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Outputs (68)

Microplastics in human urine: characterisation using µFTIR and sampling challenges using healthy donors and endometriosis participants. (2024)
Journal Article
Rotchell, J. M., Austin, C., Chapman, E., Atherall, C. A., Liddle, C. R., Dunstan, T. S., …Guinn, B. (2024). Microplastics in human urine: characterisation using µFTIR and sampling challenges using healthy donors and endometriosis participants. Ecotoxicology and environmental safety, 274, Article 116208. https://doi.org/10.1016/j.ecoenv.2024.116208

Microplastics (MPs) are found in all environments, within the human food chain, and have been recently detected in several human tissues. The objective herein was to undertake an analysis of MP contamination in human urine samples, from healthy indiv... Read More about Microplastics in human urine: characterisation using µFTIR and sampling challenges using healthy donors and endometriosis participants..

The contamination of in situ archaeological remains: A pilot analysis of microplastics in sediment samples using μFTIR (2024)
Journal Article
Rotchell, J. M., Mendrik, F., Chapman, E., Flintoft, P., Panter, I., Gallio, G., …Schofield, J. (2024). The contamination of in situ archaeological remains: A pilot analysis of microplastics in sediment samples using μFTIR. The Science of the total environment, 914, Article 169941. https://doi.org/10.1016/j.scitotenv.2024.169941

Background: Microplastics (MPs) are found in all environments: aquatic, airborne, and terrestrial. While their presence is not disputed, their potential impacts are not yet known. Objective: To undertake a pilot analysis of MP contamination in archae... Read More about The contamination of in situ archaeological remains: A pilot analysis of microplastics in sediment samples using μFTIR.

Insights into technical challenges in the field of microplastic pollution through the lens of early career researchers (ECRs) and a proposed pathway forward (2023)
Journal Article
Danopoulos, E., Stanton, T., Ma, Y., Horton, A. A., Chen, Q., Levermore, J. M., …Nel, H. A. (2023). Insights into technical challenges in the field of microplastic pollution through the lens of early career researchers (ECRs) and a proposed pathway forward. Frontiers in Earth Science, 11, Article 1271547. https://doi.org/10.3389/feart.2023.1271547

Early career researchers (ECR) face a series of challenges related to the inherent difficulties of starting their careers. Microplastic (MP) research is a topical field attracting high numbers of ECRs with diverse backgrounds and expertise from a wea... Read More about Insights into technical challenges in the field of microplastic pollution through the lens of early career researchers (ECRs) and a proposed pathway forward.

Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens (2023)
Journal Article
Richardson, S., Mayes, W. M., Faetsch, S., Hetjens, H., Teuchies, J., Walker, P., …Heise, S. (2023). Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens. The Science of the total environment, 891, Article 164280. https://doi.org/10.1016/j.scitotenv.2023.164280

Extended chemical analyses of fluvial sediments were undertaken to establish the key pollutant pressures and mixtures present across nine European Union inland waterways. A wide range of chemical components and physical parameters were investigated i... Read More about Mixtures of sediment chemical contaminants at freshwater sampling sites across Europe with different contaminant burdens.

Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study (2023)
Journal Article
Rotchell, J. M., Jenner, L. C., Chapman, E., Bennett, R., Bolanle, I. O., Loubani, M., …Palmer, T. (2023). Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study. PLoS ONE, 18(2), Article e0280594. https://doi.org/10.1371/journal.pone.0280594

Microplastics (MPs) are ubiquitous in the environment, in the human food chain, and have been recently detected in blood and lung tissues. To undertake a pilot analysis of MP contamination in human vein tissue samples with respect to their presence (... Read More about Detection of microplastics in human saphenous vein tissue using μFTIR: a pilot study.

Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device (2022)
Journal Article
Jenner, L. C., Kureshi, R. R., White, D., Chapman, E., Sadofsky, L. R., & Rotchell, J. M. (2022). Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device. Atmosphere, 13(12), Article 2017. https://doi.org/10.3390/atmos13122017

Atmospheric microplastics (MPs) are a ubiquitous environmental contaminant of emerging concern. Sampling methods provide information relating to surface area concentration and MP characteristics, without direct comparison with routinely measured stan... Read More about Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device.

Microplastics in the surgical environment (2022)
Journal Article
Field, D. T., Green, J. L., Bennett, R., Jenner, L. C., Sadofsky, L., Chapman, E., …Rotchell, J. M. (2022). Microplastics in the surgical environment. Environment International, 170, Article 107630. https://doi.org/10.1016/j.envint.2022.107630

Atmospheric microplastics (MPs) have been consistently detected within indoor and outdoor air samples. Locations with high human activity are reported to have high MP levels. The aim was to quantify and characterise the MPs present within the surgica... Read More about Microplastics in the surgical environment.

Sex and gametogenesis stage are strong drivers of gene expression in Mytilus edulis exposed to environmentally relevant plasticiser levels and pH 7.7 (2022)
Journal Article
Mincarelli, L., Chapman, E. C., Rotchell, J. M., Turner, A., & Wollenberg Valero, K. C. (in press). Sex and gametogenesis stage are strong drivers of gene expression in Mytilus edulis exposed to environmentally relevant plasticiser levels and pH 7.7. Environmental science and pollution research, https://doi.org/10.1007/s11356-022-23801-3

Plastic pollution and changes in oceanic pH are both pressing environmental issues. Little emphasis, however, has been placed on the influence of sex and gametogenesis stage when investigating the effects of such stressors. Here, we examined histolog... Read More about Sex and gametogenesis stage are strong drivers of gene expression in Mytilus edulis exposed to environmentally relevant plasticiser levels and pH 7.7.

Detection of microplastics in human lung tissue using μFTIR spectroscopy (2022)
Journal Article
Jenner, L. C., Rotchell, J. M., Bennett, R. T., Cowen, M., Tentzeris, V., & Sadofsky, L. (2022). Detection of microplastics in human lung tissue using μFTIR spectroscopy. The Science of the total environment, 831, Article 154907. https://doi.org/10.1016/j.scitotenv.2022.154907

Airborne microplastics (MPs) have been sampled globally, and their concentration is known to increase in areas of high human population and activity, especially indoors. Respiratory symptoms and disease following exposure to occupational levels of MP... Read More about Detection of microplastics in human lung tissue using μFTIR spectroscopy.

Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present (2022)
Journal Article
Jenner, L., Sadofsky, L., Danopoulos, E., Chapman, E., White, D., Jenkins, R., & Rotchell, J. M. (2022). Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present. Atmosphere, 13(2), Article 265. https://doi.org/10.3390/atmos13020265

Atmospheric microplastics (MPs) have been consistently captured within air samples on a global scale. Locations with high human activity are reported to have high MP levels. An urban sampling site in the Humber region (U.K.) has been sampled over a 1... Read More about Outdoor atmospheric microplastics within the Humber region (United Kingdom): Quantification and chemical characterisation of deposited particles present.

Gonadal atresia, estrogen-responsive, and apoptosis-specific mRNA expression in marine mussels from the East China coast: a preliminary study (2022)
Journal Article
Zhu, J., Li, J., Chapman, E. C., Shi, H., Ciocan, C. M., Chen, K., …Rotchell, J. M. (in press). Gonadal atresia, estrogen-responsive, and apoptosis-specific mRNA expression in marine mussels from the East China coast: a preliminary study. Bulletin of Environmental Contamination and Toxicology, https://doi.org/10.1007/s00128-022-03461-2

This preliminary survey analysed mussel atresia incidences, estrogen-responsive and apoptotic-specific molecular end points, and aqueous and gonadal levels of selected estrogens from the East China coast. Estrogen levels were low (e.g. < LOD-28.36ng/... Read More about Gonadal atresia, estrogen-responsive, and apoptosis-specific mRNA expression in marine mussels from the East China coast: a preliminary study.

Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device (2021)
Journal Article
Richardson, S., Iles, A., Rotchell, J. M., Charlson, T., Hanson, A., Lorch, M., & Pamme, N. (2021). Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device. PLoS ONE, 16(12), Article e0260102. https://doi.org/10.1371/journal.pone.0260102

Contamination of waterways is of increasing concern, with recent studies demonstrating elevated levels of antibiotics, antidepressants, household, agricultural and industrial chemicals in freshwater systems. Thus, there is a growing demand for method... Read More about Citizen-led sampling to monitor phosphate levels in freshwater environments using a simple paper microfluidic device.

A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. (2021)
Journal Article
Danopoulos, E., Twiddy, M., West, R., & Rotchell, J. M. (in press). A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells. Journal of hazardous materials, Article 127861. https://doi.org/10.1016/j.jhazmat.2021.127861

Humans are exposed to microplastics (MPs) daily via ingestion and inhalation. It is not known whether this results in adverse health effects and, if so, at what levels of exposure. Without epidemiological studies, human cell in vitro MP toxicological... Read More about A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells..

The Uptake of Sporopollenin Exine Capsules and Associated Bioavailability of Adsorbed Oestradiol in Selected Aquatic Invertebrates (2021)
Journal Article
Chapman, E., Meichanetzoglou, A., Boa, A. N., Hetjens, H., Faetsch, S., Teuchies, J., …Rotchell, J. M. (2021). The Uptake of Sporopollenin Exine Capsules and Associated Bioavailability of Adsorbed Oestradiol in Selected Aquatic Invertebrates. Bulletin of Environmental Contamination and Toxicology, 107, 876–882. https://doi.org/10.1007/s00128-021-03364-8

Lycopodium clavatum sporopollenin exine capsules (SpECs) are known to both adsorb and absorb chemicals. The aim of the present work was to determine whether oestradiol (E2) is ‘bioavailable’ to bioindicator species, either pre-adsorbed to, or in the... Read More about The Uptake of Sporopollenin Exine Capsules and Associated Bioavailability of Adsorbed Oestradiol in Selected Aquatic Invertebrates.

Susceptibility of polar cod (Boreogadus saida) to a model carcinogen (2021)
Journal Article
Lerebours, A., Murzina, S., Song, Y., Tollefsen, K. E., Benedetti, M., Regoli, F., …Nahrgang, J. (2021). Susceptibility of polar cod (Boreogadus saida) to a model carcinogen. Marine environmental research, 170, Article 105434. https://doi.org/10.1016/j.marenvres.2021.105434

Studies that aim to characterise the susceptibility of the ecologically relevant and non-model fish polar cod (Boreogadus saida) to model carcinogens are required. Polar cod were exposed under laboratory conditions for six months to control, 0.03 μg... Read More about Susceptibility of polar cod (Boreogadus saida) to a model carcinogen.

Consequences of combined exposure to thermal stress and the plasticiser DEHP in Mytilus spp. differ by sex (2021)
Journal Article
Mincarelli, L. F., Rotchell, J. M., Chapman, E. C., Turner, A. P., & Wollenberg Valero, K. C. (2021). Consequences of combined exposure to thermal stress and the plasticiser DEHP in Mytilus spp. differ by sex. Marine pollution bulletin, 170, Article 112624. https://doi.org/10.1016/j.marpolbul.2021.112624

Little is known about the combined effect of environmental factors and contaminants on commercially important marine species, and whether this effect differs by sex. In this study, blue mussels were exposed for seven days to both single and combined... Read More about Consequences of combined exposure to thermal stress and the plasticiser DEHP in Mytilus spp. differ by sex.

Where are we? Towards an understanding of the selective accumulation of microplastics in mussels (2021)
Journal Article
Li, J., Wang, Z., Rotchell, J. M., Shen, X., Li, Q., & Zhu, J. (2021). Where are we? Towards an understanding of the selective accumulation of microplastics in mussels. Environmental pollution, 286, Article 117543. https://doi.org/10.1016/j.envpol.2021.117543

Mussels are suggested as bioindicators of marine microplastic pollution. However, they are selective in regards to accumulation of microplastics. To make studies more targeted and comparable, ultimately helping to determine the suitability of the mus... Read More about Where are we? Towards an understanding of the selective accumulation of microplastics in mussels.

Household indoor microplastics within the Humber region (United Kingdom): quantification and chemical characterisation of particles present (2021)
Journal Article
Jenner, L., Sadofsky, L., Danopoulos, E., & Rotchell, J. M. (2021). Household indoor microplastics within the Humber region (United Kingdom): quantification and chemical characterisation of particles present. Atmospheric Environment, 259, Article 118512. https://doi.org/10.1016/j.atmosenv.2021.118512

Knowledge regarding the presence of suspended microplastics (MPs) within the air is lacking, especially indoors, yet the importance of indoor air quality and human health is rising. This study is the first to report MPs within multiple homes over a 6... Read More about Household indoor microplastics within the Humber region (United Kingdom): quantification and chemical characterisation of particles present.

Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis (2020)
Journal Article
Danopoulos, E., Jenner, L., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis. Environmental Health Perspectives, 128(12), 126002-1-126002-32. https://doi.org/10.1289/EHP7171

Background: Microplastics (MPs) have contaminated all compartments of the marine environment including biota such as seafood; ingestion from such sources is one of the two major uptake routes identified for human exposure. Objectives: The objectives... Read More about Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis.

A comparison of microplastic contamination in freshwater fish from natural and farmed sources (2020)
Journal Article
Garcia, A. G., Suárez, D. C., Li, J., & Rotchell, J. M. (in press). A comparison of microplastic contamination in freshwater fish from natural and farmed sources. Environmental science and pollution research, https://doi.org/10.1007/s11356-020-11605-2

Contamination of aquatic systems mainly by urbanization and poor sanitation, deficient or lack of wastewater treatments, dumping of solid residues and run off, has led to the presence of particles, including manmade polymers, in tissues of many marin... Read More about A comparison of microplastic contamination in freshwater fish from natural and farmed sources.

Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis (2020)
Journal Article
Danopoulos, E., Jenner, L., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis. SN Applied Sciences, 2(12), Article 1950. https://doi.org/10.1007/s42452-020-03749-0

Microplastics (MPs) are an emerging contaminant ubiquitous in the environment. There is growing concern regarding potential human health effects, a major human exposure route being dietary uptake. We have undertaken a systematic review (SR) and meta-... Read More about Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis.

Microplastic contamination of drinking water: a systematic review. (2020)
Journal Article
Danopoulos, E., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of drinking water: a systematic review. PLoS ONE, 15(7 July), Article e0236838. https://doi.org/10.1371/journal.pone.0236838

Background Microplastics (MPs) are omnipresent in the environment, including the human food chain; a likely important contributor to human exposure is drinking water. Objective To undertake a systematic review of MP contamination of drinking water... Read More about Microplastic contamination of drinking water: a systematic review..

Toxicity of polyelectrolyte-functionalized titania nanoparticles in zebrafish (Danio rerio) embryos (2020)
Journal Article
Arabeyyat, Z. H., Al-Awady, M. J., Greenway, G. M., Paunov, V. N., & Rotchell, J. M. (2020). Toxicity of polyelectrolyte-functionalized titania nanoparticles in zebrafish (Danio rerio) embryos. SN Applied Sciences, 2(7), Article 1312. https://doi.org/10.1007/s42452-020-3137-x

We investigated the effects of short-term exposure of bare TiO2NPs and polyelectrolyte-coated TiO2NPs in the 5–25nm size range, at relatively high concentrations (of 500 and 1000mg/L) under light or dark conditions, in D. rerio embryos. The biologica... Read More about Toxicity of polyelectrolyte-functionalized titania nanoparticles in zebrafish (Danio rerio) embryos.

A preliminary analysis of microplastics in edible versus non-edible tissues from seafood samples. (2020)
Journal Article
Akoueson, F., Sheldon, L., Danopoulos, E., Morris, S., Hotten, J., Chapman, E., …Rotchell, J. (2020). A preliminary analysis of microplastics in edible versus non-edible tissues from seafood samples. Environmental pollution, 263, pt. A(August), Article 114452. https://doi.org/10.1016/j.envpol.2020.114452

Plastics have been widely reported to be present in the environment yet there are still many questions regarding the extent of this and the impacts these may have on both the environment and human health. The purpose of this investigation is to deter... Read More about A preliminary analysis of microplastics in edible versus non-edible tissues from seafood samples..

Influence of light and temperature cycles on the expression of circadian clock genes in the mussel Mytilus edulis (2020)
Journal Article
Chapman, E., Bonsor, B., Parsons, D. R., & Rotchell, J. (2020). Influence of light and temperature cycles on the expression of circadian clock genes in the mussel Mytilus edulis. Marine environmental research, 159, Article 104960. https://doi.org/10.1016/j.marenvres.2020.104960

Clock genes and environmental cues regulate essential biological rhythms. The blue mussel, Mytilus edulis, is an ecologically and economically important intertidal bivalve undergoing seasonal reproductive rhythms. We previously identified seasonal... Read More about Influence of light and temperature cycles on the expression of circadian clock genes in the mussel Mytilus edulis.

Silver nanoparticles in Zebrafish (Danio rerio) embryos: Uptake, growth and molecular responses (2020)
Journal Article
Qiang, L., Arabeyyat, Z. H., Xin, Q., Paunov, V. N., Dale, I. J., Lloyd Mills, R. I., …Cheng, J. (2020). Silver nanoparticles in Zebrafish (Danio rerio) embryos: Uptake, growth and molecular responses. International Journal of Molecular Sciences, 21(5), Article 1876. https://doi.org/10.3390/ijms21051876

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Silver nanoparticles (AgNPs) are widely used in commercial applications as antimicrobial agents, but there have recently been increasing concerns raised about their possible environmental and... Read More about Silver nanoparticles in Zebrafish (Danio rerio) embryos: Uptake, growth and molecular responses.

PVC Does Not Influence Cadmium Uptake or Effects in the Mussel (Mytilus edulis) (2020)
Journal Article
Li, J., Chapman, E. C., Shi, H., & Rotchell, J. M. (2020). PVC Does Not Influence Cadmium Uptake or Effects in the Mussel (Mytilus edulis). Bulletin of Environmental Contamination and Toxicology, 104(3), 315-320. https://doi.org/10.1007/s00128-020-02789-x

Microplastics have become a global concern in recent years. In this study, we studied (i) whether the presence of polyvinyl chloride (PVC) microparticles may affect cadmium (Cd) uptake in mussel (Mytilus edulis); and (ii) the biological effects of PV... Read More about PVC Does Not Influence Cadmium Uptake or Effects in the Mussel (Mytilus edulis).

Spatial and temporal occurrence of pharmaceuticals in UK estuaries (2019)
Journal Article
Letsinger, S., Kay, P., Rodriguez-Mozaz, S., Villagrassa, M., Barceló, D., & Rotchell, J. M. (2019). Spatial and temporal occurrence of pharmaceuticals in UK estuaries. The Science of the total environment, 678, 74-84. https://doi.org/10.1016/j.scitotenv.2019.04.182

There is a lack of data on the occurrence of pharmaceuticals in estuaries worldwide, with little understanding of their temporal and spatial variations globally. Ibuprofen, paracetamol, diclofenac, trimethoprim and citalopram were measured in twelve... Read More about Spatial and temporal occurrence of pharmaceuticals in UK estuaries.

Using mussel as a global bioindicator of coastal microplastic pollution (2019)
Journal Article
Li, J., Lusher, A. L., Rotchell, J. M., Deudero, S., Turra, A., Bråte, I. L. N., …Shi, H. (2019). Using mussel as a global bioindicator of coastal microplastic pollution. Environmental Pollution, 244, 522-533. https://doi.org/10.1016/j.envpol.2018.10.032

The ubiquity and high bioavailability of microplastics have an unknown risk on the marine environment. Bio-monitoring should be used to investigate biotic impacts of microplastic exposure. While many studies have used mussels as indicators for marine... Read More about Using mussel as a global bioindicator of coastal microplastic pollution.

Microplastics in mussels sampled from coastal waters and supermarkets in the United Kingdom (2018)
Journal Article
Li, J., Green, C., Reynolds, A., Shi, H., & Rotchell, J. M. (2018). Microplastics in mussels sampled from coastal waters and supermarkets in the United Kingdom. Environmental pollution, 241, 35-44. https://doi.org/10.1016/j.envpol.2018.05.038

Global contamination of the marine environment by plastic has led to the discovery of microplastics in a range of marine species, including those for human consumption. In this study, the presence of microplastics and other anthropogenic debris in se... Read More about Microplastics in mussels sampled from coastal waters and supermarkets in the United Kingdom.

Target gene expression studies on Platynereis dumerilii and Platynereis cfr massiliensis at the shallow CO2 vents off Ischia, Italy (2017)
Journal Article
Wäge, J., Rotchell, J. M., Gambi, M., & Hardege, J. D. (2018). Target gene expression studies on Platynereis dumerilii and Platynereis cfr massiliensis at the shallow CO2 vents off Ischia, Italy. Estuarine, coastal and shelf science, 207, 351-358. https://doi.org/10.1016/j.ecss.2017.11.012

© 2017 Elsevier Ltd Many studies predict negative effects of ocean acidification on marine organisms, potentially leading to loss of biodiversity and ecosystem function. Research on species inhabiting naturally high pCO2 environments, such as volcani... Read More about Target gene expression studies on Platynereis dumerilii and Platynereis cfr massiliensis at the shallow CO2 vents off Ischia, Italy.

Seasonal expression patterns of clock-associated genes in the blue mussel Mytilus edulis (2017)
Journal Article
Chapman, E. C., O’Dell, A. R., Meligi, N. M., Parsons, D. R., & Rotchell, J. M. (2017). Seasonal expression patterns of clock-associated genes in the blue mussel Mytilus edulis. Chronobiology International, 34(9), 1300-1314. https://doi.org/10.1080/07420528.2017.1363224

Environmental cues allow organisms to synchronise their internal biological rhythms with external environmental cycles. These rhythms are regulated on a molecular level by oscillating interactions between clock genes and their proteins. Light is a pa... Read More about Seasonal expression patterns of clock-associated genes in the blue mussel Mytilus edulis.

Hepatocellular adenoma in a European flatfish (Limanda limanda) : genetic alterations in laser-capture microdissected tissue and global transcriptomic approach (2017)
Journal Article
Lerebours, A., Lyons, B. P., Bignell, J. P., Stentiford, G. D., Rotchell, J. M., Lerebours, A., …Stentiford, G. (2017). Hepatocellular adenoma in a European flatfish (Limanda limanda) : genetic alterations in laser-capture microdissected tissue and global transcriptomic approach. Marine pollution bulletin, 119(2), 120-127. https://doi.org/10.1016/j.marpolbul.2017.04.052

Liver tumours in flatfish have been diagnosed using histopathology for decades to monitor the impacts of marine pollution. Here we describe the application of specific gene (retinoblastoma, Rb) profiling in laser capture micro-dissected samples, and... Read More about Hepatocellular adenoma in a European flatfish (Limanda limanda) : genetic alterations in laser-capture microdissected tissue and global transcriptomic approach.

Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus (2016)
Journal Article
Lerebours, A., Chapman, E. C., Rotchell, J. M., Heupel, M. R., & Sweet, M. J. (2016). Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus. Marine environmental research, 120, 130-135. https://doi.org/10.1016/j.marenvres.2016.07.009

© 2016 Elsevier Ltd A high prevalence of skin pigmented lesions of 15% was recently reported in coral trout Plectropomus leopardus, a commercially important marine fish, inhabiting the Great Barrier Reef. Herein, fish were sampled at two offshore sit... Read More about Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus.

Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior (2016)
Journal Article
Qiang, L., Cheng, J., Yi, J., Rotchell, J. M., Zhu, X., & Zhou, J. (2016). Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior. Ecotoxicology, 25(7), 1426-1437. https://doi.org/10.1007/s10646-016-1694-y

Environmental pollution caused by pharmaceuticals has been recognized as a major threat to the aquatic ecosystems. Carbamazepine, as the widely prescribed antiepileptic drug, has been frequently detected in the aquatic environment and has created con... Read More about Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior.

Short-term effects of CO₂-induced low pH exposure on target gene expression in Platynereis dumerilii (2016)
Journal Article
Wäge, J., Rohr, S., Hardege, J. D., & Rotchell, J. M. (2016). Short-term effects of CO₂-induced low pH exposure on target gene expression in Platynereis dumerilii. Journal of Marine Biology and Oceanography, 5(2), https://doi.org/10.4172/2324-8661.1000155

Objective: Increasing atmospheric CO₂ concentration are causing changes to the seawater carbonate chemistry, lowering the pH and we study potential impacts of these changes at the molecular level in a non-calcifying, marine polychaete species Platyne... Read More about Short-term effects of CO₂-induced low pH exposure on target gene expression in Platynereis dumerilii.

Exposure to low pH induces molecular level changes in the marine worm, Platynereis dumerilii (2015)
Journal Article
Wäge, J., Lerebours, A., Hardege, J. D., & Rotchell, J. M. (2016). Exposure to low pH induces molecular level changes in the marine worm, Platynereis dumerilii. Ecotoxicology and environmental safety, 124(February), 105-110. https://doi.org/10.1016/j.ecoenv.2015.10.008

© 2015 Elsevier Inc. Fossil fuel emissions and changes in net land use lead to an increase in atmospheric CO 2 concentration and a subsequent decrease of ocean pH. Noticeable effects on organisms' calcification rate, shell structure and energy metabo... Read More about Exposure to low pH induces molecular level changes in the marine worm, Platynereis dumerilii.

Erratum: Identification of reproduction-specific genes associated with maturation and estrogen exposure in a marine bivalve mytilus edulis (PLoS ONE (2015) 10:7 (e0132080) DOI: :10.1371/journal.pone.0132080) (2015)
Journal Article
Ciocan, C. M., Cubero-Leon, E., Minier, C., & Rotchell, J. M. (2015). Erratum: Identification of reproduction-specific genes associated with maturation and estrogen exposure in a marine bivalve mytilus edulis (PLoS ONE (2015) 10:7 (e0132080) DOI: :10.1371/journal.pone.0132080). PLoS ONE, 10(7), Article e0132080. https://doi.org/10.1371/journal.pone.0132080

Fig 1 of the published article is incomplete. Please view the complete Fig 1 and its legend here.

Silver nanoparticles affect the neural development of zebrafish embryos: AgNPs affect the embryonic neural development (2015)
Journal Article
Xin, Q., Rotchell, J. M., Cheng, J., Yi, J., & Zhang, Q. (2015). Silver nanoparticles affect the neural development of zebrafish embryos: AgNPs affect the embryonic neural development. Journal of Applied Toxicology, 35(12), 1481-1492. https://doi.org/10.1002/jat.3164

Silver nanoparticles (AgNPs) have been widely used in commercial products. This study aims to understand the impact of AgNPs on the early developmental stages in zebrafish (Danio rerio) embryos. Embryos were exposed to two sizes of AgNPs at three dos... Read More about Silver nanoparticles affect the neural development of zebrafish embryos: AgNPs affect the embryonic neural development.

Effects of low seawater pH on the marine polychaete Platynereis dumerilii (2015)
Journal Article
Wäge, J., Hardege, J. D., Larsson, T. A., Simakov, O., Chapman, E. C., Arendt, D., & Rotchell, J. M. (2015). Effects of low seawater pH on the marine polychaete Platynereis dumerilii. Marine pollution bulletin, 95(1), 166-172. https://doi.org/10.1016/j.marpolbul.2015.04.027

An important priority for any organism is to maintain internal cellular homeostasis including acidbase balance. Yet, the molecular level impacts of changing environmental conditions, such as low pH, remain uncharacterised. Herein, we isolate partial... Read More about Effects of low seawater pH on the marine polychaete Platynereis dumerilii.

Molecular characterization of an estrogen receptor and estrogen-related receptor and their autoregulatory capabilities in two Mytilus species (2015)
Journal Article
Nagasawa, K., Treen, N., Kondo, R., Otoki, Y., Itoh, N., Rotchell, J. M., & Osada, M. (2015). Molecular characterization of an estrogen receptor and estrogen-related receptor and their autoregulatory capabilities in two Mytilus species. Gene, 564(2), 153-159. https://doi.org/10.1016/j.gene.2015.03.073

Vertebrate-like sex steroid hormones have been widely detected in mollusks, and numerous experiments have shown the importance of steroids in gonad development. Nevertheless, their signaling pathways in invertebrates have not been uncovered yet. Ster... Read More about Molecular characterization of an estrogen receptor and estrogen-related receptor and their autoregulatory capabilities in two Mytilus species.

Intersex related gene expression profiles in clams Scrobicularia plana : molecular markers and environmental application (2015)
Journal Article
Langston, W. J., Ciocan, C. M., Hill, E. M., Lerebours, A., Rotchell, J. M., Rotchell, J., …Pope, N. (2015). Intersex related gene expression profiles in clams Scrobicularia plana : molecular markers and environmental application. Marine pollution bulletin, 95(2), 610-617. https://doi.org/10.1016/j.marpolbul.2015.02.019

Intersex, the appearance of female characteristics in male gonads, has been identified in several aquatic species. It is a widespread phenomenon in populations of the bivalve, Scrobicularia plana, from the southwest coast of the U.K. Genes previously... Read More about Intersex related gene expression profiles in clams Scrobicularia plana : molecular markers and environmental application.

Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects (2014)
Journal Article
Hu, L., Zhu, J., Rotchell, J. M., Wu, L., Gao, J., & Shi, H. (2015). Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects. The Science of the total environment, 508, 258-265. https://doi.org/10.1016/j.scitotenv.2014.11.086

The frog embryo teratogenesis assay-Xenopus (FETAX) is an established method for the evaluation of the developmental toxicities of chemicals. To develop an enhanced FETAX that is appropriate for common environmental contaminants, we exposed Xenopus t... Read More about Use of the enhanced frog embryo teratogenesis assay-Xenopus (FETAX) to determine chemically-induced phenotypic effects.

Genetic alterations and cancer formation in a European flatfish at sites of different contamination burdens (2014)
Journal Article
Lerebours, A., Stentiford, G., Bignell, J. P., Lyons, B. P., Derocles, S. A. P., & Rotchell, J. (2014). Genetic alterations and cancer formation in a European flatfish at sites of different contamination burdens. Environmental Science and Technology, 48(17), 10448-10455. https://doi.org/10.1021/es502591p

Fish diseases are an indicator for marine ecosystem health since they provide a biological end-point of historical exposure to stressors. Liver cancer has been used to monitor the effects of exposure to anthropogenic pollution in flatfish for many ye... Read More about Genetic alterations and cancer formation in a European flatfish at sites of different contamination burdens.

Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos (2014)
Journal Article
Zhu, J., Shi, H., Zhu, P., Hu, L., Wu, L., Yang, Y., & Rotchell, J. M. (2014). Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos. Environmental Toxicology and Pharmacology, 38(1), 153-162. https://doi.org/10.1016/j.etap.2014.05.010

We exposed Xenopus tropicalis embryos to a selective antagonist of retinoid X receptor (UVI3003). UVI3003 induced multiple malformations at the concentrations of 200-1000. μg/L after 48. h exposure. The most prominent malformations affected brains, e... Read More about Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos.

Evidence of altered fertility in female roach (Rutilus rutilus) from the River Seine (France) (2014)
Journal Article
Gerbron, M., Geraudie, P., Fernandes, D., Rotchell, J. M., Porte, C., & Minier, C. (2014). Evidence of altered fertility in female roach (Rutilus rutilus) from the River Seine (France). Environmental pollution, 191, 58-62. https://doi.org/10.1016/j.envpol.2014.04.015

A large variety of anthropogenic chemicals present in the aquatic environment have been shown to be able to alter the endocrine system of exposed organisms, potentially impacting their reproductive function. The aim of this study was to assess the ef... Read More about Evidence of altered fertility in female roach (Rutilus rutilus) from the River Seine (France).

Advanced diagnostics applied to fish liver tumours: Relating pathology to underlying molecular aetiology (2013)
Journal Article
Lerebours, A., Bignell, J. P., Stentiford, G. D., Feist, S. W., Lyons, B. P., & Rotchell, J. M. (2013). Advanced diagnostics applied to fish liver tumours: Relating pathology to underlying molecular aetiology. Marine pollution bulletin, 72(1), 94-98. https://doi.org/10.1016/j.marpolbul.2013.04.016

Liver tumours in flatfish have been diagnosed using histopathology for decades in order to monitor the impacts of marine pollution in coastal and estuarine environments. This traditional method has been coupled with molecular analyses of tumours in t... Read More about Advanced diagnostics applied to fish liver tumours: Relating pathology to underlying molecular aetiology.

Intersex in scrobicularia plana: transcriptomic analysis reveals novel genes involved in endocrine disruption (2012)
Journal Article
Ciocan, C. M., Cubero-Leon, E., Peck, M. R., Langston, W. J., Pope, N., Minier, C., & Rotchell, J. M. (2012). Intersex in scrobicularia plana: transcriptomic analysis reveals novel genes involved in endocrine disruption. Environmental Science and Technology, 46(23), 12936-12942. https://doi.org/10.1021/es302948g

Intersex, the appearance of female characteristics in male gonads, has been identified in a wide range of aquatic species worldwide, yet the underpinning molecular etiology remains uncharacterised. The presence of intersex has been shown to be a wide... Read More about Intersex in scrobicularia plana: transcriptomic analysis reveals novel genes involved in endocrine disruption.

Combined effect of cadmium and estradiol on the endocrine system of roach (Rutilus rutilus): In vitro and in vivo approaches (2012)
Journal Article
Gerbron, M., Geraudie, P., Xuereb, B., Hill, E. M., Rotchell, J., & Minier, C. (2012). Combined effect of cadmium and estradiol on the endocrine system of roach (Rutilus rutilus): In vitro and in vivo approaches. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 163(Supplement), S34-S34. https://doi.org/10.1016/j.cbpa.2012.05.099

Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors (2012)
Journal Article
Cubero-Leon, E., Puinean, A. M., Labadie, P., Ciocan, C., Itoh, N., Kishida, M., …Rotchell, J. M. (2012). Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors. Marine environmental research, 74, 32-39. https://doi.org/10.1016/j.marenvres.2011.11.012

Members of the vertebrate CYP3A subfamily are involved in the metabolism of steroids and a wide range of xenobiotics. In this study two CYP3A- like mRNAs have been isolated from the mussel (Mytilus edulis), and their seasonal expression profile and m... Read More about Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors.

Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis (2012)
Journal Article
Cubero-Leon, E., Minier, C., Hill, E. M., & Rotchell, J. (2012). Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 7(2), 212-219. https://doi.org/10.1016/j.cbd.2012.03.002

Marine mussels have been used as sentinel organisms to monitor exposure to a variety of chemical contaminants, including endocrine disrupting chemicals, in the aquatic environment. Although they are an important species for use in ecotoxicology inves... Read More about Metabolomic analysis of sex specific metabolites in gonads of the mussel, Mytilus edulis.

Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene (2012)
Journal Article
Ruiz, P., Orbea, A., Rotchell, J. M., & Cajaraville, M. P. (2012). Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene. Ecotoxicology, 21(3), 820-831. https://doi.org/10.1007/s10646-011-0843-6

Recent spills in European waters have released polycyclic aromatic hydrocarbons, important components of heavy fuel oil, and the hydrocarbon styrene. Heavy fuel oil and styrene are classified as potentially genotoxic and carcinogenic. Here we investi... Read More about Transcriptional responses of cancer-related genes in turbot Scophthalmus maximus and mussels Mytilus edulis exposed to heavy fuel oil no. 6 and styrene.

Reference gene selection for qPCR in mussel, Mytilus edulis, during gametogenesis and exogenous estrogen exposure (2012)
Journal Article
Cubero-Leon, E., Ciocan, C. M., Minier, C., & Rotchell, J. M. (2012). Reference gene selection for qPCR in mussel, Mytilus edulis, during gametogenesis and exogenous estrogen exposure. Environmental science and pollution research, 19(7), 2728-2733. https://doi.org/10.1007/s11356-012-0772-9

Purpose: The aim of this study is to develop a normalization method for real-time PCR data by analyzing the most stably expressed control genes in mussel (Mytilus edulis) reproductive tissue. Methods: To facilitate this, six candidate genes, includin... Read More about Reference gene selection for qPCR in mussel, Mytilus edulis, during gametogenesis and exogenous estrogen exposure.

Molecular toxicology of corals: A review (2011)
Journal Article
Rotchell, J. M., & Ostrander, G. K. (2011). Molecular toxicology of corals: A review. Journal of Toxicology and Environmental Health, Part B: Critical Reviews, 14(8), 571-592. https://doi.org/10.1080/10937404.2011.615112

Coral reefs worldwide have become increasingly affected by a phenomenon known as "coral bleaching," the loss of the symbiotic algae from the host corals. The underlying causes and mechanism(s) of coral bleaching are not well known, although several h... Read More about Molecular toxicology of corals: A review.

Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification (2011)
Journal Article
Hardege, J., Rotchell, J., Terschak, J., & Greenway, G. (2011). Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification. Trends in Analytical Chemistry, 30(8), 1320-1326. https://doi.org/10.1016/j.trac.2011.07.004

Changing ocean-carbonate chemistry caused by oceanic uptake of anthropogenic atmospheric carbon dioxide leads to the formation of carbonic acid, thus lowering the pH of the sea with predictions of a decrease from current levels at 8.15 to 7.82 by the... Read More about Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification.

Identification of Reproduction-Specific genes associated with maturation and estrogen exposure in a marine bivalve Mytilus edulis (2011)
Journal Article
Ciocan, C. M., Cubero-Leon, E., Minier, C., & Rotchell, J. M. (2011). Identification of Reproduction-Specific genes associated with maturation and estrogen exposure in a marine bivalve Mytilus edulis. PLoS ONE, 6(7), e22326. https://doi.org/10.1371/journal.pone.0022326

Background: While it is established that vertebrate-like steroids, particularly estrogens (estradiol, estrone) and androgens (testosterone), are present in various tissues of molluscs, it is still unclear what role these play in reproductive endocrin... Read More about Identification of Reproduction-Specific genes associated with maturation and estrogen exposure in a marine bivalve Mytilus edulis.

A new in vitro screening bioassay for the ecotoxicological evaluation of the estrogenic responses of environmental chemicals using roach (Rutilus rutilus) liver explant culture (2010)
Journal Article
Gerbron, M., Geraudie, P., Rotchell, J., & Minier, C. (2010). A new in vitro screening bioassay for the ecotoxicological evaluation of the estrogenic responses of environmental chemicals using roach (Rutilus rutilus) liver explant culture. Environmental Toxicology, 25(5), 510-516. https://doi.org/10.1002/tox.20596

There is growing evidence that many chemicals released in the environment are able to disturb the normal endocrinology of organisms affecting the structure and function of their reproductive system. This has prompted the scientific community to devel... Read More about A new in vitro screening bioassay for the ecotoxicological evaluation of the estrogenic responses of environmental chemicals using roach (Rutilus rutilus) liver explant culture.

Effects of estrogen exposure in mussels, Mytilus edulis, at different stages of gametogenesis (2010)
Journal Article
Ciocan, C. M., Cubero-Leon, E., Puinean, A. M., Hill, E. M., Minier, C., Osada, M., …Rotchell, J. M. (2010). Effects of estrogen exposure in mussels, Mytilus edulis, at different stages of gametogenesis. Environmental pollution, 158(9), 2977-2984. https://doi.org/10.1016/j.envpol.2010.05.025

Mytilus edulis were exposed to 17β-estradiol (E2) and the synthetic estrogens ethinyl estradiol (EE2) and estradiol benzoate (EB) for 10 days. Two exposures were performed to determine their effect on vitellogenin (VTG) and estrogen receptor 2 (ER2)... Read More about Effects of estrogen exposure in mussels, Mytilus edulis, at different stages of gametogenesis.

Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis) (2010)
Journal Article
Cubero-Leon, E., Ciocan, C. M., Hill, E. M., Osada, M., Kishida, M., Itoh, N., …Rotchell, J. M. (2010). Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis). Aquatic Toxicology, 98(2), 178-187. https://doi.org/10.1016/j.aquatox.2010.02.007

Estrogenic contaminants in the aquatic environment are associated with feminisation of male fish, however their effects on some invertebrate species, such as bivalve molluscs, have yet to be characterised. Gametogenesis represents a critical step in... Read More about Estrogens disrupt serotonin receptor and cyclooxygenase mRNA expression in the gonads of mussels (Mytilus edulis).

Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination (2009)
Journal Article
Nogueira, P., Pacheco, M., Lourdes Pereira, M., Mendo, S., & Rotchell, J. M. (2010). Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination. Environmental pollution, 158(5), 1783-1790. https://doi.org/10.1016/j.envpol.2009.11.007

The responses of Dicentrarchus labrax and Liza aurata to aquatic pollution were assessed in a contaminated coastal lagoon, using both traditional and novel biomarkers combined. DNA damage, assessed by comet assay, was higher in both fish species from... Read More about Anchoring novel molecular biomarker responses to traditional responses in fish exposed to environmental contamination.

Transcript profiling and DNA damage in the European eel (Anguilla anguilla L.) exposed to 7,12-dimethylbenz[a]anthracene (2009)
Journal Article
Nogueira, P., Lourenço, J., Rodriguez, E., Pacheco, M., Santos, C., Rotchell, J. M., & Mendo, S. (2009). Transcript profiling and DNA damage in the European eel (Anguilla anguilla L.) exposed to 7,12-dimethylbenz[a]anthracene. Aquatic Toxicology, 94(2), 123-130. https://doi.org/10.1016/j.aquatox.2009.06.007

The molecular responses induced during and after an acute exposure to 7,12-dimethylbenz[a]anthracene (DMBA) were analysed in liver, gill and blood cells of juvenile Anguilla anguilla with the aim of developing molecular biomarkers of environmental PA... Read More about Transcript profiling and DNA damage in the European eel (Anguilla anguilla L.) exposed to 7,12-dimethylbenz[a]anthracene.

Estrogenic activity of cadmium, copper and zinc in the yeast estrogen screen (2009)
Journal Article
Denier, X., Hill, E. M., Rotchell, J., & Minier, C. (2009). Estrogenic activity of cadmium, copper and zinc in the yeast estrogen screen. Toxicology in Vitro, 23(4), 569-573. https://doi.org/10.1016/j.tiv.2009.01.006

Heavy metals are increasingly studied due to their apparent ability to disrupt signaling pathways of living organisms including humans. Among various mechanisms of action, metals are suspected of exerting estrogenic activity in human and wildlife. In... Read More about Estrogenic activity of cadmium, copper and zinc in the yeast estrogen screen.

A novel population health approach: using fish retinoblastoma gene profiles as a surrogate for humans (2008)
Journal Article
Rotchell, J. M., du Corbier, F. A., Stentiford, G. D., Lyons, B. P., Liddle, A. R., & Ostrander, G. K. (2009). A novel population health approach: using fish retinoblastoma gene profiles as a surrogate for humans. Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 149(2), 134-140. https://doi.org/10.1016/j.cbpc.2008.09.009

Retinoblastoma, a tumor suppressor gene, is frequently mutated in diverse types of human tumors. We have previously shown that two types of fish tumor, eye and liver, also possess mutant Rb genes. Our aim is to determine if the Rb allele status is li... Read More about A novel population health approach: using fish retinoblastoma gene profiles as a surrogate for humans.

Ras gene in marine mussels: A molecular level response to petrochemical exposure (2008)
Journal Article
Lima, I., Peck, M. R., Rendón-Von Osten, J., Soares, A. M. V. M., Guilhermino, L., & Rotchell, J. (2008). Ras gene in marine mussels: A molecular level response to petrochemical exposure. Marine pollution bulletin, 56(4), 633-640. https://doi.org/10.1016/j.marpolbul.2008.01.018

Mussels are susceptible to numerous toxicants and are often employed as bioindicators. This study investigated the status of the ras proto-oncogene in Mytilus galloprovincialis following petrochemical exposure. A M. galloprovincialis homologue of the... Read More about Ras gene in marine mussels: A molecular level response to petrochemical exposure.

To what extent are hepatic concentrations of heavy metals in Anguilla anguilla at a site in a contaminated estuary related to body size and age and reflected in the metallothionein concentrations? (2007)
Journal Article
Bird, D. J., Rotchell, J. M., Hesp, S. A., Newton, L. C., Hall, N. G., & Potter, I. C. (2008). To what extent are hepatic concentrations of heavy metals in Anguilla anguilla at a site in a contaminated estuary related to body size and age and reflected in the metallothionein concentrations?. Environmental pollution, 151(3), 641-651. https://doi.org/10.1016/j.envpol.2007.03.018

We explored how hepatic [metal]s in Anguilla anguilla at a contaminated estuarine site are influenced by body size, age and season, and the extent that [Cu], [Cd] and [Zn]s are reflected in [metallothionein (MT)]s. Although each [metal] and [MT] incr... Read More about To what extent are hepatic concentrations of heavy metals in Anguilla anguilla at a site in a contaminated estuary related to body size and age and reflected in the metallothionein concentrations?.

Conservation of cancer genes in the marine invertebrate Mytilus edulis (2005)
Journal Article
Ciocan, C. M., & Rotchell, J. M. (2005). Conservation of cancer genes in the marine invertebrate Mytilus edulis. Environmental Science and Technology, 39(9), 3029-3033. https://doi.org/10.1021/es0400887

Mussels are susceptible to a wide range of environmental toxicants, including carcinogens, and thus are often employed as bioindicator species. To elucidate the molecular aetiology of such neoplastic damage, we have cloned Mytilus edulis homologues o... Read More about Conservation of cancer genes in the marine invertebrate Mytilus edulis.