All Outputs (40)

Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor-κB (2011)
Journal Article
Ettelaie, C., Fountain, D., Collier, M. E. W., ElKeeb, A. M., Xiao, Y. P., & Maraveyas, A. (2011). Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor-κB. Biochimica et Biophysica Acta (BBA): Molecular Basis of Disease, 1812(12), 1591-1600. https://doi.org/10.1016/j.bbadis.2011.09.007

Treatment of cancer patients with low molecular weight heparin (LMWH) appears to have beneficial effects. In this study, the influence of low molecular weight heparin (LMWH) on tissue factor (TF) expression and activity in five cell lines from variou... Read More about Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor-κB.

Reply to “Analysis of NO and its metabolites by mass spectrometry. Comment on ‘Detection of nitric oxide in tissue samples by ESI-MS’” (2011)
Journal Article
Zheng, S., Webster, A., Zheng, S., Welham, K. J., Dyer, C. E., Greenman, J., …Haswell, S. J. (2011). Reply to “Analysis of NO and its metabolites by mass spectrometry. Comment on ‘Detection of nitric oxide in tissue samples by ESI-MS’”. Analyst, 136(2), 411-411. https://doi.org/10.1039/c0an00729c

Comment by Tsikas et al. (Analyst, 2011, DOI: 10.1039/c0an00411a) on the preliminary work by Shen and colleagues (Analyst, 2010, 135, 302) describing the use of ESI-MS/MS for the detection of methylpiperazinobenzenediamine, as a probe for NO in tissu... Read More about Reply to “Analysis of NO and its metabolites by mass spectrometry. Comment on ‘Detection of nitric oxide in tissue samples by ESI-MS’”.

Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum (2011)
Journal Article
Sucgang, R., Kuo, A., Tian, X., Salerno, W., Parikh, A., Feasley, C. L., …Grigoriev, I. V. (2011). Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum. Genome Biology, 12(2), Article R20. https://doi.org/10.1186/gb-2011-12-2-r20

Background: The social amoebae (Dictyostelia) are a diverse group of Amoebozoa that achieve multicellularity by aggregation and undergo morphogenesis into fruiting bodies with terminally differentiated spores and stalk cells. There are four groups of... Read More about Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum.

Effect of treatment on systemic cytokines in head and neck squamous cell carcinoma patients (2011)
Journal Article
Green, V. L., Michno, A., Greenman, J., & Stafford, N. D. (2012). Effect of treatment on systemic cytokines in head and neck squamous cell carcinoma patients. Results in immunology, 2, 1-6. https://doi.org/10.1016/j.rinim.2011.12.001

The aim of this study was to determine the effect of HNSCC tumour treatment on systemic Th1 and Th2 cytokine levels and investigate correlations with clinicopathological parameters. IL2, IL4, IL5, IL6, IL8, IL10, IL13, GMCSF, IFNγ and TNFα were measu... Read More about Effect of treatment on systemic cytokines in head and neck squamous cell carcinoma patients.

Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse (2011)
Journal Article
Matsakas, A., Macharia, R., Otto, A., Elashry, M. I., Mouisel, E., Romanello, V., …Patel, K. (2012). Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse. Experimental Physiology, 97(1), 125-140. https://doi.org/10.1113/expphysiol.2011.063008

Myostatin regulates both muscle mass and muscle metabolism. The myostatin null (MSTN -/- ) mouse has a hypermuscular phenotype owing to both hypertrophy and hyperplasia of the myofibres. The enlarged muscles display a reliance on glycolysis for ener... Read More about Exercise training attenuates the hypermuscular phenotype and restores skeletal muscle function in the myostatin null mouse.

TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis (2011)
Journal Article
Caley, M. P., Kogianni, G., Adamarek, A., Gronau, J. H., Rodriguez-Teja, M., Fonseca, A., …Sturge, J. (2012). TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. Journal of Pathology, 226(5), 775-783. https://doi.org/10.1002/path.3958

Cellular niches in adult tissue can harbour dysregulated microenvironments that become the driving force behind disease progression. The major environmental change when metastatic cells arrive in the bone is the destruction of mineralized type I coll... Read More about TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins (2011)
Journal Article
Revenu, C., Ubelmann, F., Hurbain, I., El-Marjou, F., Dingli, F., Loew, D., …Robine, S. (2012). A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Molecular Biology of the Cell, 23(2), 324-336. https://doi.org/10.1091/mbc.E11-09-0765

Actin-bundling proteins are identified as key players in the morphogenesis of thin membrane protrusions. Until now, functional redundancy among the actin-bundling proteins villin, espin, and plastin-1 has prevented definitive conclusions regarding th... Read More about A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration (2011)
Journal Article
Zech, T., Calaminus, S., Caswell, P., Spence, H. J., Carnell, M., Insall, R. H., …Machesky, L. M. (2012). The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration. Journal of cell science, 124(22), 3753-3759. https://doi.org/10.1242/jcs.080986

The actin cytoskeleton provides scaffolding and physical force to effect fundamental processes such as motility, cytokinesis and vesicle trafficking. The Arp2/3 complex nucleates actin structures and contributes to endocytic vesicle invagination and... Read More about The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration.

The International Society on Thrombosis and Haematosis von Willebrand disease database: An update (2011)
Journal Article
Hampshire, D. J., & Goodeve, A. C. (2011). The International Society on Thrombosis and Haematosis von Willebrand disease database: An update. Seminars in Thrombosis and Hemostasis, 37(5), 470-479. https://doi.org/10.1055/s-0031-1281031

The online locus-specific database for von Willebrand disease (VWFdb) acts as a repository for sequence variant data and associated resources for those with an interest in the disorder. It currently holds details of 561 mutations and 217 polymorphism... Read More about The International Society on Thrombosis and Haematosis von Willebrand disease database: An update.

Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer (2011)
Journal Article
Ettelaie, C., Gardiner, E., Maraveyas, A., Bozas, G., Fyfe, D., Lofts, F., …Wedgwood, K. (2012). Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer. European Journal of Cancer, 48(9), 1283-1292. https://doi.org/10.1016/j.ejca.2011.10.017

Background: Annualised figures show an up to 7-fold higher incidence of vascular thromboembolism (VTE) in patients with advanced pancreatic cancer (APC) compared to other common malignancies. Concurrent VTE has been shown to confer a worse overall pr... Read More about Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer.

Serum IL10, IL12 and circulating CD4+CD25high T regulatory cells in relation to long-term clinical outcome in head and neck squamous cell carcinoma patients (2011)
Journal Article
Green, V. L., Irune, E., Prasai, A., Alhamarneh, O., Greenman, J., & Stafford, N. D. (2012). Serum IL10, IL12 and circulating CD4+CD25high T regulatory cells in relation to long-term clinical outcome in head and neck squamous cell carcinoma patients. International Journal of Oncology, 40(3), 833-839. https://doi.org/10.3892/ijo.2011.1259

IL10, but not IL12 or T regulatory cells in the circulation of newly presenting, pre-treatment head and neck squamous cell carcinoma (HNSCC) patients, has been shown previously to be related to survival over a mean follow-up period of 15 months. Here... Read More about Serum IL10, IL12 and circulating CD4+CD25high T regulatory cells in relation to long-term clinical outcome in head and neck squamous cell carcinoma patients.

On-chip integrated labelling, transport and detection of tumour cells (2011)
Journal Article
Woods, J., Docker, P. T., Dyer, C. E., Haswell, S. J., & Greenman, J. (2011). On-chip integrated labelling, transport and detection of tumour cells. ELECTROPHORESIS, 32(22), 3188-3195. https://doi.org/10.1002/elps.201100172

Microflow cytometry represents a promising tool for the investigation of diagnostic and prognostic cellular cancer markers, particularly if integrated within a device that allows primary cells to be freshly isolated from the solid tumour biopsies tha... Read More about On-chip integrated labelling, transport and detection of tumour cells.

The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system (2011)
Journal Article
Nassini, R., Materazzi, S., Vriens, J., Prenen, J., Benemei, S., De Siena, G., …Geppetti, P. (2012). The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain, 135(2), 376-390. https://doi.org/10.1093/brain/awr272

The California bay laurel or Umbellularia californica (Hook. & Arn.) Nutt., is known as the 'headache tree' because the inhalation of its vapours can cause severe headache crises. However, the underlying mechanism of the headache precipitating proper... Read More about The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.

A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs (2011)
Journal Article
Hattersley, S. M., Sylvester, D. C., Dyer, C. E., Stafford, N. D., Haswell, S. J., & Greenman, J. (2012). A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs. Annals of biomedical engineering, 40(6), 1277-1288. https://doi.org/10.1007/s10439-011-0428-9

Tumors are heterogeneous masses of cells characterized pathologically by their size and spread. Their chaotic biology makes treatment of malignancies hard to generalize. We present a robust and reproducible glass microfluidic system, for the maintena... Read More about A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs.

Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure (2011)
Journal Article
Xu, S., Zeng, B., Atkin, S. L., Daskoulidou, N., Chen, G., & Lukhele, B. (2012). Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure. Toxicological Sciences, 125(1), 56 - 68. https://doi.org/10.1093/toxsci/kfr268

Mercury is an established worldwide environmental pollutant with well-known toxicity affecting neurodevelopment in humans, but the molecular basis of cytotoxicity and the detoxification procedure are still unclear. Here we examined the involvement of... Read More about Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure.

Chemometric Study on the Forensic Discrimination of Soil Types Using Their Infrared Spectral Characteristics (2011)
Journal Article
Baron, M., Gonzalez-Rodriguez, J., Croxton, R., Gonzalez, R., & Jimenez-Perez, R. (2011). Chemometric Study on the Forensic Discrimination of Soil Types Using Their Infrared Spectral Characteristics. Applied Spectroscopy, 65(10), 1151-1161. https://doi.org/10.1366/10-06197

Soil has been utilized in criminal investigations for some time because of its prevalence and transferability. It is usually the physical characteristics that are studied; however, the research carried out here aims to make use of the chemical profil... Read More about Chemometric Study on the Forensic Discrimination of Soil Types Using Their Infrared Spectral Characteristics.

Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant (2011)
Journal Article
Al-Balool, H. H., Weber, D., Liu, Y., Wade, M., Guleria, K., Nam, P. L. P., …Jackson, M. S. (2011). Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. Genome research, 21(11), 1788-1799. https://doi.org/10.1101/gr.116442.110

In silico analyses have established that transcripts from some genes can be processed into RNAs with rearranged exon order relative to genomic structure (post-transcriptional exon shuffling, or PTES). Although known to contribute to transcriptome div... Read More about Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant.

Microcrystalline identification of selected designer drugs (2011)
Journal Article
Elie, L., Baron, M., Croxton, R., & Elie, M. (2012). Microcrystalline identification of selected designer drugs. Forensic Science International, 214(1-3), 182-188. https://doi.org/10.1016/j.forsciint.2011.08.005

A microcrystalline test for the detection of 4-methylmethcathinone (mephedrone), benzylpiperazine (BZP) and 5,6-methylenedioxy-2-aminoindane (MDAI) using aqueous solutions of mercury chloride is described. Each of the compounds investigated formed sp... Read More about Microcrystalline identification of selected designer drugs.

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis (2011)
Journal Article
Botham, A., Guo, X., Xiao, Y. P., Morice, A. H., Compton, S., & Sadofsky, L. R. (2011). Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal, 438(2), 359-367. https://doi.org/10.1042/BJ20101958

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation o... Read More about Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.

Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload (2011)
Journal Article
Kim, S., Choisy, S. C., Barman, P., Zhang, H., Hancox, J. C., Jones, S. A., & James, A. F. (2011). Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload. Circulation. Arrhythmia and electrophysiology, 4(5), 761-769. https://doi.org/10.1161/CIRCEP.111.964783

BACKGROUND: Although arterial hypertension and left ventricular hypertrophy are considered good epidemiological indicators of the risk of atrial fibrillation (AF) in patients, the link between elevated afterload and AF remains unclear. We investigate... Read More about Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload.