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Home-based exercise programmes for individuals with intermittent claudication: A protocol for an updated systematic review and meta-analysis

Ingle, Lee; Pymer, Sean; Tew, Garry A; Palmer, Joanne; Ingle, Lee; Smith, George E; Chetter, Ian; Harwood, Amy E


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Mr Sean Pymer
Academic Clinical Exercise Physiologist

Garry A Tew

Joanne Palmer

George E Smith

Ian Chetter

Amy E Harwood


Sean Pymer

Gary Tew

Joanne Palmer

George E Smith

Ian Chetter
Project Manager

Amy Harwood


Background: The aim of this updated review is to consider the evidence base for the effectiveness of home-based exercise programmes (HEP) as a treatment option for improving walking distance in patients with IC.
Methods: The Medline, EMBASE, CINAHL, PEDro and Cochrane CENTRAL databases will be searched for terms including “intermittent claudication”, “peripheral arterial disease”, “home-based exercise” and “home-based walking”. No date restrictions will be used but only articles in the English language will be included. Both randomised and non-randomised trials of HEP’s versus a comparator arm will be included, and a meta-analysis using only the randomised controlled trials will be attempted if the assumptions of heterogeneity are met.
Data extraction will include study details, sample description, intervention description, length of follow up and outcomes measures. The primary outcome measure is objectively measured maximal walking distance or time, with secondary outcome measures including pain-free walking distance or time, changes in physical activity and quality of life. We will also provide a narrative description of the effective components of a home-based exercise intervention which can aid future recommendations.
Conclusion: Overall, this proposed review and meta-analysis aims to provide a comprehensive and complete overview of the evidence base for HEP’s, which can aid clinicians in the management of their patients.

PROSPERO registration number: CRD42018091248


Pymer, S., Tew, G. A., Palmer, J., Ingle, L., Smith, G. E., Chetter, I., & Harwood, A. E. (2018). Home-based exercise programmes for individuals with intermittent claudication: A protocol for an updated systematic review and meta-analysis. SAGE Open Medicine, 6, 205031211881829. doi:10.1177/2050312118818295

Journal Article Type Article
Acceptance Date Nov 16, 2018
Online Publication Date Dec 10, 2018
Publication Date Dec 10, 2018
Deposit Date Nov 27, 2018
Publicly Available Date Dec 13, 2018
Electronic ISSN 2050-3121
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 6
Pages 205031211881829
Series ISSN SAGE Open Medicine
Keywords Intermittent Claudication; Peripheral Arterial Disease; Exercise; Home-Based; Walking; Community
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This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (

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