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Bayesian Value-at-Risk backtesting: The case of annuity pricing (2021)
Journal Article
Leung, M., Li, Y., Pantelous, A. A., & Vigne, S. A. (in press). Bayesian Value-at-Risk backtesting: The case of annuity pricing. European journal of operational research, https://doi.org/10.1016/j.ejor.2020.12.051

We propose new Unconditional, Independence and Conditional Coverage VaR-forecast backtests for the case of annuity pricing under a Bayesian framework that significantly minimise the direct and indirect effects of p-hacking or other biased outcomes in... Read More about Bayesian Value-at-Risk backtesting: The case of annuity pricing.

The role of intermolecular interactions in stabilizing the structure of the nematic twist-bend phase (2021)
Journal Article
Merkel, K., Loska, B., Welch, C., Mehl, G. H., & Kocot, A. (2021). The role of intermolecular interactions in stabilizing the structure of the nematic twist-bend phase. RSC advances, 11(5), 2917-2925. https://doi.org/10.1039/d0ra10481g

The understanding of the relationship between molecular structure and the formation of the nematic twist-bend phase is still at an early stage of development. This is mainly related to molecular geometry, while the correlation between the nematic twi... Read More about The role of intermolecular interactions in stabilizing the structure of the nematic twist-bend phase.

Linking modern pollen accumulation rates to biomass: Quantitative vegetation reconstruction in the western Klamath Mountains, NW California, USA (2021)
Journal Article
Knight, C., Baskaran, M., Bunting, M. J., Champagne, M., Potts, M., Wahl, D., Wanket, J., & Battles, J. (2021). Linking modern pollen accumulation rates to biomass: Quantitative vegetation reconstruction in the western Klamath Mountains, NW California, USA. Holocene, 31(5), 814-829. https://doi.org/10.1177/0959683620988038

Quantitative reconstructions of vegetation abundance from sediment-derived pollen systems provide unique insights into past ecological conditions. Recently, the use of pollen accumulation rates (PAR, grains cm−2 year−1) has shown promise as a bioprox... Read More about Linking modern pollen accumulation rates to biomass: Quantitative vegetation reconstruction in the western Klamath Mountains, NW California, USA.

Caledonian and pre-Caledonian orogenic events in Shetland, Scotland: evidence from garnet Lu-Hf and Sm-Nd geochronology (2021)
Book Chapter
Walker, S., Bird, A. F., Thirllall, M. F., & Strachan, R. A. (2021). Caledonian and pre-Caledonian orogenic events in Shetland, Scotland: evidence from garnet Lu-Hf and Sm-Nd geochronology. In J. B. Murphy, R. A. Strachan, & C. Quesada (Eds.), Pannotia to Pangaea: Neoproterozoic and Paleozoic Orogenic Cycles in the Circum-Atlantic Region (305-331). The Geological Society. https://doi.org/10.1144/SP503-2020-32

Garnet Lu–Hf and Sm–Nd ages from the Shetland Caledonides provide evidence of a polyorogenic history as follows: (1) c. 1050 Ma Grenvillian reworking of Neoarchaean basement; (2) c. 910 Ma Renlandian metamorphism of the Westing Group; (3) c. 622–606... Read More about Caledonian and pre-Caledonian orogenic events in Shetland, Scotland: evidence from garnet Lu-Hf and Sm-Nd geochronology.

A brief review on novel pyrene based fluorometric and colorimetric chemosensors for the detection of Cu2+ (2021)
Journal Article
Kowser, Z., Rayhan, U., Akther, T., Redshaw, C., & Yamato, T. (2021). A brief review on novel pyrene based fluorometric and colorimetric chemosensors for the detection of Cu2+. Materials Chemistry Frontiers, 5(5), 2173-2200. https://doi.org/10.1039/d0qm01008a

© 2021 the Partner Organisations. The development of colorimetric and fluorometric chemosensors that capable of detecting Cu2+ ions by a change in colour and fluorescence intensity has been described. Herein, chemosensors having pyrene functional gro... Read More about A brief review on novel pyrene based fluorometric and colorimetric chemosensors for the detection of Cu2+.

PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma (2021)
Journal Article
Edge, S. D., Renard, I., Pyne, E., Li, C., Moody, H., Roy, R., Beavis, A. W., Archibald, S. J., Cawthorne, C. J., Maher, S. J., & Pires, I. M. (2021). PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma. British Journal of Radiology, 94(1119), Article 20201191. https://doi.org/10.1259/bjr.20201191

OBJECTIVE: Neoadjuvant chemoradiotherapy (neo-CRT) prior to surgery is the standard of care for oesophageal adenocarcinoma (OAC) patients. Unfortunately, most patients fail to respond to treatment. MiR-187 was previously shown to be downregulated in... Read More about PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma.

Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial (2021)
Journal Article
Evans, H. E., Forbes, C. C., Galvão, D. A., Vandelanotte, C., Newton, R. U., Wittert, G., Chambers, S., Vincent, A. D., Kichenadasse, G., Brook, N., Girard, D., & Short, C. E. (2021). Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial. Pilot and Feasibility Studies, 7(1), Article 21. https://doi.org/10.1186/s40814-020-00763-2

Introduction: Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. Despite this, many individuals do not engage in sufficient exercise to gain th... Read More about Evaluating a web- and telephone-based personalised exercise intervention for individuals living with metastatic prostate cancer (ExerciseGuide): protocol for a pilot randomised controlled trial.

Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function (2021)
Journal Article
Huang, J., Peng, J., Pearson, J. A., Efthimiou, G., Hu, Y., Tai, N., Xing, Y., Zhang, L., Gu, J., Jiang, J., Zhao, H., Zhou, Z., Wong, F. S., & Wen, L. (2021). Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular and Molecular Immunology, 18(2), 328-338. https://doi.org/10.1038/s41423-020-00590-8

Innate immunity mediated by Toll-like receptors (TLRs), which can recognize pathogen molecular patterns, plays a critical role in type 1 diabetes development. TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and ho... Read More about Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function.

Comparison of performance of alternative post combustion carbon capture processes for a biogas fueled micro gas turbine (2021)
Presentation / Conference Contribution
Font-Palma, C., Lychnos, G., Somehsaraei, H. N., Willson, P., & Assadi, M. (2020, September). Comparison of performance of alternative post combustion carbon capture processes for a biogas fueled micro gas turbine. Presented at ASME Turbo Expo 2020: Turbomachinery Technical Conference and Exposition

Copyright © 2020 ASME The urgent need to decrease greenhouse gases (GHG) has prompted countries such as the UK and Norway to commit to net zero emissions by 2050 and 2030, respectively. One of the sectors contributing to GHG emissions is agriculture,... Read More about Comparison of performance of alternative post combustion carbon capture processes for a biogas fueled micro gas turbine.

Moral injury in healthcare professionals: A scoping review and discussion (2021)
Journal Article
Čartolovni, A., Stolt, M., Scott, P. A., & Suhonen, R. (in press). Moral injury in healthcare professionals: A scoping review and discussion. Nursing Ethics, https://doi.org/10.1177/0969733020966776

Moral injury emerged in the healthcare discussion quite recently because of the difficulties and challenges healthcare workers and healthcare systems face in the context of the COVID-19 pandemic. Moral injury involves a deep emotional wound and is un... Read More about Moral injury in healthcare professionals: A scoping review and discussion.

Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II (2021)
Journal Article
Bennett, H. Q., Kingston, A., Spiers, G., Robinson, L., Corner, L., Bambra, C., Brayne, C., Matthews, F. E., & Jagger, C. (2021). Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II. International Journal of Epidemiology, 50(3), 841-851. https://doi.org/10.1093/ije/dyaa271

Background: Despite increasing life expectancy (LE), cross-sectional data show widening inequalities in disability-free LE (DFLE) by socioeconomic status (SES) in many countries. We use longitudinal data to better understand trends in DFLE and years... Read More about Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II.

A World on His Shoulders: Nat Cohen, Anglo-EMI and the British Film Industry (2021)
Journal Article
Mayne, L. (2021). A World on His Shoulders: Nat Cohen, Anglo-EMI and the British Film Industry. Journal of British cinema and television, 18(1), 34-49. https://doi.org/10.3366/jbctv.2021.0554

Despite being one of the most significant players in the British film industry of the 1960s and 1970s, Nat Cohen remains a curiously neglected figure in histories of that era. At Anglo-Amalgamated he oversaw a varied slate of productions, from B-movi... Read More about A World on His Shoulders: Nat Cohen, Anglo-EMI and the British Film Industry.

Online child sexual exploitation: a new MIS challenge (2021)
Journal Article
Demetis, D. S., & Kietzmann, J. (2021). Online child sexual exploitation: a new MIS challenge. Journal of the Association for Information Systems, 22(1), 5-40. https://doi.org/10.17705/1jais.00652

© 2021, Association for Information Systems. All rights reserved. This paper deals with the difficult yet increasingly important MIS phenomenon of online child sexual exploitation (online CSE). Through the use of secondary and publicly available data... Read More about Online child sexual exploitation: a new MIS challenge.

Global warming and mass extinctions associated with large igneous province volcanism (2021)
Book Chapter
Bond, D. P., & Sun, Y. (2021). Global warming and mass extinctions associated with large igneous province volcanism. In R. E. Ernst, A. J. Dickson, & A. Bekker (Eds.), Large Igneous Provinces: A Driver of Global Environmental and Biotic Changes (83-102). American Geophysical Union. https://doi.org/10.1002/9781119507444.ch3

The coincidence of large igneous province (LIP) eruptions with at least three, if not all, of the Big Five biotic crises of the Phanerozoic implies that volcanism is a key driver of mass extinctions. Many LIP-induced extinction scenarios invoke globa... Read More about Global warming and mass extinctions associated with large igneous province volcanism.

Dopamine induces functional extracellular traps in microglia (2021)
Journal Article
Agrawal, I., Sharma, N., Saxena, S., Arvind, S., Chakraborty, D., Chakraborty, D. B., Jha, D., Ghatak, S., Epari, S., Gupta, T., & Jha, S. (2021). Dopamine induces functional extracellular traps in microglia. iScience, 24(1), Article 101968. https://doi.org/10.1016/j.isci.2020.101968

Dopamine (DA) plays many roles in the brain, especially in movement, motivation, and reinforcement of behavior; however, its role in regulating innate immunity is not clear. Here, we show that DA can induce DNA-based extracellular traps in primary, a... Read More about Dopamine induces functional extracellular traps in microglia.

Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain (2021)
Journal Article
Bury, J. J., Chambers, A., Heath, P. R., Ince, P. G., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., & Wharton, S. B. (2021). Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathologica Communications, 9(1), Article 5. https://doi.org/10.1186/s40478-020-01109-y

Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this s... Read More about Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain.

The Virtual Dissection Room: Live-streamed Demonstrations to Complement Recorded Lectures (2021)
Presentation / Conference Contribution
Shaw, V., & Winder, I. C. (2021, January). The Virtual Dissection Room: Live-streamed Demonstrations to Complement Recorded Lectures. Presented at Anatomical Society Virtual Winter Meeting: Vision and Visualisation, Newcastle

Complying with the constraints on class size created by social distancing meant that in Bangor, it was not possible to have in-person cadaveric teaching this year. This had the biggest impact on the second-year Medical Sciences students, and the firs... Read More about The Virtual Dissection Room: Live-streamed Demonstrations to Complement Recorded Lectures.

Arginine methylation: the promise of a ‘silver bullet’ for brain tumours? (2021)
Journal Article
Samuel, S. F., Barry, A., Greenman, J., & Beltran-Alvarez, P. (2021). Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?. Amino acids, 53(4), 489-506. https://doi.org/10.1007/s00726-020-02937-x

Despite intense research efforts, our pharmaceutical repertoire against high-grade brain tumours has not been able to increase patient survival for a decade and life expectancy remains at less than 16months after diagnosis, on average. Inhibitors of... Read More about Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?.