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Outputs (37)

PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma (2021)
Journal Article
Edge, S. D., Renard, I., Pyne, E., Li, C., Moody, H., Roy, R., Beavis, A. W., Archibald, S. J., Cawthorne, C. J., Maher, S. J., & Pires, I. M. (2021). PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma. British Journal of Radiology, 94(1119), Article 20201191. https://doi.org/10.1259/bjr.20201191

OBJECTIVE: Neoadjuvant chemoradiotherapy (neo-CRT) prior to surgery is the standard of care for oesophageal adenocarcinoma (OAC) patients. Unfortunately, most patients fail to respond to treatment. MiR-187 was previously shown to be downregulated in... Read More about PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma.

Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells (2020)
Journal Article
Beeby, E., Magalhães, M., Lemos, M. F. L., Pires, I. M., & Cabral, C. (in press). Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells. Journal of Ethnopharmacology, Article 113515. https://doi.org/10.1016/j.jep.2020.113515

Ethnopharmacological relevance: The past few years have witnessed an increasing interest in essential oils (EOs) as potential therapeutic agents against a wide variety of pathologies, including cancer. EOs extracted from Ridolfia segetum (L.) Moris (... Read More about Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells.

Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells (2020)
Journal Article
Beeby, E., Magalhães, M., Poças, J., Collins, T., Lemos, M., Barros, L., Ferreira, I., Cabral, C., & Pires, I. M. (2020). Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells. Journal of Ethnopharmacology, 258, Article 112803. https://doi.org/10.1016/j.jep.2020.112803

Ethnopharmacological relevance: Despite advances in modern therapeutic strategies, cancer remains the second leading cause of death worldwide. Therefore, there is a constant need to develop more efficient anticancer targeting strategies. The anticanc... Read More about Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells.

Validation of in-house knowledge-based planning model for advance-stage lung cancer patients treated using VMAT radiotherapy (2020)
Journal Article
Tambe, N., Pires, I. M., Moore, C., Cawthorne, C., & Beavis, A. (2020). Validation of in-house knowledge-based planning model for advance-stage lung cancer patients treated using VMAT radiotherapy. British Journal of Radiology, 93(1106), https://doi.org/10.1259/bjr.20190535

Objectives: Radiotherapy plan quality may vary considerably depending on planner's experience and time constraints. The variability in treatment plans can be assessed by calculating the difference between achieved and the optimal dose distribution. T... Read More about Validation of in-house knowledge-based planning model for advance-stage lung cancer patients treated using VMAT radiotherapy.

Anticancer properties of essential oils and other natural products (2018)
Journal Article
Blowman, K., Magalhães, M., Lemos, M. F., Cabral, C., & Pires, I. M. (2018). Anticancer properties of essential oils and other natural products. Evidence-based complementary and alternative medicine : eCAM, 2018, 1-12. https://doi.org/10.1155/2018/3149362

Essential oils are secondary metabolites with a key-role in plants protection, consisting primarily of terpenes with a volatile nature and a diverse array of chemical structures. Essential oils exhibit a wide range of bioactivities, especially antimi... Read More about Anticancer properties of essential oils and other natural products.

The Secret Science of Superheroes (2017)
Book
Lorch, M., Mackenwells, B., Jesson, D., Pires, I., Day, K., Gentle, L., Whiting, M., Miles, R., Kundu, S., Verran, J., Coxon, P., Rathi, A., Byrne, K., & Heathcoate-Marcz, F. (2017). M. Lorch, & A. Miah (Eds.). The Secret Science of Superheroes. Royal Society of Chemistry

Ever wondered what a superhero eats for breakfast? Do they need a special diet to feed their superpowers? The odd metabolisms of superheroes must mean they have strange dietary needs, from the high calorie diets to fuel flaming bodies and super speed... Read More about The Secret Science of Superheroes.

Erratum: RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 (Nature Cell Biology (2014) 16 (962-971)) (2015)
Journal Article
Pefani, D. E., Latusek, R., Pires, I., Grawenda, A. M., Yee, K. S., Hamilton, G., Van Der Weyden, L., Esashi, F., Hammond, E. M., & O'neill, E. (2015). Erratum: RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2 (Nature Cell Biology (2014) 16 (962-971)). Nature Cell Biology, 17(4), 531. https://doi.org/10.1038/ncb3152

Anticancer properties of Thymbra capitata and Helichrysum italicum essential oils (2014)
Presentation / Conference Contribution
Juliana, P., Marco, L., Célia, C., Lígia, S., & Pires, I. M. D. S. (2014, July). Anticancer properties of Thymbra capitata and Helichrysum italicum essential oils. Presented at IMMR | International Meeting on Marine Research 2014, Peniche, Portugal

An essential oil (EO) is defined internationally as the product obtained by hydrodistillation, of a plant or some parts of it. They are aromatic oily liquids, volatile, characterized by a strong odour, rarely coloured, and generally with a lower dens... Read More about Anticancer properties of Thymbra capitata and Helichrysum italicum essential oils.