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Professor Fiona Matthews' Outputs (383)

Living alone and cognitive function in later life (2019)
Journal Article
Evans, I. E., Llewellyn, D. J., Matthews, F. E., Woods, R. T., Brayne, C., & Clare, L. (2019). Living alone and cognitive function in later life. Archives of Gerontology and Geriatrics, 81, 222-233. https://doi.org/10.1016/j.archger.2018.12.014

Background: Living alone may be associated with greater risk for social isolation and loneliness. Living alone, social isolation, loneliness, and limited engagement in social activity have all been associated with poorer cognitive function in later l... Read More about Living alone and cognitive function in later life.

Autism prevalence in China is comparable to Western prevalence (2019)
Journal Article
Sun, X., Allison, C., Wei, L., Matthews, F. E., Auyeung, B., Wu, Y. Y., Griffiths, S., Zhang, J., Baron-Cohen, S., & Brayne, C. (2019). Autism prevalence in China is comparable to Western prevalence. Molecular Autism, 10(1), https://doi.org/10.1186/s13229-018-0246-0

Background: Autism prevalence in the West is approximately 1% of school age children. Autism prevalence in China has been reported to be lower than in the West. This is likely due to at least two reasons: (1) most studies in China only included the s... Read More about Autism prevalence in China is comparable to Western prevalence.

Translational research on reserve against neurodegenerative disease: Consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups (2019)
Journal Article
Perneczky, R., Kempermann, G., Korczyn, A. D., Matthews, F. E., Ikram, M. A., Scarmeas, N., Chetelat, G., Stern, Y., & Ewers, M. (2019). Translational research on reserve against neurodegenerative disease: Consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups. BMC medicine, 17(1), https://doi.org/10.1186/s12916-019-1283-z

Background: The concept of reserve was established to account for the observation that a given degree of neurodegenerative pathology may result in varying degrees of symptoms in different individuals. There is a large amount of evidence on epidemiolo... Read More about Translational research on reserve against neurodegenerative disease: Consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer's Association Reserve, Resilience and Protective Factors Professional Interest Area working groups.

Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging (2019)
Journal Article
Fuhrmann, D., Nesbitt, D., Shafto, M., Rowe, J. B., Price, D., Gadie, A., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Henson, R. N., Matthews, F. E., Marslen-Wilson, W. D., Shafto, M. A., Campbell, K., Cheung, T., Davis, S., …Kievit, R. A. (2019). Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging. Neurobiology of Aging, 74, 46-55. https://doi.org/10.1016/j.neurobiolaging.2018.10.005

Cardiovascular health declines with age, increasing the risk of hypertension and elevated heart rate in middle and old age. Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure,... Read More about Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging.

Use and costs of services and unpaid care for people with mild-to-moderate dementia: Baseline results from the IDEAL cohort study (2019)
Journal Article
Henderson, C., Knapp, M., Nelis, S. M., Quinn, C., Martyr, A., Wu, Y. T., Jones, I. R., Victor, C. R., Pickett, J. A., Hindle, J. V., Jones, R. W., Kopelman, M. D., Matthews, F. E., Morris, R. G., Rusted, J. M., Thom, J. M., & Clare, L. (2019). Use and costs of services and unpaid care for people with mild-to-moderate dementia: Baseline results from the IDEAL cohort study. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 5, 685-696. https://doi.org/10.1016/j.trci.2019.09.012

Introduction: We examined 3-month service use and costs of care for people with mild-to-moderate dementia in Great Britain. Methods: We analyzed Improving the experience of Dementia and Enhancing Active Life cohort study baseline data on paid care, o... Read More about Use and costs of services and unpaid care for people with mild-to-moderate dementia: Baseline results from the IDEAL cohort study.

Does older adults’ use of social care influence their healthcare utilisation? A systematic review of international evidence (2019)
Journal Article
Spiers, G., Matthews, F. E., Moffatt, S., Barker, R., Jarvis, H., Stow, D., Kingston, A., & Hanratty, B. (2019). Does older adults’ use of social care influence their healthcare utilisation? A systematic review of international evidence. Health and Social Care in the Community, 27(5), e651-e662. https://doi.org/10.1111/hsc.12798

Improving our understanding of the complex relationship between health and social care utilisation is vital as populations age. This systematic review aimed to synthesise evidence on the relationship between older adults’ use of social care and their... Read More about Does older adults’ use of social care influence their healthcare utilisation? A systematic review of international evidence.

A comprehensive model of factors associated with capability to "live well" for family caregivers of people living with mild-to-moderate dementia: Findings from the ideal study (2019)
Journal Article
Clare, L., Wu, Y. T., Jones, I. R., Victor, C. R., Nelis, S. M., Martyr, A., Quinn, C., Litherland, R., Pickett, J. A., Hindle, J. V., Jones, R. W., Knapp, M., Kopelman, M. D., Morris, R. G., Rusted, J. M., Thom, J. M., Lamont, R. A., Henderson, C., Rippon, I., Hillman, A., & Matthews, F. E. (2019). A comprehensive model of factors associated with capability to "live well" for family caregivers of people living with mild-to-moderate dementia: Findings from the ideal study. Alzheimer Disease and Associated Disorders, 33(1), 36-41. https://doi.org/10.1097/WAD.0000000000000286

Introduction: We aimed to better understand what predicts the capability to "live well" with dementia by identifying the relative contribution of life domains associated with the subjective experience of living well. Methods: We analyzed data from 15... Read More about A comprehensive model of factors associated with capability to "live well" for family caregivers of people living with mild-to-moderate dementia: Findings from the ideal study.

Impact of social care supply on healthcare utilisation by older adults: A systematic review and meta-analysis (2019)
Journal Article
Spiers, G., Matthews, F. E., Moffatt, S., Barker, R. O., Jarvis, H., Stow, D., Kingston, A., & Hanratty, B. (2019). Impact of social care supply on healthcare utilisation by older adults: A systematic review and meta-analysis. Age and ageing, 48(1), 57-66. https://doi.org/10.1093/ageing/afy147

Objective to investigate the impact of the availability and supply of social care on healthcare utilisation (HCU) by older adults in high income countries. Design systematic review and meta-analysis. Data sources medline, EMBASE, Scopus, Health Manag... Read More about Impact of social care supply on healthcare utilisation by older adults: A systematic review and meta-analysis.

A comprehensive model of factors associated with capability to "live well" for family caregivers of people living with mild-to-moderate dementia: Findings from the ideal study (2019)
Journal Article
Clare, L., Wu, Y. T., Quinn, C., Jones, I. R., Victor, C. R., Nelis, S. M., Martyr, A., Litherland, R., Pickett, J. A., Hindle, J. V., Jones, R. W., Knapp, M., Kopelman, M. D., Morris, R. G., Rusted, J. M., Thom, J. M., Lamont, R. A., Henderson, C., Rippon, I., Hillman, A., & Matthews, F. E. (2019). A comprehensive model of factors associated with capability to "live well" for family caregivers of people living with mild-to-moderate dementia: Findings from the ideal study. Alzheimer Disease and Associated Disorders, 33(1), 29-35. https://doi.org/10.1097/WAD.0000000000000285

Introduction: Understanding key influences on outcomes for caregivers of people with dementia is hampered by inconsistent conceptualization and measurement of outcomes and limited evidence about the relative impact of different variables. We aimed to... Read More about A comprehensive model of factors associated with capability to "live well" for family caregivers of people living with mild-to-moderate dementia: Findings from the ideal study.

Erratum to: Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose (Scientific Reports, (2018), 8, 1, (15643), 10.1038/s41598-018-33678-3) (2018)
Journal Article
Wolpe, N., Zhang, J., Nombela, C., Ingram, J. N., Wolpert, D. M., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Matthews, F. E., Marslen-Wilson, W. D., Shafto, M. A., Cheung, T., Geerligs, L., McCarrey, A., Mustafa, A., Price, D., …Rowe, J. B. (2018). Erratum to: Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose (Scientific Reports, (2018), 8, 1, (15643), 10.1038/s41598-018-33678-3). Scientific reports, 8(1), https://doi.org/10.1038/s41598-018-35439-8

The original version of this Article contained an error in the order of author names, which were incorrectly listed as ‘Noham Wolpe, Jiaxiang Zhang, Cristina Nombela, James N. Ingram, Daniel M. Wolpert, James B. Rowe & Cam-CAN’. This error has now be... Read More about Erratum to: Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose (Scientific Reports, (2018), 8, 1, (15643), 10.1038/s41598-018-33678-3).

Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose (2018)
Journal Article
Wolpe, N., Zhang, J., Nombela, C., Ingram, J. N., Wolpert, D. M., Rowe, J. B., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Matthews, F. E., Marslen-Wilson, W. D., Shafto, M. A., Cheung, T., Geerligs, L., McCarrey, A., Mustafa, A., …Villis, L. (2018). Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose. Scientific reports, 8(1), https://doi.org/10.1038/s41598-018-33678-3

Abnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson’s disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly under... Read More about Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose.

Inequalities in living well with dementia—The impact of deprivation on well-being, quality of life and life satisfaction: Results from the improving the experience of dementia and enhancing active life study (2018)
Journal Article
Wu, Y. T., Clare, L., Jones, I. R., Martyr, A., Nelis, S. M., Quinn, C., Victor, C. R., Lamont, R. A., Rippon, I., & Matthews, F. E. (2018). Inequalities in living well with dementia—The impact of deprivation on well-being, quality of life and life satisfaction: Results from the improving the experience of dementia and enhancing active life study. International journal of geriatric psychiatry, 33(12), 1736-1742. https://doi.org/10.1002/gps.4998

Objectives: Area level factors, such as deprivation and urban/rural settings, have been associated with variation in local resources and services and health inequality in later life. The aim of this study is to investigate the potential impact of dep... Read More about Inequalities in living well with dementia—The impact of deprivation on well-being, quality of life and life satisfaction: Results from the improving the experience of dementia and enhancing active life study.

Loneliness as a risk factor for care home admission in the english longitudinal study of ageing (2018)
Journal Article
Hanratty, B., Stow, D., Moore, D. C., Valtorta, N. K., & Matthews, F. (2018). Loneliness as a risk factor for care home admission in the english longitudinal study of ageing. Age and ageing, 47(6), 896-900. https://doi.org/10.1093/ageing/afy095

Background: loneliness has an adverse effect on health and well-being, and is common at older ages. Evidence that it is a risk factor for care home admission is sparse. Objective: to investigate the association between loneliness and care home admiss... Read More about Loneliness as a risk factor for care home admission in the english longitudinal study of ageing.

Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality (2018)
Journal Article
Hayat, S. A., Luben, R., Dalzell, N., Moore, S., Hogervorst, E., Matthews, F. E., Wareham, N., Brayne, C., & Khaw, K. T. (2018). Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality. European Journal of Epidemiology, 33(11), 1049-1062. https://doi.org/10.1007/s10654-018-0439-z

Despite several studies demonstrating an independent and inverse association between cognition and mortality, the nature of this association still remains unclear. To examine the association of cognition and mortality after accounting for sociodemogr... Read More about Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality.

Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain (2018)
Journal Article
Waller, R., Murphy, M., Garwood, C. J., Jennings, L., Heath, P. R., Chambers, A., Matthews, F. E., Brayne, C., Ince, P. G., Wharton, S. B., & Simpson, J. E. (2018). Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain. Glia, 66(11), 2316-2323. https://doi.org/10.1002/glia.23465

Oxidative stress and oxidative DNA damage are early features of mild cognitive impairment and Alzheimer's disease (AD), occurring before the formation of classical AD neuropathology, and resulting from an imbalance between pro- and anti-oxidants. Ast... Read More about Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain.

Protocol for the IDEAL-2 longitudinal study: Following the experiences of people with dementia and their primary carers to understand what contributes to living well with dementia and enhances active life (2018)
Journal Article
Silarova, B., Nelis, S. M., Ashworth, R. M., Ballard, C., Bieńkiewicz, M., Henderson, C., Hillman, A., Hindle, J. V., Hughes, J. C., Lamont, R. A., Litherland, R., Jones, I. R., Jones, R. W., Knapp, M., Kotting, P., Martyr, A., Matthews, F. E., Morris, R. G., Quinn, C., Regan, J., …Clare, L. (2018). Protocol for the IDEAL-2 longitudinal study: Following the experiences of people with dementia and their primary carers to understand what contributes to living well with dementia and enhances active life. BMC public health, 18(1), https://doi.org/10.1186/s12889-018-6129-7

Background: There is a major need for longitudinal research examining the experiences of people with dementia and their primary carers, as relatively little is known about how the factors associated with capability to 'live well' vary over time. The... Read More about Protocol for the IDEAL-2 longitudinal study: Following the experiences of people with dementia and their primary carers to understand what contributes to living well with dementia and enhances active life.

Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities (2018)
Journal Article
Chan, D., Shafto, M., Kievit, R., Matthews, F., Spink, M., Valenzuela, M., & Henson, R. N. (2018). Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities. Neurobiology of Aging, 70, 180-183. https://doi.org/10.1016/j.neurobiolaging.2018.06.012

This study tested the hypothesis that mid-life intellectual, physical, and social activities contribute to cognitive reserve (CR). Two hundred five individuals (196 with magnetic resonance imaging) aged 66–88 years from the Cambridge Centre for Agein... Read More about Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation, and late-life activities.

Frailty trajectories to identify end of life: A longitudinal population-based study (2018)
Journal Article
Stow, D., Matthews, F. E., & Hanratty, B. (2018). Frailty trajectories to identify end of life: A longitudinal population-based study. BMC medicine, 16(1), https://doi.org/10.1186/s12916-018-1148-x

Background: Timely recognition of the end of life allows patients to discuss preferences and make advance plans, and clinicians to introduce appropriate care. We examined changes in frailty over 1 year, with the aim of identifying trajectories that c... Read More about Frailty trajectories to identify end of life: A longitudinal population-based study.

Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study (2018)
Journal Article
Wu, Y. T., Clare, L., Hindle, J. V., Nelis, S. M., Martyr, A., & Matthews, F. E. (2018). Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study. BMC medicine, 16(1), 140. https://doi.org/10.1186/s12916-018-1135-2

BACKGROUND: The heterogeneity of symptoms across dementia subtypes has important implications for clinical practice and dementia research. Variation in subtypes and associated symptoms may influence the capability to live well for people with dementi... Read More about Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study.