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All Outputs (190)

Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia (2024)
Journal Article
Greiner, J., Mohamed, E., Fletcher, D. M., Schuler, P. J., Schrezenmeier, H., Götz, M., & Guinn, B. A. (2024). Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia. Cancers, 16(20), Article 3443. https://doi.org/10.3390/cancers16203443

Acute myeloid leukemia (AML) is a malignant disease of the blood and bone marrow that is characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells. Nucleophosmin 1 (NPM1) gene mutations are the most common genetic abnorm... Read More about Immunotherapeutic Potential of Mutated NPM1 for the Treatment of Acute Myeloid Leukemia.

The environmental dependence of the stellar mass-gas metallicity relation in Horizon Run 5 (2024)
Journal Article
Rowntree, A., Singh, A., Vincenzo, F., Gibson, B. K., Gouin, C., Galárrag a-Espinosa, D., Lee, J., Kim, J., Laigle, C., Park, C., Pichon, C., Few, G., Hong, S. E., & Kim, Y. (2024). The environmental dependence of the stellar mass-gas metallicity relation in Horizon Run 5. Monthly notices of the Royal Astronomical Society, 531(4), 3858-3875. https://doi.org/10.1093/mnras/stae1384

Metallicity offers a unique window into the baryonic history of the cosmos, being instrumental in probing evolutionary processes in galaxies between different cosmic environments. We aim to quantify the contribution of these environments to the scatt... Read More about The environmental dependence of the stellar mass-gas metallicity relation in Horizon Run 5.

Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer? (2024)
Journal Article
Mohamed, E., Fletcher, D., Hart, S., & Guinn, B.-A. (2024). Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer?. Onco, 4(2), 87-100. https://doi.org/10.3390/onco4020008

Lung cancer (LC) is one of the leading causes of cancer-related deaths. Pulmonary nodules are one of the risk factors and their discovery rate has been increasing due to enhanced performance of chest CT scans but more than 90% are non-malignant causi... Read More about Can tumour antigens act as biomarkers for the early detection of non-small cell lung cancer?.

Analysis-on-a-roll platforms towards automated and high frequency in-situ sensing of natural geochemical fluxes (2024)
Thesis
Iurkov, A. Analysis-on-a-roll platforms towards automated and high frequency in-situ sensing of natural geochemical fluxes. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4702966

In the context of the rapidly intensifying crisis of climate change, the intricate dynamics of Earth's ecosystems have assumed a paramount significance. The carbon cycle plays a significant role in the dynamics of the earth’s ecosystem, and anthropog... Read More about Analysis-on-a-roll platforms towards automated and high frequency in-situ sensing of natural geochemical fluxes.

Identification of tumour anitgens that may facilitate effective cancer detection and treatment (2024)
Thesis
Mohamed, E. Identification of tumour anitgens that may facilitate effective cancer detection and treatment. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4866442

Tumour antigens (TAs) play a crucial role in terms of cancer diagnosis and targets for therapy. As TAs are normally expressed in restricted tissues such as testis, sensitivity and specificity may not be ideal, but they could still represent good biom... Read More about Identification of tumour anitgens that may facilitate effective cancer detection and treatment.

Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis (2023)
Journal Article
Mohamed, E., García Martínez, D. J., Hosseini, M. S., Yoong, S. Q., Fletcher, D., Hart, S., & Guinn, B. A. (2024). Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis. Carcinogenesis, 45(1-2), Article bgad091. https://doi.org/10.1093/carcin/bgad091

Lung cancer (LC) causes few symptoms in the earliest stages, leading to one of the highest mortality rates among cancers. Low-dose computerised tomography (LDCT) is used to screen high-risk individuals, reducing the mortality rate by 20%. However, LD... Read More about Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis.

Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens (2023)
Journal Article
Richardson, S., Mayes, W. M., Faetsch, S., Hetjens, H., Teuchies, J., Walker, P., Heitmann, K., Welham, K., Moore, D., Bervoets, L., Kay, P., Duffus, W., Smith, N., De Cooman, W., Elst, R., Ryken, E., Rotchell, J. M., & Heise, S. (2023). Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens. Science of the Total Environment, 891, Article 164280. https://doi.org/10.1016/j.scitotenv.2023.164280

Extended chemical analyses of fluvial sediments were undertaken to establish the key pollutant pressures and mixtures present across nine European Union inland waterways. A wide range of chemical components and physical parameters were investigated i... Read More about Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens.

Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system (2023)
Journal Article
Barry, A., Samuel, S. F., Hosni, I., Moursi, A., Feugere, L., Sennett, C. J., Deepak, S., Achawal, S., Rajaraman, C., Iles, A., Wollenberg Valero, K. C., Scott, I. S., Green, V., Stead, L. F., Greenman, J., Wade, M. A., & Beltran-Alvarez, P. (2023). Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system. Lab on a chip, 23(11), 2664-2682. https://doi.org/10.1039/d3lc00204g

Arginine methylation is a post-translational modification that consists of the transfer of one or two methyl (CH3) groups to arginine residues in proteins. Several types of arginine methylation occur, namely monomethylation, symmetric dimethylation a... Read More about Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system.

Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study (2023)
Journal Article
Rotchell, J. M., Jenner, L. C., Chapman, E., Bennett, R., Bolanle, I. O., Loubani, M., Sadofsky, L., & Palmer, T. (2023). Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study. PLoS ONE, 18(2), Article e0280594. https://doi.org/10.1371/journal.pone.0280594

Microplastics (MPs) are ubiquitous in the environment, in the human food chain, and have been recently detected in blood and lung tissues. To undertake a pilot analysis of MP contamination in human vein tissue samples with respect to their presence (... Read More about Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study.

Empowering clean water whilst safeguarding water distribution pipeline integrity: Towards manganese- and iron-free lime hydrate for water treatment (2023)
Journal Article
Wadhawan, J. D., Kocsis, D., Meyer, C., Ward, R., Thompson, M., Prior, T. J., Kelly, S. M., & Lawrence, N. (2023). Empowering clean water whilst safeguarding water distribution pipeline integrity: Towards manganese- and iron-free lime hydrate for water treatment. Environmental Science: Water Research & Technology, https://doi.org/10.1039/d2ew00109h

Hydrated limes are amongst the most economically valuable alkalis used by the water industry for the treatment of potable water. They are typically manufactured from the thermal decomposition of high purity limestones. However, the latter contain bot... Read More about Empowering clean water whilst safeguarding water distribution pipeline integrity: Towards manganese- and iron-free lime hydrate for water treatment.

Electronic Structure and Optical Properties of Strained Type-II InAsxSb1-x/InAs Quantum Dots for Mid-Infrared Applications (2023)
Journal Article
Yeap, G. H., Rybchenko, S., Itskevich, I., Haywood, S., Carrington, P., & Krier, A. (2023). Electronic Structure and Optical Properties of Strained Type-II InAsxSb1-x/InAs Quantum Dots for Mid-Infrared Applications. Defect and Diffusion Forum, 425, 3-8. https://doi.org/10.4028/p-72o15p

InSb-based self-assembled quantum dots (SAQDs) are very promising for the mid-infrared (3-5 μm) optical range. We have analysed the electronic structure and optical properties of InAsxSb1- x/InAs dots. In this paper, we present the results of the mod... Read More about Electronic Structure and Optical Properties of Strained Type-II InAsxSb1-x/InAs Quantum Dots for Mid-Infrared Applications.

Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device (2022)
Journal Article
Jenner, L. C., Kureshi, R. R., White, D., Chapman, E., Sadofsky, L. R., & Rotchell, J. M. (2022). Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device. Atmosphere, 13(12), Article 2017. https://doi.org/10.3390/atmos13122017

Atmospheric microplastics (MPs) are a ubiquitous environmental contaminant of emerging concern. Sampling methods provide information relating to surface area concentration and MP characteristics, without direct comparison with routinely measured stan... Read More about Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device.

Developing and testing the ExerciseGuide UK website for people with lung cancer: reflections on the added value of patient and public involvement within a doctoral degree (2022)
Journal Article
Curry, J., Roberts, H., Smith, A., Riley, D., Pearson, M., & Forbes, C. C. (2022). Developing and testing the ExerciseGuide UK website for people with lung cancer: reflections on the added value of patient and public involvement within a doctoral degree. Research Involvement and Engagement, 8(1), Article 66. https://doi.org/10.1186/s40900-022-00395-1

Background: Lung cancer has one of the highest incidence and mortality rates worldwide. Physical activity can provide those diagnosed with lung cancer with several physical and psychological benefits. However, the examination of digitally delivered p... Read More about Developing and testing the ExerciseGuide UK website for people with lung cancer: reflections on the added value of patient and public involvement within a doctoral degree.

Microplastics in the surgical environment (2022)
Journal Article
Field, D. T., Green, J. L., Bennett, R., Jenner, L. C., Sadofsky, L., Chapman, E., Loubani, M., & Rotchell, J. M. (2022). Microplastics in the surgical environment. Environment International, 170, Article 107630. https://doi.org/10.1016/j.envint.2022.107630

Atmospheric microplastics (MPs) have been consistently detected within indoor and outdoor air samples. Locations with high human activity are reported to have high MP levels. The aim was to quantify and characterise the MPs present within the surgica... Read More about Microplastics in the surgical environment.

Two closely related ureotelic fish species of the genus Alcolapia express different levels of ammonium transporters in gills (2022)
Journal Article
White, L. J., Rose, M., Lawson, M., Joyce, D., Smith, A. M., Thomas, G. H., Dasmahapatra, K. K., & Pownall, M. E. (2022). Two closely related ureotelic fish species of the genus Alcolapia express different levels of ammonium transporters in gills. Biology Open, 11(11), Article bio059575. https://doi.org/10.1242/bio.059575

Most fish excrete their nitrogenous waste across the gills as ammonia through the activity of the Rhesus glycoprotein ammonium transporters. In contrast, fish of the subgenus Alcolapia (Oreochromis) are the only vertebrates that survive the extreme c... Read More about Two closely related ureotelic fish species of the genus Alcolapia express different levels of ammonium transporters in gills.

Sex and gametogenesis stage are strong drivers of gene expression in Mytilus edulis exposed to environmentally relevant plasticiser levels and pH 7.7 (2022)
Journal Article
Mincarelli, L., Chapman, E. C., Rotchell, J. M., Turner, A., & Wollenberg Valero, K. C. (in press). Sex and gametogenesis stage are strong drivers of gene expression in Mytilus edulis exposed to environmentally relevant plasticiser levels and pH 7.7. Environmental science and pollution research, https://doi.org/10.1007/s11356-022-23801-3

Plastic pollution and changes in oceanic pH are both pressing environmental issues. Little emphasis, however, has been placed on the influence of sex and gametogenesis stage when investigating the effects of such stressors. Here, we examined histolog... Read More about Sex and gametogenesis stage are strong drivers of gene expression in Mytilus edulis exposed to environmentally relevant plasticiser levels and pH 7.7.

Development of a skin-on-a-chip platform for the study of wound healing (2022)
Thesis
Talar, K. Development of a skin-on-a-chip platform for the study of wound healing. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4508234

Wound healing abnormalities and non-healing chronic wounds are a major clinical problem, primarily affecting diabetic and elderly patients. Wound management associated costs resulted in a £5.3 billion financial burden to the NHS between 2012 and 2013... Read More about Development of a skin-on-a-chip platform for the study of wound healing.

Oca2 targeting using CRISPR/Cas9 in the Malawi cichlid Astatotilapia calliptera (2022)
Journal Article
Clark, B., Elkin, J., Marconi, A., Turner, G. F., Smith, A. M., Joyce, D., Miska, E. A., Juntti, S. A., & Santos, M. E. (2022). Oca2 targeting using CRISPR/Cas9 in the Malawi cichlid Astatotilapia calliptera. Royal Society Open Science, 9(4), Article 220077. https://doi.org/10.1098/rsos.220077

Identifying genetic loci underlying trait variation provides insights into the mechanisms of diversification, but demonstrating causality and characterizing the role of genetic loci requires testing candidate gene function, often in non-model species... Read More about Oca2 targeting using CRISPR/Cas9 in the Malawi cichlid Astatotilapia calliptera.

Study of the composition, processing and microstructure relationship of light alloys (2022)
Thesis
Sumayli, A. I. Study of the composition, processing and microstructure relationship of light alloys. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4508161

This research consists of two main parts. The first part concerns the study of the effect of pulse electromagnetic fields on the microstructural evolution and the hardness of an Al-20%Si alloy. A pulse magnetic field apparatus is used to produce diff... Read More about Study of the composition, processing and microstructure relationship of light alloys.

Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present (2022)
Journal Article
Jenner, L., Sadofsky, L., Danopoulos, E., Chapman, E., White, D., Jenkins, R., & Rotchell, J. M. (2022). Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present. Atmosphere, 13(2), Article 265. https://doi.org/10.3390/atmos13020265

Atmospheric microplastics (MPs) have been consistently captured within air samples on a global scale. Locations with high human activity are reported to have high MP levels. An urban sampling site in the Humber region (U.K.) has been sampled over a 1... Read More about Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present.