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pH-dependent modulation of reactivity in Ruthenium(II) organometallics (2018)
Journal Article
Prior, T. J., Savoie, H., Boyle, R. W., & Murray, B. S. (2018). pH-dependent modulation of reactivity in Ruthenium(II) organometallics. Organometallics, 37(3), 294-297. https://doi.org/10.1021/acs.organomet.7b00868

The pH-dependent intramolecular chelation of a tethered sulfonamide ligand in ruthenium(II) arene complexes is demonstrated, a process shown to modulate metal-centered reactivity toward the model ligand guanosine 5′-monophosphate within the physiolog... Read More

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation (2017)
Journal Article
Davey, G. E., Dyson, P. J., Davey, C. A., Davey, G., Adhireksan, Z., Ma, Z., …Davey, C. (2017). Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation. Nature communications, 8(1), https://doi.org/10.1038/s41467-017-01680-4

© 2017 The Author(s). The 'acidic patch' is a highly electronegative cleft on the histone H2A-H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially the... Read More

An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode (2016)
Journal Article
Ma, Z., Palermo, G., Adhireksan, Z., Murray, B. S., von Erlach, T., Dyson, P. J., …Davey, C. A. (2016). An organometallic compound which exhibits a DNA topology-dependent one-stranded intercalation mode. Angewandte Chemie, 128(26), 7567-7570. doi:10.1002/ange.201602145

Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions. Many different intercalator compounds have been studied because of their activity as mutagens or... Read More

The development of RAPTA compounds for the treatment of tumors (2015)
Journal Article
Murray, B. S., Babak, M. V., Hartinger, C. G., & Dyson, P. J. (2016). The development of RAPTA compounds for the treatment of tumors. Coordination chemistry reviews, 306(P1), 86-114. https://doi.org/10.1016/j.ccr.2015.06.014

© 2015 Elsevier B.V. Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given toge... Read More

Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro (2014)
Journal Article
Murray, B. S., Crot, S., Siankevich, S., & Dyson, P. J. (2014). Potential of cycloaddition reactions to generate cytotoxic metal drugs in vitro. Inorganic chemistry, 53(17), 9315-9321. https://doi.org/10.1021/ic501438k

Severe general toxicity issues blight many chemotherapeutics utilized in the treatment of cancers, resulting in the need for more selective drugs able to exert their biological activity at only the required location(s). Toward this aim, we report the... Read More

Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics (2014)
Journal Article
Murray, B. S., Menin, L., Scopelliti, R., & Dyson, P. J. (2014). Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics. Chemical science, 5(6), 2536-2545. https://doi.org/10.1039/c4sc00116h

Dinuclear metal complexes have emerged as a promising class of biologically active compounds which possess unique anticancer activity. Here, we describe a novel series of arene-linked dinuclear organometallic Ru(II) complexes, where the relative conf... Read More