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All Outputs (30)

Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure (2022)
Journal Article
Kazmi, S., Kambhampati, C., Cleland, J., Cuthbert, J., Kazmi, K. S., Pellicori, P., …Clark, A. L. (2022). Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure. ESC Heart Failure, https://doi.org/10.1002/ehf2.14028

Aims: Risk changes with the progression of disease and the impact of treatment. We developed a dynamic risk stratification Markov chain model using artificial intelligence in patients with chronic heart failure (CHF). Methods and results: We describe... Read More about Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure.

High-fidelity simulation and virtual reality: An evaluation of medical students' experiences (2021)
Journal Article
Macnamara, A. F., Bird, K., Rigby, A., Sathyapalan, T., & Hepburn, D. (2021). High-fidelity simulation and virtual reality: An evaluation of medical students' experiences. BMJ Simulation & Technology Enhanced Learning, 7(6), 528-535. https://doi.org/10.1136/bmjstel-2020-000625

Background: Simulation technology is widely used in medical education, providing an environment in which students can develop and practise a multitude of skills that are relevant to clinical practice, without the risk of harm to patients. Methods: We... Read More about High-fidelity simulation and virtual reality: An evaluation of medical students' experiences.

An audit of COPD: Diagnosis and management in general practice (2020)
Journal Article
Hamad, G., Rigby, A., & Morice, A. H. (2020). An audit of COPD: Diagnosis and management in general practice. ERJ Open Research, 6(4), Article 00330-2020. https://doi.org/10.1183/23120541.00330-2020

Introduction: COPD is a spectrum of disorders primarily caused by smoking and characterised by progressive, not fully reversible airflow obstruction with a forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio <0.7. Methods: From N...

The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome (2020)
Journal Article
Javed, Z., Papageorgiou, M., Madden, L. A., Rigby, A. S., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2020). The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome. Endocrine Connections, 9(6), 563-569. https://doi.org/10.1530/EC-20-0173

Context: Endothelial microparticles (EMPs) are novel, surrogate biomarkers of endothelial function and have been shown to be elevated in women with polycystic ovary syndrome (PCOS). It remains poorly understood how pharmacological options for managin... Read More about The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome.

Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale (2019)
Journal Article
Jones, H., Papageorgiou, M., Gordon, A., Ehtesham, Javed, Z., Wells, L. K., Greetham, S., Doyle, B., Hayes, N., Rigby, A., Atkin, S. L., Courts, F. L., & Sathyapalan, T. (2020). Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale. Biochemical Pharmacology, 173, Article 113754. https://doi.org/10.1016/j.bcp.2019.113754

© 2019 Elsevier Inc. This study describes the screening of 13 commercially-available plant extracts for pharmacological activity modulating vascular function using an endothelial cell model. A French maritime pine bark extract (FMPBE) was found to ha... Read More about Physiologically relevant screening of polyphenol-rich commercial preparations for bioactivity in vascular endothelial cells and application to healthy volunteers: a viable workflow and a cautionary tale.

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Rigby, A. S., Qamar, U., Abbas, J., Khan, A. Y., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study. Clinical Endocrinology, 90(6), 805-813. https://doi.org/10.1111/cen.13968

Background: Empagliflozin is a sodium-glucose-cotransporter-2 inhibitor that improves cardiovascular risk and promotes weight loss in patients with type 2 diabetes. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascu... Read More about Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study.

A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Kilpatrick, E., Mann, V., Corless, L., Abouda, G., Rigby, A. S., Atkin, S., & Sathyapalan, T. (2019). A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome. Nutrients, 11(1), 188. https://doi.org/10.3390/nu11010188

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Polycystic ovary syndrome (PCOS) increases the risk of metabolic syndrome and non-alcoholic-fatty-liver disease (NAFLD). Vitamin D supplementation may exert positive effects on liver biochemis... Read More about A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome.

Symptoms and exacerbations in asthma: an apparent paradox? (2019)
Journal Article
Morjaria, J. B., Rigby, A. S., & Morice, A. H. (2019). Symptoms and exacerbations in asthma: an apparent paradox?. Therapeutic Advances in Chronic Disease, 10, https://doi.org/10.1177/2040622319884387

© The Author(s), 2019. Background: There is a dearth of data on prospectively recorded symptoms in patients with uncontrolled asthma. Asthma symptoms and exacerbation rate are commonly thought to be associated. The aim of this study was to analyse as... Read More about Symptoms and exacerbations in asthma: an apparent paradox?.

The effect of high dose isoflavone supplementation on serum reverse T3 in euthyroid men with Type 2 Diabetes and post-menopausal women (2018)
Journal Article
Sathyapalan, T., Köhrle, J., Rijntjes, E., Rigby, A. S., Dargham, S. R., Kilpatrick, E. S., & Atkin, S. L. (2018). The effect of high dose isoflavone supplementation on serum reverse T3 in euthyroid men with Type 2 Diabetes and post-menopausal women. Frontiers in endocrinology, 9, Article 698. https://doi.org/10.3389/fendo.2018.00698

Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.

Materials and Methods: We examined the effect of soy isoflavones on rever... Read More about The effect of high dose isoflavone supplementation on serum reverse T3 in euthyroid men with Type 2 Diabetes and post-menopausal women.

Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Deshmukh, H., Madden, L. A., Rigby, A., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes. Diabetes, Obesity and Metabolism, 21(3), 533-540. https://doi.org/10.1111/dom.13548

Aims
Endothelial microparticles (EMPs) are novel surrogate markers of endothelial injury and dysfunction that may be differentially produced in response to acute insulin‐induced hypoglycaemia in adults with and without type 2 diabetes.

Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Javed, Z., Heise, T., Rigby, A. S., Garrett, A. T., Hepburn, D., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus. Diabetes, Obesity and Metabolism, 21(3), 569-574. https://doi.org/10.1111/dom.13555

Objective
This study aimed to explore the effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes.

Research Design
A 3‐way, cross‐over, randomised study was performed in adults with type 1 diab... Read More about Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus.

The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study (2018)
Journal Article
Sathyapalan, T., Dawson, A. J., Rigby, A. S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2018). The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study. Frontiers in endocrinology, 9(SEP), Article 531. https://doi.org/10.3389/fendo.2018.00531

Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on... Read More about The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study.

Platelet function following induced hypoglycaemia in type 2 diabetes (2018)
Journal Article
Kahal, H., Aburima, A., Spurgeon, B., Wraith, K. S., Rigby, A. S., Sathyapalan, T., Kilpatrick, E. S., Naseem, K. M., & Atkin, S. L. (2018). Platelet function following induced hypoglycaemia in type 2 diabetes. Diabetes & metabolism, 44(5), 431-436. https://doi.org/10.1016/j.diabet.2018.04.004

Aim
Strict glycaemic control has been associated with an increased mortality rate in subjects with type 2 diabetes (T2DM). Here we examined platelet function immediately and 24 hours following induced hypoglycaemia in people with type 2 diabetes comp... Read More about Platelet function following induced hypoglycaemia in type 2 diabetes.

Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause (2018)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Thatcher, N. J., Dargham, S. R., Kilpatrick, E. S., & Atkin, S. L. (2018). Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause. Nutrition, metabolism, and cardiovascular diseases : NMCD, 28(7), 691-697. https://doi.org/10.1016/j.numecd.2018.03.007

© 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University Background: Hormone replacement thera... Read More about Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause.

Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1 (2018)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Thatcher, N. J., Dargham, S. R., Kilpatrick, E. S., & Atkin, S. L. (2018). Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1. Nutrition, metabolism, and cardiovascular diseases : NMCD, 28(7), 691-697. https://doi.org/10.1016/j.numecd.2018.03.007

Background
Hormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones... Read More about Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1.

Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma? (2017)
Journal Article
Morjaria, J. B., Rigby, A. S., & Morice, A. H. (2017). Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma?. European respiratory journal, 50(6), Article 1701366. https://doi.org/10.1183/13993003.01366-2017

Copyright © ERS 2017. Little is known of the long-term symptom profile in uncontrolled asthma and whether symptoms can predict distinct phenotypes. The primary objective of these analyses was to assess diurnal profile of cough and wheeze in an uncont... Read More about Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma?.

Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study (2017)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study. Scientific reports, 7(1), Article ARTN 15366. https://doi.org/10.1038/s41598-017-15402-9

© 2017 The Author(s). Type 2 diabetes (T2DM) is associated with increased risk of fractures. Soy supplementation has been shown to have a beneficial effect on bone turnover markers (BTM) in postmenopausal women. However, the effect of soy supplementa... Read More about Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study.

Deoxynivalenol biomarkers in the urine of UK vegetarians (2017)
Journal Article
Wells, L., Hardie, L., Williams, C., White, K., Liu, Y., De Santis, B., Debegnach, F., Moretti, G., Greetham, S., Brera, C., Papageorgiou, M., Thatcher, N. J., Rigby, A., Atkin, S. L., & Sathyapalan, T. (2017). Deoxynivalenol biomarkers in the urine of UK vegetarians. Toxins, 9(7), 196. https://doi.org/10.3390/toxins9070196

Deoxynivalenol (DON) is produced by Fusarium graminearum and is one of the most commonly occurring trichothecenes. Vegetarians are alleged to be a high-risk group for DON exposure due to high intakes of cereals susceptible to the growth of the mycoto... Read More about Deoxynivalenol biomarkers in the urine of UK vegetarians.

Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study (2017)
Journal Article
Sathyapalan, T., Javed, Z., Rigby, A. S., Kilpatrick, E. S., & Atkin, S. L. (2017). Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study. Journal of the Endocrine Society, 1(5), 423-430. https://doi.org/10.1210/js.2016-1068

© 2017 Endocrine Society. Background: Soy protein with isoflavones appears to have an adverse effect on thyroid function, but it is not known whether it is the protein or isoflavone component that is deleterious. The effect of isoflavone-free soy on... Read More about Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study.