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A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth (2019)
Journal Article
Pinheiro, M., Ma, X., Fagan, M. J., McIntyre, G. T., Lin, P., Sivamurthy, G., & Mossey, P. A. (2019). A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth. Journal of Biological Engineering, 13(1), https://doi.org/10.1186/s13036-019-0171-6

© 2019 The Author(s). Background: Cephalometric analysis is used to evaluate facial growth, to study the anatomical relationships within the face. Cephalometric assessment is based on 2D radiographic images, either the sagittal or coronal planes and... Read More

Neurocranial development of the coelacanth and the evolution of the sarcopterygian head (2019)
Journal Article
Dutel, H., Galland, M., Tafforeau, P., Long, J. A., Fagan, M. J., Janvier, P., …Herbin, M. (2019). Neurocranial development of the coelacanth and the evolution of the sarcopterygian head. Nature, 569, 556–559. https://doi.org/10.1038/s41586-019-1117-3

The neurocranium of sarcopterygian fishes was originally divided into an anterior (ethmosphenoid) and posterior (otoccipital) portion by an intracranial joint, and underwent major changes in its overall geometry before fusing into a single unit in lu... Read More

Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway (2019)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2019). Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway. Computers in biology and medicine, 107, 257-264. https://doi.org/10.1016/j.compbiomed.2019.03.003

RANKL can promote the differentiation of osteoclast precursors into mature osteoclasts by binding to RANK expressed on the surfaces of osteoclast progenitor cells during bone remodelling. The NF-κB signalling pathway is downstream of RANKL and transm... Read More

Bite force and cranial bone strain in four species of lizards (2018)
Journal Article
Ross, C. F., Porro, L. B., Herrel, A., Evans, S. E., & Fagan, M. J. (2018). Bite force and cranial bone strain in four species of lizards. The journal of experimental biology, 221(23), jeb.180240. https://doi.org/10.1242/jeb.180240

In vivo bone strain data provide direct evidence of strain patterns in the cranium during biting. Compared to mammals, in vivo bone strains in lizard skulls are poorly documented. This paper presents strain data from the skulls of Anolis equestris, G... Read More

The role of miniaturization in the evolution of the mammalian jaw and middle ear (2018)
Journal Article
Lautenschlager, S., Gill, P. G., Luo, Z. X., Fagan, M. J., & Rayfield, E. J. (2018). The role of miniaturization in the evolution of the mammalian jaw and middle ear. Nature, 561(7724), 533-537. https://doi.org/10.1038/s41586-018-0521-4

The evolution of the mammalian jaw is one of the most important innovations in vertebrate history, and underpins the exceptional radiation and diversification of mammals over the last 220 million years. In particular, the transformation of the mandi... Read More

Validation of an algorithm to reveal the U wave in atrial fibrillation (2018)
Journal Article
Al-Karadi, M. S., Wilkinson, A. J., Caldwell, J., & Langley, P. (2018). Validation of an algorithm to reveal the U wave in atrial fibrillation. Scientific reports, 8(1), https://doi.org/10.1038/s41598-018-30493-8

Major cardiac organisations recommend U wave abnormalities should be reported during ECG interpretation. However, U waves cannot be measured in patients with atrial fibrillation (AF) due to the obscuring fibrillatory wave. The aim was to validate a U... Read More

Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density (2018)
Journal Article
Dostanpor, A., Dobson, C. A., & Vanicek, N. (2018). Relationships between walking speed, T-score and age with gait parameters in older post-menopausal women with low bone mineral density. Gait and Posture, 64, 230-237. https://doi.org/10.1016/j.gaitpost.2018.05.005

Background: The gait patterns of women with low bone mineral density (BMD) or osteoporosis have not been thoroughly explored, and when examined, often studied in relation to falls and kyphosis. Research question: The aim of this study was to investig... Read More

Mechanical adaptation of trabecular bone morphology in the mammalian mandible (2018)
Journal Article
Watson, P. J., Fitton, L. C., Meloro, C., Fagan, M. J., & Gröning, F. (2018). Mechanical adaptation of trabecular bone morphology in the mammalian mandible. Scientific reports, 8(1), https://doi.org/10.1038/s41598-018-25597-0

Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this struct... Read More

A biomechanical analysis of prognathous and orthognathous insect head capsules: Evidence for a many to one mapping of ridge strain to head strain (2018)
Journal Article
Blanke, A., Pinheiro, M., Watson, P. J., & Fagan, M. J. (2018). A biomechanical analysis of prognathous and orthognathous insect head capsules: Evidence for a many to one mapping of ridge strain to head strain. Journal of evolutionary biology, 31(5), 665-674. https://doi.org/10.1111/jeb.13251

Insect head shapes are remarkably variable but the influences of these changes on biomechanical performance are unclear. Among “basal” winged insects, such as dragonflies, mayflies, earwigs, and stoneflies, some of the most prominent anatomical chang... Read More

The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation (2018)
Journal Article
Pinheiro, M. D. S., Dobson, C., Clarke, N. M., & Fagan, M. (2018). The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation. Computer methods in biomechanics and biomedical engineering, 21(2), 194-200. https://doi.org/10.1080/10255842.2018.1437151

© 2018 Informa UK Limited, trading as Taylor & Francis Group Legg-Calvé-Perthes disease (LCP) is one of the most poorly understood diseases in paediatric orthopaedics. One common trait of LCP is the marked morphological difference between healthy a... Read More

New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction (2018)
Journal Article
Pinheiro, M., Dobson, C. A., Perry, D., & Fagan, M. J. (2018). New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction. Bone & joint research, 7(2), 148-156. https://doi.org/10.1302...758.72.bjr-2017-0191.r1

Objectives Legg–Calvé–Perthes’ disease (LCP) is an idiopathic osteonecrosis of the femoral head that is most common in children between four and eight years old. The factors that lead to the onset of LCP are still unclear; however, it is believed tha... Read More

Predicting calvarial growth in normal and craniosynostotic mice using a computational approach (2017)
Journal Article
Marghoub, A., Libby, J., Babbs, C., Pauws, E., Fagan, M. J., & Moazen, M. (2018). Predicting calvarial growth in normal and craniosynostotic mice using a computational approach. Journal of anatomy, 232(3), 440-448. https://doi.org/10.1111/joa.12764

© 2017 Anatomical Society During postnatal calvarial growth the brain grows gradually and the overlying bones and sutures accommodate that growth until the later juvenile stages. The whole process is coordinated through a complex series of biological... Read More

Categorisation of Mobile EEG: A Researcher's Perspective (2017)
Journal Article
Bateson, A. D., Baseler, H. A., Paulson, K. S., Ahmed, F., & Asghar, A. U. (2017). Categorisation of Mobile EEG: A Researcher's Perspective. Biomed research international, 2017, (1-15). doi:10.1155/2017/5496196. ISSN 2314-6133

© 2017 Anthony D. Bateson et al. Researchers are increasingly attempting to undertake electroencephalography (EEG) recordings in novel environments and contexts outside of the traditional static laboratory setting. The term "mobile EEG," although com... Read More

The biomechanical role of the chondrocranium and sutures in a lizard cranium (2017)
Journal Article
Jones, M. E. H., Gröning, F., Dutel, H., Sharp, A., Fagan, M. J., & Evans, S. E. (2017). The biomechanical role of the chondrocranium and sutures in a lizard cranium. Journal of the Royal Society interface / the Royal Society, 14(137), https://doi.org/10.1098/rsif.2017.0637

The role of soft tissues in skull biomechanics remains poorly understood. Not least, the chondrocranium, the portion of the braincase which persists as cartilage with varying degrees of mineralization. It also remains commonplace to overlook the biom... Read More

Inclusion of periodontal ligament fibres in mandibular finite element models leads to an increase in alveolar bone strains (2017)
Journal Article
McCormack, S. W., Witzel, U., Watson, P. J., Fagan, M. J., & Gröning, F. (2017). Inclusion of periodontal ligament fibres in mandibular finite element models leads to an increase in alveolar bone strains. PloS one, 12(11), e0188707. https://doi.org/10.1371/journal.pone.0188707

Alveolar bone remodelling is vital for the success of dental implants and orthodontic treatments. However, the underlying biomechanical mechanisms, in particular the function of the periodontal ligament (PDL) in bone loading and remodelling, are not... Read More

Heart sound classification from unsegmented phonocardiograms (2017)
Journal Article
Langley, P., & Murray, A. (2017). Heart sound classification from unsegmented phonocardiograms. Physiological Measurement, 38(8), 1658-1670. https://doi.org/10.1088/1361-6579/aa724c

Objective Most algorithms for automated analysis of phonocardiograms (PCG) require segmentation of the signal into the characteristic heart sounds. The aim was to assess the feasibility for accurate classification of heart sounds on short, unsegmente... Read More

Modelling human skull growth: a validated computational model (2017)
Journal Article
Libby, J., Marghoub, A., Johnson, D., Khonsari, R. H., Fagan, M. J., & Moazen, M. (2017). Modelling human skull growth: a validated computational model. Journal of the Royal Society interface / the Royal Society, 14(130), 20170202. https://doi.org/10.1098/rsif.2017.0202

© 2017 The Author(s) Published by the Royal Society. All rights reserved. During the first year of life, the brain grows rapidly and the neurocranium increases to about 65% of its adult size. Our understanding of the relationship between the biomecha... Read More

Micro-encapsulated phase change material (MPCM) slurries: characterization and building applications (2017)
Journal Article
Qiu, Z., Ma, X., Li, P., Zhao, X., & Wright, A. (2017). Micro-encapsulated phase change material (MPCM) slurries: characterization and building applications. Renewable & sustainable energy reviews, 77, 246-262. https://doi.org/10.1016/j.rser.2017.04.001

© 2017 Micro-encapsulated Phase Change Material (MPCM) slurries, acting as the heat transfer fluids or thermal storage mediums, have gained applications in various building thermal energy systems, significantly enhancing their energy efficiency and o... Read More

Form-function relationships in dragonfly mandibles under an evolutionary perspective (2017)
Journal Article
Blanke, A., Schmitz, H., Patera, A., Dutel, H., & Fagan, M. J. (2017). Form-function relationships in dragonfly mandibles under an evolutionary perspective. Journal of the Royal Society interface / the Royal Society, 14(128), https://doi.org/10.1098/rsif.2016.1038

© 2017 The Author(s). Functional requirements may constrain phenotypic diversification or foster it. For insect mouthparts, the quantification of the relationship between shape and function in an evolutionary framework remained largely unexplored. He... Read More

The effect of boundary constraints on finite element modelling of the human pelvis (2017)
Journal Article
Watson, P., Dostanpor, A., Fagan, M. J., & Dobson, C. A. (2017). The effect of boundary constraints on finite element modelling of the human pelvis. Medical engineering & physics, 43, 48-57. https://doi.org/10.1016/j.medengphy.2017.02.001

The use of finite element analysis (FEA) to investigate the biomechanics of anatomical systems critically relies on the specification of physiologically representative boundary conditions. The biomechanics of the pelvis has been the specific focus of... Read More