Fabrication of hierarchical macroporous biocompatible scaffolds by combining Pickering high internal phase emulsion templates with three-dimensional printing

Yang, Ting; Hu, Yang; Wang, Chaoyang; Binks, Bernard P.

Abstract

Biocompatible and biodegradable porous scaffolds with adjustable pore structure have aroused increasing interest in bone tissue engineering. Here, we report a facile method to fabricate hierarchical macroporous biocompatible (HmPB) scaffolds by combining Pickering high internal phase emulsion (HIPE) templates with three-dimensional (3D) printing. HmPB scaffolds composed of a polymer matrix of poly(L-lactic acid), PLLA, and poly(ε-caprolactone), PCL, are readily fabricated by solvent evaporation of 3D printed Pickering HIPEs which are stabilized by hydrophobically modified silica nanoparticles (h-SiO2). The pore structure of HmPB scaffolds is easily tailored to be similar to natural extracellular matrix (ECM) by varying the fabrication conditions of the Pickering emulsion or adjusting the printing parameters. In addition, in vivo drug release studies which employ enrofloxacin (ENR) as a model drug indicate the potential of HmPB scaffolds as a drug carrier. Furthermore, in vivo cell culture assays prove that HmPB scaffolds possesses good biocompatibility as mouse bone mesenchymal stem cells (mBMSCs) can adhere and proliferate well on them. All the results suggest that HmPB scaffolds hold great potential in bone tissue engineering applications.

Citation

Yang, T., Hu, Y., Wang, C., & Binks, B. P. (2017). Fabrication of hierarchical macroporous biocompatible scaffolds by combining Pickering high internal phase emulsion templates with three-dimensional printing. ACS Applied Materials & Interfaces, 9(27), 22950-22958. https://doi.org/10.1021/acsami.7b05012

• Journal Article Type: Article
• Acceptance Date: Jun 21, 2017
• Online Publication Date: Jun 21, 2017
• Publication Date: Jul 12, 2017
• Deposit Date: Jul 4, 2017
• Publicly Available Date: Jun 25, 2018
• Journal: ACS applied materials and interfaces
• Print ISSN: 1944-8244
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 27
• Pages: 22950-22958
• DOI: https://doi.org/10.1021/acsami.7b05012
• Keywords: Pickering high internal phase emulsions; Three-dimensional printing; Porous scaffold; Poly(L-lactic acid); Poly(ε-caprolactone)
• Public URL: https://hull-repository.worktribe.com/output/453192
• Publisher URL: http://pubs.acs.org/doi/abs/10.1021/acsami.7b05012
• Additional Information: This is a description of an article published in: ACS applied materials and interfaces, 2017.
• Contract Date: Jul 4, 2017