Outputs (33)

Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine (2008)
Journal Article
Sadofsky, L. R., Campi, B., Trevisani, M., Compton, S. J., & Morice, A. H. (2008). Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine. Experimental Lung Research, 34(10), 681-693. https://doi.org/10.1080/01902140802339623

American guidelines, unlike European guidelines, support the use of antihistamines as a first line of treatment for some causes of chronic cough. Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsa... Read More about Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine.

Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression (2008)
Journal Article
Kogianni, G., Walker, M. M., Waxman, J., & Sturge, J. (2009). Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression. European Journal of Cancer, 45(4), 685-693. https://doi.org/10.1016/j.ejca.2008.11.023

Endo180 (CD280; MRC2; uPARAP) regulates collagen remodelling and chemotactic cell migration through cooperation with membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase-type plasminogen activator receptor (uPAR) and urokinase-type plasminog... Read More about Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression.

Influence of exogenous tissue factor on estrogen receptor α expression in breast cancer cells: Involvement of β1-integrin, PAR2, and mitogen-activated protein kinase activation (2008)
Journal Article
Collier, M. E. W., Li, C., & Ettelaie, C. (2008). Influence of exogenous tissue factor on estrogen receptor α expression in breast cancer cells: Involvement of β1-integrin, PAR2, and mitogen-activated protein kinase activation. Molecular cancer research, 6(12), 1807-1818. https://doi.org/10.1158/1541-7786.MCR-08-0109

Increased expression of tissue factor (TF) has been associated with invasive forms of breast cancer. Conversely, the loss of estrogen receptor α (ERα) is associated with increased cell invasiveness. We have examined the influence of exogenous truncat... Read More about Influence of exogenous tissue factor on estrogen receptor α expression in breast cancer cells: Involvement of β1-integrin, PAR2, and mitogen-activated protein kinase activation.

A novel finding that Streptomyces clavuligerus can produce the antibiotic clavulanic acid using olive oil as a sole carbon source (2008)
Journal Article
Efthimiou, G., Thumser, A. E., & Avignone-Rossa, C. A. (2008). A novel finding that Streptomyces clavuligerus can produce the antibiotic clavulanic acid using olive oil as a sole carbon source. Journal of applied microbiology, 105(6), 2058-2064. https://doi.org/10.1111/j.1365-2672.2008.03975.x

Aims: This study aims to establish whether commercially available food oils can be used by Streptomyces clavuligerus as sole carbon sources for growth and clavulanic acid production. Methods and results: Batch cultures in bioreactors showed that Stre... Read More about A novel finding that Streptomyces clavuligerus can produce the antibiotic clavulanic acid using olive oil as a sole carbon source.

Vascular endothelium in cancer (2008)
Journal Article
Nikitenko, L. L. (2009). Vascular endothelium in cancer. Cell and Tissue Research, 335, 223-240. https://doi.org/10.1007/s00441-008-0707-4

The vascular endothelium plays an essential role during organogenesis and in tissue homeostasis. Growing evidence also supports its essential and complex role in tumour biology and cancer progression. In particular, excessive proliferation and transf... Read More about Vascular endothelium in cancer.

Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives (2008)
Journal Article
Vince, R. V., McNaughton, L. R., Taylor, L., Midgley, A. W., Laden, G., & Madden, L. A. (2009). Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives. European journal of applied physiology, 105(4), 507-513. https://doi.org/10.1007/s00421-008-0927-z

Microparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positi... Read More about Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives.

ATM activation and signaling under hypoxic conditions (2008)
Journal Article
Bencokova, Z., Kaufmann, M. R., Monteiro dos Santos Pires, I., Lecane, P. S., Giaccia, A. J., & Hammond, E. M. (2009). ATM activation and signaling under hypoxic conditions. Molecular and cellular biology, 29(2), 526-537. https://doi.org/10.1128/MCB.01301-08

The ATM kinase has previously been shown to respond to the DNA damage induced by reoxygenation following hypoxia by initiating a Chk 2-dependent cell cycle arrest in the G2 phase. Here we show that ATM is both phosphorylated and active during exposur... Read More about ATM activation and signaling under hypoxic conditions.

Prostate cancer stem cells (2008)
Journal Article
Lang, S., Frame, F., & Collins, A. (2009). Prostate cancer stem cells. Journal of Pathology, 217(2), 299-306. https://doi.org/10.1002/path.2478

Despite the discovery over 60 years ago by Huggins and Hodges that prostate cancers respond to androgen deprivation therapy, hormone‐refractory prostate cancer remains a major clinical challenge. There is now mounting evidence that solid tumours orig... Read More about Prostate cancer stem cells.

Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading (2008)
Journal Article
Calaminus, S. D. J., Thomas, S., McCarty, O. J. T., Machesky, L. M., & Watson, S. P. (2008). Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading. Journal of thrombosis and haemostasis : JTH, 6(11), 1944-1952. https://doi.org/10.1111/j.1538-7836.2008.03141.x

During platelet spreading, the actin cytoskeleton undergoes marked changes, forming filopodia, lamellipodia and stress fibres. In the present study, we report the identification of a novel actin-rich structure, termed an actin nodule, which appears p... Read More about Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading.

DNA damage and metabolic activity in the preimplantation embryo (2008)
Journal Article
Sturmey, R. G., Hawkhead, J. A., Barker, E. A., & Leese, H. J. (2009). DNA damage and metabolic activity in the preimplantation embryo. Human Reproduction, 24(1), 81-91. https://doi.org/10.1093/humrep/den346

BACKGROUND: Embryos with greater viability have a lower or 'quieter' amino acid metabolism than those which arrest. We have hypothesized this is due to non-viable embryos possessing greater cellular/molecular damage and consuming more nutrients, such... Read More about DNA damage and metabolic activity in the preimplantation embryo.