All Outputs (699)

Network-based activity induced by 4-aminopyridine in rat dorsal horn in vitro is mediated by both chemical and electrical synapses (2009)
Journal Article
Chapman, R. J., Cilia La Corte, P. F., Asghar, A. U. R., & King, A. E. (2009). Network-based activity induced by 4-aminopyridine in rat dorsal horn in vitro is mediated by both chemical and electrical synapses. The Journal of physiology, 587(11), 2499-2510. https://doi.org/10.1113/jphysiol.2009.171777

This study investigated the role of electrical and chemical synapses in sustaining 4-aminopyridine (4-AP)-evoked network activity recorded extracellularly from substantia gelatinosa (SG) of young rat spinal cord in vitro. Superfusion of 4-AP (50 micr... Read More about Network-based activity induced by 4-aminopyridine in rat dorsal horn in vitro is mediated by both chemical and electrical synapses.

Learning from evaluation: A descriptive, student-informed approach (2009)
Journal Article
Hammond, A., Collins, S., Booth, J., & Kalia, S. (2009). Learning from evaluation: A descriptive, student-informed approach. Clinical Teacher, 6(2), 73-78. https://doi.org/10.1111/j.1743-498X.2009.00275.x

Preamble
Meaningful engagement of students in the thoughtful evaluation of teaching is difficult
Students were involved in framing questions and in commenting on the evaluation process
The data supply insights into students' views on being taught... Read More about Learning from evaluation: A descriptive, student-informed approach.

Quality assurance in colonoscopy: role of endomucosal clips (2009)
Journal Article
Maslekar, S., Avery, G., & Duthie, G. S. (2010). Quality assurance in colonoscopy: role of endomucosal clips. Colorectal Disease, 12(7), 651-656. https://doi.org/10.1111/j.1463-1318.2009.01874.x

Objective Quality assurance in colonoscopy is important, and subjective assessment of completion based on endoscopic signs can be inaccurate leading to missed lesions. We aimed to determine the technique of endomucosal clips with follow-up X-rays in... Read More about Quality assurance in colonoscopy: role of endomucosal clips.

Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins (2009)
Journal Article
Carradice, D., Mekako, A. I., Hatfield, J., & Chetter, I. C. (2009). Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins. British journal of surgery, 96(4), 369-375. https://doi.org/10.1002/bjs.6556

Background: The management of residual varicosities following endovenous laser therapy (EVLT) for varicose veins is contentious. Ambulatory phlebectomy may be performed concomitantly with the initial EVLT, or sequentially as a secondary procedure. Th... Read More about Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins.

Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy (2009)
Journal Article
Maslekar, S., Gardiner, A., Hughes, M., Culbert, B., & Duthie, G. S. (2009). Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy. British journal of surgery, 96(4), 361-368. https://doi.org/10.1002/bjs.6467

Background: Intravenous sedation for colonoscopy is associated with cardiorespiratory complications and delayed recovery. The aim of this randomized clinical trial was to compare the efficacy of Entonox ® (50 per cent nitrous oxide and 50 per cent o... Read More about Randomized clinical trial of Entonox ® versus midazolam-fentanyl sedation for colonoscopy.

Considered evaluation of clinical placements in a new medical school (2009)
Journal Article
Booth, J., Collins, S., & Hammond, A. (2009). Considered evaluation of clinical placements in a new medical school. Assessment and Evaluation in Higher Education, 34(1), 17-29. https://doi.org/10.1080/02602930701773018

This article suggests that quality assessment in the UK has been largely set apart from learning and teaching and reports on a pilot project at the Hull York Medical School which attempted to integrate students' evaluation of their clinical placement... Read More about Considered evaluation of clinical placements in a new medical school.

In Situ Characterization of Elusive Salt Hydrates-The Crystal Structures of the Heptahydrate and Octahydrate of Sodium Sulfate (2008)
Journal Article
Oswald, I. D. H., Hamilton, A., Hall, C., Marshall, W. G., Prior, T. J., & Pulham, C. R. (2008). In Situ Characterization of Elusive Salt Hydrates-The Crystal Structures of the Heptahydrate and Octahydrate of Sodium Sulfate. Journal of the American Chemical Society, 130(52), 17795-17800. https://doi.org/10.1021/ja805429m

An important intermediate phase in the crystallization of aqueous solutions of sodium sulfate is the highly metastable sodium sulfate heptahydrate (Na2SO4 center dot 7H(2)O). This has been structurally characterized for the first time by in situ sing... Read More about In Situ Characterization of Elusive Salt Hydrates-The Crystal Structures of the Heptahydrate and Octahydrate of Sodium Sulfate.

Predictors of short term mortality in heart failure - insights from the Euro Heart Failure survey (2008)
Journal Article
Velavan, P., Khan, N. K., Goode, K., Rigby, A. S., Loh, P. H., Komajda, M., Follath, F., Swedberg, K., Madeira, H., & Cleland, J. G. (2010). Predictors of short term mortality in heart failure - insights from the Euro Heart Failure survey. International journal of cardiology, 138(1), 63-69. https://doi.org/10.1016/j.ijcard.2008.08.004

Objective: To identify factors associated with short term mortality in hospitalised patients with heart failure. Background: Hospitalisation is frequent in patients with heart failure and is associated with a high mortality. Methods: The Euro Heart F... Read More about Predictors of short term mortality in heart failure - insights from the Euro Heart Failure survey.

Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease (2008)
Journal Article
Wakil, A., Rigby, A. S., Clark, A. L., Kallvikbacka-Bennett, A., & Atkin, S. L. (2008). Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease. European journal of endocrinology, 159(4), R11-R14. https://doi.org/10.1530/eje-08-0365

OBJECTIVE: Recent trials suggest that using ergot-derived dopamine agonists such as cabergoline in the treatment of Parkinson's disease is associated with an increased risk of valvular heart disease. However, the dose of cabergoline used to treat hyp... Read More about Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease.

A1C variability and the risk of microvascular complications in type 1 diabetes: Data from the diabetes control and complications trial (2008)
Journal Article
Kilpatrick, E. S., Rigby, A. S., & Atkin, S. L. (2008). A1C variability and the risk of microvascular complications in type 1 diabetes: Data from the diabetes control and complications trial. Diabetes Care, 31(11), 2198-2202. https://doi.org/10.2337/dc08-0864

OBJECTIVE—Debate remains as to whether short- or long-term glycemic instability confers a risk of microvascular complications in addition to that predicted by mean glycemia alone. In this study, we analyzed data from the Diabetes Control and Complica... Read More about A1C variability and the risk of microvascular complications in type 1 diabetes: Data from the diabetes control and complications trial.

The accurate staging of ovarian cancer using 3T magnetic resonance imaging - a realistic option (2008)
Journal Article
Booth, S., Turnbull, L., Poole, D., & Richmond, I. (2008). The accurate staging of ovarian cancer using 3T magnetic resonance imaging - a realistic option. BJOG: An International Journal of Obstetrics and Gynaecology, 115(7), 894-901. https://doi.org/10.1111/j.1471-0528.2008.01716.x

Objectives: The aim of the study was to determine whether staging primary ovarian cancer using 3.0 Tesla (3T) magnetic resonance imaging (MRI) is comparable to surgical staging of the disease. Design: A retrospective study consisting of a search of t... Read More about The accurate staging of ovarian cancer using 3T magnetic resonance imaging - a realistic option.

An amygdala response to fearful faces with covered eyes (2008)
Journal Article
Asghar, A. U., Chiu, Y. C., Hallam, G., Liu, S., Mole, H., Wright, H., & Young, A. W. (2008). An amygdala response to fearful faces with covered eyes. Neuropsychologia, 46(9), 2364-2370. https://doi.org/10.1016/j.neuropsychologia.2008.03.015

Findings of amygdala responsiveness to the eye region of fearful faces raise the question of whether eye widening is the only facial cue involved. We used fMRI to investigate the differential amygdala response to fearful versus neutral stimuli for fa... Read More about An amygdala response to fearful faces with covered eyes.

The timing of development and subsequent clinical course of heart failure after a myocardial infarction (2008)
Journal Article
Torabi, A., Cleland, J. G., Khan, N. K., Loh, P. H., Clark, A. L., Alamgir, F., Caplin, J. L., Rigby, A. S., & Goode, K. (2008). The timing of development and subsequent clinical course of heart failure after a myocardial infarction. European Heart Journal, 29(7), 859-870. https://doi.org/10.1093/eurheartj/ehn096

Aims: Myocardial infarction (MI) is a common cause of heart failure (HF), which may develop early and persist or resolve, or develop late. The cumulative incidence, persistence, and resolution of HF after MI are poorly described. The aim of this stud... Read More about The timing of development and subsequent clinical course of heart failure after a myocardial infarction.

Brain imaging of acupuncture: comparing superficial with deep needling (2008)
Journal Article
MacPherson, H., Green, G., Nevado, A., Lythgoe, M. F., Lewith, G., Devlin, R., Haselfoot, R., & Asghar, A. U. R. (2008). Brain imaging of acupuncture: comparing superficial with deep needling. Neuroscience letters, 434(1), 144-149. https://doi.org/10.1016/j.neulet.2008.01.058

The difference between superficial and deep needling at acupuncture points has yet to be mapped with functional magnetic resonance imaging (fMRI). Using a 3 T MRI, echo planar imaging data were acquired for 17 right-handed healthy volunteer participa... Read More about Brain imaging of acupuncture: comparing superficial with deep needling.

Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2 (2008)
Journal Article
Xu, S. Z., Zhong, W., Watson, N. M., Dickerson, E., Wake, J. D., Lindow, S. W., Newton, C. J., & Atkin, S. L. (2008). Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2. Journal of thrombosis and haemostasis : JTH, 6(4), 692-700. https://doi.org/10.1111/j.1538-7836.2008.02913.x

Background: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been widely used in clinical practise and their efficacy in reducing cardiovascular risk has been well described. Objectives: To investigate the effect of low doses... Read More about Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2.

Treating the hotel like a home: the contribution of studying the single location home/workplace (2007)
Journal Article
Seymour, J. (2007). Treating the hotel like a home: the contribution of studying the single location home/workplace. Sociology, 41(6), 1097-1114. https://doi.org/10.1177/0038038507082317

This article contributes to research on the dynamic of space and social life by examining a comparatively uncommon, configuration; that of the single location home/workplace, It draws on an empirical study of family-run hotels, pubs and boarding hous... Read More about Treating the hotel like a home: the contribution of studying the single location home/workplace.

Mean blood glucose compared with HbA1c in the prediction of cardiovascular disease in patients with type 1 diabetes (2007)
Journal Article
Kilpatrick, E. S., Rigby, A. S., & Atkin, S. L. (2008). Mean blood glucose compared with HbA1c in the prediction of cardiovascular disease in patients with type 1 diabetes. Diabetologia, 51(2), 365-371. https://doi.org/10.1007/s00125-007-0883-x

Aims/hypothesisIt is not known whether mean blood glucose (MBG) predicts the risk of macrovascular complications in diabetes any differently from HbA1c. In this study we therefore analysed data from the Diabetes Control and Complications Trial (DCCT)... Read More about Mean blood glucose compared with HbA1c in the prediction of cardiovascular disease in patients with type 1 diabetes.

Shared prescribing? A focus group study with community pharmacists (2007)
Journal Article
Irving, G., Hilton, A., & Campion, P. (2007). Shared prescribing? A focus group study with community pharmacists. Primary Health Care Research and Development, 8(4), 308-314. https://doi.org/10.1017/S1463423607000400

Background: in the Community, randomised over Time) trial was a multi-centre pragmatic trial of pharmaceutical care in the community, which took place in five areas of East and North Yorkshire. of community pharmacists towards the process of ‘pharmac... Read More about Shared prescribing? A focus group study with community pharmacists.

Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy (2007)
Journal Article
Tan, P. C., Pickles, M. D., Lowry, M., Manton, D. J., & Turnbull, L. W. (2008). Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy. Magnetic Resonance Imaging, 26(1), 26-34. https://doi.org/10.1016/j.mri.2007.04.002

The aim of this study was to investigate the utility of the water T-2 values of malignant breast lesions in predicting response after the first and second cycles of neoadjuvant chemotherapy (NAC), both alone and in combination with lesion volumes. Th... Read More about Lesion T2 relaxation times and volumes predict the response of malignant breast lesions to neoadjuvant chemotherapy.

Cutaneous hyperpigmentation after endovenous laser therapy: a case report and literature review (2007)
Journal Article
Mekako, A., & Chetter, I. (2007). Cutaneous hyperpigmentation after endovenous laser therapy: a case report and literature review. Annals of vascular surgery, 21(5), 637-639. https://doi.org/10.1016/j.avsg.2007.03.013

Endovenous laser therapy (EVLT) for the treatment of varicose veins has been shown to be effective and relatively safe. Reported complications are few and transient. Whereas it is not uncommon to have cutaneous hyperpigmentation following treatment m... Read More about Cutaneous hyperpigmentation after endovenous laser therapy: a case report and literature review.