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Humidified Warmed CO2 Treatment Therapy Strategies Can Save Lives With Mitigation and Suppression of SARS-CoV-2 Infection: An Evidence Review

El-Betany, Alaa M.M.; Behiry, Enas M.; Gumbleton, Mark; Harding, Keith G.


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Dr Alaa Elbetany
Lecturer in Organic and Materials Chemistry

Enas M. Behiry

Mark Gumbleton

Keith G. Harding


The coronavirus disease (COVID-19) outbreak has presented enormous challenges for healthcare, societal, and economic systems worldwide. There is an urgent global need for a universal vaccine to cover all SARS-CoV-2 mutant strains to stop the current COVID-19 pandemic and the threat of an inevitable second wave of coronavirus. Carbon dioxide is safe and superior antimicrobial, which suggests it should be effective against coronaviruses and mutants thereof. Depending on the therapeutic regime, CO2 could also ameliorate other COVID-19 symptoms as it has also been reported to have antioxidant, anti-inflammation, anti-cytokine effects, and to stimulate the human immune system. Moreover, CO2 has beneficial effects on respiratory physiology, cardiovascular health, and human nervous systems. This article reviews the rationale of early treatment by inhaling safe doses of warmed humidified CO2 gas, either alone or as a carrier gas to deliver other inhaled drugs may help save lives by suppressing SARS-CoV-2 infections and excessive inflammatory responses. We suggest testing this somewhat counter-intuitive, but low tech and safe intervention for its suitability as a preventive measure and treatment against COVID-19. Overall, development and evaluation of this therapy now may provide a safe and economical tool for use not only during the current pandemic but also for any future outbreaks of respiratory diseases and related conditions.


El-Betany, A. M., Behiry, E. M., Gumbleton, M., & Harding, K. G. (2020). Humidified Warmed CO2 Treatment Therapy Strategies Can Save Lives With Mitigation and Suppression of SARS-CoV-2 Infection: An Evidence Review. Frontiers in Medicine, 7, Article 594295.

Journal Article Type Review
Acceptance Date Nov 25, 2020
Online Publication Date Dec 11, 2020
Publication Date Dec 11, 2020
Deposit Date Feb 25, 2023
Publicly Available Date Mar 2, 2023
Journal Frontiers in Medicine
Electronic ISSN 2296-858X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 7
Article Number 594295
Keywords Anti-COVID-19; Antiviral; Anti-cytokine storm; Improve COVID-19 symptoms; Carrier gas composition; Enhancer antiviral; Protect and improve organs function; Suppression COVID-19 pandemic
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Copyright Statement
Copyright © 2020 El-Betany, Behiry, Gumbleton and Harding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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