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The Application of Reversible Intramolecular Sulfonamide Ligation to Modulate Reactivity in Organometallic Ruthenium(II) Diamine Complexes (2020)
Journal Article
Kemp, S. A., Prior, T. J., Savoie, H., Boyle, R. W., & Murray, B. S. (2020). The Application of Reversible Intramolecular Sulfonamide Ligation to Modulate Reactivity in Organometallic Ruthenium(II) Diamine Complexes. Molecules, 25, https://doi.org/10.3390/molecules25020244

Metallation of biomacromolecular species forms the basis for the anticancer activity of many metallodrugs. A major limitation of these compounds is that their reactivity is indiscriminate and can, in principle, occur in healthy tissue as well as canc... Read More about The Application of Reversible Intramolecular Sulfonamide Ligation to Modulate Reactivity in Organometallic Ruthenium(II) Diamine Complexes.

Recent progress in the development of organometallics for the treatment of cancer (2019)
Journal Article
Murray, B. S., & Dyson, P. J. (2020). Recent progress in the development of organometallics for the treatment of cancer. Current opinion in chemical biology, 56, 28-34. https://doi.org/10.1016/j.cbpa.2019.11.001

From their early successes in medicine, organometallic compounds continue to attract interest as potential chemotherapeutics to treat a range of diseases. Here, we show from recent literature selected largely from the last two years that organometall... Read More about Recent progress in the development of organometallics for the treatment of cancer.

pH-dependent modulation of reactivity in Ruthenium(II) organometallics (2018)
Journal Article
Prior, T. J., Savoie, H., Boyle, R. W., & Murray, B. S. (2018). pH-dependent modulation of reactivity in Ruthenium(II) organometallics. Organometallics, 37(3), 294-297. https://doi.org/10.1021/acs.organomet.7b00868

The pH-dependent intramolecular chelation of a tethered sulfonamide ligand in ruthenium(II) arene complexes is demonstrated, a process shown to modulate metal-centered reactivity toward the model ligand guanosine 5′-monophosphate within the physiolog... Read More about pH-dependent modulation of reactivity in Ruthenium(II) organometallics.

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation (2017)
Journal Article
Davey, G. E., Dyson, P. J., Davey, C. A., Davey, G., Adhireksan, Z., Ma, Z., …Davey, C. (2017). Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation. Nature communications, 8(1), https://doi.org/10.1038/s41467-017-01680-4

© 2017 The Author(s). The 'acidic patch' is a highly electronegative cleft on the histone H2A-H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially the... Read More about Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation.

An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode (2016)
Journal Article
Ma, Z., Palermo, G., Adhireksan, Z., Murray, B. S., von Erlach, T., Dyson, P. J., …Davey, C. A. (2016). An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode. Angewandte Chemie, 128(26), 7567-7570. doi:10.1002/ange.201602145

Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions. Many different intercalator compounds have been studied because of their activity as mutagens or... Read More about An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode.

The development of RAPTA compounds for the treatment of tumors (2015)
Journal Article
Murray, B. S., Babak, M. V., Hartinger, C. G., & Dyson, P. J. (2016). The development of RAPTA compounds for the treatment of tumors. Coordination chemistry reviews, 306(P1), 86-114. https://doi.org/10.1016/j.ccr.2015.06.014

© 2015 Elsevier B.V. Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given toge... Read More about The development of RAPTA compounds for the treatment of tumors.

Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro (2014)
Journal Article
Murray, B. S., Crot, S., Siankevich, S., & Dyson, P. J. (2014). Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro. Inorganic chemistry, 53(17), 9315-9321. https://doi.org/10.1021/ic501438k

Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s). Toward this aim, we report the... Read More about Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro.

Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics (2014)
Journal Article
Murray, B. S., Menin, L., Scopelliti, R., & Dyson, P. J. (2014). Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics. Chemical science, 5(6), 2536-2545. https://doi.org/10.1039/c4sc00116h

Dinuclear metal complexes have emerged as a promising class of biologically active compounds which possess unique anticancer activity. Here, we describe a novel series of arene-linked dinuclear organometallic Ru(II) complexes, where the relative conf... Read More about Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics.