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A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes’ toxicity

Shestopalov, Michael A.; Krasilnikova, Anna A.; Solovieva, Anastasiya O.; Ivanov, Anton A.; Brylev, Konstantin A.; Pozmogova, Tatiana N.; Gulyaeva, Marina A.; Kurskaya, Olga G.; Alekseev, Alexander Y.; Shestopalov, Alexander M.; Shestopalova, Lidiya V.; Poveshchenko, Alexander F.; Efremova, Olga A.; Mironov, Yuri V.; Shestopalov, Michael A.

Authors

Michael A. Shestopalov

Anna A. Krasilnikova

Anastasiya O. Solovieva

Anton A. Ivanov

Konstantin A. Brylev

Tatiana N. Pozmogova

Marina A. Gulyaeva

Olga G. Kurskaya

Alexander Y. Alekseev

Alexander M. Shestopalov

Lidiya V. Shestopalova

Alexander F. Poveshchenko

Yuri V. Mironov

Michael A. Shestopalov

Abstract

Octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to difficulty to control the hydrolysis of initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].

Journal Article Type Article
Publication Date May 17, 2017
Journal Toxicology research
Print ISSN 2045-4538
Electronic ISSN 2045-4538
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 6
Issue 4
Pages 554-560
Institution Citation Krasilnikova, A. A., Solovieva, A. O., Ivanov, A. A., Brylev, K. A., Pozmogova, T. N., Gulyaeva, M. A., …Shestopalov, M. A. (2017). A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes’ toxicity. Toxicology Research, 6(4), 554-560. https://doi.org/10.1039/c7tx00083a
DOI https://doi.org/10.1039/c7tx00083a
Keywords Toxicology; Health, Toxicology and Mutagenesis
Publisher URL http://pubs.rsc.org/en/content/articlelanding/2017/tx/c7tx00083a#!divAbstract
Additional Information : This document is Similarity Check deposited; : Anna A. Krasilnikova (ORCID); : Anton A. Ivanov (ORCID); : Anton A. Ivanov (ResearcherID); : Marina A. Gulyaeva (ORCID); : Marina A. Gulyaeva (ResearcherID); : Alexander Y. Alekseev (ORCID); : Alexander Y. Alekseev (ResearcherID); : Olga A. Efremova (ORCID); : Yuri V. Mironov (ORCID); : Michael A. Shestopalov (ORCID); : Michael A. Shestopalov (ResearcherID); : The Royal Society of Chemistry has an exclusive publication licence for this journal; OPEN ACCESS: This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0); : Single-blind; : Received 24 March 2017; Accepted 16 May 2017; Accepted Manuscript published 17 May 2017; Advance Article published 1 June 2017; Version of Record published 3 July 2017

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This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.



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