All Outputs (13)

The Host-Microbiota Axis in Chronic Wound Healing (2023)
Thesis
Stafford, A. R. The Host-Microbiota Axis in Chronic Wound Healing. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4424929

Chronic, non-healing skin wounds represent a substantial area of unmet clinical need, leading to debilitating morbidity and mortality in affected individuals. Due to their high prevalence and recurrence, chronic wounds pose a significant economic bur... Read More about The Host-Microbiota Axis in Chronic Wound Healing.

Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform (2022)
Journal Article
Arsic, B., Barber, J., Cikos, A., Kadirvel, M., Kostic, E., McBain, A., Milicevic, J., Oates, A., & Regan, A. (2022). Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform. Molecules, 27(21), Article 7280. https://doi.org/10.3390/molecules27217280

Although many antibiotics are active against Gram-positive bacteria, fewer also show activity against Gram-negative bacteria. Here, we present a combination of in silico (electron ion-interaction potential, molecular docking, ADMET), NMR, and microbi... Read More about Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform.

Survey of registered nurses’ selection of compression systems for the treatment of venous leg ulcers in the UK (2019)
Journal Article
Oates, A., & Adderley, U. (2019). Survey of registered nurses’ selection of compression systems for the treatment of venous leg ulcers in the UK. Journal of tissue viability, 28(2), 115-119. https://doi.org/10.1016/j.jtv.2019.02.004

Background: Venous leg ulceration is common in older adults in the United Kingdom. The gold-standard treatment is compression therapy. There are several compression bandage and hosiery systems that can be prescribed or purchased, but it was unclear w... Read More about Survey of registered nurses’ selection of compression systems for the treatment of venous leg ulcers in the UK.

Modelling antisepsis using defined populations of facultative and anaerobic wound pathogens grown in a basally perfused biofilm model (2018)
Journal Article
Oates, A., Lindsay, S., Mistry, H., Ortega, F., & McBain, A. J. (2018). Modelling antisepsis using defined populations of facultative and anaerobic wound pathogens grown in a basally perfused biofilm model. Biofouling, 34(5), 507-518. https://doi.org/10.1080/08927014.2018.1466115

An in vitro model was developed to assess the effects of topical antimicrobials on taxonomically defined wound biofilms. Biofilms were exposed over seven days to povidone-iodine, silver acetate or polyhexamethylene biguanide (PHMB) at concentrations... Read More about Modelling antisepsis using defined populations of facultative and anaerobic wound pathogens grown in a basally perfused biofilm model.

Hyaluronan-Based Nanohydrogels for Targeting Intracellular S. Aureus in Human Keratinocytes (2018)
Journal Article
Montanari, E., Oates, A., Di Meo, C., Meade, J., Cerrone, R., Francioso, A., Devine, D., Coviello, T., Mancini, P., Mosca, L., & Matricardi, P. (2018). Hyaluronan-Based Nanohydrogels for Targeting Intracellular S. Aureus in Human Keratinocytes. Advanced Healthcare Materials, 7(12), Article 1701483. https://doi.org/10.1002/adhm.201701483

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Staphylococcus aureus is one of the most significant human pathogens that is frequently isolated in a wide range of superficial and systemic infections. The ability of S. aureus to invade and surviv... Read More about Hyaluronan-Based Nanohydrogels for Targeting Intracellular S. Aureus in Human Keratinocytes.

Pursuing intracellular pathogens with hyaluronan. From a 'pro-infection' polymer to a biomaterial for 'trojan horse' systems (2018)
Journal Article
Montanari, E., Di Meo, C., Oates, A., Coviello, T., & Matricardi, P. (2018). Pursuing intracellular pathogens with hyaluronan. From a 'pro-infection' polymer to a biomaterial for 'trojan horse' systems. Molecules, 23(4), 939. https://doi.org/10.3390/molecules23040939

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Hyaluronan (HA) is among the most important bioactive polymers in mammals, playing a key role in a number of biological functions. In the last decades, it has been increasingly studied as a bi... Read More about Pursuing intracellular pathogens with hyaluronan. From a 'pro-infection' polymer to a biomaterial for 'trojan horse' systems.

The detrimental impact of extracellular bacterial proteases on wound healing (2017)
Journal Article
Lindsay, S., Oates, A., & Bourdillon, K. (2017). The detrimental impact of extracellular bacterial proteases on wound healing. International wound journal, 14(6), 1237-1247. https://doi.org/10.1111/iwj.12790

In addition to clinical signs of infection (e.g. inflammation, purulence and pain), a microbial count of ≥105 colony‐forming units/g has historically been used to define wound infection. However, it is increasingly recognised that, rather than a high... Read More about The detrimental impact of extracellular bacterial proteases on wound healing.

Skin Microbiology☆ (2016)
Book
McBain, A., O’Neill, C., & Oates, A. (2016). Skin Microbiology☆. Elsevier. https://doi.org/10.1016/b978-0-12-801238-3.99217-1

In recent years the application of high throughput DNA sequencing for analyzing the composition of the skin microbiota has identified a highly diverse group of microorganisms. Although the factors determining the composition of the skin microbiota ar... Read More about Skin Microbiology☆.

Growth of MRSA and Pseudomonas aeruginosa in a fine-celled foam model containing sessile commensal skin bacteria (2016)
Journal Article
Oates, A., & McBain, A. J. (2016). Growth of MRSA and Pseudomonas aeruginosa in a fine-celled foam model containing sessile commensal skin bacteria. Biofouling, 32(1), 25-33. https://doi.org/10.1080/08927014.2015.1117607

Sessile cultures of the skin bacteria Staphylococcus saprophyticus and Corynebacterium xerosis were grown using novel fine-celled foam substrata to test the outcome of challenge by methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa... Read More about Growth of MRSA and Pseudomonas aeruginosa in a fine-celled foam model containing sessile commensal skin bacteria.

Faucicola mancuniensis gen. nov., sp. nov., isolated from the human oropharynx (2014)
Journal Article
Humphreys, G. J., Oates, A., Ledder, R. G., & McBain, A. J. (2015). Faucicola mancuniensis gen. nov., sp. nov., isolated from the human oropharynx. International Journal of Systematic and Evolutionary Microbiology, 65(1), 11-14. https://doi.org/10.1099/ijs.0.066837-0

© 2015 IUMS. An aerobic, Gram-stain-negative, non-motile coccus, designated strain GVCNT2T, was isolated from the tonsils of a healthy adult female. Cells were oxidase- and catalase-positive, positive for the production of esterase (C4), esterase lip... Read More about Faucicola mancuniensis gen. nov., sp. nov., isolated from the human oropharynx.

The visualization of biofilms in chronic diabetic foot wounds using routine diagnostic microscopy methods (2014)
Journal Article
Oates, A., Bowling, F. L., Boulton, A. J. M., Bowler, P. G., Metcalf, D. G., & McBain, A. J. (2014). The visualization of biofilms in chronic diabetic foot wounds using routine diagnostic microscopy methods. Journal of Diabetes Research, 2014, Article 153586. https://doi.org/10.1155/2014/153586

Diabetic foot wounds are commonly colonised by taxonomically diverse microbial communities and may additionally be infected with specific pathogens. Since biofilms are demonstrably less susceptible to antimicrobial agents than are planktonic bacteria... Read More about The visualization of biofilms in chronic diabetic foot wounds using routine diagnostic microscopy methods.

Molecular and culture-based assessment of the microbial diversity of diabetic chronic foot wounds and contralateral skin sites (2012)
Journal Article
Oates, A., Bowling, F. L., Boulton, A. J. M., & McBain, A. J. (2012). Molecular and culture-based assessment of the microbial diversity of diabetic chronic foot wounds and contralateral skin sites. Journal of clinical microbiology, 50(7), 2263-2271. https://doi.org/10.1128/JCM.06599-11

Wound debridement samples and contralateral (healthy) skin swabs acquired from 26 patients attending a specialist foot clinic were analyzed by differential isolation and eubacterium-specific PCR-denaturing gradient gel electrophoresis (DGGE) in conju... Read More about Molecular and culture-based assessment of the microbial diversity of diabetic chronic foot wounds and contralateral skin sites.

Conformational studies of tylosin A, tylosin B, erythromycin B and erythromycin C and full assignments of tylosin A in CDCl3 and tylosin B in phosphate buffered D2O
Presentation / Conference Contribution
Arsic, B., Regan, . A., Morris, G., Oates, A., McBain, . A., & Barber, J. (2017, June). Conformational studies of tylosin A, tylosin B, erythromycin B and erythromycin C and full assignments of tylosin A in CDCl3 and tylosin B in phosphate buffered D2O. Poster presented at 1st RSC Anglo-Nordic Medicinal Chemistry Symposium, Copenhagen, Denmark