All Outputs (40)

Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers? (2009)
Journal Article
Frankenstein, L., Goode, K., Ingle, L., Remppis, A., Schellberg, D., Nelles, M., Katus, H. A., Clark, A. L., Cleland, J. G. F., & Zugck, C. (2011). Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers?. International journal of cardiology, 147(1), 74-78. https://doi.org/10.1016/j.ijcard.2009.08.005

BACKGROUND It is unclear whether risk prediction strategies in chronic heart failure (CHF) need to be specific for sex or beta-blockers. We examined this problem and developed and validated the consequent risk models based on 6-minute-walk-test and N... Read More about Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers?.

Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure (2009)
Journal Article
Ingle, L., Isted, A., Witte, K. K., Cleland, J. G., & Clark, A. L. (2009). Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure. European journal of cardiovascular prevention and rehabilitation, 16(4), 451-456. https://doi.org/10.1097/HJR.0b013e32832a4f54

INTRODUCTION: Exertional oscillatory ventilation (EOV) occurs in many patients with chronic heart failure. Two different definitions of EOV have been proposed by Corrá and Leite. We aimed to compare the prevalence of EOV and its prognostic significan... Read More about Impact of different diagnostic criteria on the prevalence and prognostic significance of exertional oscillatory ventilation in patients with chronic heart failure.

Prognostic Significance of the Double Pressure Reserve in Patients with Chronic Heart Failure (2009)
Journal Article
Ingle, L., & Clark, A. (2009). Prognostic Significance of the Double Pressure Reserve in Patients with Chronic Heart Failure. Open Heart Failure Journal, 2, 1-5. https://doi.org/10.2174/1876535100902010001

Abstract: Introduction: The double pressure reserve (DPR) has recently been shown to have greater prognostic power
than metabolic equivalents, heart rate indices, and systolic blood pressure in healthy subjects. It is unclear whether DPR
offers any... Read More about Prognostic Significance of the Double Pressure Reserve in Patients with Chronic Heart Failure.

The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age (2009)
Journal Article
Frankenstein, L., Clark, A. L., Goode, K., Ingle, L., Remppis, A., Schellberg, D., Grabs, F., Nelles, M., Cleland, J. G. F., Katus, H. A., & Zugck, C. (2009). The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age. Heart, 95(10), 825-829. https://doi.org/10.1136/hrt.2008.158626

Background: It is unclear whether age-related increases in N-terminal pro-brain natriuretic peptide (NT-proBNP) represent a normal physiological process - possibly affecting the prognostic power - of NT-proBNP - or reflect age-related subclinical pat... Read More about The prognostic value of individual NT-proBNP values in chronic heart failure does not change with advancing age.

A comparison of patient and physician-rated New York Heart Association class in a community-based heart failure clinic (2008)
Journal Article
Goode, K. M., Nabb, S., Cleland, J. G., & Clark, A. L. (2008). A comparison of patient and physician-rated New York Heart Association class in a community-based heart failure clinic. Journal of cardiac failure, 14(5), 379-387. https://doi.org/10.1016/j.cardfail.2008.01.014

OBJECTIVE: The New York Heart Association (NYHA) classification is recommended for grading symptoms of chronic heart failure and is a powerful prognostic marker. Patient-rated NYHA (Pa-NYHA) and physician-rated NYHA (Dr-NYHA) class have never been co... Read More about A comparison of patient and physician-rated New York Heart Association class in a community-based heart failure clinic.

Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure" (2008)
Journal Article
Ingle, L., Cleland, J. G., & Clark, A. L. (2008). Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure". Heart, 94(6), 748-753. https://doi.org/10.1136/hrt.2007.131144

Background: Epidemiological studies suggest that "diastolic heart failure" (DHF) is common and has a prognosis similar to that of systolic heart failure (SHF). We wanted to assess whether patients with breathlessness who were being treated for DHF ha... Read More about Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure".

Combining the ventilatory response to exercise and peak oxygen consumption is no better than peak oxygen consumption alone in predicting mortality in chronic heart failure (2008)
Journal Article
Ingle, L., Witte, K. K., Cleland, J. G. F., & Clark, A. L. (2008). Combining the ventilatory response to exercise and peak oxygen consumption is no better than peak oxygen consumption alone in predicting mortality in chronic heart failure. European journal of heart failure, 10(1), 85-88. https://doi.org/10.1016/j.ejheart.2007.10.010

Background: A low peak oxygen uptake (pV(O2)) and steep V-E/V-CO2 slope are independently associated with a worse prognosis in patients with chronic heart failure (CHF). We wished to confirm whether combining these variables as a ratio would lead to... Read More about Combining the ventilatory response to exercise and peak oxygen consumption is no better than peak oxygen consumption alone in predicting mortality in chronic heart failure.

Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure'' (2007)
Journal Article
Ingle, L., Cleland, J. G. F., & Clark, A. L. (2008). Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure''. Heart, 94(6), 748-753. https://doi.org/10.1136/hrt.2007.131144

Background: Epidemiological studies suggest that "diastolic heart failure'' (DHF) is common and has a prognosis similar to that of systolic heart failure (SHF). We wanted to assess whether patients with breathlessness who were being treated for DHF h... Read More about Perception of symptoms is out of proportion to cardiac pathology in patients with "diastolic heart failure''.

The prognostic value of cardiopulmonary exercise testing with a peak respiratory exchange ratio of < 1.0 in patients with chronic heart failure (2007)
Journal Article
Ingle, L., Witte, K. K., Cleland, J. G., & Clark, A. L. (2008). The prognostic value of cardiopulmonary exercise testing with a peak respiratory exchange ratio of < 1.0 in patients with chronic heart failure. International journal of cardiology, 127(1), 88-92. https://doi.org/10.1016/j.ijcard.2007.04.075

Background: Peak oxygen consumption derived from a maximal cardiopulmonary exercise test (CPET) is a standard prognostic indicator in patients with chronic heart failure (CHF). Tests with a peak respiratory exchange ratio (pRER) < 1.0 are often tak... Read More about The prognostic value of cardiopulmonary exercise testing with a peak respiratory exchange ratio of < 1.0 in patients with chronic heart failure.

Changes in body composition in patients with left ventricular systolic dysfunction initiated on beta-blocker therapy (2007)
Journal Article
Ingle, L., Rigby, A. S., Carroll, S., Butterly, R., King, R. F., Cooke, C. B., Cleland, J. G., & Clark, A. L. (2007). Changes in body composition in patients with left ventricular systolic dysfunction initiated on beta-blocker therapy. Experimental and Clinical Cardiology, 12(1), 46-47

Background: Increasing body mass index, cholesterol and body fat are associated with a better prognosis in patients with left ventricular systolic dysfunction (LVSD). Beta-blocker usage is associated with changes in body composition and increased bod... Read More about Changes in body composition in patients with left ventricular systolic dysfunction initiated on beta-blocker therapy.

Cardiorespiratory requirements of the 6-min walk test in older patients with left ventricular systolic dysfunction and no major structural heart disease (2007)
Journal Article
Ingle, L., Wilkinson, M., Carroll, S., Boyes, C., Butterly, R., King, R., Cooke, C., Cleland, J., & Clark, A. (2007). Cardiorespiratory requirements of the 6-min walk test in older patients with left ventricular systolic dysfunction and no major structural heart disease. International journal of sports medicine, 28(8), 678-684. https://doi.org/10.1055/s-2007-964886

The six-minute walk test (6-MWT) is widely used to assess functional status in patients with chronic heart failure (CHF). The aims of the present study were: (1) to compare metabolic gas exchange during the 6-MWT in older patients with left ventricul... Read More about Cardiorespiratory requirements of the 6-min walk test in older patients with left ventricular systolic dysfunction and no major structural heart disease.

Prognostic value of the 6 min walk test and self-perceived symptom severity in older patients with chronic heart failure (2007)
Journal Article
Ingle, L., Rigby, A. S., Carroll, S., Butterly, R., King, R. F., Cooke, C. B., Cleland, J. G., & Clark, A. L. (2007). Prognostic value of the 6 min walk test and self-perceived symptom severity in older patients with chronic heart failure. European Heart Journal, 28(5), 560-568. https://doi.org/10.1093/eurheartj/ehl527

Background: The 6 min walk test (6-MWT) is a simple and popular test for evaluating functional status in patients with chronic heart failure (CHF). However, the prognostic value of the 6-MWT in a large, representative sample of CHF patients, and in p... Read More about Prognostic value of the 6 min walk test and self-perceived symptom severity in older patients with chronic heart failure.

Prognostic value of the VE/VCO2 slope calculated from different time intervals in patients with suspected heart failure (2006)
Journal Article
Ingle, L., Goode, K., Carroll, S., Sloan, R., Boyes, C., Cleland, J. G., & Clark, A. L. (2007). Prognostic value of the VE/VCO2 slope calculated from different time intervals in patients with suspected heart failure. International journal of cardiology, 118(3), 350-355. https://doi.org/10.1016/j.ijcard.2006.07.105

Background: Maximal exercises testing, whether involving cycling- or walking-based protocols, are often not well tolerated in patients with chronic heart failure (CHF). The peak oxygen consumption and the slope of the relation between ventilation (V... Read More about Prognostic value of the VE/VCO2 slope calculated from different time intervals in patients with suspected heart failure.

Clinical determinants of poor six-minute walk test performance in patients with left ventricular systolic dysfunction and no major structural heart disease (2006)
Journal Article
Ingle, L., Rigby, A. S., Nabb, S., Jones, P. K., Clark, A. L., & Cleland, J. G. (2006). Clinical determinants of poor six-minute walk test performance in patients with left ventricular systolic dysfunction and no major structural heart disease. European journal of heart failure, 8(3), 321-325. https://doi.org/10.1016/j.ejheart.2005.08.006

Background: The clinical determinants of six-minute walk test (6-MWT) performance in patients with left ventricular systolic dysfunction (LVSD) have rarely been investigated, and it is not clear whether they differ from patients referred for the asse... Read More about Clinical determinants of poor six-minute walk test performance in patients with left ventricular systolic dysfunction and no major structural heart disease.

Diabetes lowers six-minute walk test performance in heart failure (2006)
Journal Article
Ingle, L., Reddy, P., Clark, A. L., & Cleland, J. G. F. (2006). Diabetes lowers six-minute walk test performance in heart failure. Journal of the American College of Cardiology, 47(9), 1909-1910. https://doi.org/10.1016/j.jacc.2006.02.005

Poor relationship between exercise capacity and spirometric measurements in patients with more symptomatic heart failure (2005)
Journal Article
Ingle, L., Shelton, R. J., Cleland, J. G., & Clark, A. L. (2005). Poor relationship between exercise capacity and spirometric measurements in patients with more symptomatic heart failure. Journal of cardiac failure, 11(8), 619-623. https://doi.org/10.1016/j.cardfail.2005.06.430

Background: The origin of exercise limitation in patients with chronic heart failure (CHF) is multifactorial, and the relative contributions of different abnormalities may vary with severity of heart failure symptoms. The aim of the current study was... Read More about Poor relationship between exercise capacity and spirometric measurements in patients with more symptomatic heart failure.

The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure (2005)
Journal Article
Ingle, L., Shelton, R. J., Rigby, A. S., Nabb, S., Clark, A. L., & Cleland, J. G. (2005). The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure. European Heart Journal, 26(17), 1742-1751. https://doi.org/10.1093/eurheartj/ehi259

Aims: The 6-min walk test (6-MWT) is used to estimate functional capacity. However, in elderly patients with chronic heart failure (CHF): (i) 1 year reproducibility of the 6-MWT; (ii) sensitivity of the 6-MWT to self-perceived changes in symptoms of... Read More about The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure.

Longitudinal myocardial dysfunction in healthy older subjects as a manifestation of cardiac ageing (2005)
Journal Article
Nikitin, N. P., Witte, K. K., Ingle, L., Clark, A. L., Farnsworth, T. A., & Cleland, J. G. (2005). Longitudinal myocardial dysfunction in healthy older subjects as a manifestation of cardiac ageing. Age and ageing, 34(4), 343-349. https://doi.org/10.1093/ageing/afi043

Background: Abnormalities of longitudinal left ventricular (LV) contraction and relaxation may be early markers of cardiac disease. This study was designed to assess the relationship between long-axis LV function and age in healthy subjects. Methods:... Read More about Longitudinal myocardial dysfunction in healthy older subjects as a manifestation of cardiac ageing.

Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD (2004)
Journal Article
Lalukota, K., Cleland, J. G., Ingle, L., Clark, A. L., & Coletta, A. P. (2004). Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD. European journal of heart failure, 6(7), 953-955. https://doi.org/10.1016/j.ejheart.2004.10.003

This article summarises key presentations relevant to the pathophysiology, prevention or treatment of heart failure, from the Heart Failure Society of America annual meeting held in Toronto, Canada. Data from the EnoxiMone in intravenous inOTropE-dep... Read More about Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD.

Clinical trials update from the European Society of Cardiology Heart Failure meeting and the American College of Cardiology: Darbepoetin alfa study, ECHOS, and ASCOT-BPLA
Presentation / Conference Contribution
Cleland, J. G., Coletta, A. P., Clark, A. L., Velavan, P., & Ingle, L. Clinical trials update from the European Society of Cardiology Heart Failure meeting and the American College of Cardiology: Darbepoetin alfa study, ECHOS, and ASCOT-BPLA

This article provides information and a commentary on landmark trials presented at the European Society of Cardiology Heart Failure meeting held in June 2005, relevant to the pathophysiology, prevention and treatment of heart failure. All reports sho... Read More about Clinical trials update from the European Society of Cardiology Heart Failure meeting and the American College of Cardiology: Darbepoetin alfa study, ECHOS, and ASCOT-BPLA.