Professor David Allsup D.J.Allsup@hull.ac.uk
Professor of Haematology
Prospective assessment of the fungal microbiome in persons with leukaemia
People Involved
Professor Matthew Hardman M.Hardman@hull.ac.uk
Chair in Wound Healing / HYMS Director of Research
Project Description
Fungal infections are an infreqeuent but severe complication of acute leukaemia treated with intensive chemotherapy. The current standard of care to prevent such infections is the prophylactic administration of antifungal drugs to persons with acute leukaemia treated with chemotherapy. However such an approach is associated with a risk of emergent drug-resistant fungi, toxicity from the antifungal drugs and adverse interactions with other medicines used in the treatment of leukaemia.
The BioDrive AFS study is a NIHR funded phase III randomised controlled trial which will compare antifungal prophylaxis with a blood based biomarker monitoring approach in persons with acute leukaemia treated with intensive chemotherapy.
Within the BioDrive programme is an ethically approved parallel study which utilises high-throughput genomic analysis to assess the fungal microbiome in study participants. Participants in the parallel study have regular skin and mouth swabs taken. Genetic material is extracted from these swabs and analysed to assess the fungal microbiome. The aim of this parallel study is to demonstrate the feasibility of an approach to systematically assess the fungal microbiome in persons at high risk of fungal infection. Once such an approach is validated then we aim to correlate the fungal microbiome to clinical outcomes, such as infection, in study participants. This approach may lead to a personalised assessment of the fungal microbiome and conseqeuntial risk of fungal, or other infections.
This application seeks funds to support consumable costs incurred in the genomic analysis of the fungal microbiome.
| Type of Project | Commercial/Industry - Research |
|---|---|
| Status | Project Live |
| Funder(s) | Gilead |
| Value | £50,000.00 |
| Project Dates | Oct 1, 2024 - Sep 30, 2025 |
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