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Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels (2012)
Journal Article
Chen, G.-L., Zeng, B., Eastmond, S., Elsenussi, S. E., Boa, A. N., & Xu, S.-Z. (2012). Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels. British Journal of Pharmacology, 167(6), 1232-1243. https://doi.org/10.1111/j.1476-5381.2012.02058.x

BACKGROUND: Fenamate analogues, econazole and 2-APB are inhibitors of TRPM2 channels, which have been used as research tools. However, these compounds have different chemical structures and therapeutic applications. Here we aimed to investigate the p... Read More about Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels.

Chronotropic incompetence and survival in chronic heart failure (2012)
Journal Article
Al-Najjar, Y., Witte, K. K., & Clark, A. L. (2012). Chronotropic incompetence and survival in chronic heart failure. International journal of cardiology, 157(1), 48-52. https://doi.org/10.1016/j.ijcard.2010.11.018

Background: Failure of the heart rate to rise normally during an incremental exercise test is termed chronotropic incompetence (CI). It is common in patients with chronic heart failure (CHF), and we wanted to explore the relation between CI and outco... Read More about Chronotropic incompetence and survival in chronic heart failure.

Clinical Reasoning in Medicine: Developing Students' meta-cognitive skills (2012)
Presentation / Conference Contribution
Hammond, A., & Henderson, J. (2012, May). Clinical Reasoning in Medicine: Developing Students' meta-cognitive skills. Poster presented at University of York Teaching and Learning Conference, York

This poster outlines the progress of the authors’ project in introducing formal Clinical Reasoning Skills sessions. This project was instituted on the basis of observations of students’ performances in live examinations in years 4 / 5 of our five... Read More about Clinical Reasoning in Medicine: Developing Students' meta-cognitive skills.

Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies (2012)
Journal Article
Fahim, A., Chong, M. C., Crooks, M. G., & Hart, S. P. (2012). Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies. Lung, 190(4), 451-458. https://doi.org/10.1007/s00408-012-9390-z

PurposeIdiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies... Read More about Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies.

Volume conduction effects in brain network inference from electroencephalographic recordings using phase lag index (2012)
Journal Article
Peraza, L. R., Asghar, A., Green, G., & Halliday, D. M. (2012). Volume conduction effects in brain network inference from electroencephalographic recordings using phase lag index. Journal of neuroscience methods, 207(2), 189-199. https://doi.org/10.1016/j.jneumeth.2012.04.007

In this paper, we test the performance of a synchronicity estimator widely applied in Neuroscience, phase lag index (PLI), for brain network inference in EEG. We implement the four sphere head model to simulate the volume conduction problem present i... Read More about Volume conduction effects in brain network inference from electroencephalographic recordings using phase lag index.

A randomized trial of aerobic exercise and sleep quality in lymphoma patients receiving chemotherapy or no treatments (2012)
Journal Article
Courneya, K. S., Sellar, C. M., Trinh, L., Forbes, C. C., Stevinson, C., McNeely, M. L., Peddle-McIntyre, C. J., Friedenreich, C. M., & Reiman, T. (2012). A randomized trial of aerobic exercise and sleep quality in lymphoma patients receiving chemotherapy or no treatments. Cancer Epidemiology, Biomarkers and Prevention, 21(6), 887-894. https://doi.org/10.1158/1055-9965.EPI-12-0075

Background: Patients with lymphoma experience sleep problems that may be managed with aerobic exercise but no previous study has examined this issue. Methods: We randomized 122 patients with lymphoma to usual care (n = 62) or 12 weeks of supervised... Read More about A randomized trial of aerobic exercise and sleep quality in lymphoma patients receiving chemotherapy or no treatments.

Endovenous laser ablation in the treatment of small saphenous varicose veins: does site of access influence early outcomes? (2012)
Journal Article
Samuel, N., Wallace, T., Carradice, D., Shahin, Y., Mazari, F. A. K., & Chetter, I. C. (2012). Endovenous laser ablation in the treatment of small saphenous varicose veins: does site of access influence early outcomes?. Vascular and endovascular surgery, 46(4), 310-314. https://doi.org/10.1177/1538574412443316

Objective: The study was performed to evaluate the clinical and technical efficacy of endovenous laser ablation (EVLA) of small saphenous varicosities, particularly in relation to the site of endovenous access. Methods: Totally 59 patients with unila... Read More about Endovenous laser ablation in the treatment of small saphenous varicose veins: does site of access influence early outcomes?.

Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer (2012)
Journal Article
Hodgkinson, V. C., Agarwal, V., ElFadl, D., Fox, J. N., McManus, P. L., Mahapatra, T. K., Kneeshaw, P. J., Drew, P. J., Lind, M., & Cawkwell, L. (2012). Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer. Journal of Proteomics, 75(9), 2745-2752. https://doi.org/10.1016/j.jprot.2012.03.049

Neoadjuvant chemotherapy is used to treat oestrogen receptor-positive breast cancer however chemo-resistance is a major obstacle in this molecular subtype. The ability to predict tumour response would allow chemotherapy administration to be directed... Read More about Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer.

Evolution of an endovenous laser ablation practice for varicose veins (2012)
Journal Article
Samuel, N., Wallace, T., Carradice, D., Smith, G., Mazari, F., & Chetter, I. (2013). Evolution of an endovenous laser ablation practice for varicose veins. Phlebology, 28(5), 248-256. https://doi.org/10.1258/phleb.2011.011103

Objective We aimed to assess the evolution of an endovenous laser ablation (EVLA) practice in the management of varicose veins in a university teaching hospital vascular surgical unit, over five years. Methods This was a retrospective review of a pro... Read More about Evolution of an endovenous laser ablation practice for varicose veins.

Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID? (2012)
Journal Article
Hodgkinson, V. C., ELFadl, D., Agarwal, V., Garimella, V., Russell, C., Long, E. D., Fox, J. N., McManus, P. L., Mahapatra, T. K., Kneeshaw, P. J., Drew, P. J., Lind, M. J., & Cawkwell, L. (2012). Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID?. Journal of Proteomics, 75(4), 1276-1283. https://doi.org/10.1016/j.jprot.2011.11.005

Introduction: Chemotherapy resistance is a major obstacle in effective neoadjuvant treatment for estrogen receptor-positive breast cancer. The ability to predict tumour response would allow chemotherapy administration to be directed towards only thos... Read More about Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID?.

Procedure-based assessments: an evaluation of their role in reflective learning (2012)
Journal Article
Green, L., & Chetter, I. (2012). Procedure-based assessments: an evaluation of their role in reflective learning. Bulletin of the Royal College of Surgeons of England, 94(1), 28-30. https://doi.org/10.1308/147363512x13189526437838

Procedure-based assessment (PBA) has, together with other common workplace assessments, become the cornerstone of a surgical trainee's evaluation process, the annual review of competency progression.

Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: Toward fine-tuning flow in biological microfluidics applications (2012)
Journal Article
Cheah, L. T., Fritsch, I., Haswell, S. J., & Greenman, J. (2012). Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: Toward fine-tuning flow in biological microfluidics applications. Biotechnology and bioengineering, 109(7), 1827-1834. https://doi.org/10.1002/bit.24426

A microfluidic system containing a chamber for heart tissue biopsies, perfused with Krebs–Henseleit buffer containing glucose and antibiotic (KHGB) using peristaltic pumps and continuously stimulated, was used to evaluate tissue viability under redox... Read More about Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: Toward fine-tuning flow in biological microfluidics applications.

The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms (2012)
Journal Article
Kahal, H., Aye, M., Rigby, A. S., Sathyapalan, T., England, R. J. A., & Atkin, S. L. (2012). The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms. Clinical Endocrinology, 76(2), 196-200. https://doi.org/10.1111/j.1365-2265.2011.04197.x

Background With increased biochemical screening, primary hyperparathyroidism (pHPT) is often discovered incidentally whilst patients are asymptomatic. Objective To assess the impact of parathyroidectomy on neuropsychological symptoms and biochemical... Read More about The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms.

Does the physical examination still have a role in patients with suspected heart failure? (2011)
Journal Article
Damy, T., Kallvikbacka-Bennett, A., Zhang, J., Goode, K., Buga, L., Hobkirk, J., Yassin, A., Dubois-Randé, J.-L., Hittinger, L., Cleland, J. G. F., & Clark, A. L. (2011). Does the physical examination still have a role in patients with suspected heart failure?. European journal of heart failure, 13(12), 1340-1348. https://doi.org/10.1093/eurjhf/hfr128

AIMS: The prognostic value of signs of congestion in patients suspected of having chronic heart failure (CHF) is unknown. Our objectives were to define their prevalence and specificity in diagnosing CHF and to determine their prognostic value in pati... Read More about Does the physical examination still have a role in patients with suspected heart failure?.

Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials (2011)
Journal Article
Shahin, Y., Khan, J. A., & Chetter, I. (2012). Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials. Atherosclerosis, 221(1), 18-33. https://doi.org/10.1016/j.atherosclerosis.2011.12.005

ObjectiveSeveral studies have assessed the effect of angiotensin converting enzyme inhibitors (ACEIs) on arterial stiffness and wave reflections as measured by pulse wave velocity (PWV) and augmentation index (AIx), respectively. We conducted a meta-... Read More about Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials.

A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs (2011)
Journal Article
Hattersley, S. M., Sylvester, D. C., Dyer, C. E., Stafford, N. D., Haswell, S. J., & Greenman, J. (2012). A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs. Annals of biomedical engineering, 40(6), 1277-1288. https://doi.org/10.1007/s10439-011-0428-9

Tumors are heterogeneous masses of cells characterized pathologically by their size and spread. Their chaotic biology makes treatment of malignancies hard to generalize. We present a robust and reproducible glass microfluidic system, for the maintena... Read More about A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs.

Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure (2011)
Journal Article
Xu, S.-Z., Zeng, B., Atkin, S. L., Daskoulidou, N., Chen, G.-L., & Lukhele, B. (2012). Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure. Toxicological Sciences, 125(1), 56 - 68. https://doi.org/10.1093/toxsci/kfr268

Mercury is an established worldwide environmental pollutant with well-known toxicity affecting neurodevelopment in humans, but the molecular basis of cytotoxicity and the detoxification procedure are still unclear. Here we examined the involvement of... Read More about Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure.

Keeping it in the Family: Conducting Research Interviews with your own Family Members (2011)
Book Chapter
Seymour, J. (2011). Keeping it in the Family: Conducting Research Interviews with your own Family Members. In Researching Families and Relationships: Reflections on Process (90 - 92). Palgrave Macmillan

As a family researcher I am writing about a project which came literally close to home; one that involved interviewing members of my own family.  I focus mostly on the process of interviewing them and the issues that emerged from this.  I also talk b... Read More about Keeping it in the Family: Conducting Research Interviews with your own Family Members.

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. https://doi.org/10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.