All Outputs (789)

Procedure-based assessments: an evaluation of their role in reflective learning (2012)
Journal Article
Green, L., & Chetter, I. (2012). Procedure-based assessments: an evaluation of their role in reflective learning. Bulletin of the Royal College of Surgeons of England, 94(1), 28-30. https://doi.org/10.1308/147363512x13189526437838

Procedure-based assessment (PBA) has, together with other common workplace assessments, become the cornerstone of a surgical trainee's evaluation process, the annual review of competency progression.

Saphenopopliteal ligation and stripping of small saphenous vein: does extended stripping provide better results? (2012)
Journal Article
Samuel, N., Carradice, D., Wallace, T., Smith, G. E., Mazari, F. A. K., & Chetter, I. (2012). Saphenopopliteal ligation and stripping of small saphenous vein: does extended stripping provide better results?. Phlebology, 27(8), 390-397. https://doi.org/10.1258/phleb.2011.011063

Objective Saphenopopliteal ligation (SPL) for venous insufficiency is a challenging procedure, with mixed results being reported. The role of stripping of the small saphenous vein (SSV) is contentious. This prospective observational study aimed to as... Read More about Saphenopopliteal ligation and stripping of small saphenous vein: does extended stripping provide better results?.

Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts (2012)
Journal Article
Sadofsky, L. R., Ramachandran, R., Crow, C., Cowen, M., Compton, S. J., & Morice, A. H. (2012). Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts. Experimental Lung Research, 38(2), 75-81. https://doi.org/10.3109/01902148.2011.644027

Lung fibroblasts are involved in interstitial lung disease, chronic asthma, and chronic obstructive pulmonary disease (COPD). The expanded fibroblast population in airway disease leads to airway remodeling and contributes to the inflammatory process... Read More about Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts.

The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms (2012)
Journal Article
Kahal, H., Aye, M., Rigby, A. S., Sathyapalan, T., England, R. J. A., & Atkin, S. L. (2012). The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms. Clinical Endocrinology, 76(2), 196-200. https://doi.org/10.1111/j.1365-2265.2011.04197.x

Background With increased biochemical screening, primary hyperparathyroidism (pHPT) is often discovered incidentally whilst patients are asymptomatic. Objective To assess the impact of parathyroidectomy on neuropsychological symptoms and biochemical... Read More about The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms.

Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate (2011)
Journal Article
Morice, A. H., McGarvey, L. P., & Dicpinigaitis, P. V. (2012). Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate. Lung, 190(1), 3-9. https://doi.org/10.1007/s00408-011-9351-y

The major etiologies of chronic cough are generally accepted to consist of upper airway cough syndrome (formerly postnasal drip syndrome), eosinophilic airway inflammation (asthma, nonasthmatic eosinophilic bronchitis), and gastroesophageal reflux di... Read More about Cough hypersensitivity syndrome is an important clinical concept: A pro/con debate.

Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials (2011)
Journal Article
Shahin, Y., Khan, J. A., & Chetter, I. (2012). Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials. Atherosclerosis, 221(1), 18-33. https://doi.org/10.1016/j.atherosclerosis.2011.12.005

ObjectiveSeveral studies have assessed the effect of angiotensin converting enzyme inhibitors (ACEIs) on arterial stiffness and wave reflections as measured by pulse wave velocity (PWV) and augmentation index (AIx), respectively. We conducted a meta-... Read More about Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials.

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. https://doi.org/10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.

Bronchoconstriction and airway remodeling [2] (2011)
Journal Article
Morjaria, J., Hart, S., & Morice, A. H. (2011). Bronchoconstriction and airway remodeling [2]. New England Journal of Medicine, 365(12), 1156-1157. https://doi.org/10.1056/NEJMc1107353

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis (2011)
Journal Article
Botham, A., Guo, X., Xiao, Y. P., Morice, A. H., Compton, S., & Sadofsky, L. R. (2011). Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal, 438(2), 359-367. https://doi.org/10.1042/BJ20101958

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation o... Read More about Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.

Differential proteomics in the search for biomarkers of radiotherapy resistance (2011)
Journal Article
Scaife, L., Hodgkinson, V. C., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Differential proteomics in the search for biomarkers of radiotherapy resistance. Expert Review of Proteomics, 8(4), 535-552. https://doi.org/10.1586/EPR.11.32

The individualization of radiotherapy treatment would be beneficial for cancer patients; however, there are no predictive biomarkers of radiotherapy resistance in routine clinical use. This article describes the body of work in this field where compa... Read More about Differential proteomics in the search for biomarkers of radiotherapy resistance.

Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study (2011)
Journal Article
Hatfield, J., Carradice, D., Mazari, F. A. K., Josie, H., Samuel, N., Chetter, I., & Wallace, T. (2012). Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study. Phlebology, 27(3), 128-134. https://doi.org/10.1258/phleb.2011.011014

ObjectiveMany venous trials mix patients with great saphenous vein (GSV) and small saphenous vein (SSV) diseases. There is no evidence that both respond similarly to treatment and our aim was to test this assumption.Method This cohort study compares... Read More about Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study.

Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey (2011)
Journal Article
Khan, J. A., Mazari, F. A., Abdul Rahman, M., Mockford, K., Chetter, I. C., & McCollum, P. T. (2011). Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey. Annals of vascular surgery, 25(7), 878-886. https://doi.org/10.1016/j.avsg.2011.05.013

BackgroundTo evaluate patients' awareness, functional outcome, and satisfaction after abdominal aortic aneurysm (AAA) repair.MethodsA study-specific questionnaire was developed with collaboration of a multidisciplinary team. Lists of patients who und... Read More about Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey.

Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough (2011)
Journal Article
Pacheco, A., Faro, V., Cobeta, I., Royuela, A., Molyneux, I., & Morice, A. H. (2011). Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough. Respirology : official journal of the Asian Pacific Society of Respirology, 16(6), 994-999. https://doi.org/10.1111/j.1440-1843.2011.02010.x

Background and objective: Patients with eosinophilic airway inflammation (EAI) often show a therapeutic response to corticosteroids. Non-invasive methods of diagnosing EAI are potentially useful in guiding therapy, particularly in conditions such as... Read More about Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough.

Effect of bitter tastants on human bronchi (2011)
Journal Article
Morice, A. H., Bennett, R. T., Chaudhry, M. A., Cowen, M. E., Griffin, S. C., & Loubani, M. (2011). Effect of bitter tastants on human bronchi. Nature Medicine, 17(7), 775. https://doi.org/10.1038/nm0711-775

Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic (2011)
Journal Article
Smith, G. E., Samuel, N., Khan, J., Johnson, B. F., & Chetter, I. C. (2011). Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic. Annals of vascular surgery, 25(8), 1099-1103. https://doi.org/10.1016/j.avsg.2011.02.043

BackgroundMany duplex detectable factors have been shown to correlate with upper limb arteriovenous fistula (AVF) outcomes, and many practitioners now request preoperative duplex vessel mapping routinely before AVF surgery. We report outcomes from a... Read More about Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic.

Serum LDH in chronic cough: A potential marker of airway inflammation (2011)
Journal Article
Faruqi, S., Wilmot, R., Wright, C., & Morice, A. H. (2012). Serum LDH in chronic cough: A potential marker of airway inflammation. Clinical Respiratory Journal, 6(2), 81-87. https://doi.org/10.1111/j.1752-699X.2011.00250.x

Introduction and Objectives: Lactate dehydrogenase (LDH) is found in almost all tissues of the body and five different isoenzymes are known (LDH-1 to LDH-5). LDH can be elevated in many pathological conditions. We have observed serum LDH to be increa... Read More about Serum LDH in chronic cough: A potential marker of airway inflammation.

Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins (2011)
Journal Article
Carradice, D., Mekako, A. I., Mazari, F. A. K., Samuel, N., Hatfield, J., & Chetter, I. C. (2011). Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. British journal of surgery, 98(8), 1117-1123. https://doi.org/10.1002/bjs.7615

Background:This report describes the clinical effectiveness and recurrence rates from a randomized trial of endovenous laser ablation (EVLA) and surgery for varicose veins.Methods:Some 280 patients were randomized equally using sealed opaque envelope... Read More about Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins.

Does anaerobic threshold in cardiopulmonary exercise testing predicts outcome in patients undergoing abdominal aortic aneurysm (AAA) repair? (2011)
Presentation / Conference Contribution
Mazari, F., Khan, J., McCollum, P., Gohil, R., & Chetter, I. Does anaerobic threshold in cardiopulmonary exercise testing predicts outcome in patients undergoing abdominal aortic aneurysm (AAA) repair?

The relationship between serum levels of C-reactive protein and the Framingham coronary risk score in patients newly diagnosed with intermittent claudication (2011)
Presentation / Conference Contribution
Shahin, Y., Hatfield, J., & Chetter, I. C. The relationship between serum levels of C-reactive protein and the Framingham coronary risk score in patients newly diagnosed with intermittent claudication

Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation (2011)
Journal Article
Samuel, N., Wallace, T., Smith, G. E., Shahin, Y., & Chetter, I. C. (2011). Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation. Ultrasound, 19(2), 97-98. https://doi.org/10.1258/ult.2011.011006

Duplex ultrasound imaging plays a key role in the increasingly popular, minimally invasive endothermal treatment of varicose veins. Accurate placement of the echodense tip of endovenous catheter distal to the site of junctional incompetence is by far... Read More about Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation.