L., Liu, Y., Moretti, G., White, K., & Williams, C. (2016). Determination of deoxynivalenol in the urine of pregnant women in the UK. Toxins, 8(11), 306. https://doi.org/10.3390/toxins8110306

Deoxynivalenol (DON) is one of the most commonly occurring trichothecenes, produced mainly by Fusarium graminearum. Little is known about the effect of DON exposure or the levels of DON exposure that occur during pregnancy. The project aimed to provi... Read More about Determination of deoxynivalenol in the urine of pregnant women in the UK.

A systematic review of management of inadvertent arterial injury during central venous catheterisation (2016)
Journal Article
Dixon, O. G. B., Smith, G. E., Carradice, D., & Chetter, I. C. (2017). A systematic review of management of inadvertent arterial injury during central venous catheterisation. The journal of vascular access, 18(2), 97-102. https://doi.org/10.5301/jva.5000611

© 2017 Wichtig Publishing. Introduction: Central venous catheterisation (CVC) is a technique commonly used to obtain vascular access and over five million CVCs are inserted annually. This systematic review of CVC-related arterial injury aims to compa... Read More about A systematic review of management of inadvertent arterial injury during central venous catheterisation.

The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise (2016)
Journal Article
O’Doherty, A. F., Sathyapalan, T., Rigby, A. S., Ingle, L., & Carroll, S. (2018). The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise. European Journal of Nutrition, 57(1), 309-318. https://doi.org/10.1007/s00394-016-1320-z

© 2016 The Author(s) Purpose: The Oral Fat Tolerance Test (OFTT) is regarded as a repeatable measure used to assess postprandial triglyceride (TAG) levels, with higher levels observed in cardio-metabolic disorders. Acute aerobic exercise intervention... Read More about The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise.

Modelling aspects of oviduct fluid formation in vitro (2016)
Journal Article
Simintiras, C. A., Arnold, G. J., Ulbrich, S. E., Leese, H. J., Sturmey, R. G., Froehlich, T., Leese, H., Sathyapalan, T., Sturmey, R., Arnold, G., Fröhlich, T., & Ulbrich, S. (2017). Modelling aspects of oviduct fluid formation in vitro. Reproduction, 153(1), 23-33. https://doi.org/10.1530/REP-15-0508

© 2017 Society for Reproduction and Fertility. Oviduct fluid is the microenvironment that supports early reproductive processes including fertilisation, embryo cleavage and genome activation. However, the composition and regulation of this critical e... Read More about Modelling aspects of oviduct fluid formation in vitro.

Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome (2016)
Journal Article
Javed, Z., Sathyapalan, T., Atkin, S. L., Coady, A.-M., & Kilpatrick, E. S. (2017). Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome. Clinical Endocrinology, 86(3), 384-387. https://doi.org/10.1111/cen.13239

© 2016 John Wiley & Sons Ltd Context: Animal studies suggest that cannabinoid receptor-1 (CB-1) blockade reduces inflammation and neovascularization by decreasing vascular endothelial growth factor (VEGF) levels associated with a reduction in infla... Read More about Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome.

TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione (2016)
Journal Article
Morice, A. H., Sadofsky, L. R., Benemei, S., Coppi, E., De Logu, F., Di Tommaso, M., Fusi, C., Geppetti, P., Li Puma, S., Marone, I. M., Materazzi, S., Moneti, G., Nassini, R., Susini, T., Terreni, A., & Tonello, R. (2016). TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione. Cancer Research, 76(23), 7024-7035. https://doi.org/10.1158/0008-5472.CAN-16-1492

Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of p... Read More about TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione.

Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review (2016)
Journal Article
Song, W.-J., Won, H.-K., Moon, S.-D., Chung, S.-J., Kang, S.-Y., Sohn, K.-H., Kim, J.-Y., Kim, B.-K., Lim, K.-H., Kim, M.-Y., Yang, M.-S., Park, H.-W., Chang, Y.-S., Lee, B.-J., Morice, A. H., & Cho, S.-H. (2017). Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review. The journal of allergy and clinical immunology. In practice, 5(1), 135-143.e1. https://doi.org/10.1016/j.jaip.2016.07.017

© 2016 Background Fractional exhaled nitric oxide (FENO) is a safe and convenient test for assessing T H 2 airway inflammation, which is potentially useful in the management of patients with chronic cough. Objective To summarize the current evidence... Read More about Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review.

Developing a novel in vitro preparation to study the mechanisms underlying oviduct fluid formation in health and disease (2016)
Thesis
Simintiras, C. A. Developing a novel in vitro preparation to study the mechanisms underlying oviduct fluid formation in health and disease. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4223616

Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial (2016)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial. Journal of Bone and Mineral Research, 32(1), 157-164. https://doi.org/10.1002/jbmr.2927

Menopausal estrogen loss leads to an increased bone loss. Soy isoflavones can act as selective estrogen receptor modulators, their role in bone turnover is unclear. The primary outcome was assessing changes in plasma bone turnover markers. The second... Read More about Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial.

Duramycin-porphyrin conjugates for targeting of tumour cells using photodynamic therapy (2016)
Journal Article
Broughton, L. J., Giuntini, F., Savoie, H., Bryden, F., Boyle, R. W., Maraveyas, A., & Madden, L. A. (2016). Duramycin-porphyrin conjugates for targeting of tumour cells using photodynamic therapy. Journal of photochemistry and photobiology. B, Biology, 163, 374-384. https://doi.org/10.1016/j.jphotobiol.2016.09.001

Duramycin, through binding with phosphatidylethanolamine (PE), has been shown to be a selective molecular probe for the targeting and imaging of cancer cells. Photodynamic therapy aims to bring about specific cytotoxic damage to tumours through deliv... Read More about Duramycin-porphyrin conjugates for targeting of tumour cells using photodynamic therapy.

Oligoubiquitination of tissue factor on Lys255 promotes Ser253-dephosphorylation and terminates TF release (2016)
Journal Article
Ettelaie, C., Collier, M. E., Featherby, S., Greenman, J., & Maraveyas, A. (2016). Oligoubiquitination of tissue factor on Lys255 promotes Ser253-dephosphorylation and terminates TF release. BBA - Molecular Cell Research, 1863(11), 2846-2857. https://doi.org/10.1016/j.bbamcr.2016.09.005

Restriction of tissue factor (TF) activity at the cell surface and TF release are critical for prevention of excessive coagulation. This study examined the regulation of TF dephosphorylation and its release through ubiquitination. A plasmid containin... Read More about Oligoubiquitination of tissue factor on Lys255 promotes Ser253-dephosphorylation and terminates TF release.

Pilot investigation of a virtual gastric band hypnotherapy intervention (2016)
Journal Article
Greetham, S., Goodwin, S., Wells, L., Whitham, C., Jones, H., Rigby, A., Sathyapalan, T., Reid, M., & Atkin, S. (2016). Pilot investigation of a virtual gastric band hypnotherapy intervention. International Journal of Clinical and Experimental Hypnosis, 64(4), 419-433. https://doi.org/10.1080/00207144.2016.1209037

This was a pilot investigation of 30 men and women with a BMI > 27kg/m² over a 24 week period. It aimed to determine whether virtual gastric band (VGB) hypnotherapy has an effect on weight loss in overweight adults, compared to relaxation hypnotherap... Read More about Pilot investigation of a virtual gastric band hypnotherapy intervention.