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Professor Alyn Morice's Outputs (211)

Design and rationale of two phase 3 randomised controlled trials (Cough-1 and cough-2) of gefapixant, a P2X3 receptor antagonist, in refractory or unexplained chronic cough (2020)
Journal Article
Muccino, D. R., Morice, A. H., Birring, S. S., Dicpinigaitis, P. V., Pavord, I. D., Assaid, C., Kleijn, H. J., Hussain, A., La Rosa, C., McGarvey, L., & Smith, J. A. (2020). Design and rationale of two phase 3 randomised controlled trials (Cough-1 and cough-2) of gefapixant, a P2X3 receptor antagonist, in refractory or unexplained chronic cough. ERJ Open Research, 6(4), Article 00284-2020. https://doi.org/10.1183/23120541.00284-2020

Background: We present study designs, dose selection and preliminary patient characteristics from two phase 3 clinical trials of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough (RCC) or unexplained chronic cough (UCC). Methods: CO... Read More about Design and rationale of two phase 3 randomised controlled trials (Cough-1 and cough-2) of gefapixant, a P2X3 receptor antagonist, in refractory or unexplained chronic cough.

Alert system design based on experimental findings from long-term unobtrusive monitoring in COPD (2020)
Journal Article
den Brinker, A. C., van Dinther, R., Crooks, M. G., Thackray-Nocera, S., & Morice, A. H. (2021). Alert system design based on experimental findings from long-term unobtrusive monitoring in COPD. Biomedical Signal Processing and Control, 63, Article 102205. https://doi.org/10.1016/j.bspc.2020.102205

An observational study using a cough count monitor was executed in the home of 30 patients with Chronic Obstructive Pulmonary Disease (COPD). The monitoring system was unobtrusive, allowing long-term monitoring. This paper illustrates the cough count... Read More about Alert system design based on experimental findings from long-term unobtrusive monitoring in COPD.

Objective Assessment of Cough: An Early Marker of Response to Biological Therapies in Asthma? (2020)
Journal Article
Faruqi, S., Sykes, D. L., Crooks, M. G., Brindle, K., Thompson, J., & Morice, A. H. (2020). Objective Assessment of Cough: An Early Marker of Response to Biological Therapies in Asthma?. Lung, 198(5), 767-770. https://doi.org/10.1007/s00408-020-00391-w

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Cough is an important symptom of asthma. The objective assessment of chronic cough has been enhanced by the development of ambulatory cough monitoring systems. Mepolizumab has bee... Read More about Objective Assessment of Cough: An Early Marker of Response to Biological Therapies in Asthma?.

Impact of chronic cough on health-related quality of life in the Korean adult general population: The Korean National Health and Nutrition Examination Survey 2010–2016 (2020)
Journal Article
Won, H.-K., Lee, J.-H., An, J., Sohn, K.-H., Kang, M.-G., Kang, S.-Y., Morice, A. H., Cho, S.-H., & Song, W.-J. (2020). Impact of chronic cough on health-related quality of life in the Korean adult general population: The Korean National Health and Nutrition Examination Survey 2010–2016. Allergy Asthma and Immunology Research, 12(6), 964-979. https://doi.org/10.4168/aair.2020.12.6.964

Purpose: Chronic cough is a prevalent condition in the community and may pose considerable impairment to quality of life (QoL). However, its disease burden remains largely undefined in the general population. The present study investigated the relati... Read More about Impact of chronic cough on health-related quality of life in the Korean adult general population: The Korean National Health and Nutrition Examination Survey 2010–2016.

Cough persistence in adults with chronic cough: a 4-year retrospective cohort study (2020)
Journal Article
Kang, S. Y., Song, W. J., Won, H. K., Chung, S. J., Kim, J. Y., Park, H. W., Morice, A. H., & Cho, S.-H. (2020). Cough persistence in adults with chronic cough: a 4-year retrospective cohort study. Allergology International, 69(4), 588-593. https://doi.org/10.1016/j.alit.2020.03.012

Background
There is very limited evidence regarding long-term prognosis of chronic cough. We examined longitudinal outcomes among patients with chronic cough, and explored predictors of cough persistence.
Methods
A retrospective cohort was constru... Read More about Cough persistence in adults with chronic cough: a 4-year retrospective cohort study.

Drug-induced cough (2020)
Journal Article
Shim, J. S., Song, W. J., & Morice, A. H. (2020). Drug-induced cough. Physiological Research, 69(S1), S81-S92. https://doi.org/10.33549/physiolres.934406

© 2020, Czech Academy of Sciences. Since the recognition of angiotensin-converting enzyme inhibitors (ACEIs)-induced cough, drug has been considered as a potential cause of chronic cough. This review presents recent knowledge on drug-induced coughs i... Read More about Drug-induced cough.

Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial (2020)
Journal Article
Smith, J. A., Kitt, M. M., Morice, A., Birring, S. S., McGarvey, L. P., Sher, M. R., Li, Y. P., Wu, W. C., Xu, Z. J., Muccino, D. R., Ford, A. P., Hull, J., Carr, W. W., Goldsobel, A. B., Gross, G. N., Holcomb, J. R., Hussain, I., Spangenthal, S., Storms, W., Elkayam, D., …Iyer, V. (2020). Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial. The lancet. Respiratory medicine, 8(8), 775-785. https://doi.org/10.1016/S2213-2600%2819%2930471-0

Background: Gefapixant is a P2X3 receptor antagonist that has shown promise for the treatment of refractory and unexplained chronic cough. The aim of this study was to evaluate the efficacy of gefapixant compared with placebo after 12 weeks of treatm... Read More about Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial.

Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy) (2019)
Journal Article
Sadofsky, L. R., Hayman, Y. A., Vance, J., Cervantes, J. L., Fraser, S. D., Wilkinson, H. N., Williamson, J. D., Hart, S. P., & Morice, A. H. (2019). Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy). Lung, 197(6), 687-698. https://doi.org/10.1007/s00408-019-00288-3

Purpose: There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In thi... Read More about Characterisation of a New Human Alveolar Macrophage-Like Cell Line (Daisy).

Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity? (2019)
Journal Article
Holden, S. E., Morice, A., Birring, S. S., Jenkins-Jones, S., Langerman, H., Weaver, J., & Currie, C. J. (2020). Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity?. Current Medical Research and Opinion, 36(1), 139-150. https://doi.org/10.1080/03007995.2019.1673716

© 2019 Informa UK Limited, trading as Taylor & Francis Group. Objective: To investigate patterns of presentation of cough in primary care and develop an algorithm to identify probable and possible chronic cough (CC). Methods: This retrospective obs... Read More about Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity?.

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children (2019)
Journal Article
Morice, A. H., Millqvist, E., Bieksiene, K., Birring, S. S., Dicpinigaitis, P., Ribas, C. D., Boon, M. H., Kantar, A., Lai, K., McGarvey, L., Rigau, D., Satia, I., Smith, J., Song, W. J., Tonia, T., van den Berg, J. W. K., van Manen, M. J. G., & Zacharasiewicz, A. (2020). ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. European respiratory journal, 55(1), https://doi.org/10.1183/13993003.01136-2019

Copyright © ERS 2020 These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to... Read More about ERS guidelines on the diagnosis and treatment of chronic cough in adults and children.

The effect of aclidinium on symptoms including cough in chronic obstructive pulmonary disease: A phase 4, double-blind, placebo-controlled, parallel-group study (2019)
Journal Article
Smith, J. A., McGarvey, L., Morice, A. H., Birring, S. S., Wedzicha, J. A., Notari, M., Zapata, A., Segarra, R., Seoane, B., & Jarreta, D. (2019). The effect of aclidinium on symptoms including cough in chronic obstructive pulmonary disease: A phase 4, double-blind, placebo-controlled, parallel-group study. American Journal of Respiratory and Critical Care Medicine, 200(5), 642-645. https://doi.org/10.1164/rccm.201901-0048LE

Inhaled corticosteroids and placebo treatment effects in adult patients with cough: A systematic review and meta-analysis (2019)
Journal Article
Lee, S. E., Lee, J.-H., Kim, H. J., Lee, B.-J., Cho, S.-H., Price, D., Morice, A. H., & Song, W.-J. (2019). Inhaled corticosteroids and placebo treatment effects in adult patients with cough: A systematic review and meta-analysis. Allergy Asthma and Immunology Research, 11(6), 856-870. https://doi.org/10.4168/aair.2019.11.6.856

Purpose: Inhaled corticosteroids (ICSs) are often considered an empirical therapy in the management of patients with cough. However, ICS responsiveness is difficult to interpret in daily clinical practice, as the improvements may include placebo effe... Read More about Inhaled corticosteroids and placebo treatment effects in adult patients with cough: A systematic review and meta-analysis.

The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study (2019)
Journal Article
Morice, A. H., Kitt, M. M., Ford, A. P., Tershakovec, A. M., Wu, W. C., Brindle, K., Thompson, R., Thackray-Nocera, S., & Wright, C. (2019). The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study. European respiratory journal, 54(1), Article 1900439. https://doi.org/10.1183/13993003.00439-2019

We evaluated the effect of gefapixant on cough reflex sensitivity to evoked tussive challenge.

In this phase 2, double-blind, two-period study, patients with chronic cough (CC) and healthy volunteers (HV) were randomised to single-dose gefapixant... Read More about The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: A randomised placebo-controlled study.

Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: A rct (2019)
Journal Article
Devereux, G., Cotton, S., Fielding, S., McMeekin, N., Barnes, P. J., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., De Soyza, A., Gompertz, S., Haughney, J., Innes, K., Kaniewska, J., Lee, A., Morice, A., Norrie, J., Sullivan, A., Wilson, A., & Price, D. (2019). Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: A rct. Health Technology Assessment, 23(37), 1-145. https://doi.org/10.3310/hta23370

Background: Despite widespread use of therapies such as inhaled corticosteroids (ICSs), people with chronic obstructive pulmonary disease (COPD) continue to suffer, have reduced life expectancy and utilise considerable NHS resources. Laboratory inves... Read More about Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: A rct.

New understanding in the treatment of cough (NEUROCOUGH) ERS Clinical Research Collaboration: improving care and treatment for patients with cough (2019)
Journal Article
McGarvey, L., Dupont, L., Birring, S. S., Boyd, J., Chung, K. F., Dabrowska, M., Domingo, C., Fontana, G., Guilleminault, L., Kardos, P., Millqvist, E., Morice, A. H., Smith, J. A., van den Berg, J. W., & Van de Kerkhove, C. (2019). New understanding in the treatment of cough (NEUROCOUGH) ERS Clinical Research Collaboration: improving care and treatment for patients with cough. European respiratory journal, 53(5), Article 1900787. https://doi.org/10.1183/13993003.00787-2019

Chronic cough is a common and troublesome clinical problem and currently there are no effective treatments [1]. While individual specialist cough clinics have been set up in some European countries, there is no formal mechanism to develop common mana... Read More about New understanding in the treatment of cough (NEUROCOUGH) ERS Clinical Research Collaboration: improving care and treatment for patients with cough.

N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites (2019)
Journal Article
Chandrabalan, A., McPhillie, M. J., Morice, A. H., Boa, A. N., & Sadofsky, L. R. (2019). N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. European Journal of Medicinal Chemistry, 170, 141-156. https://doi.org/10.1016/j.ejmech.2019.02.074

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators... Read More about N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.

Symptoms and exacerbations in asthma: an apparent paradox? (2019)
Journal Article
Morjaria, J. B., Rigby, A. S., & Morice, A. H. (2019). Symptoms and exacerbations in asthma: an apparent paradox?. Therapeutic Advances in Chronic Disease, 10, https://doi.org/10.1177/2040622319884387

© The Author(s), 2019. Background: There is a dearth of data on prospectively recorded symptoms in patients with uncontrolled asthma. Asthma symptoms and exacerbation rate are commonly thought to be associated. The aim of this study was to analyse as... Read More about Symptoms and exacerbations in asthma: an apparent paradox?.