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Development of a portable microfluidic system for monitoring ions river water (2012)
Thesis
Ong, C. K. (2012). Development of a portable microfluidic system for monitoring ions river water. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4213552

Nowadays, there is a growing demand for predictive models that are capable of predicting future trends in water quality which is constantly being affected by environmental changes and industrialisation. The presence of various nutrient contaminants i... Read More about Development of a portable microfluidic system for monitoring ions river water.

Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification (2011)
Journal Article
Hardege, J., Rotchell, J., Terschak, J., & Greenway, G. (2011). Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification. Trends in Analytical Chemistry, 30(8), 1320-1326. https://doi.org/10.1016/j.trac.2011.07.004

Changing ocean-carbonate chemistry caused by oceanic uptake of anthropogenic atmospheric carbon dioxide leads to the formation of carbonic acid, thus lowering the pH of the sea with predictions of a decrease from current levels at 8.15 to 7.82 by the... Read More about Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification.

Biological responses to contaminants in the Humber Estuary: disentangling complex relationships (2011)
Journal Article
García-Alonso, J., Greenway, G., Munshi, A., Gómez, J., Mazik, K., Knight, A. W., Hardege, J., & Elliott, M. (2011). Biological responses to contaminants in the Humber Estuary: disentangling complex relationships. Marine environmental research, 71(4), 295-303. https://doi.org/10.1016/j.marenvres.2011.02.004

Due to the ecological importance of estuaries, it is necessary to understand the biological effects that potentially toxic contaminants induce in bioindicator species. A key aspect is whether effects at lower levels of biological organisation transfe... Read More about Biological responses to contaminants in the Humber Estuary: disentangling complex relationships.

Development of a real-world direct interface for integrated DNA extraction and amplification in a microfluidic device (2010)
Journal Article
Shaw, K. J., Joyce, D., Docker, P. T., Dyer, C. E., Greenway, G. M., Greenman, J., & Haswell, S. J. (2011). Development of a real-world direct interface for integrated DNA extraction and amplification in a microfluidic device. Lab on a chip, 11(3), 443-448. https://doi.org/10.1039/c0lc00346h

Integrated DNA extraction and amplification have been carried out in a microfluidic device using electro-osmotic pumping (EOP) for fluidic control. All the necessary reagents for performing both DNA extraction and polymerase chain reaction (PCR) ampl... Read More about Development of a real-world direct interface for integrated DNA extraction and amplification in a microfluidic device.

Design and synthesis of polymetallic nanoparticles and their catalytic applications (2010)
Journal Article
Ibhadon, A. O., Yue, Y., & Greenway, G. M. (2011). Design and synthesis of polymetallic nanoparticles and their catalytic applications. Materials letters, 65(4), 602-605. https://doi.org/10.1016/j.matlet.2010.11.011

High-temperature hydrogen reduction reactions enable the synthesis and processing of binary metal oxide composite nanoparticles starting from titanium, ruthenium, and silicon, while the use of a surface modifier and an organic surfactant enables the... Read More about Design and synthesis of polymetallic nanoparticles and their catalytic applications.

Microfluidic synthesis of silica nanoparticles using polyethylenimine polymers (2010)
Journal Article
He, P., Greenway, G., & Haswell, S. J. (2011). Microfluidic synthesis of silica nanoparticles using polyethylenimine polymers. Chemical Engineering Journal, 167(2-3), 694-699. https://doi.org/10.1016/j.cej.2010.08.079

A microfluidic reactor system for the synthesis of silica nanoparticles has been developed from commercially available ETFE tubing (0.17-1.0 mm diameter) connected in series to support the hydrolysis, nucleation and particle growth based on a sol-gel... Read More about Microfluidic synthesis of silica nanoparticles using polyethylenimine polymers.

Microscreening toxicity system based on living magnetic yeast and gradient chips (2010)
Journal Article
García-Alonso, J., Fakhrullin, R. F., Paunov, V. N., Shen, Z., Hardege, J. D., Pamme, N., Haswell, S. J., & Greenway, G. M. (2011). Microscreening toxicity system based on living magnetic yeast and gradient chips. Analytical and Bioanalytical Chemistry, 400(4), 1009-1013. https://doi.org/10.1007/s00216-010-4241-3

There is an increasing demand for easy and cost-effective methods to screen the toxicological impact of the growing number of chemical mixtures being generated by industry. Such a screening method has been developed using viable, genetically modified... Read More about Microscreening toxicity system based on living magnetic yeast and gradient chips.

Development of an electro-kinetically driven integrated DNA profile separation and detection system (2010)
Thesis
Oakley, J. A. (2010). Development of an electro-kinetically driven integrated DNA profile separation and detection system. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4212978

Described in current literature is the methodology of different aspects of creating a DNA profile which has been successfully performed within a micro-fluidic environment; however integration of each of the different procedures onto a single device h... Read More about Development of an electro-kinetically driven integrated DNA profile separation and detection system.

A microflow chemiluminescence system for determination of chloramphenicol in honey with preconcentration using a molecularly imprinted polymer (2010)
Journal Article
Thongchai, W., Liawruangath, B., Liawruangrath, S., & Greenway, G. M. (2010). A microflow chemiluminescence system for determination of chloramphenicol in honey with preconcentration using a molecularly imprinted polymer. Talanta, 82(2), 560-566. https://doi.org/10.1016/j.talanta.2010.05.007

A novel chemiluminescence (CL) microfluidic system incorporating a molecularly imprinted polymer (MIP) preconcentration step was used for the determination of chloramphenicol in honey samples. The MIP was prepared by using chloramphenicol as the temp... Read More about A microflow chemiluminescence system for determination of chloramphenicol in honey with preconcentration using a molecularly imprinted polymer.

Rapid PCR amplification using a microfluidic device with integrated microwave heating and air impingement cooling (2010)
Journal Article
Shaw, K. J., Docker, P. T., Yelland, J. V., Dyer, C. E., Greenman, J., Greenway, G. M., & Haswell, S. J. (2010). Rapid PCR amplification using a microfluidic device with integrated microwave heating and air impingement cooling. Lab on a chip, 10(13), 1725-1728. https://doi.org/10.1039/c000357n

A microwave heating system is described for performing polymerase chain reaction (PCR) in a microfluidic device. The heating system, in combination with air impingement cooling, provided rapid thermal cycling with heating and cooling rates of up to 6... Read More about Rapid PCR amplification using a microfluidic device with integrated microwave heating and air impingement cooling.

The development and evaluation of a conducting matrix for the electrochemical regeneration of the immobilised co-factor NAD(H) under continuous flow (2010)
Journal Article
Ngamsom, B., Hickey, A. M., Greenway, G. M., Littlechild, J. A., McCreedy, T., Watts, P., & Wiles, C. (2010). The development and evaluation of a conducting matrix for the electrochemical regeneration of the immobilised co-factor NAD(H) under continuous flow. Organic & biomolecular chemistry, 8(10), 2419-2424. https://doi.org/10.1039/b924100k

Through the preparation of a novel controlled pore glass-poly(pyrrole) material we have developed a conducting support that is not only suitable for the co-immobilisation of enzymes and co-factors, but also enables the facile electrochemical regenera... Read More about The development and evaluation of a conducting matrix for the electrochemical regeneration of the immobilised co-factor NAD(H) under continuous flow.

Comparative PBT screening using (Q)SAR tools within REACH legislation (2009)
Journal Article
Zachary, M., & Greenway, G. M. (2009). Comparative PBT screening using (Q)SAR tools within REACH legislation. SAR and QSAR in Environmental Research, 20(1-2), 145-157. https://doi.org/10.1080/10629360902724143

Small to medium sized enterprises (SMEs) in the EU are facing challenges due to the introduction of new legislation designed to protect consumers and the environment, REACH (Registration, Evaluation, Authorisation and Restriction of CHemicals). There... Read More about Comparative PBT screening using (Q)SAR tools within REACH legislation.

Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme (2009)
Journal Article
Ngamsom, B., Hickey, A. M., Greenway, G. M., Littlechild, J. A., Watts, P., & Wiles, C. (2010). Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme. Journal of Molecular Catalysis B: Enzymatic, 63(1-2), 81-86. https://doi.org/10.1016/j.molcatb.2009.12.013

Micro-reactors containing a monolith-immobilised thermophilic l-aminoacylase, from Thermococcus litoralis, have been developed for use in biotransformation reactions and a study has been carried out to investigate the stereospecificity and stability... Read More about Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme.

Development of a monolith based immobilized lipase micro-reactor for biocatalytic reactions in a biphasic mobile system (2009)
Journal Article
He, P., Greenway, G., & Haswell, S. J. (2010). Development of a monolith based immobilized lipase micro-reactor for biocatalytic reactions in a biphasic mobile system. Process Biochemistry, 45(4), 593-597. https://doi.org/10.1016/j.procbio.2009.12.008

This paper reports a simple method for producing macroporous silica-monoliths with controllable porosity that can be used for the immobilization of lipases to generate an active and stable micro-reactor for biocatalysis. A range of commercially avail... Read More about Development of a monolith based immobilized lipase micro-reactor for biocatalytic reactions in a biphasic mobile system.

Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection (2009)
Journal Article
He, P., Davies, J., Greenway, G., & Haswell, S. J. (2010). Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection. Analytica Chimica Acta, 659(1-2), 9-14. https://doi.org/10.1016/j.aca.2009.11.052

This paper reports a simple μ-FIA based method for the rapid evaluation of acetylcholinesterase inhibition based on bienzymes immobilized monolith micro-reactor, with integrated electrochemical detection. The monolith was prepared inside a micro-flui... Read More about Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection.

PDMS Microfluidic Device with an Integrated Optical Sensor for Determination of Zinc (II) in Pharmaceuticals: Toward the Production of Miniaturized Green Chemistry Analytical Systems (2009)
Journal Article
AlSuhaimi, A., Greenway, G. M., McCreedy, T., & Youngvises, N. (in press). PDMS Microfluidic Device with an Integrated Optical Sensor for Determination of Zinc (II) in Pharmaceuticals: Toward the Production of Miniaturized Green Chemistry Analytical Systems. Spectroscopy letters, 42(6-7), 370-375. https://doi.org/10.1080/00387010903187260

A simple miniaturized system was fabricated in general laboratory from polydimethylsiloxane (PDMS) according to a prototype casting and molding process permitting the construction of three-dimensional (3D) microchannel (100 mu m i.d.) with T-type net... Read More about PDMS Microfluidic Device with an Integrated Optical Sensor for Determination of Zinc (II) in Pharmaceuticals: Toward the Production of Miniaturized Green Chemistry Analytical Systems.

Development of environmental water monitors based on hydrostatic and flourescence detection techniques (2009)
Thesis
Scott, R. M. (2009). Development of environmental water monitors based on hydrostatic and flourescence detection techniques. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4209333

The research for this thesis led to the development of two environmental detectors, whose function was to identify predetermined threshold levels of the analyte. The research centred onto two types of analyte; immiscible and dissolved, both occurring... Read More about Development of environmental water monitors based on hydrostatic and flourescence detection techniques.

Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser (2009)
Journal Article
Oakley, J. A., Robinson, S., Dyer, C. E., Greenman, J., Greenway, G. M., & Haswell, S. J. (2009). Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser. Analytica Chimica Acta, 652(1-2), 239-244. https://doi.org/10.1016/j.aca.2009.07.063

An integrated gel supported micro-fluidic system is reported, in which PCR products can be efficiently injected into a capillary electrophoresis device. The gel supported system is designed to provide greater stability to reagents during long periods... Read More about Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser.

Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics (2009)
Journal Article
Greenway, G., Haswell, S. J., & He, P. (2010). Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics. Microfluidics and Nanofluidics, 8(5), 565-573. https://doi.org/10.1007/s10404-009-0476-8

This paper describes a simple and efficient method for producing an on-chip enzyme immobilized monolith micro-reactor that integrates a microfluidic electrochemical cell for rapid characterization of enzymatic kinetics. The monolith was generated usi... Read More about Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics.