Professor Bernie Binks B.P.Binks@hull.ac.uk
Emeritus Professor of Physical Chemistry
Professor Bernie Binks B.P.Binks@hull.ac.uk
Emeritus Professor of Physical Chemistry
Yage Zhang
Xiangyu Fu
Wei Guo
Yi Deng
Ho Cheung Shum
Liquid marbles need to be controlled precisely to benefit applications, for instance, as microreactors on digital microfluidic platforms for chemical and biological assays. In this work, a strategy is introduced to coalesce liquid marbles via electrostatics, where two liquid marbles in contact can coalesce when a sufficiently high voltage is applied to embedded electrodes. With the understanding of the mechanism of coalescence through relating the electric stress and the restoring capillary pressure at the contact interface, this method coalesces liquid marbles efficiently. When compared with the existing electrocoalescence method, our approach does not require immersion of electrodes to trigger coalescence. We demonstrate this to exchange the medium for the culture of cell spheroids and to measure the cell metabolic activity through a CCK-8 assay. The manipulation of liquid marbles driven by electrostatics creates new opportunities to conduct chemical reactions and biomedical assays in these novel microreactors.
Binks, B. P., Zhang, Y., Fu, X., Guo, W., Deng, Y., & Shum, H. C. (2019). Electrocoalescence of liquid marbles driven by embedded electrodes for triggering bioreactions. Lab on a chip, 19(20), 3526-3534. https://doi.org/10.1039/c9lc00722a
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 3, 2019 |
Online Publication Date | Sep 4, 2019 |
Publication Date | Oct 21, 2019 |
Deposit Date | Sep 4, 2019 |
Publicly Available Date | Sep 5, 2020 |
Journal | Lab on a Chip |
Print ISSN | 1473-0197 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 19 |
Issue | 20 |
Pages | 3526-3534 |
DOI | https://doi.org/10.1039/c9lc00722a |
Public URL | https://hull-repository.worktribe.com/output/2605836 |
Publisher URL | https://pubs.rsc.org/en/content/articlehtml/2019/lc/c9lc00722a |
Contract Date | Sep 4, 2019 |
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©2019 University of Hull
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