All Outputs (699)

Which outcome domains are important in palliative care and when? An international expert consensus workshop, using the nominal group technique (2019)
Journal Article
de Wolf-Linder, S., Dawkins, M., Wicks, F., Pask, S., Eagar, K., Evans, C. J., Higginson, I. J., & Murtagh, F. E. (in press). Which outcome domains are important in palliative care and when? An international expert consensus workshop, using the nominal group technique. Palliative medicine, 026921631985415. https://doi.org/10.1177/0269216319854154

© The Author(s) 2019. Background: When capturing patient-level outcomes in palliative care, it is essential to identify which outcome domains are most important and focus efforts to capture these, in order to improve quality of care and minimise coll... Read More about Which outcome domains are important in palliative care and when? An international expert consensus workshop, using the nominal group technique.

Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes (2019)
Journal Article
Lucock, M., Thota, R., Garg, M., Martin, C., Jones, P., Furst, J., Yates, Z., Jablonski, N. G., Chaplin, G., Veysey, M., & Beckett, E. (2019). Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes. American journal of human biology : the official journal of the Human Biology Council, 31(4), Article e23272. https://doi.org/10.1002/ajhb.23272

Objectives
Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long‐term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This ar... Read More about Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes.

WS19. From pedagogy to practice: implementing transformative learning in clinical reasoning (2019)
Presentation / Conference Contribution
Singh, M., Boyle, J., Hammond, A., & Henderson, J. (2019, May). WS19. From pedagogy to practice: implementing transformative learning in clinical reasoning. Presented at 8th International Clinical Skills Conference, Prato, Italy

Background
Healthcare professionals must provide high quality care that is both efficient and safe. Underpinning this requirement is a presumption
that individuals are able to make accurate clinical decisions. Knowledge is not sufficient: judgment... Read More about WS19. From pedagogy to practice: implementing transformative learning in clinical reasoning.

Roundtable Discussion (RTD03) - Is there a downside to using Simulated Patients to teach and assess communication skills? (2019)
Presentation / Conference Contribution
Hammond, A., & Henderson, J. (2019, May). Roundtable Discussion (RTD03) - Is there a downside to using Simulated Patients to teach and assess communication skills?. Presented at 8th International Clinical Skills Conference, Prato, Italy

Background
Simulated Patients (SPs) are widely used to facilitate the learning of communication skills enabling students to receive detailed feedback on experiential practice in a safe environment. They are also used in the assessment of students’... Read More about Roundtable Discussion (RTD03) - Is there a downside to using Simulated Patients to teach and assess communication skills?.

Effectiveness of surgical fixation for lateral compression type one (LC-1) fragility fractures of the pelvis: a systematic review (2019)
Journal Article
Booth, A., Ingoe, H. M. A., Northgraves, M., Coleman, E., Harden, M., Kassam, J., Kwok, I., Hilton, C., Bates, P., & McDaid, C. (2019). Effectiveness of surgical fixation for lateral compression type one (LC-1) fragility fractures of the pelvis: a systematic review. BMJ open, 9(5), Article e024737. https://doi.org/10.1136/bmjopen-2018-024737

© 2019 Author(s). Objectives: To undertake a systematic review of the evidence base for the effectiveness of surgical fixation of lateral compression (LC-1) fragility fractures of the pelvis compared with non-surgical approaches. Searches: MEDLINE, E... Read More about Effectiveness of surgical fixation for lateral compression type one (LC-1) fragility fractures of the pelvis: a systematic review.

The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study (2019)
Journal Article
Konya, J., Sathyapalan, T., Kilpatrick, E. S., & Atkin, S. L. (2019). The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study. Frontiers in endocrinology, 10(MAY), Article 296. https://doi.org/10.3389/fendo.2019.00296

Objective: Soy and cocoa have been suggested to be beneficial for diabetes. The aim of this study was to identify the effects of soy protein, isoflavones, and cocoa on glycemic control parameters.

Research design and methods: The study was a paral... Read More about The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study.

The effects of social protection policies on health inequalities: Evidence from systematic reviews (2019)
Journal Article
Hillier-Brown, F., Thomson, K., Mcgowan, V., Cairns, J., Eikemo, T. A., Gil-Gonzále, D., & Bambra, C. (2019). The effects of social protection policies on health inequalities: Evidence from systematic reviews. Scandinavian journal of public health, 47(6), 655-665. https://doi.org/10.1177/1403494819848276

© Author(s) 2019. Background: The welfare state distributes financial resources to its citizens – protecting them in times of adversity. Variations in how such social protection policies are administered have been attributed to important differences... Read More about The effects of social protection policies on health inequalities: Evidence from systematic reviews.

Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos (2019)
Preprint / Working Paper
Muller, B., Lewis, N., Adeniyi, T., Leese, H. J., Brison, D., & Sturmey, R. G. Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos

Background Mitochondria provide the major source of ATP for mammalian oocyte maturation and early embryo development. Oxygen Consumption Rate (OCR) is an established measure of mitochondrial function. OCR by mammalian oocytes and embryos has generall... Read More about Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos.

Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects (2019)
Journal Article
Ramanjaneya, M., Jerobin, J., Bettahi, I., Bensila, M., Aye, M., Siveen, K. S., Sathyapalan, T., Skarulis, M., Abou‐Samra, A., & Atkin, S. L. (2019). Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects. Clinical Endocrinology, 91(2), 278-287. https://doi.org/10.1111/cen.14007

Objective: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder associated with mitochondrial dysfunction and insulin resistance (IR). MOTS-c, a mitochondrial peptide, promotes insulin sensitivity (IS) through activating AKT and A... Read More about Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.

Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes (2019)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2019). Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes. Diabetes and Vascular Disease Research, 16(6), 489-497. https://doi.org/10.1177/1479164119845561

© The Author(s) 2019. Background: Effect of pre-diabetes mellitus on post-myocardial infarction prognosis is unclear. Methods: Retrospective cohort analysis of 1056 myocardial infarction survivors with fasting plasma glucose and 2-h post-load plasma... Read More about Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes.

An integrated understanding of the complex drivers of emergency presentations and admissions in cancer patients: qualitative modelling of secondary-care health professionals’ experiences and views (2019)
Journal Article
Chen, H., Walabyeki, J., Johnson, M., Boland, E., Seymour, J., & Macleod, U. (2019). An integrated understanding of the complex drivers of emergency presentations and admissions in cancer patients: qualitative modelling of secondary-care health professionals’ experiences and views. PLoS ONE, 14(5), Article e0216430. https://doi.org/10.1371/journal.pone.0216430

The number of cancer-related emergency presentations and admissions has been steadily increasing in the UK. Drivers of this phenomenon are complex, multifactorial and interlinked. The main objective of this study was to understand the complexity of e... Read More about An integrated understanding of the complex drivers of emergency presentations and admissions in cancer patients: qualitative modelling of secondary-care health professionals’ experiences and views.

Facilitated group work for people with long-term conditions: a systematic review of benefits from studies of group-work interventions (2019)
Journal Article
Jackson, M., Jones, D., Dyson, J., & Macleod, U. (2019). Facilitated group work for people with long-term conditions: a systematic review of benefits from studies of group-work interventions. The British journal of general practice : the journal of the Royal College of General Practitioners, 69(682), E363-E372. https://doi.org/10.3399/bjgp19X702233

Background: About 15.4 million people in the UK live with a long-term condition. Of the health and social care spend, 70% is invested in caring for this population. Evidence suggests that group-work interventions offer patient support, improved outco... Read More about Facilitated group work for people with long-term conditions: a systematic review of benefits from studies of group-work interventions.

Gene expression and metabolic response of bovine oviduct epithelial cells to the early embryo (2019)
Journal Article
Hamdi, M., Sánchez-Calabuig, M. J., Rodríguez-Alonso, B., Bagés-Arnal, S., Roussi, K., Sturmey, R., Gutiérrez-Adán, A., Lonergan, P., & Rizos, D. (2019). Gene expression and metabolic response of bovine oviduct epithelial cells to the early embryo. Reproduction, 158(1), 85-94. https://doi.org/10.1530/REP-18-0561

© 2019 Society for Reproduction and Fertility During its journey through the oviduct, the bovine embryo may induce transcriptomic and metabolic responses, via direct or indirect contact, from bovine oviduct epithelial cells (BOECs). An in vitro model... Read More about Gene expression and metabolic response of bovine oviduct epithelial cells to the early embryo.

Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports (2019)
Journal Article
Scully, D., & Matsakas, A. (2019). Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports. International journal of sports medicine, 40(7), 427-433. https://doi.org/10.1055/a-0884-0734

Platelet-based applications are currently used for the delivery of growth factors and other biomolecules as autologous biomaterials in regenerative medicine and cosmetic therapies. Many studies have revealed that platelet-based applications such as p... Read More about Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports.

The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome (2019)
Journal Article
Dawson, A. J., Sathyapalan, T., Vince, R., Coady, A. M., Ajjan, R. A., Kilpatrick, E. S., & Atkin, S. L. (2019). The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome. Frontiers in endocrinology, 10(APR), Article 189. https://doi.org/10.3389/fendo.2019.00189

Background: Polycystic ovary syndrome (PCOS) is associated with an adverse cardiovascular risk profile including a prothrombotic state. Exenatide has been shown to be effective at improving insulin sensitivity and weight loss in PCOS; therefore this... Read More about The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome.

The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma (2019)
Journal Article
Oguh-Olayinka, L., Agarwal, V., Ranatunge, D., Campbell, A., Laufer, S., Cawkwell, L., & Lind, M. J. (2020). The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma. Pathology and Oncology Research, 26(2), 985-995. https://doi.org/10.1007/s12253-019-00652-x

Advanced malignant pleural mesothelioma (MPM) has an extremely poor prognosis with limited chemotherapy options, therefore the identification of new therapeutic targets would aid in disease management. Arachidonic acid is metabolised by cyclooxygenas... Read More about The investigation of lipoxygenases as therapeutic targets in malignant pleural mesothelioma.

050 Maximising Sexual Wellbeing after diagnosis of Prostate Cancer. Developing and Testing Support Resources: A Global Approach (2019)
Journal Article
McCaughan, E., O'Connor, S., Flannagan, C., Maguire, R., Connaghan, J., Bamidele, O., Ellis, S., Steele, M., Wittmann, D., Thompson, S., Jain, S., Kirby, M., Brady, N., & Parahoo, K. (2019). 050 Maximising Sexual Wellbeing after diagnosis of Prostate Cancer. Developing and Testing Support Resources: A Global Approach. The journal of sexual medicine, 16(4, supp.1), S27. https://doi.org/10.1016/j.jsxm.2019.01.061

Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome (2019)
Journal Article
Kirk, R. J., Madden, L. A., Peart, D. J., Aye, M. M., Atkin, S. L., & Vince, R. V. (2019). Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome. Frontiers in endocrinology, 10(MAR), Article 200. https://doi.org/10.3389/fendo.2019.00200

Purpose: Endothelial dysfunction is a known comorbidity in women with polycystic ovary syndrome (PCOS). The aim was to assess if supervised, moderate intensity exercise could potentially impact markers of endothelial disruption; endothelial cell deri... Read More about Circulating endothelial microparticles reduce in concentration following an exercise programme in women with polycystic ovary syndrome.

Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease (2019)
Journal Article
D’Cunha, N. M., Georgousopoulou, E. N., Boyd, L., Veysey, M., Sturm, J., O’Brien, B., Lucock, M., McKune, A. J., Mellor, D. D., Roach, P. D., & Naumovski, N. (2019). Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease. Journal of Nutrition in Gerontology and Geriatrics, 38(2), 173-195. https://doi.org/10.1080/21551197.2019.1590287

The potential for B-vitamins to reduce plasma homocysteine (Hcy) and reduce the risk of Alzheimer’s disease (AD) has been described previously. However, the role of Apolipoprotein E є4 (APOE4) in this relationship has not been adequately addressed. T... Read More about Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease.

A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform (2019)
Journal Article
Riley, A., Green, V., Cheah, R., McKenzie, G., Karsai, L., England, J., & Greenman, J. (2019). A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform. BMC Cancer, 19(1), Article 259. https://doi.org/10.1186/s12885-019-5465-z

Background
Though the management of malignancies has improved vastly in recent years, many treatment options lack the desired efficacy and fail to adequately augment patient morbidity and mortality. It is increasingly clear that patient response to... Read More about A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform.