Professor Matthew Hardman's Outputs (6)

Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model (2020)
Journal Article
Wilkinson, H. N., Longhorne, F. L., Roberts, E. R., Brownhill, V. R., & Hardman, M. J. (in press). Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model. Wound Repair and Regeneration, https://doi.org/10.1111/wrr.12888

Negative pressure wound therapy is a widely used treatment for chronic, nonhealing wounds. Surprisingly, few studies have systematically evaluated the cellular and molecular effects of negative pressure treatment on human skin. In addition, no study... Read More about Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model.

Smart active antibiotic nanocarriers with protease surface functionality can overcome biofilms of resistant bacteria (2020)
Journal Article
Weldrick, P. J., Hardman, M. J., & Paunov, V. N. (2021). Smart active antibiotic nanocarriers with protease surface functionality can overcome biofilms of resistant bacteria. Materials Chemistry Frontiers, 5(2), 961-972. https://doi.org/10.1039/d0qm00874e

Treating bacterial infections with species demonstrating antibiotic resistance to the chosen antibiotic is often hindered due to the ability of certain bacteria to grow biofilms where they can effectively hide and resist the antibiotic action. We rep... Read More about Smart active antibiotic nanocarriers with protease surface functionality can overcome biofilms of resistant bacteria.

Wound healing: cellular mechanisms and pathological outcomes (2020)
Journal Article
Wilkinson, H. N., & Hardman, M. J. (2020). Wound healing: cellular mechanisms and pathological outcomes. Open Biology, 10(9), Article 200223. https://doi.org/10.1098/rsob.200223

Wound healing is a complex, dynamic process supported by a myriad of cellular events that must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound-linked cellular behaviours, as occurs with diabetes and ageing, can lead... Read More about Wound healing: cellular mechanisms and pathological outcomes.

Wound healing: Cellular mechanisms and pathological outcomes (2020)
Journal Article
Wilkinson, H. N., & Hardman, M. J. (2020). Wound healing: Cellular mechanisms and pathological outcomes. Open Biology, 10(9), Article 200223. https://doi.org/10.1098/rsob.200223

Wound healing is a complex, dynamic process supported by a myriad of cellular events that must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound-linked cellular behaviours, as occurs with diabetes and ageing, can lead... Read More about Wound healing: Cellular mechanisms and pathological outcomes.

Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds (2020)
Journal Article
Wilkinson, H. N., & Hardman, M. J. (2020). Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds. Frontiers in Cell and Developmental Biology, 8, Article 773. https://doi.org/10.3389/fcell.2020.00773

© Copyright © 2020 Wilkinson and Hardman. Cellular senescence is a fundamental stress response that restrains tumour formation. Yet, senescence cells are also present in non-cancerous states, accumulating exponentially with chronological age and cont... Read More about Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds.

Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy During In Vivo Porcine Wound Healing (2020)
Journal Article
Brownhill, V., Huddleston, E., Bell, A., Hart, J., Webster, I., Hardman, M., & Wilkinson, H. (2021). Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy During In Vivo Porcine Wound Healing. Advances in wound care, 10(7), 345-356. https://doi.org/10.1089/wound.2020.1218

Objective: Traditional negative pressure wound therapy systems can be large and cumbersome, limiting patient mobility and adversely affecting quality of life. PICO™, a no canister single-use system offers a lightweight, portable alternative to tradit... Read More about Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy During In Vivo Porcine Wound Healing.