All Outputs (54)

Implementing person-centred outcome measures in palliative care: An exploratory qualitative study using Normalisation Process Theory to understand processes and context (2020)
Journal Article
Bradshaw, A., Santarelli, M., Mulderrig, M., Khamis, A., Sartain, K., Boland, J. W., Bennett, M. I., Johnson, M., Pearson, M., & Murtagh, F. E. (in press). Implementing person-centred outcome measures in palliative care: An exploratory qualitative study using Normalisation Process Theory to understand processes and context. Palliative medicine, https://doi.org/10.1177/0269216320972049

© The Author(s) 2020. Background: Despite evidence demonstrating the utility of using Person-Centred Outcome Measures within palliative care settings, implementing them into routine practice is challenging. Most research has described barriers to, wi... Read More about Implementing person-centred outcome measures in palliative care: An exploratory qualitative study using Normalisation Process Theory to understand processes and context.

Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT (2020)
Journal Article
Dias, J., Brealey, S., Cook, L., Fairhurst, C., Hinde, S., Leighton, P., Choudary, S., Costa, M., Hewitt, C., Hodgson, S., Jefferson, L., Jeyapalan, K., Keding, A., Northgraves, M., Palmer, J., Rangan, A., Richardson, G., Taub, N., Tew, G., Thompson, J., & Torgerson, D. (2020). Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT. Health Technology Assessment, 24(52), 1-234. https://doi.org/10.3310/hta24520

Participants: Adults (aged ≥ 16 years) presenting within 2 weeks of injury with a clear, bicortical fracture of the scaphoid waist on plain radiographs. Interventions: Early surgical fixation using Conformité Européenne-marked headless compression sc... Read More about Surgical fixation compared with cast immobilisation for adults with a bicortical fracture of the scaphoid waist: the SWIFFT RCT.

Management of adults with primary frozen shoulder in secondary care (UK FROST): a multicentre, pragmatic, three-arm, superiority randomised clinical trial (2020)
Journal Article
Ahrens, P., Baldwick, C., Bidwai, A., Butt, A., Candal-Couto, J., Crowther, M., Malal, J. G., Drew, S., Garg, S., Hawken, R., Kelly, C., Kent, M., Kumar, K., Lawrence, T., Little, C., Macleod, I., Motkur, P., Matthews, T., Venateswaran, B., McClelland, D., …Toye, F. (2020). Management of adults with primary frozen shoulder in secondary care (UK FROST): a multicentre, pragmatic, three-arm, superiority randomised clinical trial. Lancet, 396(10256), 977-989. https://doi.org/10.1016/S0140-6736%2820%2931965-6

© 2020 The Author(s). Publishedx by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Background: Manipulation under anaesthesia and arthroscopic capsular release are costly and invasive treatments for frozen shoulder, bu... Read More about Management of adults with primary frozen shoulder in secondary care (UK FROST): a multicentre, pragmatic, three-arm, superiority randomised clinical trial.

Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial (2020)
Journal Article
Dias, J., Brealey, S., Fairhurst, C., Amirfeyz, R., Bhowal, B., Blewitt, N., Brewster, M., Brown, D., Choudhary, S., Coapes, C., Cook, L., Costa, M., Davis, T., DisMascio, L., Giddins, G., Hedley, H., Hewitt, C., Hinde, S., Hobby, J., Hodgson, S., …Warwick, D. (2020). Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial. Lancet, 396(10248), 390-401. https://doi.org/10.1016/S0140-6736%2820%2930931-4

Background
Scaphoid fractures account for 90% of carpal fractures and occur predominantly in young men. The use of immediate surgical fixation to manage this type of fracture has increased, despite insufficient evidence of improved outcomes over non... Read More about Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial.

The influence of pitch size on the efficacy of maturity status ‘bio-banding’ when using a multidisciplinary approach to identify talented adolescent soccer players (2020)
Thesis
Lowthorpe, A. The influence of pitch size on the efficacy of maturity status ‘bio-banding’ when using a multidisciplinary approach to identify talented adolescent soccer players. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4223010

The present study aimed to evaluate the effect of relative pitch size on the tactical, technical, physical and psychological performance of youth academy soccer players, during maturity status ‘bio-banded’ small-sided game (SSG) match play, to eviden... Read More about The influence of pitch size on the efficacy of maturity status ‘bio-banding’ when using a multidisciplinary approach to identify talented adolescent soccer players.

Implementation of geriatric assessment in oncology settings: A systematic realist review (2020)
Journal Article
McKenzie, G. A., Bullock, A. F., Greenley, S. L., Lind, M. J., Johnson, M. J., & Pearson, M. (2021). Implementation of geriatric assessment in oncology settings: A systematic realist review. Journal of Geriatric Oncology, 12(1), 22-33. https://doi.org/10.1016/j.jgo.2020.07.003

Older adults with cancer are more likely to have worse clinical outcomes than their younger counterparts, and shared decision-making can be difficult, due to both complexity from adverse ageing and under-representation in clinical trials. Geriatric a... Read More about Implementation of geriatric assessment in oncology settings: A systematic realist review.

Management of adults with primary frozen shoulder in secondary care: the UK FROST randomised controlled trial with economic evaluation (2020)
Journal Article
Brealey, S., Northgraves, M., Kottam, L., Keding, A., Corbacho, B., Goodchild, L., Srikesevan, C., Rex, S., Charalambous, C., Hanchard, N., Armstrong, A., Brooksbank, A., Carr, A., Cooper, C., Dias, J., Donnelly, I., Hewitt, C., Lamb, S., McDaid, C., Richardson, G., …Rangan, A. (in press). Management of adults with primary frozen shoulder in secondary care: the UK FROST randomised controlled trial with economic evaluation. Health Technology Assessment,

Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis (2020)
Journal Article
Bullock, A. F., Greenley, S. L., McKenzie, G. A., Paton, L. W., & Johnson, M. J. (2020). Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis. European journal of clinical nutrition, 74, 1519–1535. https://doi.org/10.1038/s41430-020-0629-0

© 2020, The Author(s). Malnutrition predicts poorer clinical outcomes for people with cancer. Older adults with cancer are a complex, growing population at high risk of weight-losing conditions. A number of malnutrition screening tools exist, however... Read More about Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis.

Clinical Competencies for the Care of Hospitalized Patients with Alcohol Use Disorders (2020)
Journal Article
Phillips, T., Porter, A., & Sinclair, J. (2020). Clinical Competencies for the Care of Hospitalized Patients with Alcohol Use Disorders. Alcohol and Alcoholism, 55(4), 395-400. https://doi.org/10.1093/alcalc/agaa024

© 2020 The Author(s) 2020. Medical Council on Alcohol and Oxford University Press. Aims: The UK government aims to develop alcohol care teams (ACTs) that provide care for alcohol dependence in general hospital settings. Service descriptors have been... Read More about Clinical Competencies for the Care of Hospitalized Patients with Alcohol Use Disorders.

Timing of electronic reminders did not improve trial participant questionnaire response: a randomized trial and meta-analyses (2020)
Journal Article
Partha Sarathy, P., Kottam, L., Mitchell, A., Parker, A., Brealey, S., Coleman, E., Northgraves, M., Torgerson, D., Rangan, A., & Keding, A. (2020). Timing of electronic reminders did not improve trial participant questionnaire response: a randomized trial and meta-analyses. Journal of clinical epidemiology, 122, 70-77. https://doi.org/10.1016/j.jclinepi.2020.03.001

Objectives: The objective of this study was to assess whether timing of short messaging service (SMS) reminders improved postal questionnaire return rates from participants in a randomized controlled trial (RCT). Study Design and Setting: A Study Wit... Read More about Timing of electronic reminders did not improve trial participant questionnaire response: a randomized trial and meta-analyses.

Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial (2019)
Journal Article
Northgraves, M. J., Arunachalam, L., Madden, L. A., Marshall, P., Hartley, J. E., MacFie, J., & Vince, R. V. (2019). Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, https://doi.org/10.1007/s00520-019-05098-0

© 2019, The Author(s). Background and objectives: To investigate the feasibility of delivering a functional exercise-based prehabilitation intervention and its effects on postoperative length of hospital stay, preoperative physical functioning and he... Read More about Feasibility of a novel exercise prehabilitation programme in patients scheduled for elective colorectal surgery: a feasibility randomised controlled trial.

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol (2019)
Journal Article
Wright, C., Hart, S. P., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Hussain, J., Johnson, M., Hargreaves, I., & Crooks, M. G. (2019). A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol. ERJ Open Research, 5(4), Article 0186. https://doi.org/10.1183/23120541.00186-2019

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life. Although treatments are now av... Read More about A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol.

Effectiveness of surgical fixation for lateral compression type one (LC-1) fragility fractures of the pelvis: a systematic review (2019)
Journal Article
Booth, A., Ingoe, H. M. A., Northgraves, M., Coleman, E., Harden, M., Kassam, J., Kwok, I., Hilton, C., Bates, P., & McDaid, C. (2019). Effectiveness of surgical fixation for lateral compression type one (LC-1) fragility fractures of the pelvis: a systematic review. BMJ open, 9(5), Article e024737. https://doi.org/10.1136/bmjopen-2018-024737

© 2019 Author(s). Objectives: To undertake a systematic review of the evidence base for the effectiveness of surgical fixation of lateral compression (LC-1) fragility fractures of the pelvis compared with non-surgical approaches. Searches: MEDLINE, E... Read More about Effectiveness of surgical fixation for lateral compression type one (LC-1) fragility fractures of the pelvis: a systematic review.

Knee Replacement Bandaging Study (KReBS) evaluating the effect of a two-layer compression bandage system on knee function following total knee arthroplasty: study protocol for a randomised controlled trial. (2019)
Journal Article
Cook, L., Northgraves, M. J., Fairhurst, C., Ronaldson, S., Torgerson, D. J., Kent, J., & Reed, M. (2019). Knee Replacement Bandaging Study (KReBS) evaluating the effect of a two-layer compression bandage system on knee function following total knee arthroplasty: study protocol for a randomised controlled trial. Trials, 20(1), Article 261. https://doi.org/10.1186/s13063-019-3344-1

Background: Data from a feasibility study suggest that the use of an inelastic, short-stretch compression bandage following total knee arthroplasty is a safe technique that may improve patient-reported health outcomes, and that it is feasible to recr... Read More about Knee Replacement Bandaging Study (KReBS) evaluating the effect of a two-layer compression bandage system on knee function following total knee arthroplasty: study protocol for a randomised controlled trial..

Study reporting guidelines : how valid are they? (2019)
Journal Article
Arundel, C., James, S., Northgraves, M., & Booth, A. (2019). Study reporting guidelines : how valid are they?. Contemporary clinical trials communications, 14, Article 100343. https://doi.org/10.1016/j.conctc.2019.100343

Reporting guidelines help improve the reporting of specific study designs, and clear guidance on the best approaches for developing guidelines is available. The methodological strength, or validation of guidelines is however unclear. This article exp... Read More about Study reporting guidelines : how valid are they?.

Statistical design and analysis in trials of proportionate interventions: a systematic review (2019)
Journal Article
Candlish, J., Teare, M. D., Cohen, J., & Bywater, T. (2019). Statistical design and analysis in trials of proportionate interventions: a systematic review. Trials, 20(1), Article 151. https://doi.org/10.1186/s13063-019-3206-x

Background: In proportionate or adaptive interventions, the dose or intensity can be adjusted based on individual need at predefined decision stages during the delivery of the intervention. The development of such interventions may require an evaluat... Read More about Statistical design and analysis in trials of proportionate interventions: a systematic review.

Tissue inflammation signatures point towards resolution in adhesive capsulitis (2019)
Journal Article
Dakin, S. G., Rangan, A., Martinez, F., Brealey, S., Northgraves, M., Kottam, L., Cooper, C., Buckley, C. D., & Carr, A. J. (2019). Tissue inflammation signatures point towards resolution in adhesive capsulitis. Rheumatology, 58(6), 1109–1111. https://doi.org/10.1093/rheumatology/kez007

Proresolving receptors, macrophage and fibroblast activation point towards a resolving inflammatory milieu in adhesive capsulitis.

Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial (2018)
Journal Article
Hutchinson, A., Rees, S., Young, A., Maraveyas, A., Date, K., & Johnson, M. J. (2019). Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial. Palliative medicine, 33(5), 510-517. https://doi.org/10.1177/0269216318815377

Background: Cancer patients have a four- to fivefold greater risk of thrombosis than the general population. Recommended treatment for cancer-associated thrombosis is 3–6 months of low-molecular-weight heparin. The ‘select-d’ trial is an open-label,... Read More about Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial.

Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: The DiPEP diagnostic study with decision-analysis modelling (2018)
Journal Article
Goodacre, S., Horspool, K., Shephard, N., Pollard, D., Hunt, B. J., Fuller, G., Nelson-Piercy, C., Knight, M., Thomas, S., Lecky, F., & Cohen, J. (2018). Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: The DiPEP diagnostic study with decision-analysis modelling. Health Technology Assessment, 22(47), V-229. https://doi.org/10.3310/hta22470

Background
Pulmonary embolism (PE) is a leading cause of death in pregnancy and post partum, but the symptoms of PE are common in normal pregnancy. Simple diagnostic tests are needed to select women for diagnostic imaging.

Objective
To estimate the... Read More about Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: The DiPEP diagnostic study with decision-analysis modelling.

Does early intervention improve outcomes in the physiotherapy management of lumbar radicular syndrome? Results of the POLAR pilot randomised controlled trial (2018)
Journal Article
Reddington, M., Walters, S. J., Cohen, J., Baxter, S. K., & Cole, A. (2018). Does early intervention improve outcomes in the physiotherapy management of lumbar radicular syndrome? Results of the POLAR pilot randomised controlled trial. BMJ open, 8(7), Article e021631. https://doi.org/10.1136/bmjopen-2018-021631

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ. Objective To investigate the feasibility of undertaking a definitive randomised controlled trial (RCT). Setting This was a pilot, pragmatic superiority RCT with... Read More about Does early intervention improve outcomes in the physiotherapy management of lumbar radicular syndrome? Results of the POLAR pilot randomised controlled trial.