Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity
Raine, Daniel; Langley, Philip; Shepherd, Ewen; Lord, Stephen; Murray, Stephen; Murray, Alan; Bourke, John P.
Dr Philip Langley P.Langley@hull.ac.uk
Senior Lecturer/ Admissions Tutor (Engineering)
John P. Bourke
Background Lead V₁ is routinely analysed due to its large amplitude AF waveform. V₁ correlates strongly with right atrial activity but only moderately with left atrial activity. Posterior lead V₉ correlates strongest with left atrial activity. Aims (1) To establish whether surface dominant AF frequency (DAF) calculated using principal component analysis (PCA) of a modified 12-lead ECG (including posterior leads) has a stronger correlation with left atrial activity compared to the standard ECG. (2) To assess the contribution of individual ECG leads to the AF principal component in both ECG configurations. Methods Patients were assigned to modified or standard ECG groups. In the modified ECG, posterior leads V₈ and V₉ replaced V₄ and V₆. AF waveform was extracted from one-minute surface ECG recordings using PCA. Surface DAF was correlated with intracardiac DAF from the high right atrium (HRA), coronary sinus (CS) and pulmonary veins (PVs). Results 96 patients were studied. Surface DAF from the modified ECG did not have a stronger correlation with left atrial activity compared to the standard ECG. Both ECG configurations correlated strongly with HRA, CS and right PVs but only moderately with left PVs. V₁ contributed most to the AF principal component in both ECG configurations.
|Journal Article Type||Article|
|Publication Date||Feb 1, 2015|
|Journal||Medical engineering and physics|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Raine, D., Langley, P., Shepherd, E., Lord, S., Murray, S., Murray, A., & Bourke, J. P. (2015). Principal component analysis of atrial fibrillation: Inclusion of posterior ECG leads does not improve correlation with left atrial activity. Medical engineering & physics, 37(2), (251-255). doi:10.1016/j.medengphy.2014.12.008. ISSN 1350-4533|
|Keywords||Surface electrocardiogram; Principal component analysis; QRST subtraction; Dominant frequency; Atrial fibrillation|
|Copyright Statement||© 2015 The authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).|
|Additional Information||Copy of article first published in: Medical engineering and physics, 2015, v.37, issue 2.|
© 2015 The authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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