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Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity

Raine, Daniel; Langley, Philip; Shepherd, Ewen; Lord, Stephen; Murray, Stephen; Murray, Alan; Bourke, John P.

Authors

Daniel Raine

Ewen Shepherd

Stephen Lord

Stephen Murray

Alan Murray

John P. Bourke

Abstract

Background Lead V₁ is routinely analysed due to its large amplitude AF waveform. V₁ correlates strongly with right atrial activity but only moderately with left atrial activity. Posterior lead V₉ correlates strongest with left atrial activity. Aims (1) To establish whether surface dominant AF frequency (DAF) calculated using principal component analysis (PCA) of a modified 12-lead ECG (including posterior leads) has a stronger correlation with left atrial activity compared to the standard ECG. (2) To assess the contribution of individual ECG leads to the AF principal component in both ECG configurations. Methods Patients were assigned to modified or standard ECG groups. In the modified ECG, posterior leads V₈ and V₉ replaced V₄ and V₆. AF waveform was extracted from one-minute surface ECG recordings using PCA. Surface DAF was correlated with intracardiac DAF from the high right atrium (HRA), coronary sinus (CS) and pulmonary veins (PVs). Results 96 patients were studied. Surface DAF from the modified ECG did not have a stronger correlation with left atrial activity compared to the standard ECG. Both ECG configurations correlated strongly with HRA, CS and right PVs but only moderately with left PVs. V₁ contributed most to the AF principal component in both ECG configurations.

Journal Article Type Article
Publication Date Feb 1, 2015
Journal Medical engineering and physics
Print ISSN 1350-4533
Electronic ISSN 1873-4030
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 37
Issue 2
Pages 251-255
Institution Citation Raine, D., Langley, P., Shepherd, E., Lord, S., Murray, S., Murray, A., & Bourke, J. P. (2015). Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity. Medical engineering & physics, 37(2), (251-255). doi:10.1016/j.medengphy.2014.12.008. ISSN 1350-4533
DOI https://doi.org/10.1016/j.medengphy.2014.12.008
Keywords Surface electrocardiogram; Principal component analysis; QRST subtraction; Dominant frequency; Atrial fibrillation
Publisher URL http://www.sciencedirect.com/science/article/pii/S1350453315000077
Copyright Statement © 2015 The authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Additional Information Copy of article first published in: Medical engineering and physics, 2015, v.37, issue 2.

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Copyright Statement
© 2015 The authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).



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