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Fabrication of hierarchical macroporous biocompatible scaffolds by combining Pickering high internal phase emulsion templates with three-dimensional printing

Yang, Ting; Hu, Yang; Wang, Chaoyang; Binks, Bernard P.

Authors

Ting Yang

Yang Hu

Chaoyang Wang



Abstract

Biocompatible and biodegradable porous scaffolds with adjustable pore structure have aroused increasing interest in bone tissue engineering. Here, we report a facile method to fabricate hierarchical macroporous biocompatible (HmPB) scaffolds by combining Pickering high internal phase emulsion (HIPE) templates with three-dimensional (3D) printing. HmPB scaffolds composed of a polymer matrix of poly(L-lactic acid), PLLA, and poly(ε-caprolactone), PCL, are readily fabricated by solvent evaporation of 3D printed Pickering HIPEs which are stabilized by hydrophobically modified silica nanoparticles (h-SiO2). The pore structure of HmPB scaffolds is easily tailored to be similar to natural extracellular matrix (ECM) by varying the fabrication conditions of the Pickering emulsion or adjusting the printing parameters. In addition, in vivo drug release studies which employ enrofloxacin (ENR) as a model drug indicate the potential of HmPB scaffolds as a drug carrier. Furthermore, in vivo cell culture assays prove that HmPB scaffolds possesses good biocompatibility as mouse bone mesenchymal stem cells (mBMSCs) can adhere and proliferate well on them. All the results suggest that HmPB scaffolds hold great potential in bone tissue engineering applications.

Journal Article Type Article
Publication Date Jul 12, 2017
Journal ACS applied materials and interfaces
Print ISSN 1944-8244
Electronic ISSN 1944-8252
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 9
Issue 27
Pages 22950-22958
APA6 Citation Yang, T., Hu, Y., Wang, C., & Binks, B. P. (2017). Fabrication of hierarchical macroporous biocompatible scaffolds by combining Pickering high internal phase emulsion templates with three-dimensional printing. ACS applied materials & interfaces, 9(27), 22950-22958. https://doi.org/10.1021/acsami.7b05012
DOI https://doi.org/10.1021/acsami.7b05012
Keywords Pickering high internal phase emulsions; Three-dimensional printing; Porous scaffold; Poly(L-lactic acid); Poly(ε-caprolactone)
Publisher URL http://pubs.acs.org/doi/abs/10.1021/acsami.7b05012
Copyright Statement ©2018 University of Hull
Additional Information This is a description of an article published in: ACS applied materials and interfaces, 2017.

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