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Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. https://doi.org/10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.

Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study (2011)
Journal Article
Bourantas, C. V., Nikitin, N. P., Loh, H. P., Lukaschuk, E. I., Sherwi, N., de Silva, R., Tweddel, A. C., Alamgir, M. F., Wong, K., Gupta, S., Clark, A. L., & Cleland, J. G. (2011). Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 13(53), Article ARTN 53. https://doi.org/10.1186/1532-429x-13-53

BackgroundCardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) can provide unique data on the transmural extent of scar/viability. We assessed the prevalence of dysfunctional myocardium, including partial thickness scar, whi... Read More about Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study.

Limited role for ivabradine in the treatment of chronic heart failure (2011)
Journal Article
Cullington, D., Goode, K. M., Cleland, J. G. F., & Clark, A. L. (2011). Limited role for ivabradine in the treatment of chronic heart failure. Heart, 97(23), 1961-1966. https://doi.org/10.1136/heartjnl-2011-300041

ObjectiveTo quantify the proportion of patients attending a community heart failure clinic with left ventricular systolic impairment who might be suitable for ivabradine therapy.BackgroundHigh resting heart rate is an important and potentially modifi... Read More about Limited role for ivabradine in the treatment of chronic heart failure.

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis (2011)
Journal Article
Botham, A., Guo, X., Xiao, Y. P., Morice, A. H., Compton, S., & Sadofsky, L. R. (2011). Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal, 438(2), 359-367. https://doi.org/10.1042/BJ20101958

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation o... Read More about Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.

Differential proteomics in the search for biomarkers of radiotherapy resistance (2011)
Journal Article
Scaife, L., Hodgkinson, V. C., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Differential proteomics in the search for biomarkers of radiotherapy resistance. Expert Review of Proteomics, 8(4), 535-552. https://doi.org/10.1586/EPR.11.32

The individualization of radiotherapy treatment would be beneficial for cancer patients; however, there are no predictive biomarkers of radiotherapy resistance in routine clinical use. This article describes the body of work in this field where compa... Read More about Differential proteomics in the search for biomarkers of radiotherapy resistance.

Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey (2011)
Journal Article
Khan, J. A., Mazari, F. A., Abdul Rahman, M., Mockford, K., Chetter, I. C., & McCollum, P. T. (2011). Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey. Annals of vascular surgery, 25(7), 878-886. https://doi.org/10.1016/j.avsg.2011.05.013

BackgroundTo evaluate patients' awareness, functional outcome, and satisfaction after abdominal aortic aneurysm (AAA) repair.MethodsA study-specific questionnaire was developed with collaboration of a multidisciplinary team. Lists of patients who und... Read More about Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey.

Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol (2011)
Journal Article
Sharma, A., Liu, B., Waudby, P., & Duthie, G. S. (2011). Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol. International Journal of Colorectal Disease, 26(12), 1583-1587. https://doi.org/10.1007/s00384-011-1257-x

Background
Constipation is a common multifactorial gastrointestinal symptom with quality of life implications. Sacral neuromodulation has been used in the management of severe constipation with mixed results. The aim of this study was to review our... Read More about Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol.

Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic (2011)
Journal Article
Smith, G. E., Samuel, N., Khan, J., Johnson, B. F., & Chetter, I. C. (2011). Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic. Annals of vascular surgery, 25(8), 1099-1103. https://doi.org/10.1016/j.avsg.2011.02.043

BackgroundMany duplex detectable factors have been shown to correlate with upper limb arteriovenous fistula (AVF) outcomes, and many practitioners now request preoperative duplex vessel mapping routinely before AVF surgery. We report outcomes from a... Read More about Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic.

Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins (2011)
Journal Article
Carradice, D., Mekako, A. I., Mazari, F. A. K., Samuel, N., Hatfield, J., & Chetter, I. C. (2011). Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. British journal of surgery, 98(8), 1117-1123. https://doi.org/10.1002/bjs.7615

Background:This report describes the clinical effectiveness and recurrence rates from a randomized trial of endovenous laser ablation (EVLA) and surgery for varicose veins.Methods:Some 280 patients were randomized equally using sealed opaque envelope... Read More about Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins.

Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation (2011)
Journal Article
Samuel, N., Wallace, T., Smith, G. E., Shahin, Y., & Chetter, I. C. (2011). Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation. Ultrasound, 19(2), 97-98. https://doi.org/10.1258/ult.2011.011006

Duplex ultrasound imaging plays a key role in the increasingly popular, minimally invasive endothermal treatment of varicose veins. Accurate placement of the echodense tip of endovenous catheter distal to the site of junctional incompetence is by far... Read More about Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation.