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Electrostatically gated membrane permeability in inorganic protocells

Li, Mei; Harbron, Rachel L.; Weaver, Jonathan V.M.; Binks, Bernard P.; Mann, Stephen; Weaver, Jonathan V. M.


Mei Li

Rachel L. Harbron

Jonathan V.M. Weaver

Stephen Mann

Jonathan V. M. Weaver


Although several strategies are now available to produce functional microcompartments analogous to primitive cell-like structures, little progress has been made in generating protocell constructs with self-controlled membrane permeability. Here we describe the preparation of water-dispersible colloidosomes based on silica nanoparticles and delineated by a continuous semipermeable inorganic membrane capable of self-activated, electrostatically gated permeability. We use crosslinking and covalent grafting of a pH-responsive copolymer to generate an ultrathin elastic membrane that exhibits selective release and uptake of small molecules. This behaviour, which depends on the charge of the copolymer coronal layer, serves to trigger enzymatic dephosphorylation reactions specifically within the protocell aqueous interior. This system represents a step towards the design and construction of alternative types of artificial chemical cells and protocell models based on spontaneous processes of inorganic self-organization.

Journal Article Type Article
Publication Date Jun 1, 2013
Journal Nature chemistry
Print ISSN 1755-4330
Electronic ISSN 1755-4349
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 5
Issue 6
Pages 529-536
APA6 Citation Li, M., Harbron, R. L., Weaver, J. V., Binks, B. P., & Mann, S. (2013). Electrostatically gated membrane permeability in inorganic protocells. Nature Chemistry, 5(6), (529-536). doi:10.1038/nchem.1644. ISSN 1755-4330
Keywords General Chemistry; General Chemical Engineering
Publisher URL
Copyright Statement ©2016 University of Hull
Additional Information Authors' accepted manuscript of article published in: Nature chemistry, 2013, v.5, issue 6


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