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Professor Alyn Morice's Outputs (211)

Hypoxic pulmonary vasoconstriction in humans: Tale or myth (2017)
Journal Article
Hussain, A., Suleiman, M. S., George, S. J., Loubani, M., & Morice, A. (2017). Hypoxic pulmonary vasoconstriction in humans: Tale or myth. Open Cardiovascular Medicine Journal, 11, 1-13. https://doi.org/10.2174/1874192401711010001

© Hussain et al. Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of... Read More about Hypoxic pulmonary vasoconstriction in humans: Tale or myth.

Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis (2017)
Journal Article
Song, W. J., Kim, H. J., Shim, J. S., Won, H. K., Kang, S. Y., Sohn, K. H., Kim, B. K., Jo, E. J., Kim, M. H., Kim, S. H., Park, H. W., Kim, S. S., Chang, Y. S., Morice, A. H., Lee, B. J., & Cho, S. H. (2017). Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis. Journal of Allergy and Clinical Immunology, 140(3), 701-709. https://doi.org/10.1016/j.jaci.2016.11.037

© 2017 American Academy of Allergy, Asthma & Immunology Background Individual studies have suggested the utility of fractional exhaled nitric oxide (FENO) measurement in detecting cough-variant asthma (CVA) and eosinophilic bronchitis (EB) in patie... Read More about Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis.

Rococo study: a real-world evaluation of an over-the-counter medicine in acute cough (a multicentre, randomised, controlled study) (2017)
Journal Article
Birring, S. S., Brew, J., Kilbourn, A., Edwards, V., Wilson, R., & Morice, A. H. (2017). Rococo study: a real-world evaluation of an over-the-counter medicine in acute cough (a multicentre, randomised, controlled study). BMJ open, 7(1), e014112. https://doi.org/10.1136/bmjopen-2016-014112

Objectives To investigate the efficacy and safety of CS1002, an over-the-counter cough treatment containing diphenhydramine, ammonium chloride and levomenthol in a cocoa-based demulcent.

Design A multicentre, randomised, parallel group, controlled... Read More about Rococo study: a real-world evaluation of an over-the-counter medicine in acute cough (a multicentre, randomised, controlled study).

Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis (2016)
Journal Article
Faruqi, S., Shiferaw, D., & Morice, A. H. (2016). Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis. Open Respiratory Medicine Journal, 10, 105-108. https://doi.org/10.2174/1874306401610010105

© Faruqi et al. Background and Objectives: Cough is a major symptom in cystic fibrosis. Ivacaftor is a novel drug which targets the G551D mutation and has been demonstrated to improve lung function and weight in the long term. It also improves sympto... Read More about Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis.

Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials (2016)
Journal Article
McGarvey, L., Morice, A. H., Smith, J. A., Birring, S. S., Chuecos, F., Seoane, B., & Jarreta, D. (2016). Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials. BMJ Open Respiratory Research, 3(1), Article e000148. https://doi.org/10.1136/bmjresp-2016-000148

© 2016, BMJ Publishing Group. All rights reserved. Background: Cough and sputum are troublesome symptoms in chronic obstructive pulmonary disease (COPD) and are associated with adverse outcomes. The efficacy of aclidinium bromide 400 μg twice daily i... Read More about Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials.

TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione (2016)
Journal Article
Morice, A. H., Sadofsky, L. R., Benemei, S., Coppi, E., De Logu, F., Di Tommaso, M., Fusi, C., Geppetti, P., Li Puma, S., Marone, I. M., Materazzi, S., Moneti, G., Nassini, R., Susini, T., Terreni, A., & Tonello, R. (2016). TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione. Cancer Research, 76(23), 7024-7035. https://doi.org/10.1158/0008-5472.CAN-16-1492

Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of p... Read More about TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione.

Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review (2016)
Journal Article
Song, W.-J., Won, H.-K., Moon, S.-D., Chung, S.-J., Kang, S.-Y., Sohn, K.-H., Kim, J.-Y., Kim, B.-K., Lim, K.-H., Kim, M.-Y., Yang, M.-S., Park, H.-W., Chang, Y.-S., Lee, B.-J., Morice, A. H., & Cho, S.-H. (2017). Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review. The journal of allergy and clinical immunology. In practice, 5(1), 135-143.e1. https://doi.org/10.1016/j.jaip.2016.07.017

© 2016 Background Fractional exhaled nitric oxide (FENO) is a safe and convenient test for assessing T H 2 airway inflammation, which is potentially useful in the management of patients with chronic cough. Objective To summarize the current evidence... Read More about Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review.

Comprehensive evidence-based review on European antitussives (2016)
Journal Article
Morice, A., & Kardos, P. (2016). Comprehensive evidence-based review on European antitussives. BMJ Open Respiratory Research, 3(1), Article e000137. https://doi.org/10.1136/bmjresp-2016-000137

© 2016 BMJ Publishing Group. All rights reserved. Acute cough caused by viral respiratory tract infections is probably the most common illness to afflict mankind. Despite the widespread but ineffective prescribing of antibiotics, there is no specific... Read More about Comprehensive evidence-based review on European antitussives.

Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation (2016)
Journal Article
Zeybel, G. L., Pearson, J. P., Krishnan, A., Bourke, S. J., Doe, S., Anderson, A., Faruqi, S., Morice, A. H., Jones, R., McDonnell, M., Zeybel, M., Dettmar, P. W., Brodlie, M., & Ward, C. (2017). Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation. Journal of Cystic Fibrosis, 16(1), 124-131. https://doi.org/10.1016/j.jcf.2016.07.004

© 2016 The Authors Background Extra-oesophageal reflux (EOR) may lead to microaspiration in patients with cystic fibrosis (CF), a probable cause of deteriorating lung function. Successful clinical trials of ivacaftor highlight opportunities to unders... Read More about Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation.

How does rhinovirus cause the common cold cough? (2016)
Journal Article
Atkinson, S. K., Sadofsky, L. R., & Morice, A. H. (2016). How does rhinovirus cause the common cold cough?. BMJ Open Respiratory Research, 3(1), Article e000118. https://doi.org/10.1136/bmjresp-2015-000118

© 2016, BMJ Publishing Group. All rights reserved. Cough is a protective reflex to prevent aspiration and can be triggered by a multitude of stimuli. The commonest form of cough is caused by upper respiratory tract infection and has no benefit to the... Read More about How does rhinovirus cause the common cold cough?.

Defining chronic cough: A systematic review of the epidemiological literature (2015)
Journal Article
Song, W. J., Chang, Y. S., Faruqi, S., Kang, M. K., Kim, J. Y., Kang, M. G., Kim, S., Jo, E. J., Lee, S. E., Kim, M. H., Plevkova, J., Park, H. W., Cho, S. H., & Morice, A. H. (2016). Defining chronic cough: A systematic review of the epidemiological literature. Allergy Asthma and Immunology Research, 8(2), 146-155. https://doi.org/10.4168/aair.2016.8.2.146

© The Korean Academy of Asthma, Allergy and Clinical Immunology. Purpose: Recent evidence suggests a global burden of chronic cough in general populations. However, the definitions vary greatly among epidemiological studies, and none have been valida... Read More about Defining chronic cough: A systematic review of the epidemiological literature.

Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable' (2015)
Journal Article
Morgan, K., Sadofsky, L. R., & Morice, A. H. (2015). Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Bioscience Reports, 35(5), Article e00255. https://doi.org/10.1042/BSR20150108

© 2015 Authors. Multiple mis-sense variants of TRPA1 (transient receptor potential A1) and TRPM8 (transient receptor potential M8) are recorded in the human genome single nt polymorphism (SNP) database, but their potential impact on channel signallin... Read More about Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.

Objective measurement of cough frequency during COPD exacerbation convalescence (2015)
Journal Article
Crooks, M. G., Hayman, Y., Innes, A., Williamson, J., Wright, C. E., & Morice, A. H. (2016). Objective measurement of cough frequency during COPD exacerbation convalescence. Lung, 194(1), 117-120. https://doi.org/10.1007/s00408-015-9782-y

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Cough and sputum production are associated with adverse outcomes in COPD and are common during COPD exacerbation (AE-COPD). This study of objective co... Read More about Objective measurement of cough frequency during COPD exacerbation convalescence.