All Outputs (78)

Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs. A computational study (2017)
Journal Article
Alday, E. A. P., Colman, M. A., Langley, P., & Zhang, H. (2017). Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs. A computational study. PLoS Computational Biology, 13(3), e1005270. https://doi.org/10.1371/journal.pcbi.1005270

Atrial tachy-arrhytmias, such as atrial fibrillation (AF), are characterised by irregular electrical activity in the atria, generally associated with erratic excitation underlain by re-entrant scroll waves, fibrillatory conduction of multiple wavelet... Read More about Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs. A computational study.

Morphological evolution of the mammalian jaw adductor complex (2016)
Journal Article
Lautenschlager, S., Gill, P., Luo, Z., Fagan, M. J., & Rayfield, E. J. (2017). Morphological evolution of the mammalian jaw adductor complex. Biological Reviews, 92(4), 1910-1940. https://doi.org/10.1111/brv.12314

The evolution of the mammalian jaw during the transition from non-mammalian synapsids to crown mammals is a key event in vertebrate history and characterised by the gradual reduction of its individual bones into a single element and the concomitant t... Read More about Morphological evolution of the mammalian jaw adductor complex.

Accuracy of pulse interval timing in ambulatory blood pressure measurement (2016)
Journal Article
Kane, S. A., Blake, J. R., McArdle, F. J., Langley, P., & Sims, A. J. (2016). Accuracy of pulse interval timing in ambulatory blood pressure measurement. Scientific reports, 6(1), Article 37472. https://doi.org/10.1038/srep37472

Blood pressure (BP) monitors rely on pulse detection. Some blood pressure monitors use pulse timings to analyse pulse interval variability for arrhythmia screening, but this assumes that the pulse interval timings detected from BP cuffs are accurate... Read More about Accuracy of pulse interval timing in ambulatory blood pressure measurement.

A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs (2016)
Journal Article
Sivaraman, J., Uma, G., Langley, P., Umapathy, M., Venkatesan, S., & Palanikumar, G. (2016). A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs. Computer Methods and Programs in Biomedicine, 137, 341-351. https://doi.org/10.1016/j.cmpb.2016.10.005

© 2016 Elsevier Ireland Ltd Background The interaction between the PTa and PP interval dynamics from the surface ECG is seldom explained. Mathematical modeling of these intervals is of interest in finding the relationship between the heart rate and r... Read More about A study on stability analysis of atrial repolarization variability using ARX model in sinus rhythm and atrial tachycardia ECGs.

A non-invasive, home-based EEG hypoglycaemia warning system for personal monitoring using skin surface electrodes : a single-case feasibility study (2016)
Journal Article
Clewett, C. J., Langley, P., Bateson, A. D., Asghar, A., & Wilkinson, A. J. (2016). A non-invasive, home-based EEG hypoglycaemia warning system for personal monitoring using skin surface electrodes : a single-case feasibility study. Health Technology Letters, 3(1), 2-5. https://doi.org/10.1049/htl.2015.0037

Hypoglycaemia unawareness is a common condition associated with increased risk of severe hypoglycaemia. The purpose of the authors' study was to develop a simple to use, home-based and non-invasive hypoglycaemia warning system based on electroencepha... Read More about A non-invasive, home-based EEG hypoglycaemia warning system for personal monitoring using skin surface electrodes : a single-case feasibility study.

Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study (2016)
Journal Article
Moazen, M., Leonidou, A., Pagkalos, J., Marghoub, A., Fagan, M. J., & Tsiridis, E. (2016). Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study. Journal of Arthroplasty, 31(8), 1849-1856. https://doi.org/10.1016/j.arth.2016.02.013

© 2016 Elsevier Inc. Background Lack of fracture movement could be a potential cause of periprosthetic femoral fracture (PFF) fixation failures. This study aimed to test whether the use of distal far cortical locking screws reduces the overall stiffn... Read More about Application of Far Cortical Locking Technology in Periprosthetic Femoral Fracture Fixation: A Biomechanical Study.

Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance (2015)
Journal Article
Toro-Ibacache, V., Fitton, L. C., Fagan, M. J., & O'Higgins, P. (2016). Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance. Journal of anatomy, 228(1), 70-84. https://doi.org/10.1111/joa.12384

Finite element analysis (FEA) is a modelling technique increasingly used in anatomical studies investigating skeletal form and function. In the case of the cranium this approach has been applied to both living and fossil taxa to (for example) investi... Read More about Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance.

Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation (2015)
Journal Article
Langley, P. (2015). Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation. Entropy, 17(9), 6397-6411. https://doi.org/10.3390/e17096397

A novel method of quantifying the effectiveness of the suppression of ventricular activity from electrocardiograms (ECGs) in atrial fibrillation is proposed. The temporal distribution of the energy of wavelet coefficients is quantified by wavelet ent... Read More about Wavelet entropy as a measure of ventricular beat suppression from the electrocardiogram in atrial fibrillation.

Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome (2015)
Journal Article
Raine, D., Langley, P., Shepherd, E., Lord, S., Murray, S., Murray, A., & Bourke, J. P. (2015). Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome. Open heart, 2(1), e000302. https://doi.org/10.1136/openhrt-2015-000302

Objective To assess the effect of catheter ablation on atrial fibrillation (AF) symptoms and quality of life (QoL). Methods Patients with AF scheduled for ablation were recruited. Pulmonary vein isolation (PVI) was performed and complex fractionated... Read More about Effect of catheter ablation on quality of life in patients with atrial fibrillation and its correlation with arrhythmia outcome.

A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease (2015)
Journal Article
Ji, B., Genever, P. G., & Fagan, M. J. (2016). A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease. International journal for numerical methods in biomedical engineering, 32(3), e02735. https://doi.org/10.1002/cnm.2735

Multiple myeloma bone disease is devastating for patients and a major cause of morbidity. The disease leads to bone destruction by inhibiting osteoblast activity while stimulating osteoclast activity. Recent advances in multiple myeloma research have... Read More about A virtual approach to evaluate therapies for management of multiple myeloma induced bone disease: Modelling Therapies for Multiple Myeloma Induced Bone Disease.

Mechanical properties of calvarial bones in a mouse model for craniosynostosis (2015)
Journal Article
Moazen, M., Peskett, E., Babbs, C., Pauws, E., & Fagan, M. J. (2015). Mechanical properties of calvarial bones in a mouse model for craniosynostosis. PLoS ONE, 10(5), e0125757. https://doi.org/10.1371/journal.pone.0125757

The mammalian cranial vault largely consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Premature closure of the cranial sutures, craniosynostosis, can lead to serious clinical pathology unle... Read More about Mechanical properties of calvarial bones in a mouse model for craniosynostosis.

Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity (2015)
Journal Article
Raine, D., Langley, P., Shepherd, E., Lord, S., Murray, S., Murray, A., & Bourke, J. P. (2015). Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity. Medical engineering & physics, 37(2), 251-255. https://doi.org/10.1016/j.medengphy.2014.12.008

Background Lead V₁ is routinely analysed due to its large amplitude AF waveform. V₁ correlates strongly with right atrial activity but only moderately with left atrial activity. Posterior lead V₉ correlates strongest with left atrial activity. Aims (... Read More about Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity.

A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso (2015)
Journal Article
Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., …Zhang, H. (2015). A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso. PLoS Computational Biology, 11(1), Article e1004026. https://doi.org/10.1371/journal.pcbi.1004026

Rapid atrial arrhythmias such as atrial fibrillation (AF) predispose to ventricular arrhythmias, sudden cardiac death and stroke. Identifying the origin of atrial ectopic activity from the electrocardiogram (ECG) can help to diagnose the early onset... Read More about A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems - insights from 3D virtual human atria and torso.

Characteristics of the atrial repolarization phase of the ECG in paroxysmal atrial fibrillation patients and controls (2015)
Journal Article
Langley, P., Bourke, J. P., & Giacopelli, D. (2015). Characteristics of the atrial repolarization phase of the ECG in paroxysmal atrial fibrillation patients and controls. Acta Cardiologica, 70(6), 672-677. https://doi.org/10.2143/AC.70.6.3120179

© 2015, Acta Cardiologica. All rights reserved. Objective The aim of this study is to characterize the observable segment of the atrial repolarization (Ta wave) of the standard ECG during sinus rhythm in paroxysmal atrial fibrillation (PAF) patients... Read More about Characteristics of the atrial repolarization phase of the ECG in paroxysmal atrial fibrillation patients and controls.

Non-invasive estimation of left atrial dominant frequency in atrial fibrillation from different electrode sites: Insight from body surface potential mapping (2014)
Journal Article
Bojarnejad, M., Blake, J. R., Bourke, J., Shepherd, E., Murray, A., & Langley, P. (2014). Non-invasive estimation of left atrial dominant frequency in atrial fibrillation from different electrode sites: Insight from body surface potential mapping. Journal of atrial fibrillation, 7(3), 6-10

© 2014, CardioFront LLC. All rights reserved. The dominant driving sources of atrial fibrillation are often found in the left atrium, but the expression of left atrial activation on the body surface is poorly understood. Using body surface potential... Read More about Non-invasive estimation of left atrial dominant frequency in atrial fibrillation from different electrode sites: Insight from body surface potential mapping.

Recurring patterns of atrial fibrillation in surface ECG predict restoration of sinus rhythm by catheter ablation (2014)
Journal Article
Di Marco, L. Y., Raine, D., Bourke, J. P., & Langley, P. (2014). Recurring patterns of atrial fibrillation in surface ECG predict restoration of sinus rhythm by catheter ablation. Computers in biology and medicine, 54, 172-179. https://doi.org/10.1016/j.compbiomed.2014.09.005

Background Non-invasive tools to help identify patients likely to benefit from catheter ablation (CA) of atrial fibrillation (AF) would facilitate personalised treatment planning. Aim To investigate atrial waveform organisation through recurrence plo... Read More about Recurring patterns of atrial fibrillation in surface ECG predict restoration of sinus rhythm by catheter ablation.

Masticatory biomechanics in the rabbit: a multi-body dynamics analysis (2014)
Journal Article
Watson, P. J., Gröning, F., Curtis, N., Fitton, L. C., Herrel, A., McCormack, S. W., & Fagan, M. J. (2014). Masticatory biomechanics in the rabbit: a multi-body dynamics analysis. Journal of the Royal Society interface / the Royal Society, 11(99), Article 20140564. https://doi.org/10.1098/rsif.2014.0564

Multi-body dynamics is a powerful engineering tool which is becoming increasingly popular for the simulation and analysis of skull biomechanics. This paper presents the first application of multi-body dynamics to analyse the biomechanics of the rabbi... Read More about Masticatory biomechanics in the rabbit: a multi-body dynamics analysis.

Recurring patterns in stationary intervals of abdominal uterine electromyograms during gestation (2014)
Journal Article
Di Marco, L. Y., Di Maria, C., Tong, W., Taggart, M. J., Robson, S. C., & Langley, P. (2014). Recurring patterns in stationary intervals of abdominal uterine electromyograms during gestation. Medical and Biological Engineering and Computing, 52(8), 707-716. https://doi.org/10.1007/s11517-014-1174-6

Abdominal uterine electromyograms (uEMG) studies have focused on uterine contractions to describe the evolution of uterine activity and preterm birth (PTB) prediction. Stationary, non-contracting uEMG has not been studied. The aim of the study was to... Read More about Recurring patterns in stationary intervals of abdominal uterine electromyograms during gestation.

In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri (2014)
Journal Article
Porro, L. B., Ross, C. F., Iriarte-Diaz, J., O'Reilly, J. C., Evans, S. E., & Fagan, M. J. (2014). In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri. The journal of experimental biology, 217(11), 1983-1992. https://doi.org/10.1242/jeb.096362

In vivo bone strain data are the most direct evidence of deformation and strain regimes in the vertebrate cranium during feeding and can provide important insights into skull morphology. Strain data have been collected during feeding across a wide ra... Read More about In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri.

Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls (2014)
Journal Article
Curtis, N., Witzel, U., & Fagan, M. J. (2014). Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls. Folia primatologica, 85(2), 77-87. https://doi.org/10.1159/000357526

Cranial sutures are an essential part of the growing skull, allowing bones to increase in size during growth, with their morphology widely believed to be dictated by the forces and displacements that they experience. The zygomaticotemporal suture in... Read More about Development and three-dimensional morphology of the zygomaticotemporal suture in primate skulls.