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Imaging COX-2 expression in cancer using PET/SPECT radioligands: current status and future directions

Pacelli, A.; Greenman, J.; Cawthorne, C.; Smith, G.

Authors

A. Pacelli

C. Cawthorne

G. Smith



Abstract

The role of cyclooxygenase (COX)-2 as a driving force in early tumourigenesis and the current interest in the combination of COX-2 inhibitors with standard therapy in clinical trials creates an urgent need to establish clinically relevant diagnostic tests for COX-2 expression. Molecular imaging using small-molecule probes radiolabelled for both positron emission tomography (PET) and single photon emission computed tomography (SPECT) offers the potential to meet this need, providing a minimally invasive readout for the whole disease burden. This review summarises current approaches to the radiolabelling of small-molecule COX-2 inhibitors and their analogues for PET and SPECT imaging, and gives an overview of their biological evaluation and likely success of clinical application. © 2013 John Wiley & Sons, Ltd.

Journal Article Type Article
Publication Date 2014-04
Journal Journal of labelled compounds and radiopharmaceuticals
Print ISSN 0362-4803
Electronic ISSN 1099-1344
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 57
Issue 4
Pages 317-322
APA6 Citation Pacelli, A., Greenman, J., Cawthorne, C., & Smith, G. (2014). Imaging COX-2 expression in cancer using PET/SPECT radioligands: current status and future directions. Journal of Labelled Compounds and Radiopharmaceuticals, 57(4), 317-322. doi:10.1002/jlcr.3160
DOI https://doi.org/10.1002/jlcr.3160
Keywords Coxib; Indole; Imidazole; [11C]-methylation; PET; SPECT; COX-2; Prostaglandin; Cancer; Imaging biomarker
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/jlcr.3160/abstract
Additional Information This is the author's accepted manuscript of an article published in Journal of labelled compounds and radiopharmaceuticals, 2014, v.57 issue 4.

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