All Outputs (209)

Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy (2025)
Journal Article
Mohamed, E., Goodman, S., Cooksey, L., Fletcher, D. M., Dean, O., Boncheva, V. B., Mills, K. I., Orchard, K. H., & Guinn, B.-A. (2025). Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy. Onco, 5(2), Article 19. https://doi.org/10.3390/onco5020019

Background: Adult B-cell acute lymphoblastic leukaemia (aB-ALL) is charac-terised by abnormal differentiation and proliferation of lymphoid progenitors. Despite a significant improvement in relapse-free and overall survival for children with BALL , a... Read More about Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy.

Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes (2025)
Journal Article
Almeida, M. V., Blumer, M., Yuan, C. U., Sierra, P., Price, J. L., Quah, F. X., Friman, A., Dallaire, A., Vernaz, G., Putman, A. L., Smith, A. M., Joyce, D. A., Butter, F., Haase, A. D., Durbin, R., Santos, M. E., & Miska, E. A. (2025). Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes. Genome Biology, 26(1), Article 14. https://doi.org/10.1186/s13059-025-03475-z

BACKGROUND: East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of the phenotypic diversity of these fishes remains largely unknown. Although transposable elements (TEs) have been associated with phenotypi... Read More about Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes.

Airborne microplastic monitoring: developing a simplified outdoor sampling approach using pollen monitoring equipment (2024)
Journal Article
Chapman, E., Liddle, C. R., Williams, B., Hilmer, E., Quick, L. J., Garcia, A. G., Suárez, D. C., White, D., Bunting, M. J., Walker, P., Cabaneros, S. M. S., Kinnersley, R., Hansen, M. F., Atherall, C. A., & Rotchell, J. M. (2024). Airborne microplastic monitoring: developing a simplified outdoor sampling approach using pollen monitoring equipment. Journal of hazardous materials, 480, Article 136129. https://doi.org/10.1016/j.jhazmat.2024.136129

A novel, yet simple, airborne microplastic (MP) sampling approach using global pollen monitoring equipment was applied to identify, characterise and quantify outdoor airborne MPs for the first time. Modification of Burkard spore trap tape adhesive pr... Read More about Airborne microplastic monitoring: developing a simplified outdoor sampling approach using pollen monitoring equipment.

Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia (2024)
Journal Article
Greiner, J., Mohamed, E., Fletcher, D. M., Schuler, P. J., Schrezenmeier, H., Götz, M., & Guinn, B. A. (2024). Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia. Cancers, 16(20), Article 3443. https://doi.org/10.3390/cancers16203443

Acute myeloid leukemia (AML) is a malignant disease of the blood and bone marrow that is characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells. Nucleophosmin 1 (NPM1) gene mutations are the most common genetic abnorm... Read More about Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia.

The environmental dependence of the stellar mass-gas metallicity relation in Horizon Run 5 (2024)
Journal Article
Rowntree, A., Singh, A., Vincenzo, F., Gibson, B. K., Gouin, C., Galárrag a-Espinosa, D., Lee, J., Kim, J., Laigle, C., Park, C., Pichon, C., Few, G., Hong, S. E., & Kim, Y. (2024). The environmental dependence of the stellar mass-gas metallicity relation in Horizon Run 5. Monthly notices of the Royal Astronomical Society, 531(4), 3858-3875. https://doi.org/10.1093/mnras/stae1384

Metallicity offers a unique window into the baryonic history of the cosmos, being instrumental in probing evolutionary processes in galaxies between different cosmic environments. We aim to quantify the contribution of these environments to the scatt... Read More about The environmental dependence of the stellar mass-gas metallicity relation in Horizon Run 5.

Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer? (2024)
Journal Article
Mohamed, E., Fletcher, D., Hart, S., & Guinn, B.-A. (2024). Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer?. Onco, 4(2), 87-100. https://doi.org/10.3390/onco4020008

Lung cancer (LC) is one of the leading causes of cancer-related deaths. Pulmonary nodules are one of the risk factors and their discovery rate has been increasing due to enhanced performance of chest CT scans but more than 90% are non-malignant causi... Read More about Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer?.

Analysis-on-a-roll platforms towards automated and high frequency in-situ sensing of natural geochemical fluxes (2024)
Thesis
Iurkov, A. Analysis-on-a-roll platforms towards automated and high frequency in-situ sensing of natural geochemical fluxes. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4702966

In the context of the rapidly intensifying crisis of climate change, the intricate dynamics of Earth's ecosystems have assumed a paramount significance. The carbon cycle plays a significant role in the dynamics of the earth’s ecosystem, and anthropog... Read More about Analysis-on-a-roll platforms towards automated and high frequency in-situ sensing of natural geochemical fluxes.

Identification of tumour anitgens that may facilitate effective cancer detection and treatment (2024)
Thesis
Mohamed, E. Identification of tumour anitgens that may facilitate effective cancer detection and treatment. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4866442

Tumour antigens (TAs) play a crucial role in terms of cancer diagnosis and targets for therapy. As TAs are normally expressed in restricted tissues such as testis, sensitivity and specificity may not be ideal, but they could still represent good biom... Read More about Identification of tumour anitgens that may facilitate effective cancer detection and treatment.

Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis (2023)
Journal Article
Mohamed, E., García Martínez, D. J., Hosseini, M. S., Yoong, S. Q., Fletcher, D., Hart, S., & Guinn, B. A. (2024). Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis. Carcinogenesis, 45(1-2), Article bgad091. https://doi.org/10.1093/carcin/bgad091

Lung cancer (LC) causes few symptoms in the earliest stages, leading to one of the highest mortality rates among cancers. Low-dose computerised tomography (LDCT) is used to screen high-risk individuals, reducing the mortality rate by 20%. However, LD... Read More about Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis.

Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens (2023)
Journal Article
Richardson, S., Mayes, W. M., Faetsch, S., Hetjens, H., Teuchies, J., Walker, P., Heitmann, K., Welham, K., Moore, D., Bervoets, L., Kay, P., Duffus, W., Smith, N., De Cooman, W., Elst, R., Ryken, E., Rotchell, J. M., & Heise, S. (2023). Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens. Science of the Total Environment, 891, Article 164280. https://doi.org/10.1016/j.scitotenv.2023.164280

Extended chemical analyses of fluvial sediments were undertaken to establish the key pollutant pressures and mixtures present across nine European Union inland waterways. A wide range of chemical components and physical parameters were investigated i... Read More about Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens.

Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system (2023)
Journal Article
Barry, A., Samuel, S. F., Hosni, I., Moursi, A., Feugere, L., Sennett, C. J., Deepak, S., Achawal, S., Rajaraman, C., Iles, A., Wollenberg Valero, K. C., Scott, I. S., Green, V., Stead, L. F., Greenman, J., Wade, M. A., & Beltran-Alvarez, P. (2023). Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system. Lab on a chip, 23(11), 2664-2682. https://doi.org/10.1039/d3lc00204g

Arginine methylation is a post-translational modification that consists of the transfer of one or two methyl (CH3) groups to arginine residues in proteins. Several types of arginine methylation occur, namely monomethylation, symmetric dimethylation a... Read More about Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system.

Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study (2023)
Journal Article
Rotchell, J. M., Jenner, L. C., Chapman, E., Bennett, R., Bolanle, I. O., Loubani, M., Sadofsky, L., & Palmer, T. (2023). Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study. PLoS ONE, 18(2), Article e0280594. https://doi.org/10.1371/journal.pone.0280594

Microplastics (MPs) are ubiquitous in the environment, in the human food chain, and have been recently detected in blood and lung tissues. To undertake a pilot analysis of MP contamination in human vein tissue samples with respect to their presence (... Read More about Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study.

A robust, flow-based, microfluidic device for siRNA-mediated gene knockdown in glioblastoma spheroids (2023)
Journal Article
Hosni, I., Iles, A., Greenman, J., & Wade, M. A. (2023). A robust, flow-based, microfluidic device for siRNA-mediated gene knockdown in glioblastoma spheroids. Innovation and Emerging Technologies, 10, Article 2340005. https://doi.org/10.1142/S2737599423400054

Glioblastoma (GBM) is a deadly disease with a poor prognosis, there is therefore a crucial need for novel therapeutic targets. Current preclinical models of GBM fail to predict clinical outcomes, thus, new translationally relevant models are urgently... Read More about A robust, flow-based, microfluidic device for siRNA-mediated gene knockdown in glioblastoma spheroids.

Empowering clean water whilst safeguarding water distribution pipeline integrity: Towards manganese- and iron-free lime hydrate for water treatment (2023)
Journal Article
Wadhawan, J. D., Kocsis, D., Meyer, C., Ward, R., Thompson, M., Prior, T. J., Kelly, S. M., & Lawrence, N. (2023). Empowering clean water whilst safeguarding water distribution pipeline integrity: Towards manganese- and iron-free lime hydrate for water treatment. Environmental Science: Water Research & Technology, https://doi.org/10.1039/d2ew00109h

Hydrated limes are amongst the most economically valuable alkalis used by the water industry for the treatment of potable water. They are typically manufactured from the thermal decomposition of high purity limestones. However, the latter contain bot... Read More about Empowering clean water whilst safeguarding water distribution pipeline integrity: Towards manganese- and iron-free lime hydrate for water treatment.

Electronic Structure and Optical Properties of Strained Type-II InAsxSb1-x/InAs Quantum Dots for Mid-Infrared Applications (2023)
Journal Article
Yeap, G. H., Rybchenko, S., Itskevich, I., Haywood, S., Carrington, P., & Krier, A. (2023). Electronic Structure and Optical Properties of Strained Type-II InAsxSb1-x/InAs Quantum Dots for Mid-Infrared Applications. Defect and Diffusion Forum, 425, 3-8. https://doi.org/10.4028/p-72o15p

InSb-based self-assembled quantum dots (SAQDs) are very promising for the mid-infrared (3-5 μm) optical range. We have analysed the electronic structure and optical properties of InAsxSb1- x/InAs dots. In this paper, we present the results of the mod... Read More about Electronic Structure and Optical Properties of Strained Type-II InAsxSb1-x/InAs Quantum Dots for Mid-Infrared Applications.

Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device (2022)
Journal Article
Jenner, L. C., Kureshi, R. R., White, D., Chapman, E., Sadofsky, L. R., & Rotchell, J. M. (2022). Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device. Atmosphere, 13(12), Article 2017. https://doi.org/10.3390/atmos13122017

Atmospheric microplastics (MPs) are a ubiquitous environmental contaminant of emerging concern. Sampling methods provide information relating to surface area concentration and MP characteristics, without direct comparison with routinely measured stan... Read More about Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device.

Developing and testing the ExerciseGuide UK website for people with lung cancer: reflections on the added value of patient and public involvement within a doctoral degree (2022)
Journal Article
Curry, J., Roberts, H., Smith, A., Riley, D., Pearson, M., & Forbes, C. C. (2022). Developing and testing the ExerciseGuide UK website for people with lung cancer: reflections on the added value of patient and public involvement within a doctoral degree. Research Involvement and Engagement, 8(1), Article 66. https://doi.org/10.1186/s40900-022-00395-1

Background: Lung cancer has one of the highest incidence and mortality rates worldwide. Physical activity can provide those diagnosed with lung cancer with several physical and psychological benefits. However, the examination of digitally delivered p... Read More about Developing and testing the ExerciseGuide UK website for people with lung cancer: reflections on the added value of patient and public involvement within a doctoral degree.

Fabrication of Stable Oleofoams with Sorbitan Ester Surfactants (2022)
Journal Article
Liu, Y., & Binks, B. P. (2022). Fabrication of Stable Oleofoams with Sorbitan Ester Surfactants. Langmuir : the ACS journal of surfaces and colloids, 38(48), 14779–14788. https://doi.org/10.1021/acs.langmuir.2c02413

Sorbitan esters have been extensively used as surfactants to stabilize emulsions in many fields. However, the preparation of an oleofoam with sorbitan ester alone has not been reported. Here, we apply a novel protocol to fabricate stable oleofoams of... Read More about Fabrication of Stable Oleofoams with Sorbitan Ester Surfactants.

Patient specific training: development of a CT-based mixed reality fibreoptic intubation simulator (2022)
Journal Article
Wright, D., Ma, X., Atkin, W., Wang, L., Fagan, M., & Wellbelove, Z. (2022). Patient specific training: development of a CT-based mixed reality fibreoptic intubation simulator. International Journal of Healthcare Simulation, 2(1), A86. https://doi.org/10.54531/QOJS8275

Fibreoptic intubation training has traditionally been performed using real fibreoptic scopes and manikins or improvised airway ‘boxes’, recently progressing to virtual reality training devices [1]. The latter are populated with computer generated ima... Read More about Patient specific training: development of a CT-based mixed reality fibreoptic intubation simulator.

Microplastics in the surgical environment (2022)
Journal Article
Field, D. T., Green, J. L., Bennett, R., Jenner, L. C., Sadofsky, L., Chapman, E., Loubani, M., & Rotchell, J. M. (2022). Microplastics in the surgical environment. Environment International, 170, Article 107630. https://doi.org/10.1016/j.envint.2022.107630

Atmospheric microplastics (MPs) have been consistently detected within indoor and outdoor air samples. Locations with high human activity are reported to have high MP levels. The aim was to quantify and characterise the MPs present within the surgica... Read More about Microplastics in the surgical environment.