Developing ATP-responsive Manganese-based Magnetic Resonance Imaging (MRI) Contract Agents

ThrombiGlow: ‘Smart’ Multimodal Platelet Specific ‘Theranostic’ Drug Delivery Imaging Feb 1, 2017 - Jan 31, 2020
Cardiovascular diseases (CVD) including heart attacks and strokes constitute the leading cause of mortality in the UK. The pathology underlying CVD is called atherothrombosis and is a complex, multi-cellular-inflammatory disorder. Central to this is... Read More about ThrombiGlow: ‘Smart’ Multimodal Platelet Specific ‘Theranostic’ Drug Delivery Imaging.

Development of Heavy Metal Free Quantum dot Lanthanide Conjugates for Sensing Aug 16, 2016 - Dec 31, 2018
The overall aim of this project to use innovative inorganic chemistry for the supramolecular self-assembly of novel heavy metal free nanocrystal (quantum dots) and lanthanide complexes to give multimodal contrast agents for molecular imaging. Key goa... Read More about Development of Heavy Metal Free Quantum dot Lanthanide Conjugates for Sensing.

Development Of A Multimodal Bioimaging Platform For Detecting The Switch To Aggressive Prostate Cancer Oct 1, 2015 - Dec 31, 2018

Is zinc a critical modulator of cyclic nucleotide signalling? Oct 1, 2019 - Dec 31, 2022
inc (Zn2+) deficiency is present in multiple conditions from obesity to cancer. However importantly Zn2+ deficiency can lead to a bleeding phenotype.In this proposal we investigate how Zn2+ is important for the control of platelet cyclic nucleotide... Read More about Is zinc a critical modulator of cyclic nucleotide signalling?.