Marius E. Mayerhoefer
MRI and PET/MRI in hematologic malignancies
Mayerhoefer, Marius E.; Archibald, Stephen J.; Messiou, Christina; Staudenherz, Anton; Berzaczy, Dominik; Schöder, Heiko
Professor Steve Archibald S.J.Archibald@hull.ac.uk
Professor in Molecular Imaging
The role of MRI differs considerably between the three main groups of hematological malignancies: lymphoma, leukemia, and myeloma. In myeloma, whole-body MRI (WB-MRI) is recognized as a highly sensitive test for the assessment of myeloma, and is also endorsed by clinical guidelines, especially for detection and staging. In lymphoma, WB-MRI is presently not recommended, and merely serves as an alternative technique to the current standard imaging test, [18F]FDG-PET/CT, especially in pediatric patients. Even for lymphomas with variable FDG avidity, such as extranodal mucosa-associated lymphoid tissue lymphoma (MALT), contrast-enhanced computed tomography (CT), but not WB-MRI, is presently recommended, despite the high sensitivity of diffusion-weighted MRI and its ability to capture treatment response that has been reported in the literature. In leukemia, neither MRI nor any other cross-sectional imaging test (including positron emission tomography [PET]) is currently recommended outside of clinical trials. This review article discusses current clinical applications as well as the main research topics for MRI, as well as PET/MRI, in the field of hematological malignancies, with a focus on functional MRI techniques such as diffusion-weighted imaging and dynamic contrast-enhanced MRI, on the one hand, and novel, non-FDG PET imaging probes such as the CXCR4 radiotracer [68Ga]Ga-Pentixafor and the amino acid radiotracer [11C]methionine, on the other hand. Level of Evidence: 5. Technical Efficacy Stage: 3.
|Journal Article Type||Review|
|Publication Date||May 1, 2020|
|Journal||Journal of Magnetic Resonance Imaging|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Mayerhoefer, M. E., Archibald, S. J., Messiou, C., Staudenherz, A., Berzaczy, D., & Schöder, H. (2020). MRI and PET/MRI in hematologic malignancies. Journal of magnetic resonance imaging : JMRI, 51(5), 1325-1335. https://doi.org/10.1002/jmri.26848|
|Keywords||Radiology Nuclear Medicine and imaging|
© 2019 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine
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