Outputs (1113)

A cellular screening assay using analysis of metal-modified fluorescence lifetime (2010)
Journal Article
Cade, N. I., Fruhwirth, G., Archibald, S. J., Ng, T., & Richards, D. (2010). A cellular screening assay using analysis of metal-modified fluorescence lifetime. Biophysical journal, 98(11), 2752-2757. https://doi.org/10.1016/j.bpj.2010.03.016

Current methods for screening cell receptor internalization often require complex image analysis with limited sensitivity. Here we describe a novel bioassay based on detection of changes in global fluorescence lifetime above a gold substrate, with su... Read More about A cellular screening assay using analysis of metal-modified fluorescence lifetime.

Regulation of autophagy by ATF4 in response to severe hypoxia (2010)
Journal Article
Rzymski, T., Milani, M., Pike, L., Buffa, F., Mellor, H. R., Winchester, L., Pires, I., Hammond, E., Ragoussis, I., & Harris, A. L. (2010). Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene, 29(31), 4424-4435. https://doi.org/10.1038/onc.2010.191

Activating transcription factor 4 (ATF4) is a transcription factor induced under severe hypoxia and a component of the PERK pathway involved in the unfolded protein response (UPR), a process that protects cells from the negative consequences of endop... Read More about Regulation of autophagy by ATF4 in response to severe hypoxia.

Macrophage-mediated breast cancer cell chemotaxis: the role of sphingosine kinase-1 activation (2010)
Presentation / Conference Contribution
Nunes, J., Sauer, L., Turner, J., Waxman, J., Sturge, J., & Pshezhetskiy, D. Macrophage-mediated breast cancer cell chemotaxis: the role of sphingosine kinase-1 activation

Rapid PCR amplification using a microfluidic device with integrated microwave heating and air impingement cooling (2010)
Journal Article
Shaw, K. J., Docker, P. T., Yelland, J. V., Dyer, C. E., Greenman, J., Greenway, G. M., & Haswell, S. J. (2010). Rapid PCR amplification using a microfluidic device with integrated microwave heating and air impingement cooling. Lab on a chip, 10(13), 1725-1728. https://doi.org/10.1039/c000357n

A microwave heating system is described for performing polymerase chain reaction (PCR) in a microfluidic device. The heating system, in combination with air impingement cooling, provided rapid thermal cycling with heating and cooling rates of up to 6... Read More about Rapid PCR amplification using a microfluidic device with integrated microwave heating and air impingement cooling.

A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity (2010)
Journal Article
Otto, A., Macharia, R., Matsakas, A., Valasek, P., Mankoo, B. S., & Patel, K. (2010). A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity. Developmental Biology, 343(1-2), 51-62. https://doi.org/10.1016/j.ydbio.2010.04.014

The major component of skeletal muscle is the myofibre. Genetic intervention inducing over-enlargement of myofibres beyond a certain threshold through acellular growth causes a reduction in the specific tension generating capacity of the muscle. Howe... Read More about A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity.

Variation in amino acid and lipid composition of latent fingerprints (2010)
Journal Article
Croxton, R. S., Baron, M. G., Butler, D., Kent, T., & Sears, V. G. (2010). Variation in amino acid and lipid composition of latent fingerprints. Forensic Science International, 199(1-3), 93-102. https://doi.org/10.1016/j.forsciint.2010.03.019

The enhancement of latent fingerprints, both at the crime scene and in the laboratory using an array of chemical, physical and optical techniques, permits their use for identification. Despite the plethora of techniques available, there are occasions... Read More about Variation in amino acid and lipid composition of latent fingerprints.

Genetics and cardiac channelopathies (2010)
Journal Article
Campuzano, O., Beltrán-Álvarez, P., Iglesias, A., Scornik, F., Pérez, G., & Brugada, R. (2010). Genetics and cardiac channelopathies. Genetics in Medicine, 12(5), 260-267. https://doi.org/10.1097/GIM.0b013e3181d81636

Sudden cardiac death is a major contributor to mortality in industrialized nations; in fact, it is the cause of more deaths than acquired immune deficiency syndrome, lung and breast cancer, and stroke together. Frequently, the autopsy becomes the pri... Read More about Genetics and cardiac channelopathies.

The development and evaluation of a conducting matrix for the electrochemical regeneration of the immobilised co-factor NAD(H) under continuous flow (2010)
Journal Article
Ngamsom, B., Hickey, A. M., Greenway, G. M., Littlechild, J. A., McCreedy, T., Watts, P., & Wiles, C. (2010). The development and evaluation of a conducting matrix for the electrochemical regeneration of the immobilised co-factor NAD(H) under continuous flow. Organic & biomolecular chemistry, 8(10), 2419-2424. https://doi.org/10.1039/b924100k

Through the preparation of a novel controlled pore glass-poly(pyrrole) material we have developed a conducting support that is not only suitable for the co-immobilisation of enzymes and co-factors, but also enables the facile electrochemical regenera... Read More about The development and evaluation of a conducting matrix for the electrochemical regeneration of the immobilised co-factor NAD(H) under continuous flow.

Biological and clinical implications of nicastrin expression in invasive breast cancer (2010)
Journal Article
Filipović, A., Gronau, J. H., Green, A. R., Wang, J., Vallath, S., Shao, D., Rasul, S., Ellis, I. O., Yagüe, E., Sturge, J., & Coombes, R. C. (2011). Biological and clinical implications of nicastrin expression in invasive breast cancer. Breast cancer research and treatment, 125(1), 43-53. https://doi.org/10.1007/s10549-010-0823-1

Nicastrin is an essential component of the gamma secretase (GS) enzyme complex, required for its synthesis and recognition of substrates for proteolytic cleavage. The purpose of this study was to investigate whether nicastrin has prognostic value or... Read More about Biological and clinical implications of nicastrin expression in invasive breast cancer.

CD66a (CEACAM1) is the only CD66 variant expressed on the surface of plasma cells in multiple myeloma: A refined target for radiotherapy trials?: Correspondence (2010)
Journal Article
Lee, C., Guinn, B. A., Brooks, S. E., Richardson, D., & Orchard, K. (2010). CD66a (CEACAM1) is the only CD66 variant expressed on the surface of plasma cells in multiple myeloma: A refined target for radiotherapy trials?: Correspondence. British journal of haematology, 149(5), 795-796. https://doi.org/10.1111/j.1365-2141.2010.08100.x