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Professor Peter Zioupos' Outputs (63)

Strain rate dependence of work of fracture tests on bone and similar tissues: Reflections on testing methods and mineral content effects (2019)
Journal Article
Currey, J. D., Brear, K., & Zioupos, P. (2019). Strain rate dependence of work of fracture tests on bone and similar tissues: Reflections on testing methods and mineral content effects. Bone, 128, Article 115038. https://doi.org/10.1016/j.bone.2019.115038

This paper is concerned with the effect of different strain rate on the Work of Fracture (Wf) of various vertebrate mineralised tissues, controlling for the effect of mineral content and Young's modulus of elasticity. Using specimens of uniform shape... Read More about Strain rate dependence of work of fracture tests on bone and similar tissues: Reflections on testing methods and mineral content effects.

Age-related changes in femoral head trabecular microarchitecture (2018)
Journal Article
Greenwood, C., Clement, J., Dicken, A., Evans, P., Lyburn, I., Martin, R. M., Stone, N., Zioupos, P., & Rogers, K. (2018). Age-related changes in femoral head trabecular microarchitecture. Aging and Disease, 9(6), 976-987. https://doi.org/10.14336/AD.2018.0124

Osteoporosis is a prevalent bone condition, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density... Read More about Age-related changes in femoral head trabecular microarchitecture.

Bone Apparent and Material Densities Examined by Cone Beam Computed Tomography and the Archimedes Technique: Comparison of the Two Methods and Their Results (2018)
Journal Article
Adams, G. J., Cook, R. B., Hutchinson, J. R., & Zioupos, P. (2018). Bone Apparent and Material Densities Examined by Cone Beam Computed Tomography and the Archimedes Technique: Comparison of the Two Methods and Their Results. Frontiers in Mechanical Engineering, 3, Article 23. https://doi.org/10.3389/fmech.2017.00023

An understanding of bone apparent and material densities and how they vary within bone at the organ level is of great interest in the understanding of degenerative bone conditions and for biomedical engineering applications. The densities of bone tis... Read More about Bone Apparent and Material Densities Examined by Cone Beam Computed Tomography and the Archimedes Technique: Comparison of the Two Methods and Their Results.

Early arthritis induces disturbances at bone nanostructural level reflected in decreased tissue hardness in an animal model of arthritis (2018)
Journal Article
Vidal, B., Cascão, R., Finnilä, M. A., Lopes, I. P., Saarakkala, S., Zioupos, P., Canhão, H., & Fonseca, J. E. (2018). Early arthritis induces disturbances at bone nanostructural level reflected in decreased tissue hardness in an animal model of arthritis. PLoS ONE, 13(1), Article e0190920. https://doi.org/10.1371/journal.pone.0190920

Introduction Arthritis induces joint erosions and skeletal bone fragility. Objectives The main goal of this work was to analyze the early arthritis induced events at bone architecture and mechanical properties at tissue level. Methods Eighty-eight Wi... Read More about Early arthritis induces disturbances at bone nanostructural level reflected in decreased tissue hardness in an animal model of arthritis.

'Phoenix polymers': Fire induced nanohardness in fibril-forming aromatic cyanate esters (2018)
Journal Article
Mooring, L., Thompson, S., Hall, S. A., Pani, S., Zioupos, P., Swan, M., Stone, C., Howlin, B. J., & Hamerton, I. (2018). 'Phoenix polymers': Fire induced nanohardness in fibril-forming aromatic cyanate esters. RSC advances, 8(63), 36264-36271. https://doi.org/10.1039/c8ra07449f

For the first time we present nanoindentation analysis of charred, cured aromatic cyanate esters, which exhibit outstanding mechanical properties when analysed under applied loads of 0.1-300 mN. Following charring (900 °C for 10 minutes to achieve gr... Read More about 'Phoenix polymers': Fire induced nanohardness in fibril-forming aromatic cyanate esters.

Can vibration statistics of an idealised sine wave be used to examine fatigue properties of porcine trabecular bone? (2017)
Presentation / Conference Contribution
Shanker, T.-A., & Zioupos, P. (2017, September). Can vibration statistics of an idealised sine wave be used to examine fatigue properties of porcine trabecular bone?. Presented at HRV2017: 52nd Human Response to Vibration Conference & Workshop, Shrivenham, UK

Fatigue testing on trabecular bone has been performed throughout the years, the data contained could be of use to researchers attempting to find a qualitative link between whole-body vibration and spinal damage. 10 porcine trabecular cores were testi... Read More about Can vibration statistics of an idealised sine wave be used to examine fatigue properties of porcine trabecular bone?.

Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model (2017)
Journal Article
Vidal, B., Cascão, R., Finnilä, M. A., Lopes, I. P., Da Glória, V. G., Saarakkala, S., Zioupos, P., Canhão, H. O., & Fonseca, J. E. (2018). Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model. Rheumatology, 57(8), 1461-1471. https://doi.org/10.1093/rheumatology/kex258

Objectives. The main goal of this work was to analyse how treatment intervention with tofacitinib prevents the early disturbances of bone structure and mechanics in the rat model of adjuvant-induced arthritis. This is the first study to access the im... Read More about Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model.

Rib biomechanical properties exhibit diagnostic potential for accurate ageing in forensic investigations (2017)
Journal Article
Bonicelli, A., Xhemali, B., Kranioti, E. F., & Zioupos, P. (2017). Rib biomechanical properties exhibit diagnostic potential for accurate ageing in forensic investigations. PLoS ONE, 12(5), Article e0176785. https://doi.org/10.1371/journal.pone.0176785

Age estimation remains one of the most challenging tasks in forensic practice when establishing a biological profile of unknown skeletonised remains. Morphological methods based on developmental markers of bones can provide accurate age estimates at... Read More about Rib biomechanical properties exhibit diagnostic potential for accurate ageing in forensic investigations.

Sharp and blunt force trauma concealment by thermal alteration in homicides: An in-vitro experiment for methodology and protocol development in forensic anthropological analysis of burnt bones (2017)
Journal Article
Macoveciuc, I., Márquez-Grant, N., Horsfall, I., & Zioupos, P. (2017). Sharp and blunt force trauma concealment by thermal alteration in homicides: An in-vitro experiment for methodology and protocol development in forensic anthropological analysis of burnt bones. Forensic Science International, 275, 260-271. https://doi.org/10.1016/j.forsciint.2017.03.014

Burning of human remains is one method used by perpetrators to conceal fatal trauma and expert opinions regarding the degree of skeletal evidence concealment are often disparate. This experiment aimed to reduce this incongruence in forensic anthropol... Read More about Sharp and blunt force trauma concealment by thermal alteration in homicides: An in-vitro experiment for methodology and protocol development in forensic anthropological analysis of burnt bones.

Localized tissue mineralization regulated by bone remodelling: A computational approach (2017)
Journal Article
Berli, M., Borau, C., Decco, O., Adams, G., Cook, R. B., Aznar, J. M. G., & Zioupos, P. (2017). Localized tissue mineralization regulated by bone remodelling: A computational approach. PLoS ONE, 12(3), Article e0173228. https://doi.org/10.1371/journal.pone.0173228

Bone is a living tissue whose main mechanical function is to provide stiffness, strength and protection to the body. Both stiffness and strength depend on the mineralization of the organic matrix, which is constantly being remodelled by the coordinat... Read More about Localized tissue mineralization regulated by bone remodelling: A computational approach.

Impact of P2RX7 ablation on the morphological, mechanical and tissue properties of bones in a murine model of duchenne muscular dystrophy (2016)
Journal Article
Mohamad, N. S., Sinadinos, A., Górecki, D. C., Zioupos, P., & Tong, J. (2016). Impact of P2RX7 ablation on the morphological, mechanical and tissue properties of bones in a murine model of duchenne muscular dystrophy. Journal of biomechanics, 49(14), 3444-3451. https://doi.org/10.1016/j.jbiomech.2016.09.016

Duchenne muscular dystrophy (DMD) is an inherited, lethal disorder characterised by progressive muscle degeneration and associated bone abnormalities. We have previously demonstrated that P2RX7 purinergic receptors contribute to the pathogenesis of D... Read More about Impact of P2RX7 ablation on the morphological, mechanical and tissue properties of bones in a murine model of duchenne muscular dystrophy.

Towards new material biomarkers for fracture risk (2016)
Journal Article
Greenwood, C., Clement, J., Dicken, A., Evans, J. P., Lyburn, I., Martin, R. M., Rogers, K., Stone, N., & Zioupos, P. (2016). Towards new material biomarkers for fracture risk. Bone, 93, 55-63. https://doi.org/10.1016/j.bone.2016.09.006

Osteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density (BMD) usin... Read More about Towards new material biomarkers for fracture risk.

Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter (2016)
Journal Article
Dicken, A. J., Evans, J. P. O., Rogers, K. D., Stone, N., Greenwood, C., Godber, S. X., Clement, J. G., Lyburn, I. D., Martin, R. M., & Zioupos, P. (2016). Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter. Scientific reports, 6, Article 29011. https://doi.org/10.1038/srep29011

Osteoporotic fractures present a significant social and economic burden, which is set to rise commensurately with the aging population. Greater understanding of the physicochemical differences between osteoporotic and normal conditions will facilitat... Read More about Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter.

Estimation of local anisotropy of plexiform bone: Comparison between depth sensing micro-indentation and Reference Point Indentation (2015)
Journal Article
Dall'Ara, E., Grabowski, P., Zioupos, P., & Viceconti, M. (2015). Estimation of local anisotropy of plexiform bone: Comparison between depth sensing micro-indentation and Reference Point Indentation. Journal of biomechanics, 48(15), 4073-4080. https://doi.org/10.1016/j.jbiomech.2015.10.001

The recently developed Reference Point Indentation (RPI) allows the measurements of bone properties at the tissue level in vivo. The goal of this study was to compare the local anisotropic behaviour of bovine plexiform bone measured with depth sensin... Read More about Estimation of local anisotropy of plexiform bone: Comparison between depth sensing micro-indentation and Reference Point Indentation.

The micro-architecture of human cancellous bone from fracture neck of femur patients in relation to the structural integrity and fracture toughness of the tissue (2015)
Journal Article
Greenwood, C., Clement, J. G., Dicken, A. J., Evans, J. P., Lyburn, I. D., Martin, R. M., Rogers, K. D., Stone, N., Adams, G., & Zioupos, P. (2015). The micro-architecture of human cancellous bone from fracture neck of femur patients in relation to the structural integrity and fracture toughness of the tissue. Bone Reports, 3, 67-75. https://doi.org/10.1016/j.bonr.2015.10.001

Osteoporosis is clinically assessed from bone mineral density measurements using dual energy X-ray absorption (DXA). However, these measurements do not always provide an accurate fracture prediction, arguably because DXA does not grapple with 'bone q... Read More about The micro-architecture of human cancellous bone from fracture neck of femur patients in relation to the structural integrity and fracture toughness of the tissue.

X-ray diffraction from bone employing annular and semi-annular beams (2015)
Journal Article
Dicken, A. J., Evans, J. P., Rogers, K. D., Stone, N., Greenwood, C., Godber, S. X., Prokopiou, D., Clement, J. G., Lyburn, I. D., Martin, R. M., & Zioupos, P. (2015). X-ray diffraction from bone employing annular and semi-annular beams. Physics in Medicine and Biology, 60(15), 5803-5812. https://doi.org/10.1088/0031-9155/60/15/5803

There is a compelling need for accurate, low cost diagnostics to identify osteo-tissues that are associated with a high risk of fracture within an individual. To satisfy this requirement the quantification of bone characteristics such as 'bone qualit... Read More about X-ray diffraction from bone employing annular and semi-annular beams.

Energy-dispersive X-ray diffraction using an annular beam (2015)
Journal Article
Dicken, A. J., Evans, J. P., Rogers, K. D., Greenwood, C., Godber, S. X., Prokopiou, D., Stone, N., Clement, J. G., Lyburn, I., Martin, R. M., & Zioupos, P. (2015). Energy-dispersive X-ray diffraction using an annular beam. Optics express, 23(10), 13443-13454. https://doi.org/10.1364/OE.23.013443

We demonstrate material phase identification by measuring polychromatic diffraction spots from samples at least 20 mm in diameter and up to 10 mm thick with an energy resolving point detector. Within our method an annular X-ray beam in the form of a... Read More about Energy-dispersive X-ray diffraction using an annular beam.

Can masticatory electromyography be normalised to submaximal bite force? (2015)
Journal Article
Crawford, S. R., Burden, A. M., Yates, J. M., Zioupos, P., & Winwood, K. (2015). Can masticatory electromyography be normalised to submaximal bite force?. Journal of Oral Rehabilitation, 42(5), 323-330. https://doi.org/10.1111/joor.12268

The combination of bite force and jaw muscle electromyography (EMG) provides an insight into the performance of the stomatognathic system, especially in relation to dynamic movement tasks. Literature has extensively investigated possible methods for... Read More about Can masticatory electromyography be normalised to submaximal bite force?.

Timescales of self-healing in human bone tissue and polymeric ionic liquids (2014)
Journal Article
Akbarzadeh, J., Puchegger, S., Stojanovic, A., Kirchner, H. O., Binder, W. H., Bernstorff, S., Zioupos, P., & Peterlik, H. (2014). Timescales of self-healing in human bone tissue and polymeric ionic liquids. Bioinspired, Biomimetic and Nanobiomaterials, 3(3), 123-130. https://doi.org/10.1680/bbn.14.00007

Strain (stress-free) relaxation in mechanically prestrained bone has a time constant of 75 s. It occurs by a reorganization of the proteoglycan-glycoprotein matrix between collagen fibers, which requires ionic interactions. Dissolving and relinking t... Read More about Timescales of self-healing in human bone tissue and polymeric ionic liquids.