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Outputs (55)

Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol (2024)
Journal Article
Prosser, J., Staniland, T., Harwood, A., Ravindhran, B., McGregor, G., Huang, C., Twiddy, M., Nicholls, A., Ingle, L., Long, J., Chetter, I., & Pymer, S. (2024). Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol. Journal of Vascular Societies Great Britain and Ireland, 3(3), 155-159. https://doi.org/10.54522/jvsgbi.2024.103

Introduction: The aim of this systematic review is to consider the evidence base for home-based high intensity interval training (HIIT) in patients with intermittent claudication (IC). Prior knowledge of the evidence base suggests that there may be l... Read More about Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol.

Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care (2024)
Journal Article
Jackson, G. P., Jackson, C., Boland, J. W., Featherstone, I., Huang, C., Ogden, M., …Johnson, M. J. (2024). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. Palliative medicine, 38(4), 447-456. https://doi.org/10.1177/02692163241236325

Background: Delirium is a complex condition, stressful for all involved. Although highly prevalent in palliative care settings, it remains underdiagnosed and associated with poor outcomes. Guideline-adherent delirium care may improve its detection, a... Read More about Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care.

Association between protein intake and muscle wasting in critically ill children: a prospective cohort study (2024)
Journal Article
Tume, L. N., Simons, C., Latten, L., Huang, C., Comfort, P., Compton, V., …Valla, F. V. (in press). Association between protein intake and muscle wasting in critically ill children: a prospective cohort study. Journal of Parenteral and Enteral Nutrition, https://doi.org/10.1002/jpen.2627

Background: Survival from pediatric critical illness in high-income countries is high, and the focus now must be on optimizing the recovery of survivors. Muscle mass wasting during critical illness is problematic, so identifying factors that may redu... Read More about Association between protein intake and muscle wasting in critically ill children: a prospective cohort study.

A randomised controlled trial of Pre-Operative Oncotype DX testing in early-stage breast cancer (PRE-DX study) - Study protocol (2024)
Journal Article
Northgraves, M., Cohen, J., Harvey, J., Huang, C., Palmieri, C., Pinder, S., …Cain, H. (2024). A randomised controlled trial of Pre-Operative Oncotype DX testing in early-stage breast cancer (PRE-DX study) - Study protocol. PLoS ONE, 19(3), Article e0300339. https://doi.org/10.1371/journal.pone.0300339

Background The Oncotype DX® Breast Recurrence Score assay can guide recommendations made to patients with oestrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer regarding post-surgery adjuvant the... Read More about A randomised controlled trial of Pre-Operative Oncotype DX testing in early-stage breast cancer (PRE-DX study) - Study protocol.

High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study (2024)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Nicholls, A., Ingle, L., Long, J., Rooms, M., Chetter, I. C., & Twiddy, M. (2024). High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study. Annals of vascular surgery, 102, 17-24. https://doi.org/10.1016/j.avsg.2023.11.043

Background: A novel high-intensity interval training (HIIT) program has demonstrated feasibility for patients with intermittent claudication (IC). The aim of this study was to explore patient perspectives of the HIIT program to inform refinement and... Read More about High INtensity Interval Training in pATiEnts with Intermittent Claudication: A Qualitative Acceptability Study.

High-intensity interval training in patients with intermittent claudication (2023)
Presentation / Conference Contribution
Pymer, S., Harwood, A. E., Prosser, J., Waddell, A., Rhavindhran, B., McGregor, G., Ibeggazene, S., Huang, C., Twiddy, M., Nicholls, A. R., Ingle, L., Carroll, S., He, H., Long, J., Rooms, M., & Chetter, I. C. High-intensity interval training in patients with intermittent claudication. Presented at 2022 Vascular Society of Great Britain and Ireland Annual Scientific Meeting, Brighton, UK

Objective: Provision, uptake, adherence, and completion rates for supervised exercise programs (SEP) for intermittent claudication (IC) are low. A shorter, more time-efficient, 6-week, high-intensity interval training (HIIT) program may be an effecti... Read More about High-intensity interval training in patients with intermittent claudication.

A preoperative supervised exercise program potentially improves long-term survival after elective abdominal aortic aneurysm repair (2023)
Presentation / Conference Contribution
Sethi, S., Ravindhran, B., Long, J., Gurung, R., Huang, C., Smith, G. E., …Pymer, S. (2024). A preoperative supervised exercise program potentially improves long-term survival after elective abdominal aortic aneurysm repair. Journal of vascular surgery, 79(1), 15-23. https://doi.org/10.1016/j.jvs.2023.09.004

Objective: A preoperative supervised exercise program (SEP) improves cardiorespiratory fitness and perioperative outcomes for patients undergoing elective abdominal aortic aneurysm (AAA) repair. The aim of this study was to assess the effect of a pre... Read More about A preoperative supervised exercise program potentially improves long-term survival after elective abdominal aortic aneurysm repair.

Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials (2023)
Journal Article
Sidebottom, D. B., Huang, C., Carradice, D., Holt, P. J., John-Pierre, K., & Roy, I. N. (2023). Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials. BMJ open, 13(8), Article e072355. https://doi.org/10.1136/bmjopen-2023-072355

INTRODUCTION: The optimal antithrombotic regimen to reduce the risk of vascular events in patients with peripheral arterial disease (PAD) is contentious. This systematic review and network meta-analysis (NMA) aims to define the relative efficacy and... Read More about Antithrombotic drugs for cardiovascular risk reduction in patients with lower limb peripheral arterial disease: protocol for a systematic review and network meta-analysis of randomised controlled trials.

Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study (2023)
Journal Article
Schoenbuchner, S. M., Huang, C., Waldron, C. A., Thomas-Jones, E., Hood, K., Carrol, E. D., & Pallmann, P. (2023). Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study. Trials, 24(1), Article 364. https://doi.org/10.1186/s13063-022-06956-9

Introduction: The BATCH trial is a multi-centre randomised controlled trial to compare procalcitonin-guided management of severe bacterial infection in children with current management. PRECISE is a mechanistic sub-study embedded into the BATCH trial... Read More about Biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: statistical analysis plan for the BATCH trial and PRECISE sub-study.

Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site (2023)
Journal Article
Crooks, M. G., Crowther, L., Cummings, H., Cohen, J., Huang, C., Pitel, L., …Xu, Y. (2023). Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site. ERJ Open Research, 9(3), Article 00685-2022. https://doi.org/10.1183/23120541.00685-2022

Aim: Short-acting β2-agonist (SABA) overuse adversely impacts asthma-related outcomes and the environment. The SABA rEductioN Through ImplemeNting Hull asthma guidELines (SENTINEL) programme aims to reduce SABA overuse through supported implementatio... Read More about Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site.

Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site (2023)
Journal Article
Crooks, M. G., Crowther, L., Cummings, H., Cohen, J., Huang, C., Pitel, L., …Xu, Y. (2023). Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site. ERJ Open Research, 9(3), Article 00685-2022. https://doi.org/10.1183/23120541.00685-2022

Aim: Short-acting β2-agonist (SABA) overuse adversely impacts asthma-related outcomes and the environment. The SABA rEductioN Through ImplemeNting Hull asthma guidELines (SENTINEL) programme aims to reduce SABA overuse through supported implementatio... Read More about Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site.

The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: protocol of a feasibility RCT (2023)
Journal Article
Pollux, P. M., Surr, C., Cohen, J., Huang, C., Wolverson, E., Mountain, P., …Hudson, J. M. (2023). The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: protocol of a feasibility RCT. Pilot and Feasibility Studies, 9(1), Article 34. https://doi.org/10.1186/s40814-023-01256-8

Background: Cognitive problems associated with dementia affect a large proportion of older adults living in residential care. Knowledge of cognitive impairments is important for providing person-centred care (PCC). The impact of specific cognitive im... Read More about The Cognitive Daisy (COG-D) for improving care for residents with dementia in care homes: protocol of a feasibility RCT.

Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients (2023)
Journal Article
Haque, F., Ryde, J., Broughton, L., Huang, C., Sethi, S., Stephens, A., …Maraveyas, A. (2023). Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients. ERJ Open Research, 9(3), Article 00651-2022. https://doi.org/10.1183/23120541.00651-2022

Background Clinical prediction rules (CPRs) developed to predict adverse outcomes of suspected pulmonary embolism (PE) and facilitate outpatient management have limitations in discriminating outcomes for ambulatory cancer patients with unsuspected PE... Read More about Validation of the HULL Score clinical prediction rule for unsuspected pulmonary embolism in ambulatory cancer patients.

Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis (2022)
Journal Article
Walshaw, J., Lathan, R., Huang, C., Staniland, T., Chetter, I., & Pymer, S. (2023). Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis. Journal of Vascular Societies Great Britain and Ireland, 2(2), 91-96. https://doi.org/10.54522/jvsgbi.2022.053

Background: The ankle brachial pressure index (ABPI) is a common diagnostic tool used in the assessment of peripheral arterial disease (PAD). The Doppler ultrasound technique is regarded as the gold-standard method for ABPI measurement; however, time... Read More about Assessment of the diagnostic accuracy of automated ankle brachial pressure index devices in patients with diagnosed or suspected peripheral arterial disease: protocol for a systematic review and meta-analysis.

A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol (2022)
Journal Article
Northgraves, M., Allsup, D., Cohen, J., Huang, C., Turgoose, J., & Ali, S. (2022). A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol. PLoS ONE, 17(2), Article e0263195. https://doi.org/10.1371/journal.pone.0263195

Background Acute leukaemias (AL) are aggressive but potentially curable blood cancers that can potentially affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking... Read More about A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol.

Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): Protocol for a randomised controlled trial (2022)
Journal Article
Waldron, C. A., Thomas-Jones, E., Bernatoniene, J., Brookes-Howell, L., Faust, S. N., Faust, S. N., …Carrol, E. D. (2022). Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): Protocol for a randomised controlled trial. BMJ open, 12(1), Article e047490. https://doi.org/10.1136/bmjopen-2020-047490

Introduction Procalcitonin (PCT) is a biomarker more specific for bacterial infection and responds quicker than other commonly used biomarkers such as C reactive protein, but is not routinely used in the National Health Service (NHS). Studies mainly... Read More about Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): Protocol for a randomised controlled trial.

Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study (2022)
Journal Article
Allen, D., Lloyd, A., Edwards, D., Grant, A., Hood, K., Huang, C., …Roland, D. (2022). Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study. Health and Social Care Delivery Research, 10(1), 307. https://doi.org/10.3310/CHCK4556

Objectives: (1) Identify, through systematic review, the following: evidence for core components of effective paediatric track-and-trigger tools and paediatric early warning systems, and contextual factors consequential for paediatric track-and-trigg... Read More about Development, implementation and evaluation of an early warning system improvement programme for children in hospital: the PUMA mixed-methods study.

Development, implementation and evaluation of an evidence-based paediatric early warning system improvement programme: the PUMA mixed methods study (2022)
Journal Article
Allen, D., Lloyd, A., Edwards, D., Hood, K., Huang, C., Hughes, J., …Roland, D. (2022). Development, implementation and evaluation of an evidence-based paediatric early warning system improvement programme: the PUMA mixed methods study. BMC health services research, 22(1), Article 9. https://doi.org/10.1186/s12913-021-07314-2

Background: Paediatric mortality rates in the United Kingdom are amongst the highest in Europe. Clinically missed deterioration is a contributory factor. Evidence to support any single intervention to address this problem is limited, but a cumulative... Read More about Development, implementation and evaluation of an evidence-based paediatric early warning system improvement programme: the PUMA mixed methods study.

Simplification or simulation: power calculation in clinical trials (2021)
Journal Article
Huang, C., Li, P., & Martin, C. R. (2022). Simplification or simulation: power calculation in clinical trials. Contemporary clinical trials, 113, Article 106663. https://doi.org/10.1016/j.cct.2021.106663

Background and objectives: A justifiable sample size is essential at trial design stage. Generally this task is completed by forming the main research question into a statistical procedure and then implementing the published formulae or software pack... Read More about Simplification or simulation: power calculation in clinical trials.

The Tokophobia Severity Scale (TSS): measurement model, power and sample size considerations (2021)
Journal Article
Martin, C. R., Jones, C., Huang, C., Jomeen, J., Boubert, L., & Marshall, C. A. (in press). The Tokophobia Severity Scale (TSS): measurement model, power and sample size considerations. Journal of reproductive and infant psychology, https://doi.org/10.1080/02646838.2021.1931070

Objective: To examine the measurement model of the Tokophobia Severity Scale and consider issues of statistical power and sample size from the original instrument development study. Background: Fear of childbirth (FoC) and tokophobia represents an ar... Read More about The Tokophobia Severity Scale (TSS): measurement model, power and sample size considerations.

Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum (2021)
Journal Article
Robles, J. A., Simpson, S. A., Coulman, E., Gallagher, D., Jewell, K., Cohen, D., …Playle, R. (2021). Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum. International journal of obesity, 45(8), 1728-1739. https://doi.org/10.1038/s41366-021-00835-0

Objective: To assess whether a weight management intervention for pregnant women with obesity was effective in reducing body mass index (BMI) 12 months after giving birth. Methods: Pragmatic, cluster randomised controlled trial (RCT) with embedded co... Read More about Healthy eating and lifestyle in pregnancy (HELP): a cluster randomised trial to evaluate the effectiveness of a weight management intervention for pregnant women with obesity on weight at 12 months postpartum.

Do patient characteristics matter when calculating sample size for eczema clinical trials? (2021)
Journal Article
Howells, L., Gran, S., Chalmers, J. R., Stuart, B., Santer, M., Bradshaw, L., …Thomas, K. S. (2021). Do patient characteristics matter when calculating sample size for eczema clinical trials?. Skin Health and Disease, 1(3), Article e42. https://doi.org/10.1002/ski2.42

Background: The Patient-Oriented Eczema Measure (POEM) is the core outcome instrument recommended for measuring patient-reported atopic eczema symptoms in clinical trials. To ensure that the statistical significance of clinical trial results is meani... Read More about Do patient characteristics matter when calculating sample size for eczema clinical trials?.

Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers (2021)
Journal Article
Johnson, M. J., Huang, C., Chen, H., Jones, L., & Twiddy, M. (2021). Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2021-003438

Objectives: Men living with prostate cancer have supportive and palliative needs. However, few studies detail unmet needs (vs quality of life measurement) or include data from those with advanced disease. We aimed to identify unmet needs of people li... Read More about Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers.

Fear of childbirth measurement: Appraisal of the content overlap of four instruments (2020)
Journal Article
Martin, C., Jones, C., Marshall, C., Huang, C., Reeve, J., Fleming, M., …Jomeen, J. (in press). Fear of childbirth measurement: Appraisal of the content overlap of four instruments. Journal of reproductive and infant psychology, https://doi.org/10.1080/02646838.2020.1861226

Objective: To evaluate empirically the degree of content overlap between four self-report measures of fear of childbirth (FoC) identified as ‘best in class’ by a recent review. Background: FoC and tokophobia is an area of increasing clinical conce... Read More about Fear of childbirth measurement: Appraisal of the content overlap of four instruments.

Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (Review) (2020)
Journal Article
Palmer, J., Pymer, S., Smith, G. E., Harwood, A., Ingle, L., Huang, C., & Chetter, I. C. (2020). Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (Review). The Cochrane database of systematic reviews, 2020(9), Article CD013407. https://doi.org/10.1002/14651858.CD013407.pub2

Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Background: Lower limb peripheral arterial disease (PAD) is a type of cardiovascular disease where the blood vessels that carry the blood to the legs are hardened and... Read More about Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (Review).

Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease. (2020)
Journal Article
Palmer, J., Pymer, S., Smith, G. E., Elizabeth Harwood, A., Ingle, L., Huang, C., & Chetter, I. C. (2020). Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease. Cochrane Database of Systematic Reviews, Article CD013407. https://doi.org/10.1002/14651858.CD013407.pub2

Background Lower limb peripheral arterial disease (PAD) is a type of cardiovascular disease where the blood vessels that carry the blood to the legs are hardened and narrowed. The most severe manifestation of PAD is critical limb ischaemia (CLI). Th... Read More about Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease..

Specialist alcohol inpatient treatment admissions and non-specialist hospital admissions for alcohol withdrawal in England: an inverse relationship (2020)
Journal Article
Phillips, T., Huang, C., Roberts, E., & Drummond, C. (2021). Specialist alcohol inpatient treatment admissions and non-specialist hospital admissions for alcohol withdrawal in England: an inverse relationship. Alcohol and Alcoholism, 56(1), 28-33. https://doi.org/10.1093/alcalc/agaa086

© The Author(s) 2020. Medical Council on Alcohol and Oxford University Press. AIMS: We assessed the relationship between specialist and non-specialist admissions for alcohol withdrawal since the introduction of the UK government Health and Social Car... Read More about Specialist alcohol inpatient treatment admissions and non-specialist hospital admissions for alcohol withdrawal in England: an inverse relationship.

The relationship between maternal personality disorder and early birth outcomes: A systematic review and meta-analysis (2020)
Journal Article
Marshall, C., Jomeen, J., Huang, C., & Martin, C. (2020). The relationship between maternal personality disorder and early birth outcomes: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 17(16), 1-19. https://doi.org/10.3390/ijerph17165778

Title: Systematic review and meta-analysis of the relationship between maternal personality disorder and early birth outcomes. Background: Women with personality disorder are at risk of social and emotional problems which impact deleteriously on eve... Read More about The relationship between maternal personality disorder and early birth outcomes: A systematic review and meta-analysis.

Minimal clinically important differences in average, best, worst and current intensity and unpleasantness of chronic breathlessness (2020)
Journal Article
Ekström, M., Johnson, M. J., Huang, C., & Currow, D. C. (2020). Minimal clinically important differences in average, best, worst and current intensity and unpleasantness of chronic breathlessness. European respiratory journal, 56(2), Article 1902202. https://doi.org/10.1183/13993003.02202-2019

Copyright ©ERS 2020. BACKGROUND: Chronic breathlessness has devastating consequences. The minimal clinically important difference (MCID) for current intensity has been estimated as 9 mm on a 100-mm visual analogue scale (VAS). We aimed to determine M... Read More about Minimal clinically important differences in average, best, worst and current intensity and unpleasantness of chronic breathlessness.

Letter in Response to Grobler AC, Lee K. Intention-To-Treat Analyses for Randomized Controlled Trials in Hospice/Palliative Care Enhanced by Principled Methods to Handle Missing Data (2020)
Journal Article
Huang, C., Kochovska, S., & Currow, D. C. (2020). Letter in Response to Grobler AC, Lee K. Intention-To-Treat Analyses for Randomized Controlled Trials in Hospice/Palliative Care Enhanced by Principled Methods to Handle Missing Data. Journal of pain and symptom management, 60(4), e30-e31. https://doi.org/10.1016/j.jpainsymman.2020.07.004

high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study (2020)
Journal Article
Pymer, S., Harwood, A., Ibeggazene, S., McGregor, G., Huang, C., Twiddy, M., …Chetter, I. C. (2020). high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study. BMJ open, 10(7), Article e038825. https://doi.org/10.1136/bmjopen-2020-038825

Introduction: The first-line recommended treatment for patients with intermittent claudication (IC), is a supervised exercise programme (SEP), which includes a minimum of 2 hours exercise per week over a 12-week period. However, provision, uptake, an... Read More about high INtensity Interval Training In pATiEnts with intermittent claudication (INITIATE): protocol for a multi-centre, proof-of-concept, prospective interventional study.

The effects of the iPlayClean education programme on doping attitudes and susceptibility to use banned substances among high-level adolescent athletes from the UK: A cluster-randomised controlled trial (2020)
Journal Article
Nicholls, A. R., Morley, D., Thompson, M. A., Huang, C., Abt, G., Rothwell, M., …Ntoumanis, N. (2020). The effects of the iPlayClean education programme on doping attitudes and susceptibility to use banned substances among high-level adolescent athletes from the UK: A cluster-randomised controlled trial. International Journal of Drug Policy, 82, Article 102820. https://doi.org/10.1016/j.drugpo.2020.102820

Background: This study examined the effects of the iPlayClean anti-doping intervention on attitudes towards doping and susceptibility, and whether delivery mode affected the results. Methods: A total of 1,081 high-level UK athletes (14-18 years old... Read More about The effects of the iPlayClean education programme on doping attitudes and susceptibility to use banned substances among high-level adolescent athletes from the UK: A cluster-randomised controlled trial.

The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial (2020)
Journal Article
Nicholls, A., Morley, D., Thompson, M. A., Huang, C., Abt, G., Rothwell, M., …Ntoumanis, N. (in press). The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial. International Journal of Drug Policy,

Background: This study examined the effects of the iPlayClean anti-doping intervention on attitudes towards doping and susceptibility, and whether delivery mode affected the results. Methods: A total of 1,081 high-level UK athletes (14-18 years old... Read More about The Effects of the iPlayClean Education Programme on Doping Attitudes and Susceptibility to use Banned Substances among High-Level Adolescent Athletes from the UK: A Cluster-Randomised Control Trial.

A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first-line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin (2020)
Journal Article
Jones, R., Crabb, S., Chester, J., Elliott, T., Huddart, R., Birtle, A., …Griffiths, G. (2020). A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first-line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin. BJU international, 126(2), 292-299. https://doi.org/10.1111/bju.15096

Objectives To assess the efficacy and tolerability of the dual epidermal growth factor receptor/vascular endothelial growth factor receptor inhibitor, vandetanib, in combination with carboplatin and gemcitabine in the first‐line treatment of patient... Read More about A randomised Phase II trial of carboplatin and gemcitabine ± vandetanib in first-line treatment of patients with advanced urothelial cell cancer not suitable to receive cisplatin.

Development and evaluation of a screening tool to aid the diagnosis of a cluster headache (2020)
Journal Article
Buture, A., Boland, J. W., Dikomitis, L., Huang, C., & Ahmed, F. (2020). Development and evaluation of a screening tool to aid the diagnosis of a cluster headache. Brain Sciences, 10(2), Article 77. https://doi.org/10.3390/brainsci10020077

Cluster headache (CH), a severe primary headache, is often misdiagnosed and mismanaged. The aim of this study was to develop and evaluate a screening tool to aid the diagnosis of CH. We developed a novel 12-item screening tool. This was comprised of... Read More about Development and evaluation of a screening tool to aid the diagnosis of a cluster headache.

Intention-to-treat analyses for randomised controlled trials in hospice/palliative care: the case for analyses to be of people exposed to the intervention. (2019)
Journal Article
Kochovska, S., Huang, C., Johnson, M. J., Agar, M. R., Fallon, M. T., Kaasa, S., …Currow, D. C. (2020). Intention-to-treat analyses for randomised controlled trials in hospice/palliative care: the case for analyses to be of people exposed to the intervention. Journal of pain and symptom management, 59(3), 637-645. https://doi.org/10.1016/j.jpainsymman.2019.10.026

© 2019 American Academy of Hospice and Palliative Medicine Context: Minimizing bias in randomized controlled trials (RCTs) includes intention-to-treat analyses. Hospice/palliative care RCTs are constrained by high attrition unpredictable when consent... Read More about Intention-to-treat analyses for randomised controlled trials in hospice/palliative care: the case for analyses to be of people exposed to the intervention..

Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (2019)
Journal Article
Palmer, J., Pymer, S., Smith, G. E., Harwood, A. E., Ingle, L., Huang, C., & Chetter, I. C. (2019). Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease. The Cochrane database of systematic reviews, 2019(9), Article CD013407. https://doi.org/10.1002/14651858.cd013407

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effectiveness of prehabilitation (preoperative exercise, either alone or in combination with nutritional or psychological interventions or both)... Read More about Presurgery conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease.

Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: a systematic review (2019)
Journal Article
Trubey, R., Huang, C., Lugg-Widger, F. V., Hood, K., Allen, D., Edwards, D., …Powell, C. (2019). Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: a systematic review. BMJ open, 9(5), Article e022105. https://doi.org/10.1136/bmjopen-2018-022105

© 2019 Author(s) (or their employer(s)). Re-use permitted under CC BY. Published by BMJ. Objective To assess (1) how well validated existing paediatric track and trigger tools (PTTT) are for predicting adverse outcomes in hospitalised children, and (... Read More about Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: a systematic review.

The relationship between red blood cell distribution width and metabolic syndrome in elderly Chinese: a cross-sectional study (2019)
Journal Article
Yan, Z., Fan, Y., Meng, Z., Huang, C., Liu, M., Zhang, Q., …Jia, Q. (2019). The relationship between red blood cell distribution width and metabolic syndrome in elderly Chinese: a cross-sectional study. Lipids in Health and Disease, 18(1), Article 34. https://doi.org/10.1186/s12944-019-0978-7

© 2019 The Author(s). Objective: Metabolic syndrome (MS) is a group of risk factors which includes hypertension, hyperglycemia, abnormal cholesterol levels, and obesity. Red blood cell distribution width (RDW) is a parameter that reflects the heterog... Read More about The relationship between red blood cell distribution width and metabolic syndrome in elderly Chinese: a cross-sectional study.

Association between platelet distribution width and serum uric acid in Chinese population (2019)
Journal Article
Liu, X., Wang, H., Huang, C., Meng, Z., Zhang, W., Li, Y., …Fan, Y. (2019). Association between platelet distribution width and serum uric acid in Chinese population. BioFactors, 45(3), 326-334. https://doi.org/10.1002/biof.1491

© 2019 International Union of Biochemistry and Molecular Biology Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role... Read More about Association between platelet distribution width and serum uric acid in Chinese population.

Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study (2019)
Journal Article
Ekström, M., Williams, M., Johnson, M. J., Huang, C., & Currow, D. C. (2019). Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study. Journal of pain and symptom management, 57(4), 715-723.e5. https://doi.org/10.1016/j.jpainsymman.2019.01.001

Context: Chronic breathlessness is a cardinal symptom in cardiopulmonary disease where both overall intensity or severity (S) and unpleasantness (U) are commonly quantified. Objective: We aimed to evaluate agreement between breathlessness severity an... Read More about Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study.

Cardiovascular and musculoskeletal response to supervised exercise in patients with intermittent claudication (2018)
Journal Article
Harwood, A. E., Totty, J. P., Pymer, S., Huang, C., Hitchman, L., Carradice, D., …Chetter, I. C. (2019). Cardiovascular and musculoskeletal response to supervised exercise in patients with intermittent claudication. Journal of vascular surgery, 69(6), 1899-1908.e1. https://doi.org/10.1016/j.jvs.2018.10.065

Objective Intermittent claudication occurs in 20 % of the population over 70 and treatment includes a supervised exercise programme (SEP). Whilst there is evidence demonstrating walking improvements following a SEP there is conflicting data on the ph... Read More about Cardiovascular and musculoskeletal response to supervised exercise in patients with intermittent claudication.

A validation and calibration process for self-reported tobacco use with participants’ cotinine levels: an example from the Building Blocks trial (2018)
Journal Article
Huang, C., Roberts, Z., Cannings-John, R., Sanders, J., Pickett, K., Montgomery, A., & Robling, M. (2019). A validation and calibration process for self-reported tobacco use with participants’ cotinine levels: an example from the Building Blocks trial. Nicotine and Tobacco Research, 21(12), 1660-1664. https://doi.org/10.1093/ntr/nty232

Reducing smoking in pregnancy was a primary outcome in our Building Blocks trial of the Family Nurse Partnership. We calibrated maternal reports of smoking using cotinine values derived from urine samples to assess tobacco use. This involves identify... Read More about A validation and calibration process for self-reported tobacco use with participants’ cotinine levels: an example from the Building Blocks trial.

A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol (2018)
Journal Article
Thomas-Jones, E., Lloyd, A., Roland, D., Sefton, G., Tume, L., Hood, K., …Powell, C. (2018). A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol. BMC Pediatrics, 18(1), Article 244. https://doi.org/10.1186/s12887-018-1210-z

© 2018 The Author(s). Background: In hospital, staff need to routinely monitor patients to identify those who are seriously ill, so that they receive timely treatment to improve their condition. A Paediatric Early Warning System is a multi-faceted so... Read More about A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol.

Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils (2018)
Journal Article
Birkin, E., Moore, K. S., Huang, C., Christopher, M., Rees, J. I., Jayaprakasam, V., & Fielding, P. A. (2018). Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils. Medicine, 97(24), Article e11040. https://doi.org/10.1097/md.0000000000011040

To determine the extent of physiological variation of uptake of 18F-flurodeoxyglucose (FDG) within palatine tonsils. To define normal limits for side-to-side variation and characterize factors affecting tonsillar uptake of FDG. Over a period of 16... Read More about Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils.

The effectiveness of an intervention to reduce alcohol-related violence in premises licensed for the sale and on-site consumption of alcohol: a randomized controlled trial (2017)
Journal Article
Moore, S. C., Alam, M. F., Heikkinen, M., Hood, K., Huang, C., Moore, L., …Williams, A. (2017). The effectiveness of an intervention to reduce alcohol-related violence in premises licensed for the sale and on-site consumption of alcohol: a randomized controlled trial. Addiction, 112(11), 1898-1906. https://doi.org/10.1111/add.13878

Background and Aims: Premises licensed for the sale and consumption of alcohol can contribute to levels of assault-related injury through poor operational practices that, if addressed, could reduce violence. We tested the real-world effectiveness of... Read More about The effectiveness of an intervention to reduce alcohol-related violence in premises licensed for the sale and on-site consumption of alcohol: a randomized controlled trial.

Ignorability for general longitudinal data (2017)
Journal Article
Farewell, D. M., Huang, C., & Didelez, V. (2017). Ignorability for general longitudinal data. Biometrika, 104(2), 317-326. https://doi.org/10.1093/biomet/asx020

Likelihood factors that can be disregarded for inference are termed ignorable. We demonstrate that close ties exist between ignorability and identification of causal effects by covariate adjustment. A graphical condition, stability, plays a role anal... Read More about Ignorability for general longitudinal data.

Oral and topical antibiotics for clinically infected eczema in children: A pragmatic randomized controlled trial in ambulatory care (2017)
Journal Article
Francis, N. A., Ridd, M. J., Thomas-Jones, E., Butler, C. C., Hood, K., Shepherd, V., …Sullivan, F. (2017). Oral and topical antibiotics for clinically infected eczema in children: A pragmatic randomized controlled trial in ambulatory care. Annals of Family Medicine, 15(2), 124-130. https://doi.org/10.1370/afm.2038

PURPOSE Eczema may flare because of bacterial infection, but evidence supporting antibiotic treatment is of low quality. We aimed to determine the effect of oral and topical antibiotics in addition to topical emollient and corticosteroids in children... Read More about Oral and topical antibiotics for clinically infected eczema in children: A pragmatic randomized controlled trial in ambulatory care.

A calibration method for non-positive definite covariance matrix in multivariate data analysis (2017)
Journal Article
Huang, C., Farewell, D., & Pan, J. (2017). A calibration method for non-positive definite covariance matrix in multivariate data analysis. Journal of Multivariate Analysis, 157, 45-52. https://doi.org/10.1016/j.jmva.2017.03.001

Covariance matrices that fail to be positive definite arise often in covariance estimation. Approaches addressing this problem exist, but are not well supported theoretically. In this paper, we propose a unified statistical and numerical matrix calib... Read More about A calibration method for non-positive definite covariance matrix in multivariate data analysis.

Exploratory trial of a school-based alcohol prevention intervention with a family component: Implications for implementation (2016)
Journal Article
Segrott, J., Rothwell, H., Pignatelli, I., Playle, R., Hewitt, G., Huang, C., …Moore, L. (2016). Exploratory trial of a school-based alcohol prevention intervention with a family component: Implications for implementation. Health Education, 116(4), 410-431. https://doi.org/10.1108/HE-01-2015-0005

Purpose – Involvement of parents/carers may increase effectiveness of primary school-based alcohol-misuse prevention projects through strengthening family-based protective factors, but rates of parental engagement are typically low. This paper report... Read More about Exploratory trial of a school-based alcohol prevention intervention with a family component: Implications for implementation.

A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: The ChildRen with eczema, antibiotic management (CREAM) study (2016)
Journal Article
Francis, N. A., Ridd, M. J., Thomas-Jones, E., Shepherd, V., Butler, C. C., Hood, K., …on behalf of the CREAM team. (2016). A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: The ChildRen with eczema, antibiotic management (CREAM) study. Health Technology Assessment, 20(19), 1-84. https://doi.org/10.3310/hta20190

Background Secondary skin infection is common during eczema exacerbations and many children are treated with antibiotics when this is suspected, although there is little high-quality evidence to justify this practice. Objective To determine the... Read More about A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: The ChildRen with eczema, antibiotic management (CREAM) study.

TOUCAN: A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer in patients who are not suitable to receive cisplatin. (2016)
Journal Article
Jones, R. J., Crabb, S. J., Chester, J. D., Elliott, T., Huddart, R. A., Birtle, A. J., …Griffiths, G. (2016). TOUCAN: A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer in patients who are not suitable to receive cisplatin. Journal of Clinical Oncology, 34(2_suppl), 448-448. https://doi.org/10.1200/jco.2016.34.2_suppl.448

Background: Whilst cisplatin combination therapy remains the standard of care for patients with advanced urothelial cancers, many patients are unsuitable for cisplatin and go on to receive carboplatin combination therapy. Although responses are frequ... Read More about TOUCAN: A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer in patients who are not suitable to receive cisplatin..

All-Wales licensed premises intervention (AWLPI): A randomised controlled trial to reduce alcohol-related violence (2014)
Journal Article
Moore, S. C., O'Brien, C., Alam, M. F., Cohen, D., Hood, K., Huang, C., …Shepherd, J. (2014). All-Wales licensed premises intervention (AWLPI): A randomised controlled trial to reduce alcohol-related violence. BMC public health, 14(1), Article 21. https://doi.org/10.1186/1471-2458-14-21

Background: Alcohol-related violence in and in the vicinity of licensed premises continues to place a considerable burden on the United Kingdom's (UK) health services. Robust interventions targeted at licensed premises are therefore required to reduc... Read More about All-Wales licensed premises intervention (AWLPI): A randomised controlled trial to reduce alcohol-related violence.