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Microfluidic synthesis of silica nanoparticles using polyethylenimine polymers

He, Ping; Greenway, Gillian; Haswell, Stephen J.


Ping He

Gillian Greenway

Stephen J. Haswell


A microfluidic reactor system for the synthesis of silica nanoparticles has been developed from commercially available ETFE tubing (0.17-1.0 mm diameter) connected in series to support the hydrolysis, nucleation and particle growth based on a sol-gel method in the presence of PEI polymer at room temperature. Two microfluidic reactor configurations, laminar flow and segmented flow, have been evaluated. Both microfluidic reactors produce particles with narrower size distributions and higher particle yields compared to batch based process. In addition, microfluidic methods offer the possibility to tune particle sizes and size distributions by varying the operation variables such as flow rate, reactor tube diameter and residence time. (C) 2010 Elsevier B.V. All rights reserved.


He, P., Greenway, G., & Haswell, S. J. (2011). Microfluidic synthesis of silica nanoparticles using polyethylenimine polymers. Chemical Engineering Journal, 167(2-3), 694-699.

Journal Article Type Article
Acceptance Date Aug 17, 2010
Online Publication Date Oct 23, 2010
Publication Date Mar 1, 2011
Print ISSN 1385-8947
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 167
Issue 2-3
Pages 694-699
Keywords Microfluidics; Silica nanoparticles; PEI polymer
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