Professor Fiona Matthews' Outputs (383)

Organising general practice for care homes: a multi-method study (2025)
Journal Article
Hanratty, B., Stocker, R., Sinclair, D., Brittain, K., Spilsbury, K., Stow, D., Robinson, L., & Matthews, F. E. (2025). Organising general practice for care homes: a multi-method study. Health and Social Care Delivery Research, 13(11), https://doi.org/10.3310/YNDV6358

Background: General practice provides first-line National Health Service care for around 400,000 care home residents. Good primary care can enhance residents' health and well-being and optimise use of hospital services.
Objectives: This study aimed... Read More about Organising general practice for care homes: a multi-method study.

Area-level socioeconomic inequalities in activities of daily living disability-free life expectancy in England: a modelling study (2025)
Journal Article
Davies, L. E., Sinclair, D. R., Todd, C., Hanratty, B., Matthews, F. E., & Kingston, A. (in press). Area-level socioeconomic inequalities in activities of daily living disability-free life expectancy in England: a modelling study. The Lancet Healthy Longevity, 6(4), Article 100700. https://doi.org/10.1016/j.lanhl.2025.100700

Background: More evidence of socioeconomic inequalities in disability-free life expectancy (DFLE) is needed to help develop approaches to narrow the gap between the most and least socioeconomically deprived people. Activities of daily living (ADL) di... Read More about Area-level socioeconomic inequalities in activities of daily living disability-free life expectancy in England: a modelling study.

Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia (2025)
Journal Article
Wright, L. M., Donaghy, P. C., Burn, D. J., Taylor, J.-P., O'OBrien, J. T., Yarnall, A. J., Matthews, F. E., Firbank, M. J., Sigurdsson, H. P., Schumacher, J., Thomas, A. J., & Lawson, R. A. (in press). Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia. Neurobiology of Aging, https://doi.org/10.1016/j.neurobiolaging.2025.04.007

Neuropsychiatric symptoms (NPS) are prevalent, emerge early, and are associated with poorer outcomes in Lewy body dementia (LBD). Research suggests NPS may reflect LBD-related dysfunction in distributed neuronal networks. This study investigated NPS... Read More about Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia.

Differences in the risk of frailty based on care receipt, unmet care needs and socio-economic inequalities: A longitudinal analysis of the English Longitudinal Study of Ageing (2025)
Journal Article
Sinclair, D. R., Maharani, A., Clegg, A., Hanratty, B., Tampubolon, G., Todd, C., Wittenberg, R., O’Neill, T. W., & Matthews, F. E. (2025). Differences in the risk of frailty based on care receipt, unmet care needs and socio-economic inequalities: A longitudinal analysis of the English Longitudinal Study of Ageing. The Journal of Frailty & Aging, 14(2), Article 100012. https://doi.org/10.1016/j.tjfa.2025.100012

Background: The older population is increasingly reliant on social care, especially those who are frail. However, an estimated 1.5 million people over 65 in England have unmet care needs. The relationship between receiving care, or receiving insuffic... Read More about Differences in the risk of frailty based on care receipt, unmet care needs and socio-economic inequalities: A longitudinal analysis of the English Longitudinal Study of Ageing.

Building ADMISSION – A research collaborative to transform understanding of multiple long-term conditions for people admitted to hospital (2025)
Journal Article
Witham, M. D., Bartle, V., Bellass, S., Bunn, J. G., Cartner, D., Cordell, H. J., Doal, R., Evison, F., Gallier, S., Harris, S., Hillman, S. J., Holding, R., Leroux, P., Marshall, T., Matthews, F. E., Missier, P., Nair, A., Osman, M., Pearson, E. R., Plummer, C., …Sayer, A. A. (2025). Building ADMISSION – A research collaborative to transform understanding of multiple long-term conditions for people admitted to hospital. Journal of Multimorbidity and Comorbidity, 15, https://doi.org/10.1177/26335565251317940

Background
Multiple long-term conditions (MLTCs; commonly referred to as multimorbidity) are highly prevalent among people admitted to hospital and are therefore of critical importance to hospital-based healthcare systems. To date, most research on... Read More about Building ADMISSION – A research collaborative to transform understanding of multiple long-term conditions for people admitted to hospital.

Cognitive reserve and its impact on cognitive and functional abilities, physical activity and quality of life following a diagnosis of dementia: longitudinal findings from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study (2025)
Journal Article
Gamble, L. D., Clare, L., Opdebeeck, C., Martyr, A., Jones, R. W., Rusted, J. M., Pentecost, C., Thom, J. M., & Matthews, F. E. (2025). Cognitive reserve and its impact on cognitive and functional abilities, physical activity and quality of life following a diagnosis of dementia: longitudinal findings from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study. Age and ageing, 54(1), Article afae284. https://doi.org/10.1093/ageing/afae284

Background: The concept of cognitive reserve may explain inter-individual differences in susceptibility to neuropathological changes. Studies suggest that experiences over a lifetime impact on cognitive reserve, and it is hypothesised that following... Read More about Cognitive reserve and its impact on cognitive and functional abilities, physical activity and quality of life following a diagnosis of dementia: longitudinal findings from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study.

Ecological study of the association between the English national vaccination programme and area deprivation inequalities in COVID-19 mortality (2025)
Journal Article
Bennett, N., Bambra, C., Sinclair, D., Todd, A., & Matthews, F. (2025). Ecological study of the association between the English national vaccination programme and area deprivation inequalities in COVID-19 mortality. BMJ open, 15(1), Article e085195. https://doi.org/10.1136/bmjopen-2024-085195

Objective To understand how area deprivation inequalities in COVID-19 mortality changed during the national vaccination programme in England and to identify the extent to which these inequalities might be explained by unequal vaccination uptake. Desi... Read More about Ecological study of the association between the English national vaccination programme and area deprivation inequalities in COVID-19 mortality.

A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies (2024)
Journal Article
Huque, M. H., Kootar, S., Kiely, K. M., Anderson, C. S., van Boxtel, M., Brodaty, H., Sachdev, P. S., Carlson, M., Fitzpatrick, A. L., Whitmer, R. A., Kivipelto, M., Jorm, L., Köhler, S., Lautenschlager, N. T., Lopez, O. L., Shaw, J. E., Matthews, F. E., Peters, R., & Anstey, K. J. (2024). A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies. BMC medicine, 22(1), Article 501. https://doi.org/10.1186/s12916-024-03711-6

BACKGROUND: We aimed to develop risk tools for dementia, stroke, myocardial infarction (MI), and diabetes, for adults aged ≥ 65years using shared risk factors. METHODS: Data were obtained from 10 population-based cohorts (N = 41,755) with median foll... Read More about A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies.

Evaluating Models of the Ageing BOLD Response (2024)
Journal Article
Henson, R. N., Olszowy, W., Tsvetanov, K. A., Yadav, P. S., Tyler, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., Cusack, R., Dalgleish, T., Duncan, J., Matthews, F. E., Marslen-Wilson, W. D., Rowe, J. B., Shafto, M. A., Campbell, K., Cheung, T., Davis, S., Geerligs, L., Kievit, R., …Zeidman, P. (2024). Evaluating Models of the Ageing BOLD Response. Human Brain Mapping, 45(15), Article e70043. https://doi.org/10.1002/hbm.70043

Neural activity cannot be directly observed using fMRI; rather it must be inferred from the hemodynamic responses that neural activity causes. Solving this inverse problem is made possible through the use of forward models, which generate predicted h... Read More about Evaluating Models of the Ageing BOLD Response.

Associations between depression and anxiety in midlife and dementia more than 30 years later: The HUNT Study (2024)
Journal Article
Aunsmo, R. H., Strand, B. H., Anstey, K. J., Bergh, S., Kivimäki, M., Köhler, S., Krokstad, S., Livingston, G., Matthews, F. E., & Selbæk, G. (2024). Associations between depression and anxiety in midlife and dementia more than 30 years later: The HUNT Study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 16(4), Article e70036. https://doi.org/10.1002/dad2.70036

INTRODUCTION: It is unclear how midlife depression and anxiety affect dementia risk. We examined this in a Norwegian cohort followed for 30 years. METHODS: Dementia status at age 70+ in the fourth wave of the Trøndelag Health Study (HUNT4, 2017–2019,... Read More about Associations between depression and anxiety in midlife and dementia more than 30 years later: The HUNT Study.

The association between frailty, care receipt and unmet need for care with the risk of hospital admissions (2024)
Journal Article
Maharani, A., Sinclair, D. R., Clegg, A., Hanratty, B., Nazroo, J., Tampubolon, G., Todd, C., Wittenberg, R., O’Neill, T. W., & Matthews, F. E. (2024). The association between frailty, care receipt and unmet need for care with the risk of hospital admissions. PLoS ONE, 19(9), Article e0306858. https://doi.org/10.1371/journal.pone.0306858

Background Frailty is characterised by a decline in physical, cognitive, energy, and health reserves and is linked to greater functional dependency and higher social care utilisation. However, the relationship between receiving care, or receiving ins... Read More about The association between frailty, care receipt and unmet need for care with the risk of hospital admissions.

Identifying predictors of transition to a care home for people with dementia: findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Gamble, L. D., Matthews, F. E., Thom, J. M., Henderson, C., Allan, L., Pentecost, C., Quinn, C., Hunt, A., & Clare, L. (2025). Identifying predictors of transition to a care home for people with dementia: findings from the IDEAL programme. Aging and Mental Health, 29(2), 256-264. https://doi.org/10.1080/13607863.2024.2383367

Objectives: This study investigates factors associated with the person with dementia and the caregiver to identify those associated with an increased risk of transition to a care home. Method: IDEAL data were collected at baseline and at 12- and 24-m... Read More about Identifying predictors of transition to a care home for people with dementia: findings from the IDEAL programme.

Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies (2024)
Journal Article
Mukadam, N., Wolters, F. J., Walsh, S., Wallace, L., Brayne, C., Matthews, F. E., Sacuiu, S., Skoog, I., Seshadri, S., Beiser, A., Ghosh, S., & Livingston, G. (2024). Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies. The Lancet. Public Health, 9(7), e443-e460. https://doi.org/10.1016/S2468-2667%2824%2900120-8

Background: Some cohort studies have reported a decline in dementia prevalence and incidence over time, although these findings have not been consistent across studies. We reviewed evidence on changes in dementia prevalence and incidence over time us... Read More about Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies.

Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme (2024)
Journal Article
Martyr, A., Gamble, L. D., Hunt, A., Quinn, C., Morris, R. G., Henderson, C., Allan, L., Opdebeeck, C., Charlwood, C., Jones, R. W., Pentecost, C., Kopelman, M. D., Thom, J. M., Matthews, F. E., & Clare, L. (2024). Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme. BMC medicine, 22(1), Article 265. https://doi.org/10.1186/s12916-024-03492-y

Background: People with different types of dementia may have distinct symptoms and experiences that affect their quality of life. This study investigated whether quality of life varied across types of dementia and over time. Methods: The participants... Read More about Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme.

Living Alone With Mild-to-Moderate Dementia Over a Two-Year Period: Longitudinal Findings From the IDEAL Cohort (2024)
Journal Article
Clare, L., Gamble, L. D., Martyr, A., Henderson, C., Knapp, M., & Matthews, F. E. (2024). Living Alone With Mild-to-Moderate Dementia Over a Two-Year Period: Longitudinal Findings From the IDEAL Cohort. American Journal of Geriatric Psychiatry, 32(11), 1309-1321. https://doi.org/10.1016/j.jagp.2024.05.012

Objectives: To compare the experiences of people with dementia living alone or with others and how these may change over two years. Design: We analysed longitudinal data from three assessment waves, one year apart, in the British IDEAL cohort. Settin... Read More about Living Alone With Mild-to-Moderate Dementia Over a Two-Year Period: Longitudinal Findings From the IDEAL Cohort.

The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales (2024)
Journal Article
Wu, Y. T., Kitwiroon, N., Beevers, S., Barratt, B., Brayne, C., Cerin, E., Franklin, R., Houlden, V., Woods, B., Zied Abozied, E., Prina, M., & Matthews, F. (2024). The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales. BMC public health, 24(1), Article 1233. https://doi.org/10.1186/s12889-024-18723-3

Background: Air pollution has been recognised as a potential risk factor for dementia. Yet recent epidemiological research shows mixed evidence. The aim of this study is to investigate the longitudinal associations between ambient air pollution expos... Read More about The longitudinal associations between ambient air pollution exposure and dementia in the UK: results from the cognitive function and ageing study II and Wales.

Associations between multimorbidity and neuropathology in dementia: Consideration of functional cognitive disorders, psychiatric illness and dementia mimics (2024)
Journal Article
Hamilton, C. A., Matthews, F. E., Attems, J., Donaghy, P. C., Erskine, D., Taylor, J. P., & Thomas, A. J. (2024). Associations between multimorbidity and neuropathology in dementia: Consideration of functional cognitive disorders, psychiatric illness and dementia mimics. British Journal of Psychiatry, 224(6), 237-244. https://doi.org/10.1192/bjp.2024.25

Background Multimorbidity, the presence of two or more health conditions, has been identified as a possible risk factor for clinical dementia. It is unclear whether this is due to worsening brain health and underlying neuropathology, or other factors... Read More about Associations between multimorbidity and neuropathology in dementia: Consideration of functional cognitive disorders, psychiatric illness and dementia mimics.

The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction (2024)
Journal Article
Almansouri, T., Waller, R., Wharton, S. B., Heath, P. R., Matthews, F. E., Brayne, C., van Eeden, F., & Simpson, J. E. (2024). The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction. International Journal of Molecular Sciences, 25(8), Article 4445. https://doi.org/10.3390/ijms25084445

Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68+ microglia. This study aimed to characterize the transcriptomic profile of microglia in DSCLs and surrounding rad... Read More about The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction.

Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., Jones, R. W., Allan, L., Knapp, M., Quinn, C., Victor, C., Pentecost, C., Rusted, J. M., Morris, R. G., & Clare, L. (2024). Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 171. https://doi.org/10.1186/s12877-024-04707-w

Objectives: Longitudinal evidence documenting health conditions in spousal caregivers of people with dementia and whether these influence caregivers’ outcomes is scarce. This study explores type and number of health conditions over two years in careg... Read More about Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme.

Relationships of Brain Cholesterol and Cholesterol Biosynthetic Enzymes to Alzheimer’s Pathology and Dementia in the CFAS Population-Derived Neuropathology Cohort (2024)
Journal Article
Mistry, H., Richardson, C. D., Higginbottom, A., Ashford, B., Ahamed, S. U., Moore, Z., Matthews, F. E., Brayne, C., Simpson, J. E., & Wharton, S. B. (2024). Relationships of Brain Cholesterol and Cholesterol Biosynthetic Enzymes to Alzheimer’s Pathology and Dementia in the CFAS Population-Derived Neuropathology Cohort. Neuroscience Research, 204, Article 22-33. https://doi.org/10.1016/j.neures.2024.01.003

Altered cholesterol metabolism is implicated in brain ageing and Alzheimer's disease. We examined whether key genes regulating cholesterol metabolism and levels of brain cholesterol are altered in dementia and Alzheimer's disease neuropathological ch... Read More about Relationships of Brain Cholesterol and Cholesterol Biosynthetic Enzymes to Alzheimer’s Pathology and Dementia in the CFAS Population-Derived Neuropathology Cohort.