All Outputs (170)

A Food Monitoring System using Image Segmentation and Machine Learning (2019)
Thesis
Alatawi, M. I. (2019). A Food Monitoring System using Image Segmentation and Machine Learning. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4912448

In recent years, the number of people requiring dietary monitoring has risen, and dietary records are an essential part of the diagnosis and treatment of many health problems. This project designs and evaluates a food monitoring system for use in ins... Read More about A Food Monitoring System using Image Segmentation and Machine Learning.

A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth (2019)
Journal Article
Pinheiro, M., Ma, X., Fagan, M. J., McIntyre, G. T., Lin, P., Sivamurthy, G., & Mossey, P. A. (2019). A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth. Journal of Biological Engineering, 13(1), https://doi.org/10.1186/s13036-019-0171-6

© 2019 The Author(s). Background: Cephalometric analysis is used to evaluate facial growth, to study the anatomical relationships within the face. Cephalometric assessment is based on 2D radiographic images, either the sagittal or coronal planes and... Read More about A 3D cephalometric protocol for the accurate quantification of the craniofacial symmetry and facial growth.

Neurocranial development of the coelacanth and the evolution of the sarcopterygian head (2019)
Journal Article
Dutel, H., Galland, M., Tafforeau, P., Long, J. A., Fagan, M. J., Janvier, P., Herrel, A., Santin, M. D., Clément, G., & Herbin, M. (2019). Neurocranial development of the coelacanth and the evolution of the sarcopterygian head. Nature, 569, 556–559. https://doi.org/10.1038/s41586-019-1117-3

The neurocranium of sarcopterygian fishes was originally divided into an anterior (ethmosphenoid) and posterior (otoccipital) portion by an intracranial joint, and underwent major changes in its overall geometry before fusing into a single unit in lu... Read More about Neurocranial development of the coelacanth and the evolution of the sarcopterygian head.

Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway (2019)
Journal Article
Ji, B., Zhang, Y., Zhen, C., Fagan, M. J., & Yang, Q. (2019). Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway. Computers in biology and medicine, 107, 257-264. https://doi.org/10.1016/j.compbiomed.2019.03.003

RANKL can promote the differentiation of osteoclast precursors into mature osteoclasts by binding to RANK expressed on the surfaces of osteoclast progenitor cells during bone remodelling. The NF-κB signalling pathway is downstream of RANKL and transm... Read More about Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway.

Characterizing and Modeling Bone Formation during Mouse Calvarial Development (2019)
Journal Article
Marghoub, A., Libby, J., Babbs, C., Ventikos, Y., Fagan, M. J., & Moazen, M. (2019). Characterizing and Modeling Bone Formation during Mouse Calvarial Development. Physical review letters, 122(4), Article 048103. https://doi.org/10.1103/PhysRevLett.122.048103

© 2019 American Physical Society. The newborn mammalian cranial vault consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to a medical condition known as c... Read More about Characterizing and Modeling Bone Formation during Mouse Calvarial Development.

An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus) (2018)
Journal Article
Sellés de Lucas, V., Dutel, H., Evans, S. E., Gröning, F., Sharp, A. C., Watson, P. J., & Fagan, M. J. (2018). An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus). Interface, 15(147), Article 20180278. https://doi.org/10.1098/rsif.2018.0278

© 2018 The Author(s). The falx cerebri and the tentorium cerebelli are two projections of the dura mater in the cranial cavity which ossify to varying degrees in some mammalian species. The idea that the ossification of these structures may be necess... Read More about An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus).

Bite force and cranial bone strain in four species of lizards (2018)
Journal Article
Ross, C. F., Porro, L. B., Herrel, A., Evans, S. E., & Fagan, M. J. (2018). Bite force and cranial bone strain in four species of lizards. The journal of experimental biology, 221(23), jeb.180240. https://doi.org/10.1242/jeb.180240

In vivo bone strain data provide direct evidence of strain patterns in the cranium during biting. Compared to mammals, in vivo bone strains in lizard skulls are poorly documented. This paper presents strain data from the skulls of Anolis equestris, G... Read More about Bite force and cranial bone strain in four species of lizards.

The role of miniaturization in the evolution of the mammalian jaw and middle ear (2018)
Journal Article
Lautenschlager, S., Gill, P. G., Luo, Z. X., Fagan, M. J., & Rayfield, E. J. (2018). The role of miniaturization in the evolution of the mammalian jaw and middle ear. Nature, 561(7724), 533-537. https://doi.org/10.1038/s41586-018-0521-4

The evolution of the mammalian jaw is one of the most important innovations in vertebrate history, and underpins the exceptional radiation and diversification of mammals over the last 220 million years. In particular, the transformation of the mandi... Read More about The role of miniaturization in the evolution of the mammalian jaw and middle ear.

Validation of an algorithm to reveal the U wave in atrial fibrillation (2018)
Journal Article
Al-Karadi, M. S., Wilkinson, A. J., Caldwell, J., & Langley, P. (2018). Validation of an algorithm to reveal the U wave in atrial fibrillation. Scientific reports, 8(1), Article 11946. https://doi.org/10.1038/s41598-018-30493-8

Major cardiac organisations recommend U wave abnormalities should be reported during ECG interpretation. However, U waves cannot be measured in patients with atrial fibrillation (AF) due to the obscuring fibrillatory wave. The aim was to validate a U... Read More about Validation of an algorithm to reveal the U wave in atrial fibrillation.

Comparison of an oral factor xa inhibitor with low molecular weight heparin in patients with cancer with venous thromboembolism: Results of a randomized trial (SELECT-D) (2018)
Journal Article
Young, A. M., Marshall, A., Thirlwall, J., Chapman, O., Lokare, A., Hill, C., Hale, D., Dunn, J. A., Lyman, G. H., Hutchinson, C., MacCallum, P., Kakkar, A., Richard Hobbs, F. D., Petrou, S., Dale, J., Poole, C. J., Maraveyas, A., & Levine, M. (2018). Comparison of an oral factor xa inhibitor with low molecular weight heparin in patients with cancer with venous thromboembolism: Results of a randomized trial (SELECT-D). Journal of Clinical Oncology, 36(20), 2017-2023. https://doi.org/10.1200/JCO.2018.78.8034

© 2018 by American Society of Clinical Oncology. Purpose Venous thromboembolism (VTE) is common in patients with cancer. Long-term daily subcutaneous low molecular weight heparin has been standard treatment for such patients. The purpose of this stud... Read More about Comparison of an oral factor xa inhibitor with low molecular weight heparin in patients with cancer with venous thromboembolism: Results of a randomized trial (SELECT-D).

Mechanical adaptation of trabecular bone morphology in the mammalian mandible (2018)
Journal Article
Watson, P. J., Fitton, L. C., Meloro, C., Fagan, M. J., & Gröning, F. (2018). Mechanical adaptation of trabecular bone morphology in the mammalian mandible. Scientific reports, 8(1), Article 7277. https://doi.org/10.1038/s41598-018-25597-0

Alveolar bone, together with the underlying trabecular bone, fulfils an important role in providing structural support against masticatory forces. Diseases such as osteoporosis or periodontitis cause alveolar bone resorption which weakens this struct... Read More about Mechanical adaptation of trabecular bone morphology in the mammalian mandible.

A biomechanical analysis of prognathous and orthognathous insect head capsules: Evidence for a many to one mapping of ridge strain to head strain (2018)
Journal Article
Blanke, A., Pinheiro, M., Watson, P. J., & Fagan, M. J. (2018). A biomechanical analysis of prognathous and orthognathous insect head capsules: Evidence for a many to one mapping of ridge strain to head strain. Journal of evolutionary biology, 31(5), 665-674. https://doi.org/10.1111/jeb.13251

Insect head shapes are remarkably variable but the influences of these changes on biomechanical performance are unclear. Among “basal” winged insects, such as dragonflies, mayflies, earwigs, and stoneflies, some of the most prominent anatomical chang... Read More about A biomechanical analysis of prognathous and orthognathous insect head capsules: Evidence for a many to one mapping of ridge strain to head strain.

The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation (2018)
Journal Article
Pinheiro, M. D. S., Dobson, C., Clarke, N. M., & Fagan, M. (2018). The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation. Computer methods in biomechanics and biomedical engineering, 21(2), 194-200. https://doi.org/10.1080/10255842.2018.1437151

© 2018 Informa UK Limited, trading as Taylor & Francis Group Legg-Calvé-Perthes disease (LCP) is one of the most poorly understood diseases in paediatric orthopaedics. One common trait of LCP is the marked morphological difference between healthy a... Read More about The potential role of variations in juvenile hip geometry on the development of Legg-Calvé-Perthes disease: a biomechanical investigation.

New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction (2018)
Journal Article
Pinheiro, M., Dobson, C. A., Perry, D., & Fagan, M. J. (2018). New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction. Bone & joint research, 7(2), 148-156. https://doi.org/10.1302/2046-3758.72.bjr-2017-0191.r1

Objectives
Legg–Calvé–Perthes’ disease (LCP) is an idiopathic osteonecrosis of the femoral head that is most common in children between four and eight years old. The factors that lead to the onset of LCP are still unclear; however, it is believed th... Read More about New insights into the biomechanics of Legg-Calvé-Perthes’ disease: The role of epiphyseal skeletal immaturity in vascular obstruction.

Predicting calvarial growth in normal and craniosynostotic mice using a computational approach (2017)
Journal Article
Marghoub, A., Libby, J., Babbs, C., Pauws, E., Fagan, M. J., & Moazen, M. (2018). Predicting calvarial growth in normal and craniosynostotic mice using a computational approach. Journal of anatomy, 232(3), 440-448. https://doi.org/10.1111/joa.12764

© 2017 Anatomical Society During postnatal calvarial growth the brain grows gradually and the overlying bones and sutures accommodate that growth until the later juvenile stages. The whole process is coordinated through a complex series of biological... Read More about Predicting calvarial growth in normal and craniosynostotic mice using a computational approach.

The biomechanical role of the chondrocranium and sutures in a lizard cranium (2017)
Journal Article
Jones, M. E. H., Gröning, F., Dutel, H., Sharp, A., Fagan, M. J., & Evans, S. E. (2017). The biomechanical role of the chondrocranium and sutures in a lizard cranium. Journal of the Royal Society interface / the Royal Society, 14(137), Article 20170637. https://doi.org/10.1098/rsif.2017.0637

The role of soft tissues in skull biomechanics remains poorly understood. Not least, the chondrocranium, the portion of the braincase which persists as cartilage with varying degrees of mineralization. It also remains commonplace to overlook the biom... Read More about The biomechanical role of the chondrocranium and sutures in a lizard cranium.

Inclusion of periodontal ligament fibres in mandibular finite element models leads to an increase in alveolar bone strains (2017)
Journal Article
McCormack, S. W., Witzel, U., Watson, P. J., Fagan, M. J., & Gröning, F. (2017). Inclusion of periodontal ligament fibres in mandibular finite element models leads to an increase in alveolar bone strains. PLoS ONE, 12(11), e0188707. https://doi.org/10.1371/journal.pone.0188707

Alveolar bone remodelling is vital for the success of dental implants and orthodontic treatments. However, the underlying biomechanical mechanisms, in particular the function of the periodontal ligament (PDL) in bone loading and remodelling, are not... Read More about Inclusion of periodontal ligament fibres in mandibular finite element models leads to an increase in alveolar bone strains.

Heart sound classification from unsegmented phonocardiograms (2017)
Journal Article
Langley, P., & Murray, A. (2017). Heart sound classification from unsegmented phonocardiograms. Physiological Measurement, 38(8), 1658-1670. https://doi.org/10.1088/1361-6579/aa724c

Objective Most algorithms for automated analysis of phonocardiograms (PCG) require segmentation of the signal into the characteristic heart sounds. The aim was to assess the feasibility for accurate classification of heart sounds on short, unsegmente... Read More about Heart sound classification from unsegmented phonocardiograms.

Modelling human skull growth: a validated computational model (2017)
Journal Article
Libby, J., Marghoub, A., Johnson, D., Khonsari, R. H., Fagan, M. J., & Moazen, M. (2017). Modelling human skull growth: a validated computational model. Journal of the Royal Society interface / the Royal Society, 14(130), 20170202. https://doi.org/10.1098/rsif.2017.0202

© 2017 The Author(s) Published by the Royal Society. All rights reserved. During the first year of life, the brain grows rapidly and the neurocranium increases to about 65% of its adult size. Our understanding of the relationship between the biomecha... Read More about Modelling human skull growth: a validated computational model.

Form-function relationships in dragonfly mandibles under an evolutionary perspective (2017)
Journal Article
Blanke, A., Schmitz, H., Patera, A., Dutel, H., & Fagan, M. J. (2017). Form-function relationships in dragonfly mandibles under an evolutionary perspective. Journal of the Royal Society interface / the Royal Society, 14(128), Article 20161038. https://doi.org/10.1098/rsif.2016.1038

© 2017 The Author(s). Functional requirements may constrain phenotypic diversification or foster it. For insect mouthparts, the quantification of the relationship between shape and function in an evolutionary framework remained largely unexplored. He... Read More about Form-function relationships in dragonfly mandibles under an evolutionary perspective.