All Outputs (701)

The Role of Chemokines in Thyroid Carcinoma (2017)
Journal Article
Yapa, S., Mulla, O., Green, V., England, J., & Greenman, J. (2017). The Role of Chemokines in Thyroid Carcinoma. Thyroid : official journal of the American Thyroid Association, 27(11), 1347-1359. https://doi.org/10.1089/thy.2016.0660

© Copyright 2017, Mary Ann Liebert, Inc. 2017. The global incidence of thyroid cancer is increasing, and metastatic spread to the lymph nodes is common in papillary thyroid carcinoma. The metastatic course of thyroid carcinoma is an intricate process... Read More about The Role of Chemokines in Thyroid Carcinoma.

Life after prostate cancer: A systematic literature review and thematic synthesis of the post-treatment experiences of Black African and Black Caribbean men (2017)
Journal Article
Bamidele, O., McGarvey, H., Lagan, B. M., Ali, N., Chinegwundoh MBE, F., Parahoo, K., & McCaughan, E. (2018). Life after prostate cancer: A systematic literature review and thematic synthesis of the post-treatment experiences of Black African and Black Caribbean men. European Journal of Cancer Care, 27(1), Article e12784. https://doi.org/10.1111/ecc.12784

© 2017 John Wiley & Sons Ltd Evidence shows that there are significant ethnic variations in prostate cancer prevalence and outcomes. Specifically, Black African and Black Caribbean men may encounter different post-treatment experiences than Caucasi... Read More about Life after prostate cancer: A systematic literature review and thematic synthesis of the post-treatment experiences of Black African and Black Caribbean men.

Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials (2017)
Journal Article
Cleland, J. G., Bunting, K. V., Flather, M., Altman, D. G., Holmes, J., Coats, A. J., Manzano, L., McMurray, J. J., Ruschitzka, F., van Veldhuisen, D. J., Von Lueder, T. G., Böhm, M., Andersson, B., Kjekshus, J., Packer, M., Rigby, A. S., Rosano, G., Wedel, H., Hjalmarson, Å., Wikstrand, J., …Beta-blockers in Heart Failure Collaborative Group. (2018). Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials. European Heart Journal, 39(1), 26-35. https://doi.org/10.1093/eurheartj/ehx564

Aims: Recent guidelines recommend that patients with heart failure and left ventricular ejection fraction (LVEF) 40-49% should be managed similar to LVEF ≥50%. We investigated the effect of beta-blockers according to LVEF in double-blind, randomised,... Read More about Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials.

Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain (2017)
Journal Article
Talley, N., Holtmann, G., Nguyen, Q., Gibson, P., Bampton, P., Veysey, M., Wong, J., Philcox, S., Koloski, N., Bunby, L., & Jones, M. (2017). Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain. Journal of Gastroenterology and Hepatology, 32(11), 1813-1817. https://doi.org/10.1111/jgh.13791

© 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd Background and Aim: A previous UK study showed that 6.1% of patients with diarrhea-predominant irritable bowel syndrome (IBS-D) had evidence of severe... Read More about Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain.

Multimorbidity in Atlantic Canada and association with low levels of physical activity (2017)
Journal Article
Keats, M. R., Cui, Y., DeClercq, V., Dummer, T. J., Forbes, C., Grandy, S. A., Hicks, J., Sweeney, E., Yu, Z. M., & Parker, L. (2017). Multimorbidity in Atlantic Canada and association with low levels of physical activity. Preventive Medicine, 105, 326-331. https://doi.org/10.1016/j.ypmed.2017.10.013

Owing to an aging population and medical advances, the anticipated growth and prevalence of multimorbidity has been recognized as a significant challenge and priority in health care settings. Although physical activity has been shown to play a vital... Read More about Multimorbidity in Atlantic Canada and association with low levels of physical activity.

Area-level socioeconomic disadvantage and suicidal behaviour in Europe: A systematic review (2017)
Journal Article
Cairns, J. M., Graham, E., & Bambra, C. (2017). Area-level socioeconomic disadvantage and suicidal behaviour in Europe: A systematic review. Social science & medicine, 192, 102-111. https://doi.org/10.1016/j.socscimed.2017.09.034

© 2017 The relationship between adverse individual socio-economic circumstances and suicidal behaviour is well established. However, the impact of adverse collective circumstances – such as the socio-economic context where people live - is less well... Read More about Area-level socioeconomic disadvantage and suicidal behaviour in Europe: A systematic review.

Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy (2017)
Journal Article
Cheah, R., Srivastava, R., Stafford, N. D., Beavis, A. W., Green, V., & Greenman, J. (2017). Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy. International Journal of Oncology, 51(4), 1227-1238. https://doi.org/10.3892/ijo.2017.4118

Radiotherapy is the standard treatment for head and neck squamous cell carcinoma (HNSCC), however, radioresistance remains a major clinical problem despite significant improvements in treatment protocols. Therapeutic outcome could potentially be impr... Read More about Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy.

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study (2017)
Journal Article
Walsh, S. L., Maher, T. M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., …Wells, A. (2017). Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study. European respiratory journal, 50(2), Article 1700936. https://doi.org/10.1183/13993003.00936-2017

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts.

A total of 1141 respiratory physicians and 34 IPF experts p... Read More about Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study.

Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome (2017)
Journal Article
Bauersachs, S., Simintiras, C. A., Sturmey, R. G., Krebs, S., Bick, J., Blum, H., Wolf, E., Lonergan, P., & Forde, N. (2017). Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome. Biology of Reproduction, 97(3), 413-425. https://doi.org/10.1093/biolre/iox095

The aim of this study was to test the hypothesis that the metabolic stresses associated with lactation alter the ability of the endometrium to respond appropriately to the conceptus by examining endometrial gene expression on Day 19 of pregnancy. Imm... Read More about Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome.

Experience of, awareness of and help-seeking for potential cancer symptoms in smokers and non-smokers: a cross-sectional study (2017)
Journal Article
Walabyeki, J., Adamson, J., Buckley, H. L., Sinclair, H., Atkin, K., Graham, H., Whitaker, K., Wardle, J., & Macleod, U. (2017). Experience of, awareness of and help-seeking for potential cancer symptoms in smokers and non-smokers: a cross-sectional study. PLoS ONE, 12(8), e0183647. https://doi.org/10.1371/journal.pone.0183647

Background
Presenting to primary care with potential cancer symptoms is contingent on one’s ability to recognize potentially serious symptoms. We investigated differences between smokers and non-smokers in symptoms experienced, awareness and consulti... Read More about Experience of, awareness of and help-seeking for potential cancer symptoms in smokers and non-smokers: a cross-sectional study.

“Intermittent claudication a real pain in the calf”—Patient experience of diagnosis and treatment with a supervised exercise program (2017)
Journal Article
Harwood, A., Broadbent, E., Totty, J. P., Smith, G. E., & Chetter, I. C. (2017). “Intermittent claudication a real pain in the calf”—Patient experience of diagnosis and treatment with a supervised exercise program. Journal of Vascular Nursing, 35(3), 131-135. https://doi.org/10.1016/j.jvn.2017.03.001

© 2017 Society for Vascular Nursing, Inc. Intermittent claudication (IC) is a common condition which has severe impacts on quality of life, physical function, and mental health. Supervised exercise is the recommended first-line treatment for patients... Read More about “Intermittent claudication a real pain in the calf”—Patient experience of diagnosis and treatment with a supervised exercise program.

Cohort profile: The Atlantic partnership for tomorrow's health (Atlantic PATH) study (2017)
Journal Article
Sweeney, E., Cui, Y., DeClercq, V., Devichand, P., Forbes, C., Grandy, S., Hicks, J. M., Keats, M., Parker, L., Thompson, D., Volodarsky, M., Yu, Z. M., & Dummer, T. J. (2017). Cohort profile: The Atlantic partnership for tomorrow's health (Atlantic PATH) study. International Journal of Epidemiology, 46(6), 1762-1763i. https://doi.org/10.1093/ije/dyx124

Cancer microvesicles induce tissue factor-related procoagulant activity in endothelial cells in vitro (2017)
Journal Article
Adesanya, M. A., Maraveyas, A., & Madden, L. A. (2017). Cancer microvesicles induce tissue factor-related procoagulant activity in endothelial cells in vitro. Blood Coagulation and Fibrinolysis, 28(5), 365-372. https://doi.org/10.1097/MBC.0000000000000607

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Microvesicles associated with tissue factor (TF) may play a role in cancer-related venous thromboembolism; however, not much is known about their interaction with the tumour stroma, es... Read More about Cancer microvesicles induce tissue factor-related procoagulant activity in endothelial cells in vitro.

In-hospital worsening heart failure: a clinically relevant endpoint? (2017)
Journal Article
Clark, A. L., Cherif, M., McDonagh, T. A., & Squire, I. B. (2018). In-hospital worsening heart failure: a clinically relevant endpoint?. ESC Heart Failure, 5(1), 9-18. https://doi.org/10.1002/ehf2.12195

Outcome measures used for the clinical evaluation of patients with acute heart failure differ between studies and may neither adequately address the characteristic presenting symptoms and signs nor reflect the pathophysiological processes involved. I... Read More about In-hospital worsening heart failure: a clinically relevant endpoint?.

cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway (2017)
Journal Article
Aburima, A., Walladbegi, K., Wake, J. D., & Naseem, K. M. (2017). cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway. Journal of thrombosis and haemostasis : JTH, 15(8), 1668-1678. https://doi.org/10.1111/jth.13738

Essentials
Platelet shape change requires cytoskeletal rearrangement via myosin‐mediated actin contraction.
We investigated whether nitric oxide (NO) affected thrombin‐induced platelet shape change.
NO inhibits shape change, RhoA/ROCK signalling a... Read More about cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway.

Deoxynivalenol biomarkers in the urine of UK vegetarians (2017)
Journal Article
Wells, L., Hardie, L., Williams, C., White, K., Liu, Y., De Santis, B., Debegnach, F., Moretti, G., Greetham, S., Brera, C., Papageorgiou, M., Thatcher, N. J., Rigby, A., Atkin, S. L., & Sathyapalan, T. (2017). Deoxynivalenol biomarkers in the urine of UK vegetarians. Toxins, 9(7), 196. https://doi.org/10.3390/toxins9070196

Deoxynivalenol (DON) is produced by Fusarium graminearum and is one of the most commonly occurring trichothecenes. Vegetarians are alleged to be a high-risk group for DON exposure due to high intakes of cereals susceptible to the growth of the mycoto... Read More about Deoxynivalenol biomarkers in the urine of UK vegetarians.

Interatrial shunt devices for heart failure with normal ejection fraction: a technology update (2017)
Journal Article
Cuthbert, J. J., Pellicori, P., & Clark, A. L. (2017). Interatrial shunt devices for heart failure with normal ejection fraction: a technology update. Medical Devices: Evidence and Research, 10, 123-132. https://doi.org/10.2147/mder.s113105

Heart failure with normal ejection fraction (HeFNEF) accounts for ~50% of heart failure admissions. Its pathophysiology and diagnostic criteria are yet to be defined clearly which may hinder the search for effective treatments. The clinical hallmark... Read More about Interatrial shunt devices for heart failure with normal ejection fraction: a technology update.

Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure (2017)
Journal Article
Kotecha, D., Flather, M. D., Altman, D. G., Holmes, J., Rosano, G., Wikstrand, J., Packer, M., Coats, A. J., Manzano, L., Böhm, M., van Veldhuisen, D. J., Andersson, B., Wedel, H., von Lueder, T. G., Rigby, A. S., Hjalmarson, Å., Kjekshus, J., & Cleland, J. G. (2017). Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure. Journal of the American College of Cardiology, 69(24), 2885-2896. https://doi.org/10.1016/j.jacc.2017.04.001

Background
The relationship between mortality and heart rate remains unclear for patients with heart failure with reduced ejection fraction in either sinus rhythm or atrial fibrillation (AF).

Objectives
This analysis explored the prognostic importan... Read More about Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure.

Genistein crosses the bioartificial oviduct and alters secretion composition (2017)
Journal Article
Simintiras, C. A., & Sturmey, R. G. (2017). Genistein crosses the bioartificial oviduct and alters secretion composition. Reproductive Toxicology, 71, 63-70. https://doi.org/10.1016/j.reprotox.2017.04.010

The dietary derived isoflavone and oestrogen analogue, genistein, is known to perturb fundamental reproductive events such as implantation and embryo cleavage. However the question of whether genistein is able to traverse the oviduct epithelial monol... Read More about Genistein crosses the bioartificial oviduct and alters secretion composition.

VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences (2017)
Journal Article
Beckett, E., Jones, P., Veysey, M., Duesing, K., Martin, C., Furst, J., Yates, Z., Jablonski, N., Chaplin, G., & Lucock, M. (2017). VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences. American Journal of Human Biology, 29(5), Article e23010. https://doi.org/10.1002/ajhb.23010

Objectives
The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of phot... Read More about VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences.