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Polymer-protein conjugate particles with biocatalytic activity for stabilization of water-in-water emulsions

Xue, Long-Hui; Xie, Chun-Yan; Meng, Shi-Xin; Bai, Rui-Xue; Yang, Xin; Wang, Yaolei; Wang, Shu; Binks, Bernard P.; Guo, Ting; Meng, Tao


Long-Hui Xue

Chun-Yan Xie

Shi-Xin Meng

Rui-Xue Bai

Xin Yang

Yaolei Wang

Shu Wang

Ting Guo

Tao Meng


Water-in-water (w/w) emulsions are attractive micro-compartmentalized platforms due to their outstanding biocom-patibility. To address the main disadvantage of poor stability that hampers their practical application, here we report a novel type of polymer-protein conjugate emulsifier obtained by Schiff base synthesis to stabilize w/w emulsions. In par-ticular, the proposed mild approach benefits the modification of proteins of suitable size and wettability as particulate emulsifiers retaining their bioactivity. As demonstrated in a model system, the methoxy polyethylene glycol (mPEG)-urease conjugate particles anchor at the w/w interfaces, where they serve as an effective emulsifier-combined-catalyst and catalyze the hydrolysis of urea in water to ammonium carbonate. Our study is unique in that it employs bioactive particles to stabilize w/w emulsions. Considering the characteristics of all-aqueous, compartmental and interfacial bio-catalysis of the system, it will open up new possibilities in the life sciences.


Xue, L., Xie, C., Meng, S., Bai, R., Yang, X., Wang, Y., …Meng, T. (2017). Polymer-protein conjugate particles with biocatalytic activity for stabilization of water-in-water emulsions. ACS Macro Letters, 6(7), 679-683.

Acceptance Date Jun 12, 2017
Online Publication Date Jun 14, 2017
Publication Date Jul 18, 2017
Deposit Date Jun 14, 2017
Publicly Available Date Jun 15, 2018
Journal ACS macro letters
Electronic ISSN 2161-1653
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 6
Issue 7
Pages 679-683
Keywords mPEG-protein conjugate particles, Emulsifiers, Water-in-water emulsions, Biocatalytic activity, Compartmentalization
Public URL
Publisher URL
Additional Information This is a description of an article which has been published in: ACS macro letters, 2017, v.6, issue 7


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