A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes’ toxicity

Krasilnikova, Anna A.; Solovieva, Anastasiya O.; Ivanov, Anton A.; Brylev, Konstantin A.; Pozmogova, Tatiana N.; Gulyaeva, Marina A.; Kurskaya, Olga G.; Alekseev, Alexander Y.; Shestopalov, Alexander M.; Shestopalova, Lidiya V.; Poveshchenko, Alexander F.; Efremova, Olga A.; Mironov, Yuri V.; Shestopalov, Michael A.

Abstract

Octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to difficulty to control the hydrolysis of initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].

Citation

Krasilnikova, A. A., Solovieva, A. O., Ivanov, A. A., Brylev, K. A., Pozmogova, T. N., Gulyaeva, M. A., …Shestopalov, M. A. (2017). A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes’ toxicity. Toxicology Research, 6(4), 554-560. https://doi.org/10.1039/c7tx00083a

• Journal Article Type: Article
• Acceptance Date: May 16, 2017
• Online Publication Date: May 17, 2017
• Publication Date: May 17, 2017
• Deposit Date: May 23, 2017
• Publicly Available Date: May 23, 2017
• Journal: Toxicology research
• Print ISSN: 2045-4538
• Electronic ISSN: 2045-4538
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 4
• Pages: 554-560
• DOI: https://doi.org/10.1039/c7tx00083a
• Keywords: Toxicology; Health, Toxicology and Mutagenesis
• Public URL: https://hull-repository.worktribe.com/output/451532
• Publisher URL: http://pubs.rsc.org/en/content/articlelanding/2017/tx/c7tx00083a#!divAbstract
• Additional Information: : This document is Similarity Check deposited; : Anna A. Krasilnikova (ORCID); : Anton A. Ivanov (ORCID); : Anton A. Ivanov (ResearcherID); : Marina A. Gulyaeva (ORCID); : Marina A. Gulyaeva (ResearcherID); : Alexander Y. Alekseev (ORCID); : Alexander Y. Alekseev (ResearcherID); : Olga A. Efremova (ORCID); : Yuri V. Mironov (ORCID); : Michael A. Shestopalov (ORCID); : Michael A. Shestopalov (ResearcherID); : The Royal Society of Chemistry has an exclusive publication licence for this journal; OPEN ACCESS: This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0); : Single-blind; : Received 24 March 2017; Accepted 16 May 2017; Accepted Manuscript published 17 May 2017; Advance Article published 1 June 2017; Version of Record published 3 July 2017