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Wound healing: cellular mechanisms and pathological outcomes

Wilkinson, Holly N.; Hardman, Matthew J.

Authors



Abstract

Wound healing is a complex, dynamic process supported by a myriad of cellular events that must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound-linked cellular behaviours, as occurs with diabetes and ageing, can lead to healing impairment and the formation of chronic, non-healing wounds. These wounds are a significant socioeconomic burden due to their high prevalence and recurrence. Thus, there is an urgent requirement for the improved biological and clinical understanding of the mechanisms that underpin wound repair. Here, we review the cellular basis of tissue repair and discuss how current and emerging understanding of wound pathology could inform future development of efficacious wound therapies.

Citation

Wilkinson, H. N., & Hardman, M. J. (2020). Wound healing: cellular mechanisms and pathological outcomes. Open Biology, 10(9), https://doi.org/10.1098/rsob.200223

Journal Article Type Article
Acceptance Date Sep 8, 2020
Online Publication Date Sep 30, 2020
Publication Date 2020-09
Deposit Date Jun 3, 2021
Publicly Available Date Jun 4, 2021
Journal Open Biology
Print ISSN 2046-2441
Electronic ISSN 2046-2441
Publisher The Royal Society
Peer Reviewed Peer Reviewed
Volume 10
Issue 9
Article Number 200223
DOI https://doi.org/10.1098/rsob.200223
Keywords Skin; Wound healing; Tissue repair; Chronic wounds; Ageing; Diabetes
Public URL https://hull-repository.worktribe.com/output/3620880

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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2020 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.





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