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All Outputs (1264)

Seizure control by decanoic acid through direct AMPA receptor inhibition (2015)
Journal Article
Chang, P., Augustin, K., Boddum, K., Williams, S., Sun, M., Terschak, J. A., Hardege, J. D., Chen, P. E., Walker, M. C., & Williams, R. S. (2016). Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain, 139(2), 431-443. https://doi.org/10.1093/brain/awv325

The medium chain triglyceride ketogenic diet is an established treatment for drug-resistant epilepsy that increases plasma levels of decanoic acid and ketones. Recently, decanoic acid has been shown to provide seizure control in vivo, yet its mechani... Read More about Seizure control by decanoic acid through direct AMPA receptor inhibition.

Modulation of outer bank erosion by slump blocks: disentangling the protective and destructive role of failed material on the three-dimensional flow structure (2015)
Journal Article
Hackney, C., Best, J., Leyland, J., Darby, S. E., Parsons, D., Aalto, R., & Nicholas, A. (2015). Modulation of outer bank erosion by slump blocks: disentangling the protective and destructive role of failed material on the three-dimensional flow structure. Geophysical research letters, 42(24), 10663-10670. https://doi.org/10.1002/2015GL066481

The three-dimensional flow field near the banks of alluvial channels is the primary factor controlling rates of bank erosion. Although submerged slump blocks and associated large-scale bank roughness elements have both previously been proposed to div... Read More about Modulation of outer bank erosion by slump blocks: disentangling the protective and destructive role of failed material on the three-dimensional flow structure.

Sustainability management : insights from the viable system model (2015)
Journal Article
Panagiotakopoulos, P. D., Espinosa Salazar, A. M., & Walker, J. (2016). Sustainability management : insights from the viable system model. Journal of cleaner production, 113, 792-806. https://doi.org/10.1016/j.jclepro.2015.11.035

A review of current literature on sustainability standards reveals a significant gap between their adoption and the implementation of sustainability into every level of the organisation. In this paper, it is argued that in order to overcome this chal... Read More about Sustainability management : insights from the viable system model.

Feasibility and preliminary efficacy of an online intervention to increase physical activity in Nova Scotian cancer survivors: A Randomized Controlled Trial (2015)
Journal Article
Forbes, C. C., Blanchard, C. M., Mummery, W. K., & Courneya, K. S. (2015). Feasibility and preliminary efficacy of an online intervention to increase physical activity in Nova Scotian cancer survivors: A Randomized Controlled Trial. JMIR Cancer, 1(2), Article e12. https://doi.org/10.2196/cancer.4586

Background: Physical activity (PA) behavior change interventions among cancer survivors have used face-to-face, telephone, email, and print-based methods. However, computer-tailored, Internet-delivered programs may be a more viable option to achieve... Read More about Feasibility and preliminary efficacy of an online intervention to increase physical activity in Nova Scotian cancer survivors: A Randomized Controlled Trial.

A study of the impact of building geometry on the thermal performance of road pavement solar collectors (2015)
Journal Article
Nasir, D. S., Hughes, B. R., & Calautit, J. K. (2015). A study of the impact of building geometry on the thermal performance of road pavement solar collectors. Energy, 93, 2614-2630. https://doi.org/10.1016/j.energy.2015.09.128

Studies on RPSC (road pavement solar collectors) have shown the potential of reducing the UHI (urban heat island) effects by dissipating the heat from the pavement for energy harness. Several works have shown that the generated heat could be utilised... Read More about A study of the impact of building geometry on the thermal performance of road pavement solar collectors.

Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis (2015)
Journal Article
Frame, F. M., Savoie, H., Bryden, F., Giuntini, F., Mann, V. M., Simms, M. S., Boyle, R. W., & Maitland, N. J. (2016). Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis. Cancer medicine, 5(1), 61-73. https://doi.org/10.1002/cam4.553

In comparison to more differentiated cells, prostate cancer stem-like cells are radioresistant, which could explain radio-recurrent prostate cancer. Improvement of radiotherapeutic efficacy may therefore require combination therapy. We have investiga... Read More about Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis.

Succotash (2015)
Journal Article
Porter, J. (2015). Succotash. Times Literary Supplement, 27

Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis (2015)
Journal Article
Sathyapalan, T., Atkin, S. L., David, R., & Gooderham, N. J. (2015). Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis. Scientific reports, 5(1), 16890-1-16890-8. https://doi.org/10.1038/srep16890

MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS). The objective was to determine if miRNA-93 and m... Read More about Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis.

A multichannel thiacalix[4]arene-based fluorescent chemosensor for Zn²⁺, F⁻ ions and imaging of living cells (2015)
Journal Article
Ran, M.-Q., Zhao, J.-L., Zhao, Y.-H., Mou, L., Zeng, X., Redshaw, C., Yuan, J.-Y., & Yamato, T. (2016). A multichannel thiacalix[4]arene-based fluorescent chemosensor for Zn²⁺, F⁻ ions and imaging of living cells. Supramolecular chemistry, 28(5-6), 418-426. https://doi.org/10.1080/10610278.2015.1109645

The fluorescent sensor (3) based on the 1,3-alternate conformation of the thiacalix[4]arene bearing the coumarin fluorophore, appended via an imino group, has been synthesised. Sensing properties were evaluated in terms of a colorimetric and fluoresc... Read More about A multichannel thiacalix[4]arene-based fluorescent chemosensor for Zn²⁺, F⁻ ions and imaging of living cells.

Characteristics of direct human impacts on the rivers Karun and Dez in lowland south-west Iran and their interactions with earth surface movements (2015)
Journal Article
Woodbridge, K. P., Heyvaert, V. M., Frostick, L. E., Parsons, D. R., Woodbridge, K., Heyvaert, V. M. A., & Walstra, J. (2016). Characteristics of direct human impacts on the rivers Karun and Dez in lowland south-west Iran and their interactions with earth surface movements. Quaternary International, 392, 315-334. https://doi.org/10.1016/j.quaint.2015.10.088

Two of the primary external factors influencing the variability of major river systems, over river reach scales, are human activities and tectonics. Based on the rivers Karun and Dez in south-west Iran, this paper presents an analysis of the geomorph... Read More about Characteristics of direct human impacts on the rivers Karun and Dez in lowland south-west Iran and their interactions with earth surface movements.

Feedback from massive stars and gas expulsion from proto-globular clusters (2015)
Journal Article
Calura, F., Few, C. G., Romano, D., & D'Ercole, A. (2015). Feedback from massive stars and gas expulsion from proto-globular clusters. Astrophysical journal. Letters, 814(1), Article ARTN L14. https://doi.org/10.1088/2041-8205/814/1/L14

© 2015. The American Astronomical Society. All rights reserved. Globular clusters (GCs) are considerably more complex structures than previously thought, harboring at least two stellar generations that present clearly distinct chemical abundances. Sc... Read More about Feedback from massive stars and gas expulsion from proto-globular clusters.

The responsibility to protect and the use of force: remaking the procrustean bed? (2015)
Journal Article
Morris, J. (2016). The responsibility to protect and the use of force: remaking the procrustean bed?. Cooperation and Conflict, 51(2), 200-215. https://doi.org/10.1177/0010836715612852

The emergence of the Responsibility to Protect (R2P) owed much to the need to enhance the UN’s ability to act forcibly in the face of the most extreme cases of gross human suffering. Too often in the past such responses were emasculated or thwarted b... Read More about The responsibility to protect and the use of force: remaking the procrustean bed?.

Intracranial pressure changes during mouse development (2015)
Journal Article
Moazen, M., Alazmani, A., Rafferty, K., Liu, Z.-J., Gustafson, J., Cunningham, M. L., Fagan, M. J., & Herring, S. W. (2016). Intracranial pressure changes during mouse development. Journal of biomechanics, 49(1), 123-126. https://doi.org/10.1016/j.jbiomech.2015.11.012

During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. intracranial pressure (ICP), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at t... Read More about Intracranial pressure changes during mouse development.

Visualisation techniques to support public interpretation of future climate change and land-use choices: a case study from N-E Scotland (2015)
Journal Article
Wang, C., Miller, D., Brown, I., Jiang, Y., & Castellazzi, M. (2016). Visualisation techniques to support public interpretation of future climate change and land-use choices: a case study from N-E Scotland. International Journal of Digital Earth, 9(6), 586-605. https://doi.org/10.1080/17538947.2015.1111949

Mitigating and adapting to climate change includes a requirement to evaluate the role of future land uses in delivering robust integrated responses that are sensitive to local landscape contexts. In practice, this emphasises the need for community en... Read More about Visualisation techniques to support public interpretation of future climate change and land-use choices: a case study from N-E Scotland.

A systematic review of interventions for the secondary prevention of skin cancer by self-examination (protocol) (2015)
Preprint / Working Paper
Ersser, S., Dyson, J., Kellar, I., Effah, A., Caperon, L., Thomas, S., McNichol, E., Thomas, P., & Newton-Bishop, J. A systematic review of interventions for the secondary prevention of skin cancer by self-examination (protocol)

Review question:

What factors determine the effectiveness of interventions (directed towards secondary prevention of skin cancer programme achieved through self-examination of the skin by adults in the community?

What interventions facilitate... Read More about A systematic review of interventions for the secondary prevention of skin cancer by self-examination (protocol).

Design optimization of TBM disc cutters for different geological conditions (2015)
Journal Article
Xia, Y., Zhang, K., & Liu, J. (2015). Design optimization of TBM disc cutters for different geological conditions. World Journal of Engineering and Technology, 3(4), 218-231. https://doi.org/10.4236/wjet.2015.34023

A novel optimization methodology for the disc cutter designs of tunnel boring machines (TBM) was presented. To fully understand the characteristics and performance of TBM cutters, a comprehensive list of performance parameters were investigated, incl... Read More about Design optimization of TBM disc cutters for different geological conditions.

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain (2015)
Journal Article
Fluteau, A., Ince, P. G., Minett, T., Matthews, F. E., Brayne, C., Garwood, C. J., …Simpson, J. E. (2015). The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience letters, 609, 11-17. https://doi.org/10.1016/j.neulet.2015.10.001

The accumulation of reactive oxygen species leading to oxidative damage and cell death plays an important role in a number of neurodegenerative disorders. FOXO3a, the main isoform of FOXO transcription factors, mediates the cellular response to oxida... Read More about The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain.

On the generation of hydrodynamic shocks by mixed beams and occurrence of sunquakes in flares (2015)
Journal Article
Zharkov, S., & Zharkova, V. (2015). On the generation of hydrodynamic shocks by mixed beams and occurrence of sunquakes in flares. Solar Physics, 290(11), 3163-3188. https://doi.org/10.1007/s11207-015-0813-x

Observations of solar flares with sunquakes by space- and ground-based instruments reveal essentially different dynamics of seismic events in different flares. Some sunquakes are found to be closely associated with the locations of hard X-ray (HXR) a... Read More about On the generation of hydrodynamic shocks by mixed beams and occurrence of sunquakes in flares.