All Outputs (146)

Towards codesign in respiratory care: development of an implementation-ready intervention to improve guideline-adherent adult asthma care across primary and secondary care settings (The SENTINEL Project) (2022)
Journal Article
Crowther, L., Pearson, M., Cummings, H., & Crooks, M. G. (2022). Towards codesign in respiratory care: development of an implementation-ready intervention to improve guideline-adherent adult asthma care across primary and secondary care settings (The SENTINEL Project). BMJ Open Respiratory Research, 9(1), Article e001155. https://doi.org/10.1136/bmjresp-2021-001155

Short-acting beta agonist (SABA) overuse (≥3 canisters annually) is associated with worse asthma outcomes and accounts for the majority of greenhouse gas emissions from asthma inhalers in England. Reducing SABA overuse aligns with the National Health... Read More about Towards codesign in respiratory care: development of an implementation-ready intervention to improve guideline-adherent adult asthma care across primary and secondary care settings (The SENTINEL Project).

The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication (2022)
Journal Article
Ibeggazene, S., Cai, P. L., Smith, G. E., Ibbegazene, S., Stirrup, A., Pymer, S., Palmer, J., Cai, P., Smith, G., & Chetter, I. C. (in press). The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication. Vascular, https://doi.org/10.1177/17085381211059665

Background: The screening and diagnosis of intermittent claudication is a challenging process and often relies on the expertise of specialist vascular clinicians. We sought to investigate the diagnostic performance of the Edinburgh Claudication Quest... Read More about The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication.

Bullying, Cyberbullying, and Hate Speech (2022)
Journal Article
Cohen-Almagor, R. (2022). Bullying, Cyberbullying, and Hate Speech. International journal of technoethics, 13(1), 1-17. https://doi.org/10.4018/IJT.291552

The Internet's design and raison d'être are complete freedom, but complete freedom might lead to anarchy and to harmful and anti-social activities. In this paper I address the concepts of moral and social responsibility, applying them to the Internet... Read More about Bullying, Cyberbullying, and Hate Speech.

Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer (2022)
Journal Article
Pashirzad, M., Sathyapalan, T., Sheikh, A., Kesharwani, P., & Sahebkar, A. (2022). Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer. Process Biochemistry, 115, 19-29. https://doi.org/10.1016/j.procbio.2022.02.006

Colorectal cancer (CRC) is one of the most common types of cancer globally. A subpopulation of tumour cells, cancer stem cells (CSC), is speculated to be responsible for tumor initiation, development, maintenance, metastasis, and recurrence. Colorect... Read More about Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer.

Pharmacy and Exercise as Complimentary Partners for Successful Cardiovascular Ageing (2022)
Journal Article
Howlett, L. A., Jones, S. A., & Lancaster, M. K. (2022). Pharmacy and Exercise as Complimentary Partners for Successful Cardiovascular Ageing. Current Vascular Pharmacology, 20(3), 284-302. https://doi.org/10.2174/1570161120666220107105840

Diseases of the cardiovascular system have been the biggest cause of mortality for the majority of the last century, currently contributing to almost a third of deaths every year globally. Ageing associates with changes to the structure and function... Read More about Pharmacy and Exercise as Complimentary Partners for Successful Cardiovascular Ageing.

Experiences of staff providing specialist palliative care during COVID-19: a multiple qualitative case study (2022)
Journal Article
Bradshaw, A., Dunleavy, L., Garner, I., Preston, N., Bajwah, S., Cripps, R., Fraser, L. K., Maddocks, M., Hocaoglu, M., Murtagh, F. E., Oluyase, A. O., Sleeman, K. E., Higginson, I. J., Walshe, C., & CovPall study team. (in press). Experiences of staff providing specialist palliative care during COVID-19: a multiple qualitative case study. Journal of the Royal Society of Medicine, https://doi.org/10.1177/01410768221077366

Objective: To explore the experiences of, and impact on, staff working in palliative care during the COVID-19 pandemic. Design: Qualitative multiple case study using semi-structured interviews between November 2020 and April 2021 as part of the CovPa... Read More about Experiences of staff providing specialist palliative care during COVID-19: a multiple qualitative case study.

The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19 (2022)
Journal Article
Saghafi, N., Rezaee, S. A., Momtazi-Borojeni, A. A., Tavasolian, F., Sathyapalan, T., Abdollahi, E., & Sahebkar, A. (2022). The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19. Life Sciences, 294, Article 120392. https://doi.org/10.1016/j.lfs.2022.120392

The SARS coronavirus 2 (SARS CoV-2) causes Coronavirus Disease (COVID-19), is an emerging viral infection. SARS CoV-2 infects target cells by attaching to Angiotensin-Converting Enzyme (ACE2). SARS CoV-2 could cause cardiac damage in patients with se... Read More about The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19.

PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease (2022)
Journal Article
Shahbaz, S. K., Koushki, K., Sathyapalan, T., Majeed, M., & Sahebkar, A. (2022). PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease. Current Neuropharmacology, 20(2), 309-323. https://doi.org/10.2174/1570159X19666210823103020

Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic ne... Read More about PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease.

Long‐term follow‐up of 415 patients with chronic lymphocytic leukaemia treated with fludarabine and cyclophosphamide‐based chemoimmunotherapy in the frontline ADMIRE and ARCTIC trials, a comprehensive assessment of prognostic factors (2022)
Journal Article
Allsup, D. J., Craig, Z., Cairns, D., Howard, D., Hockaday, A., Bloor, A., Soe, Z., Pepper, C., Gattei, V., Zucchetto, A., Robbe, P., Clifford, R., Schuh, A., Munir, T., Rawstron, A., & Hillmen, P. (in press). Long‐term follow‐up of 415 patients with chronic lymphocytic leukaemia treated with fludarabine and cyclophosphamide‐based chemoimmunotherapy in the frontline ADMIRE and ARCTIC trials, a comprehensive assessment of prognostic factors. American Journal of Hematology, https://doi.org/10.1002/ajh.26483

Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease (2022)
Journal Article
Bolanle, I. O., & Palmer, T. M. (2022). Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease. Cells, 11(4), Article 705. https://doi.org/10.3390/cells11040705

Unresolved hyperglycaemia, a hallmark of type 2 diabetes mellitus (T2DM), is a well characterised manifestation of altered fuel homeostasis and our understanding of its role in the pathologic activation of the inflammatory system continues to grow. M... Read More about Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease.

Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review (2022)
Journal Article
Butler, H., Saulat, O., & Guinn, B. A. (2022). Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review. Carcinogenesis, 43(3), 183-189. https://doi.org/10.1093/carcin/bgac012

Clear cell ovarian cancer (CCOC) is a rare type of epithelial cancer often resistant to platinum-based chemotherapy. Biomarkers for the diagnosis of CCOC, and targets for immunotherapy, both have the potential to improve outcomes for patients. Our re... Read More about Identification of biomarkers for the diagnosis and targets for therapy in patients with clear cell ovarian cancer: a systematic literature review.

Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review (2022)
Journal Article
Metwally, M., Chatters, R., Pye, C., Dimairo, M., White, D., Walters, S., Cohen, J., Young, T., Cheong, Y., Laird, S., Mohiyiddeen, L., Chater, T., Pemberton, K., Turtle, C., Hall, J., Taylor, L., Brian, K., Sizer, A., & Hunter, H. (2022). Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review. Health Technology Assessment, 26(10), vii-122. https://doi.org/10.3310/JNZT9406

Background: In vitro fertilisation is a widely used reproductive technique that can be undertaken with or without intracytoplasmic sperm injection. The endometrial scratch procedure is an in vitro fertilisation ‘add-on’ that is sometimes provided pri... Read More about Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review.

Adolescents’ sexual and reproductive health education: perspectives from secondary school teachers in Northern Nigeria (2022)
Journal Article
Emenike, N., Onukwugha, F. I., Sarki, A., & Smith, L. (in press). Adolescents’ sexual and reproductive health education: perspectives from secondary school teachers in Northern Nigeria. Sex Education, https://doi.org/10.1080/14681811.2022.2028613

Lack of sexual and reproductive health (SRH) education contributes to poor SRH outcomes for adolescents and young people in Sub-Saharan Africa. School-based comprehensive SRH education programmes in low- and middle-income countries aim to advance gen... Read More about Adolescents’ sexual and reproductive health education: perspectives from secondary school teachers in Northern Nigeria.

Concurrent validity and prognostic utility of the Needs Assessment Tool: Progressive Disease Heart Failure (2022)
Journal Article
King, C., Khamis, A., Ross, J., Murtagh, F. E., Johnson, M. J., & Ramsenthaler, C. (in press). Concurrent validity and prognostic utility of the Needs Assessment Tool: Progressive Disease Heart Failure. Journal of pain and symptom management, https://doi.org/10.1016/j.jpainsymman.2022.01.014

Context: People with advanced heart failure have supportive and palliative needs requiring systematic assessment. Objectives: We aimed to assess the validity of the Needs Assessment Tool: Progressive Disease – Heart Failure (NAT:PD-HF). Methods: Seco... Read More about Concurrent validity and prognostic utility of the Needs Assessment Tool: Progressive Disease Heart Failure.

The effectiveness and characteristics of mHealth interventions to increase adolescent's use of Sexual and Reproductive Health services in Sub-Saharan Africa: A systematic review (2022)
Journal Article
Onukwugha, F. I., Smith, L., Kaseje, D., Wafula, C., Kaseje, M., Orton, B., Hayter, M., & Magadi, M. (2022). The effectiveness and characteristics of mHealth interventions to increase adolescent's use of Sexual and Reproductive Health services in Sub-Saharan Africa: A systematic review. PLoS ONE, 17(1), Article e0261973. https://doi.org/10.1371/journal.pone.0261973

Background mHealth innovations have been proposed as an effective solution to improving adolescent access to and use of Sexual and Reproductive Health (SRH) services; particularly in regions with deeply entrenched traditional social norms. However, r... Read More about The effectiveness and characteristics of mHealth interventions to increase adolescent's use of Sexual and Reproductive Health services in Sub-Saharan Africa: A systematic review.

The role of glucosinolates from cruciferous vegetables (Brassicaceae) in gastrointestinal cancers: from prevention to therapeutics (2022)
Journal Article
Melim, C., Lauro, M., Pires, I. M., Oliveira, P., & Cabral, C. (2022). The role of glucosinolates from cruciferous vegetables (Brassicaceae) in gastrointestinal cancers: from prevention to therapeutics. Pharmaceutics, 14(1), Article 190. https://doi.org/10.3390/pharmaceutics14010190

The gastrointestinal (GI) tract is composed of rapidly renewing cells, which increase the likelihood of cancer. Colorectal cancer is one of the most frequently diagnosed GI cancers and currently stands in second place regarding cancer-related mortali... Read More about The role of glucosinolates from cruciferous vegetables (Brassicaceae) in gastrointestinal cancers: from prevention to therapeutics.

Factors Associated With Normal Physiologic Birth for Women Who Labor In Water: A Secondary Analysis of A Prospective Observational Study (2022)
Journal Article
Carpenter, J., Burns, E., & Smith, L. (2022). Factors Associated With Normal Physiologic Birth for Women Who Labor In Water: A Secondary Analysis of A Prospective Observational Study. Journal of Midwifery and Women's Health, 67(1), 13-20. https://doi.org/10.1111/jmwh.13315

Introduction: Research to understand factors associated with normal physiologic birth (unassisted vaginal birth, spontaneous labor onset without epidural analgesia, spinal, or general anesthetic, without episiotomy) is required. Laboring and/or givin... Read More about Factors Associated With Normal Physiologic Birth for Women Who Labor In Water: A Secondary Analysis of A Prospective Observational Study.

The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review (2022)
Journal Article
Bagherniya, M., Mahdavi, A., Abbasi, E., Iranshahy, M., Sathyapalan, T., & Sahebkar, A. (2022). The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review. Inflammopharmacology, 30(1), 91-110. https://doi.org/10.1007/s10787-021-00902-y

Obesity is abnormal fat accumulation in the body which acts as a risk factor for various cardiometabolic states. Adipose tissue in excess can release inflammatory factors, including TNF-α and IL-6, and suppress adiponectin production. TNF-α increases... Read More about The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.

Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets (2022)
Journal Article
Fernández, D., Segura, C., Arman, M., McGill, S., Burchmore, R., & Lopera-Mesa, T. (2022). Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets. Clinical Proteomics, 19, Article 1. https://doi.org/10.1186/s12014-021-09337-7

Background: Thrombocytopenia is frequent in Plasmodium vivax malaria but the role of platelets in pathogenesis is unknown. Our study explores the platelet (PLT) proteome from uncomplicated P. vivax patients, to fingerprint molecular pathways related... Read More about Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets.

Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review (2022)
Journal Article
Gholami, L., Ivari, J. R., Nasab, N. K., Oskuee, R. K., Sathyapalan, T., & Sahebkar, A. (2023). Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review. Current medicinal chemistry, 30(3), 335-355. https://doi.org/10.2174/0929867328666210810160901

Lung cancer is one of the commonest cancers with a significant mortality rate for both genders, particularly in men. Lung cancer is recognized as one of the leading causes of death worldwide, which threatens the lives of over 1.6 million people every... Read More about Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review.