All Outputs (36)

Current Insights into Cellular Senescence and Myotoxicity Induced by Doxorubicin: The Role of Exercise and Growth Factors (2022)
Journal Article
Andreou, C., & Matsakas, A. (2022). Current Insights into Cellular Senescence and Myotoxicity Induced by Doxorubicin: The Role of Exercise and Growth Factors. International journal of sports medicine, 43(13), 1084-1096. https://doi.org/10.1055/a-1797-7622

Doxorubicin is an anti-neoplasmic drug that prevents DNA replication but induces senescence and cellular toxicity. Intensive research has focused on strategies to alleviate the doxorubicin-induced skeletal myotoxicity. The aim of the present review i... Read More about Current Insights into Cellular Senescence and Myotoxicity Induced by Doxorubicin: The Role of Exercise and Growth Factors.

Author Correction: Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (Scientific Reports, (2018), 8, 1, (9062), 10.1038/s41598-018-27429-7) (2021)
Journal Article
Paolini, A., Omairi, S., Mitchell, R., Vaughan, D., Matsakas, A., Vaiyapuri, S., Ricketts, T., Rubinsztein, D. C., & Patel, K. (2021). Author Correction: Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (Scientific Reports, (2018), 8, 1, (9062), 10.1038/s41598-018-27429-7). Scientific reports, 11(1), Article 24532. https://doi.org/10.1038/s41598-021-04140-8

The original version of this Article contained errors. In Figure 5, the distance that “leaky” images were taken from the damaged tissue was not consistent, and there was a partial overlap of the “leaky” and undamaged images for Figure 5D and 5J. In a... Read More about Author Correction: Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (Scientific Reports, (2018), 8, 1, (9062), 10.1038/s41598-018-27429-7).

Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs (2021)
Journal Article
Solagna, F., Tezze, C., Lindenmeyer, M. T., Lu, S., Wu, G., Liu, S., Zhao, Y., Mitchell, R., Meyer, C., Omairi, S., Kilic, T., Paolini, A., Ritvos, O., Pasternack, A., Matsakas, A., Kylies, D., zur Wiesch, J. S., Turner, J. E., Wanner, N., Nair, V., …Huber, T. B. (2021). Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. Journal of Clinical Investigation, 131(11), Article e135821. https://doi.org/10.1172/JCI135821

Skeletal muscle wasting is commonly associated with chronic kidney disease (CKD), resulting in increased morbidity and mortality. However, the link between kidney and muscle function remains poorly understood. Here, we took a complementary interorgan... Read More about Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs.

A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities (2021)
Journal Article
Vaughan, D., Mitchell, R., Kretz, O., Chambers, D., Lalowski, M., Amthor, H., Ritvos, O., Pasternack, A., Matsakas, A., Vaiyapuri, S., Huber, T. B., Denecke, B., Mukherjee, A., Widera, D., & Patel, K. (2021). A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities. Disease Models and Mechanisms, 14(2), Article dmm047555. https://doi.org/10.1242/dmm.047555

© 2021. Published by The Company of Biologists Ltd. Activin/myostatin signalling acts to induce skeletal muscle atrophy in adult mammals by inhibiting protein synthesis as well as promoting protein and organelle turnover. Numerous strategies have bee... Read More about A muscle growth-promoting treatment based on the attenuation of activin/myostatin signalling results in long-term testicular abnormalities.

Evaluating trastuzumab in the treatment of HER2 positive breast cancer (2020)
Journal Article
Jaques, R., Xu, S., & Matsakas, A. (2020). Evaluating trastuzumab in the treatment of HER2 positive breast cancer. Histology and Histopathology, 35(10), 1059-1075. https://doi.org/10.14670/HH-18-221

© 2020, Histology and Histopathology. All rights reserved. The transmembrane oncoprotein HER2 is encoded by ERBB2 gene and overexpressed in around 20% of invasive breast cancers. It can be specifically targeted by Trastuzumab (Herceptin®), a humanise... Read More about Evaluating trastuzumab in the treatment of HER2 positive breast cancer.

Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention (2020)
Journal Article
Vaughan, D., Kretz, O., Alqallaf, A., Mitchell, R., von der Heide, J., Vaiyapuri, S., Matsakas, A., Pasternack, A., Collins-Hooper, H., Ritvos, O., Ballesteros, R., Huber, T. B., Amthor, H., Mukherjee, A., & Patel, K. (in press). Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention. European Journal of Translational Myology, 30(2), 276-285. https://doi.org/10.4081/ejtm.0.8904

Duchenne Muscular Dystrophy is a devastating disease caused by the absence of a functional rod-shaped cytoplasmic protein called dystrophin. Several avenues are being developed aimed to restore dystrophin expression in boys affected by this X-linked... Read More about Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention.

Quantitative Redox Biology of Exercise (2020)
Journal Article
Nikolaidis, M. G., Margaritelis, N. V., & Matsakas, A. (2020). Quantitative Redox Biology of Exercise. International journal of sports medicine, 41(10), 633-645. https://doi.org/10.1055/a-1157-9043

© Georg Thieme Verlag KG Stuttgart · New York. Biology is rich in claims that reactive oxygen and nitrogen species are involved in every biological process and disease. However, many quantitative aspects of redox biology remain elusive. The important... Read More about Quantitative Redox Biology of Exercise.

Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development (2020)
Journal Article
Vaughan, D., Ritvos, O., Mitchell, R., Kretz, O., Lalowski, M., Amthor, H., Chambers, D., Matsakas, A., Pasternack, A., Collins-Hooper, H., Ballesteros, R., Huber, T. B., Denecke, B., Widera, D., Mukherjee, A., & Patel, K. (2020). Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development. European Journal of Translational Myology, 30(1), 62-78. https://doi.org/10.4081/ejtm.2019.8737

© 2020 PAGEPress Publications. All rights reserved. Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer c... Read More about Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development.

Inhibition of Activin/Myostatin signalling impairs mouse testis Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development (2020)
Journal Article
Vaughan, D., Ritvos, O., Mitchell, R., Kretz, O., Lalowski, M., Amthor, H., Chambers, D., Matsakas, A., Pasternack, A., Collins-Hooper, H., Ballesteros, R., Denecke, B., Widera, D., Mukherjee, A., Patel, K., & Huber, T. B. (online). Inhibition of Activin/Myostatin signalling impairs mouse testis Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development. Œconomia, 30(1), 1-17

Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer cachexia and sarcopenia. However there have been conc... Read More about Inhibition of Activin/Myostatin signalling impairs mouse testis Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development.

Optimising platelet secretomes to deliver robust tissue-specific regeneration (2019)
Journal Article
Scully, D., Sfyri, P., Wilkinson, H. N., Acebes‐Huerta, A., Verpoorten, S., Muñoz‐Turrillas, M. C., Parnell, A., Patel, K., Hardman, M. J., Gutiérrez, L., & Matsakas, A. (2020). Optimising platelet secretomes to deliver robust tissue-specific regeneration. Journal of tissue engineering and regenerative medicine, 14(1), 82-98. https://doi.org/10.1002/term.2965

Promoting cell proliferation is the cornerstone of most tissue regeneration therapies. As platelet-based applications promote cell division and can be customised for tissue-specific efficacy, this makes them strong candidates for developing novel reg... Read More about Optimising platelet secretomes to deliver robust tissue-specific regeneration.

The effect of high-fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice (2019)
Journal Article
Elashry, M. I., Eldaey, A., Glenske, K., Matsakas, A., Wenisch, S., Arnhold, S., & Patel, K. (2019). The effect of high-fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice. Journal of anatomy, 235(4), 825-835. https://doi.org/10.1111/joa.13025

Obesity is a worldwide nutritional disorder affecting body performance, including skeletal muscle. Inhibition of myostatin not only increases the muscle mass but also it reduces body fat accumulation. We examined the effect of high-fat diet on the ph... Read More about The effect of high-fat diet on the morphological properties of the forelimb musculature in hypertrophic myostatin null mice.

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling (2019)
Journal Article
Alyodawi, K., Vermeij, W., Omairi, S., Kretz, O., Hopkinson, M., Solagna, F., Joch, B., Brandt, R., Barnhoorn, S., Van Vliet, N., Ridwan, Y., Essers, J., Mitchell, R., Morash, T., Pasternack, A., Ritvos, O., Matsakas, A., Collins-Hooper, H., Huber, T., Hoeijmakers, J., & Patel, K. (2019). Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling. Journal of Cachexia, Sarcopenia and Muscle, 10(3), 662-686. https://doi.org/10.1002/jcsm.12404

© 2019 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders Background: One of the principles underpinning our understanding of ageing is t... Read More about Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling.

The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart (2019)
Journal Article
Onwuli, D. O., Samuel, S., Sfyri, P., Welham, K., Goddard, M., Abu-Omar, Y., Loubani, M., Rivero, F., Matsakas, A., Benoit, D. M., Wade, M., Greenman, J., & Beltran-Alvarez, P. (2019). The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart. International journal of cardiology, 282, 76-80. https://doi.org/10.1016/j.ijcard.2019.01.102

Background
The inhibitory subunit of cardiac troponin (cTnI) is a gold standard cardiac biomarker and also an essential protein in cardiomyocyte excitation-contraction coupling. The interactions of cTnI with other proteins are fine-tuned by post-tra... Read More about The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.

Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease (2019)
Journal Article
Williams, H. F., Mellows, B. A., Mitchell, R., Sfyri, P., Layfield, H. J., Salamah, M., Vaiyapuri, R., Collins-Hooper, H., Bicknell, A. B., Matsakas, A., Patel, K., & Vaiyapuri, S. (2019). Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease. PLoS Neglected Tropical Diseases, 13(1), Article e0007041. https://doi.org/10.1371/journal.pntd.0007041

Snakebite is a major neglected tropical health issue that affects over 5 million people worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year. Snakebite envenomation also causes innumerable morbidities specifically loss... Read More about Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease.

Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury (2018)
Journal Article
Scully, D., Sfyri, P., Verpoorten, S., Papadopoulos, P., Muñoz-Turrillas, M. C., Mitchell, R., Aburima, A., Patel, K., Gutiérrez, L., Naseem, K. M., & Matsakas, A. (2019). Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury. Acta Physiologica, 225(3), Article e13207. https://doi.org/10.1111/apha.13207

Aim

The use of platelets as biomaterials has gained intense research interest. However, the mechanisms regarding platelet‐mediated skeletal myogenesis remain to be established. The aim of this study was to determine the role of platelet releasate in... Read More about Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury.

Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity (2018)
Journal Article
Sfyri, P. P., Yuldasheva, N. Y., Tzimou, A., Giallourou, N., Crispi, V., Aburima, A., Beltran-Alvarez, P., Patel, K., Mougios, V., Swann, J. R., Kearney, M. T., & Matsakas, A. (2018). Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity. Free radical biology & medicine, 129, 504-519. https://doi.org/10.1016/j.freeradbiomed.2018.10.422

Obesity leading to hyperlipidaemia and atherosclerosis is recognised to induce morphological and metabolic changes in many tissues. However, hyperlipidaemia can occur in the absence of obesity. The impact of the latter scenario on skeletal muscle and... Read More about Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity.

Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (2018)
Journal Article
Paolini, A., Omairi, S., Mitchell, R., Vaughan, D., Matsakas, A., Vaiyapuri, S., Ricketts, T., Rubinsztein, D. C., & Patel, K. (in press). Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury. Scientific reports, 8(1), Article 9062. https://doi.org/10.1038/s41598-018-27429-7

Autophagy has been implicated as a major factor in the development of a number of diseases of skeletal muscle. However, its role in skeletal muscle homeostasis is still evolving. We examined skeletal muscle architecture in a mouse model, Atg16L1, whe... Read More about Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury.

Platelet biology in regenerative medicine of skeletal muscle (2018)
Journal Article
Scully, D., Naseem, K. M., & Matsakas, A. (2018). Platelet biology in regenerative medicine of skeletal muscle. Acta Physiologica, 223(3), Article e13071. https://doi.org/10.1111/apha.13071

Platelet‐based applications such as platelet‐rich plasma (PRP) and platelet releasate have gained unprecedented attention in regenerative medicine across a variety of tissues as of late. The rationale behind utilizing PRP originates in the delivery o... Read More about Platelet biology in regenerative medicine of skeletal muscle.

Duchenne muscular dystrophy: genome editing gives new hope for treatment (2018)
Journal Article
Crispi, V., & Matsakas, A. (2018). Duchenne muscular dystrophy: genome editing gives new hope for treatment. Postgraduate Medical Journal, 94(1111), 296-304. https://doi.org/10.1136/postgradmedj-2017-135377

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Duchenne muscular dystrophy (DMD) is a progressive wasting dis... Read More about Duchenne muscular dystrophy: genome editing gives new hope for treatment.

Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease (2017)
Journal Article
Sfyri, P., & Matsakas, A. (2017). Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease. Journal of Biomedical Science, 24(1), Article ARTN 42. https://doi.org/10.1186/s12929-017-0346-8

Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system. It also affects peripheral arteries with major implications for... Read More about Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease.