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Enhanced clearing of Candida biofilms on a 3D urothelial cell in vitro model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles (2021)
Journal Article
Wang, A., Weldrick, P. J., Madden, L. A., & Paunov, V. N. (2021). Enhanced clearing of Candida biofilms on a 3D urothelial cell in vitro model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles. Biomaterials science / Royal Society of Chemistry, 9(20), 6927-6939. https://doi.org/10.1039/d1bm01035b

Candida urinary tract biofilms are increasingly witnessed in nosocomial infections due to reduced immunity of patients and the hospital ecosystem. The indwelling devices utilized to support patients with urethral diseases that connect the unsterilize... Read More about Enhanced clearing of Candida biofilms on a 3D urothelial cell in vitro model using lysozyme-functionalized fluconazole-loaded shellac nanoparticles.

Identification of soluble tissue‑derived biomarkers from human thyroid tissue explants maintained on a microfluidic device (2021)
Journal Article
Riley, A., Jones, H., England, J., Kuvshinov, D., Green, V., & Greenman, J. (2021). Identification of soluble tissue‑derived biomarkers from human thyroid tissue explants maintained on a microfluidic device. Oncology Letters, 22(5), Article 780. https://doi.org/10.3892/ol.2021.13041

Although a large cohort of potential biomarkers for thyroid cancer aggressiveness have been tested in various formats in recent years, to the best of our knowledge, thyro‑ globulin and calcitonin remain the only two established biomarkers associated... Read More about Identification of soluble tissue‑derived biomarkers from human thyroid tissue explants maintained on a microfluidic device.

Predicting personalised optimal arc parameter using knowledge-based planning model for inoperable locally advanced lung cancer patients to reduce organ at risk doses (2021)
Journal Article
Tambe, N. S., Pires, I. M., Moore, C., Wieczorek, A., Upadhyay, S., & Beavis, A. W. (2021). Predicting personalised optimal arc parameter using knowledge-based planning model for inoperable locally advanced lung cancer patients to reduce organ at risk doses. Biomedical Physics and Engineering Express, 7(6), Article 065016. https://doi.org/10.1088/2057-1976/ac2635

Objectives. Volumetric modulated arc therapy (VMAT) allows for reduction of organs at risk (OAR) volumes receiving higher doses, but increases OAR volumes receiving lower radiation doses and can subsequently increasing associated toxicity. Therefore,... Read More about Predicting personalised optimal arc parameter using knowledge-based planning model for inoperable locally advanced lung cancer patients to reduce organ at risk doses.

Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy (2021)
Journal Article
Leese, H. J., McKeegan, P., & Sturmey, R. G. (2021). Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy. International Journal of Environmental Research and Public Health, 18(18), Article 9874. https://doi.org/10.3390/ijerph18189874

Amino acids are now recognised as having multiple cellular functions in addition to their traditional role as constituents of proteins. This is well-illustrated in the early mammalian embryo where amino acids are now known to be involved in intermedi... Read More about Amino acids and the early mammalian embryo: Origin, fate, function and life‐long legacy.

The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules (2021)
Journal Article
Archibald, S. J., & Allott, L. (2021). The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules. EJNMMI Radiopharmacy and Chemistry, 6(1), Article 30. https://doi.org/10.1186/s41181-021-00141-0

The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical... Read More about The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules.

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics (2021)
Journal Article
Heestermans, M., Naudin, C., Mailer, R. K., Konrath, S., Klaetschke, K., Jämsä, A., Frye, M., Deppermann, C., Pula, G., Kuta, P., Friese, M. A., Gelderblom, M., Sickmann, A., Preston, R. J., Nofer, J. R., Rose-John, S., Butler, L. M., Salomon, O., Stavrou, E. X., & Renné, T. (2021). Identification of the factor XII contact activation site enables sensitive coagulation diagnostics. Nature communications, 12(1), Article 5596. https://doi.org/10.1038/s41467-021-25888-7

Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic impli... Read More about Identification of the factor XII contact activation site enables sensitive coagulation diagnostics.

Validation of in-house knowledge-based planning model for predicting change in target coverage during VMAT radiotherapy to in-operable advanced-stage NSCLC patients (2021)
Journal Article
Tambe, N. S., Pires, I. M., Moore, C., Wieczorek, A., Upadhyay, S., & Beavis, A. W. (2021). Validation of in-house knowledge-based planning model for predicting change in target coverage during VMAT radiotherapy to in-operable advanced-stage NSCLC patients. Biomedical Physics and Engineering Express, 7(6), https://doi.org/10.1088/2057-1976/ac1f94

Objectives. anatomical changes are inevitable during the course of radiotherapy treatments and, if significant, can severely alter expected dose distributions and affect treatment outcome. Adaptive radiotherapy (ART) is employed to maintain the plann... Read More about Validation of in-house knowledge-based planning model for predicting change in target coverage during VMAT radiotherapy to in-operable advanced-stage NSCLC patients.

In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences (2021)
Journal Article
Reus, B., Caserta, S., Larsen, M., Morrow, G., Bano, A., Hallensleben, M., Rajkumar, C., Pera, A., & Kern, F. (2021). In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences. Frontiers in immunology, 12, Article 707830. https://doi.org/10.3389/fimmu.2021.707830

The impact of biological sex on T-cell immunity to Cytomegalovirus (CMV) has not been investigated in detail with only one published study comparing CMV-specific T-cell responses in men and women. Many studies, however, have shown an association betw... Read More about In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences.

Inhibition of arginine methylation impairs platelet function (2021)
Journal Article
Marsden, A. J., Riley, D. R. J., Barry, A., Khalil, J. S., Guinn, B. A., Kemp, N. T., Rivero, F., & Beltran-Alvarez, P. (in press). Inhibition of arginine methylation impairs platelet function. ACS Pharmacology & Translational Science, https://doi.org/10.1021/acsptsci.1c00135

Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to arginine residues in proteins. PRMT inhibitors are novel, promising drugs against cancer that are currently in clinical trials, which include oral administration of... Read More about Inhibition of arginine methylation impairs platelet function.

Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro (2021)
Journal Article
Collins, T., Pyne, E., Christensen, M., Iles, A., Pamme, N., & Pires, I. M. (2021). Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro. Biomicrofluidics, 15(4), Article 044103. https://doi.org/10.1063/5.0061373

The majority of cancer deaths are linked to tumor spread, or metastasis, but 3D in vitro metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) remain an area of unmet need. Microfluidics allows us to introduce c... Read More about Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro.